ACSMEDI-EFMC Medicinal Chemistry Frontiers 2023

Confirmed Speakers


Plenary Speakers

PL02 - RIPTACs: A New ‘Hold and Kill’-based Therapeutic Modality
Prof. Craig CREWSProf. Craig CREWS
(YALE UNIVERSITY, New Haven, CT, United States)

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PL03 -Carbohydrates in Health and Disease
Prof. Laura KIESSLINGProf. Laura KIESSLING
(MIT, Cambridge, MA, United States)

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PL01- Medicinal Chemistry of the Future: Trends, Targets and Technologies
Dr Klaus URBAHNSDr Klaus URBAHNS
(EMD SERONO, Billerican, MA, United States)

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Invited Speakers

IL11 - Photocatalysis in the Pharmaceutical Industry: Synthesis under a New Light
Dr Giulia BERGONZINIDr Giulia BERGONZINI
(ASTRAZENECA, Gothenburg, Sweden)

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IL08 - An Intramolecular Bivalent Degrader Glues an Intrinsic BRD4-DCAF16 Interaction
Prof. Alessio CIULLIProf. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)

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IL20 - Exploiting Allostery for Computer-Aided Drug Design of Oncogenes
Dr Zoe COURNIADr Zoe COURNIA
(BIOMEDICAL RESEARCH FOUNDATION ACADEMY OF ATHENS, Athens, Greece)

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IL10 - Frontier SBDD across the Orthosteric and Allosteric GPCRome
Dr Chris DE GRAAFDr Chris DE GRAAF
(SOSEI HEPTARES, Cambridge, United Kingdom)

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IL02 - Targeting Non-Coding RNAs Using Synthetic Small Molecules: Original Targets for Innovative Therapies
Dr Maria DUCADr Maria DUCA
(UNIVERSITY OF CÔTE D'AZUR, Nice, France)

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IL22 - Covalent Fragment-Based Drug Discovery
Dr Daniel ERLANSONDr Daniel ERLANSON
(FRONTIER MEDICINES, South San Francisco, CA, United States)

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IL16 - Chemical Approaches to Enhance Cellular Immunotherapies
Dr Mark P. FARRELLDr Mark P. FARRELL
(UNIVERSITY OF KANSAS, Lawrence, KS, United States)
IL01 - Modulating the Conformation and Function of Disease-Relevant RNA with Small Molecules
Prof. Amanda HARGROVEProf. Amanda HARGROVE
(DUKE UNIVERSITY, Durham, NC, United States)

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IL04 - Small Molecules Targeting RNA - a Safety Perspective
Dr Helen Louise LIGHTFOOTDr Helen Louise LIGHTFOOT
(F. HOFFMANN-LA ROCHE AG, BASEL, Switzerland)

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IL12 - HTE Chemistry to Accelerate Medicinal Chemistry Programs
Dr Fabio LIMADr Fabio LIMA
(NOVARTIS, Basel, Switzerland)

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IL05 - Ligand Directed Degradation: from Proof-of-Concept Degradation to Clinical Studies
Dr Deborah MORTENSENDr Deborah MORTENSEN
(BRISTOL MYERS SQUIBB, San Diego, CA, United States)

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IL09 - New Hot Targets? Medicinal Chemistry of G Protein-Coupled Receptors Involved in Immunity and Cancer
Prof. Christa MÜLLERProf. Christa MÜLLER
(UNIVERSITY OF BONN, Bonn, Germany)

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IL07 -Chemoproteomic-Enabled Development of Proximity-Inducing Molecules
Dr Christopher PARKERDr Christopher PARKER
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States)

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IL15 - E3 Ligase Ligand Discovery for TPD
Dr Benika PINCHDr Benika PINCH
(NOVARTIS, Cambridge, MA, United States)

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IL21 - RAPID – a Next-Generation Chemoproteomics Technology Enabling the Discovery of Reversible Binders to Pre-specified Targets in Living Cells
Dr Justin RETTENMAIERDr Justin RETTENMAIER
(JNANA THERAPEUTICS, Boston, MA, United States)

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IL17 - Machine Learning Tools to Accelerate Chemical Biology Studies
Dr Tiago RODRIGUESDr Tiago RODRIGUES
(UNIVERSITY OF LISBON, Lisbon, Portugal)

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IL18 - A Computation-First Approach to Drug Challenging Disease Targets
Dr Woody SHERMANDr Woody SHERMAN
(PSIVANT THERAPEUTICS, Boston, MA, United States)

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IL13 - Chemical Probes Enabling Drug Target Discovery and Validation
Prof. Edward TATEProf. Edward TATE
(IMPERIAL COLLEGE LONDON, London, United Kingdom)
IL23 - Large-scale in Silico Fragment Screening of ~200 Million Fragments Based on Absolute Free Energy Perturbation
Dr Eric THERRIENDr Eric THERRIEN
(SCHRODINGER, New York, NY, United States)

