| Saturday 10/06/2023 |
| 15:00 | Registration |
|
| Opening Session |
|
| 17:30 | Opening of the Symposium and Welcome address |
Prof. Daniel HARKI
(UNIVERSITY OF MINNESOTA, Minneapolis, MN, United States) |
| 17:45 | PL01- Medicinal Chemistry of the Future: Trends, Targets and Technologies |
Dr Klaus URBAHNS
(EMD SERONO, Billerican, MA, United States) |
| 18:30 | Welcome Reception |
|
| Sunday 11/06/2023 |
| 08:00 | Registration |
|
| Session 1 - Chemical Modulation of RNA |
|
| Session chair |
Dr Darby SCHMIDT
(SONATA THERAPEUTICS, Cambridge, MA, United States) |
| 09:00 | IL01 - Modulating the Conformation and Function of Disease-Relevant RNA with Small Molecules |
Prof. Amanda HARGROVE
(DUKE UNIVERSITY, Durham, NC, United States) |
| 09:30 | IL02 - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies |
Dr Maria DUCA
(UNIVERSITY OF CÔTE D'AZUR, Nice, France) |
| 10:00 | IL03 - Discovery and Development of Selective Splicing Modifiers as Therapeutics |
Dr Matthew WOLL
(PTC THERAPEUTICS, South Plainfield, NJ, United States) |
| 10:15 | IL04 - Small Molecules Targeting RNA - a Safety Perspective |
Dr Helen Louise LIGHTFOOT
(F. HOFFMANN-LA ROCHE AG, BASEL, Switzerland) |
| 10:30 | Coffee break & Exhibition |
|
| Session 2 - Advances in Targeted Protein Degradation |
|
| Session chair |
Prof. Terry MOORE
(UNIVERSITY OF ILLINOIS, Chicago, IL, United States) |
| 11:00 | IL05 - Ligand Directed Degradation: from Proof-of-Concept Degradation to Clinical Studies |
Dr Deborah MORTENSEN
(BRISTOL MYERS SQUIBB, San Diego, CA, United States) |
| 11:30 | IL06 - Chemical Approaches to Edit Post-Translational Modification In Cells |
Prof. Christina WOO
(HARVARD UNIVERSITY, Cambridge, MA, United States) |
| 12:00 | OC01 - Treatment of Pediatric AML Via Protac-Mediated Degration of CDK9 |
Ms Alexandria CHAN
(UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY, Baltimore, United States) |
| 12:15 | OC02 - Targeting Progerin Degradation as a New Therapeutic Approach for Treating Progeria |
Prof. Silvia ORTEGA-GUTIERREZ
(COMPLUTENSE UNIVERSITY, Madrid, Spain) |
| 12:30 | Lunch & Exhibition |
|
| 12:45 | Company Workshop by Pelago Bioscience: CETSA® Enabled Drug Discovery: An Applied Workshop on Target Identification/Validation and Target Engagement-Driven Lead Generation and Optimization |
Dr Fredrik RAHM (PELAGO BIOSCIENCE, Solna, Sweden)
Dr Stina LUNDGREN (PELAGO BIOSCIENCE, Solna, Sweden) |
| Session 3 - Proximity-inducing Molecules and their Therapeutic Applications |
|
| Session chair |
Dr Amit CHOUDHARY
(THE BROAD INSTITUTE, Cambridge, MA, United States) |
| 14:00 | IL07 -Chemoproteomic-Enabled Development of Proximity-Inducing Molecules |
Dr Christopher PARKER
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States) |
| 14:30 | IL08 - An Intramolecular Bivalent Degrader Glues an Intrinsic BRD4-DCAF16 Interaction |
Prof. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
| 15:00 | OC03 - Discovery of MRT-2359, an Orally Bioavailable GSPT1 Molecular Glue Degrader, for MYC-Driven Cancers
|
Dr Bernhard FASCHING
(MONTE ROSA THERAPEUTICS, Basel, Switzerland) |
| 15:15 | OC04 - Integrated Platform Approach for Molecular Degrader Discovery in Proxidrugs
|
Dr Johanna HUCHTING
(FRAUNHOFER INSTITUTE FOR TRANSLATIONAL MEDICINE AND PHARMACOLOGY, Hamburg, Germany) |
| 15:30 | Coffee break & Exhibition |
|
| 16:00 | PL02 - RIPTACs: A New ‘Hold and Kill’-based Therapeutic Modality
|
Prof. Craig CREWS
(YALE UNIVERSITY, New Haven, CT, United States) |
| 16:45 | Poster session 1 (odd numbers) |
|
| 18:00 | End of the scientific programme |
|
| 18:10 | City Tour |
|
| Monday 12/06/2023 |
| 08:00 | ACMEDI-YMCC | EFMC-YSN Programme for Early Career Researchers |
|
| Chair |
Dr Melissa GRENIER-DAVIES
(GLAXOSMITHKLINE, Cambridge, MA, United States) |
| 08:00 | Panel Discussion - "Landing a Job in Industry" |
Dr Chris DE GRAAF (SOSEI HEPTARES, Cambridge, United Kingdom)
Dr Abdellatif EL MARROUNI (MERCK & CO., West Point, United States)
(SANOFI-AVENTIS DEUTSCHLAND GMBH)
Dr Malin LEMURELL (ASTRAZENECA, Gothenburg, Sweden)
Dr Darby SCHMIDT (SONATA THERAPEUTICS, Cambridge, MA, United States) |
| Session 4 - Drug Targets in GPCR Signaling |
|
| Session chair |
Prof. György KESERU
(HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary) |
| 09:00 | IL09 - New Hot Targets? Medicinal Chemistry of G Protein-Coupled Receptors Involved in Immunity and Cancer |
Prof. Christa MÜLLER
(UNIVERSITY OF BONN, Bonn, Germany) |
| 09:30 | IL10 - Frontier SBDD across the Orthosteric and Allosteric GPCRome |
Dr Chris DE GRAAF
(SOSEI HEPTARES, Cambridge, United Kingdom) |
| 10:00 | OC05 - Best-In-Class Orally Bioavailable CXCR4 Antagonists to Treat Renal Cell Carcinoma |
Dr Eric MILLER
(EMORY UNIVERSITY SCHOOL OF MEDICINE, Atlanta, United States) |
| 10:15 | OC06 - Targeting Sodium Binding Pocket in Mu Opioid Receptor to Design Safer Analgesics |
Dr Susruta MAJUMDAR
(UHSP & WASHINGTON UNIVERSITY, Saint Louis, United States) |
| 10:30 | Coffee break & Exhibition |
|
| Session 5 - Organic Synthesis Impacting Medicinal Chemistry & Chemical Biology |
|
| Session chair |
Prof. Rui MOREIRA
(UNIVERSITY OF LISBON, Lisbon, Portugal) |
| 11:00 | IL11 - Photocatalysis in the Pharmaceutical Industry: Synthesis under a New Light |
Dr Giulia BERGONZINI
(ASTRAZENECA, Gothenburg, Sweden) |
| 11:30 | IL12 - HTE Chemistry to Accelerate Medicinal Chemistry Programs |
Dr Fabio LIMA
(NOVARTIS, Basel, Switzerland) |
| 12:00 | OC07 - New Precision Anti-TB Agents by Allosteric Inhibition of Glutamate-5-Kinase Enzyme |
Prof. Concepcion GONZALEZ-BELLO
(UNIVERSIDADE DE SANTIAGO DE COMPOSTELA - CIQUS, santiago de compostela, Spain) |
| 12:15 | OC08 - Impact of gem-Difluoromethylene Group on Physicochemical Properties in Medchem-Relevant Building Blocks |
Dr Sergey RYABUKHIN
(ENAMINE LTD, Kyiv, Ukraine) |
| 12:30 | Lunch & Exhibition |
|
| 12:45 | Company Workshop by Schrödinger: Augmenting Medicinal Chemistry with Digital Chemistry: A Lead Optimization Design Challenge for D-Amino Acid Oxidase Inhibitors |
Mr Wade MILLER
(SCHRÖDINGER, Cambridge, United States) |
| Session 6 - Enabling Chemistries for Chemical Biology Research |
|
| Session chair |
Prof. Daniel HARKI
(UNIVERSITY OF MINNESOTA, Minneapolis, MN, United States) |
| 14:00 | IL13 - Chemical Probes Enabling Drug Target Discovery and Validation |
Prof. Edward TATE
(IMPERIAL COLLEGE LONDON, London, United Kingdom) |
| 14:30 | IL14 - Generating Stem-Like T Cells with Small-Molecule Modulators for Cancer Immunotherapy |
Prof. Peng WU
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States) |
| 15:00 | OC09 - Targeting Receptor Complexes with Therapeutic Peptides |
Prof. Kristian STROMGAARD
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark) |
| 15:15 | OC10 - Azetidin-2-Ones as Quenched Activity-Based Probes to Profile Human Neutrophil Elastase in Proteomes |
Ms Rita FÉLIX
(IMED.ULISBOA - RESEARCH INSTITUTE FOR MEDICINES, Lisbon, Portugal) |
| 15:30 | Coffee break & Exhibition |
|