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IL03 - Discovery and Development of Selective Splicing Modifiers as Therapeutics
Dr Matthew WOLLDr Matthew WOLL
(PTC THERAPEUTICS, South Plainfield, NJ, United States)

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IL06 - Chemical Approaches to Edit Post-Translational Modification In Cells
Prof. Christina WOOProf. Christina WOO
(HARVARD UNIVERSITY, Cambridge, MA, United States)

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IL19 - X-ray Crystallographic Fragment Screening for the Identification of Allosteric Binding Sites
Dr Andrew WOODHEADDr Andrew WOODHEAD
(ASTEX THERAPEUTICS, Cambridge , United Kingdom)

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IL14 - Generating Stem-Like T Cells with Small-Molecule Modulators for Cancer Immunotherapy
Prof. Peng WUProf. Peng WU
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA, United States)

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Oral Communications

OC11 - Chemical Probes for RHO GEF/GTPase Complexes
Ms Mia CALLENSMs Mia CALLENS
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)

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OC01 - Treatment of Pediatric AML Via Protac-Mediated Degration of CDK9
Ms Alexandria CHANMs Alexandria CHAN
(UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY, Baltimore, United States)

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OC12 - Potent Targeted Activator of Cell Kill Molecules Selectively Eliminate HIV Infected Cells
Dr Abdellatif  EL MARROUNIDr Abdellatif EL MARROUNI
(MERCK & CO., West Point, United States)
OC03 - Discovery of MRT-2359, an Orally Bioavailable GSPT1 Molecular Glue Degrader, for MYC-Driven Cancers
Dr Bernhard FASCHINGDr Bernhard FASCHING
(MONTE ROSA THERAPEUTICS, Basel, Switzerland)
OC10 - Azetidin-2-Ones as Quenched Activity-Based Probes to Profile Human Neutrophil Elastase in Proteomes
Ms Rita FÉLIXMs Rita FÉLIX
(IMED.ULISBOA - RESEARCH INSTITUTE FOR MEDICINES, Lisbon, Portugal)
OC07 - New Precision Anti-TB Agents by Allosteric Inhibition of Glutamate-5-Kinase Enzyme
Prof. Concepcion GONZALEZ-BELLOProf. Concepcion GONZALEZ-BELLO
(UNIVERSIDADE DE SANTIAGO DE COMPOSTELA - CIQUS, santiago de compostela, Spain)

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OC15 - Small Molecule Drug Discovery with Peptide-Encoded Libraries
Dr Nathalie GROBDr Nathalie GROB
(MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, United States)

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OC04 - Integrated Platform Approach for Molecular Degrader Discovery in Proxidrugs
Dr Johanna HUCHTINGDr Johanna HUCHTING
(FRAUNHOFER INSTITUTE FOR TRANSLATIONAL MEDICINE AND PHARMACOLOGY, Hamburg, Germany)

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OC14 - Structure-Based Drug Discovery and Umbrella Sampling Simulations Identify Novel Potent Troponin Calcium Sensitizers and Elucidate their Function
Prof. Steffen LINDERTProf. Steffen LINDERT
(OSU, Columbus, United States)

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OC06 - Targeting Sodium Binding Pocket in Mu Opioid Receptor to Design Safer Analgesics
Dr Susruta MAJUMDARDr Susruta MAJUMDAR
(UHSP & WASHINGTON UNIVERSITY, Saint Louis, United States)

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OC05 - Best-In-Class Orally Bioavailable CXCR4 Antagonists to Treat Renal Cell Carcinoma
Dr Eric MILLERDr Eric MILLER
(EMORY UNIVERSITY SCHOOL OF MEDICINE, Atlanta, United States)

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OC02 - Targeting Progerin Degradation as a New Therapeutic Approach for Treating Progeria
Prof. Silvia ORTEGA-GUTIERREZProf. Silvia ORTEGA-GUTIERREZ
(COMPLUTENSE UNIVERSITY, Madrid, Spain)
OC08 - Impact of gem-Difluoromethylene Group on Physicochemical Properties in Medchem-Relevant Building Blocks
Dr Sergey RYABUKHINDr Sergey RYABUKHIN
(ENAMINE LTD, Kyiv, Ukraine)

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OC13 - Borrowing Transcriptional Kinases to Activate Apoptosis Using Chemically Induced Proximity
Dr Roman SAROTTDr Roman SAROTT
(STANFORD UNIVERSITY, Menlo Park, United States)
OC09 - Targeting Receptor Complexes with Therapeutic Peptides
Prof. Kristian STROMGAARDProf. Kristian STROMGAARD
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark)

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