| 16:00 | PL03 -Carbohydrates in Health and Disease |
Prof. Laura KIESSLING
(MIT, Cambridge, MA, United States) |
| 16:45 | Poster session 2 (even numbers) |
|
| 18:00 | End of the scientific programme |
|
| 20:00 | Banquet (optional) |
|
| Tuesday 13/06/2023 |
| Session 7 - A Focus on Early Career Investigators |
|
| Session chair |
Dr Melissa GRENIER-DAVIES
(GLAXOSMITHKLINE, Cambridge, MA, United States) |
| 09:00 | IL15 - E3 Ligase Ligand Discovery for TPD |
Dr Benika PINCH
(NOVARTIS, Cambridge, MA, United States) |
| 09:15 | IL16 - Chemical Approaches to Enhance Cellular Immunotherapies |
Dr Mark P. FARRELL
(UNIVERSITY OF KANSAS, Lawrence, KS, United States) |
| 09:30 | IL17 - Machine Learning Tools to Accelerate Chemical Biology Studies |
Dr Tiago RODRIGUES
(UNIVERSITY OF LISBON, Lisbon, Portugal) |
| 09:45 | OC11 - Chemical Probes for RHO GEF/GTPase Complexes |
Ms Mia CALLENS
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 10:00 | OC12 - Potent Targeted Activator of Cell Kill Molecules Selectively Eliminate HIV Infected Cells |
Dr Abdellatif EL MARROUNI
(MERCK & CO., West Point, United States) |
| 10:15 | OC13 - Borrowing Transcriptional Kinases to Activate Apoptosis Using Chemically Induced Proximity |
Dr Roman SAROTT
(STANFORD UNIVERSITY, Menlo Park, United States) |
| 10:30 | Coffee break & Exhibition |
|
| Session 8 - Approaches to Identify and Target Cryptic and Allosteric Pocket |
|
| Session chair |
Dr Malin LEMURELL
(ASTRAZENECA, Gothenburg, Sweden) |
| 11:00 | IL18 - A Computation-First Approach to Drug Challenging Disease Targets |
Dr Woody SHERMAN
(PSIVANT THERAPEUTICS, Boston, MA, United States) |
| 11:30 | IL19 - X-ray Crystallographic Fragment Screening for the Identification of Allosteric Binding Sites |
Dr Andrew WOODHEAD
(ASTEX THERAPEUTICS, Cambridge , United Kingdom) |
| 12:00 | IL20 - Exploiting Allostery for Computer-Aided Drug Design of Oncogenes |
Dr Zoe COURNIA
(BIOMEDICAL RESEARCH FOUNDATION ACADEMY OF ATHENS, Athens, Greece) |
| 12:30 | OC14 - Structure-Based Drug Discovery and Umbrella Sampling Simulations Identify Novel Potent Troponin Calcium Sensitizers and Elucidate their Function |
Prof. Steffen LINDERT
(OSU, Columbus, United States) |
| 12:45 | Lunch & Exhibition |
|
| 13:00 | Company Workshop by CAS: The Evolution of Science at CAS: Connections Between Multi-disciplinary Data and Capabilities |
Mrs Vee LINDSAY (CAS, Columbus, United States)
Dr Angela ZHOU (CAS, Columbus, United States) |
| Session 9 - Getting Out of the Starting Block: New Hit Finding and Chemotype Advancement Methods |
|
| Session chair |
Dr Carolyn DZIERBA
(BRISTOL-MYERS SQUIBB, Cambridge, MA, United States) |
| 14:00 | IL21 - RAPID – a Next-Generation Chemoproteomics Technology Enabling the Discovery of Reversible Binders to Pre-specified Targets in Living Cells |
Dr Justin RETTENMAIER
(JNANA THERAPEUTICS, Boston, MA, United States) |
| 14:30 | IL22 - Covalent Fragment-Based Drug Discovery |
Dr Daniel ERLANSON
(FRONTIER MEDICINES, South San Francisco, CA, United States) |
| 15:00 | IL23 - Large-scale in Silico Fragment Screening of ~200 Million Fragments Based on Absolute Free Energy Perturbation |
Dr Eric THERRIEN
(SCHRODINGER, New York, NY, United States) |
| 15:15 | OC15 - Small Molecule Drug Discovery with Peptide-Encoded Libraries |
Dr Nathalie GROB
(MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States) |
| 16:00 | Closing Ceremony & Poster Prizes Ceremony |
|
| 16:30 | End of the Symposium |
|
| 19:10 | Boston Red Sox's game (optional) |
|
