| Thursday September 6, 2018 |
| 13:45 | Registration |
|
| 14:30 | Welcome and opening |
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| Session Chair
|
Prof. Tihomir TOMASIC
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| 14:35 | KL01 - From Hits, to Leads to Chemical Probes: An Exciting Journey |
Prof. Cristina NEVADO
(UNIVERSITY OF ZURICH, Zurich, Switzerland) |
| YMCS competition presentation session I |
|
| Session Chair |
Dr Daniel MERK
(ETH ZÜRICH, Zürich, Switzerland) |
| 15:05 | OC01 - Impact and Prediction of Binding Kinetics on in Vivo Drug Efficacy
Winner of the young medicinal chemist meeting in France
|
Dr Abdennour BRAKA
(IRIM, Gif-sur-Yvette, France) |
| 15:25 | OC02 - Prospective Applications of Artificial Intelligence in de Novo Molecular Design for Drug Discovery |
Mr Lukas FRIEDRICH
(ETH ZURICH, Zurich, Switzerland) |
| 15:45 | OC03 - Targeted Metabolomics Profiling as a Basis for Predictive Models in Multiple Sclerosis Research
Winner of the young medicinal chemist meeting in Russia |
Mr Marat KASAKIN
(INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE, Novosibirsk, Russia) |
| 16:05 | Flash poster presentations (0-10) |
|
| FP01 - Targeting Basic Defect in Cystic Fibrosis: Discovery and Development of Novel Nanomolar F508-Del CFTR Correctors |
Dr Alejandra RODRIGUEZ-GIMENO
(ISTITUTO ITALIANO DI TECNOLOGIA, Genova, Italy) |
| FP02 - Buruli Ulcer and The mTOR Pathway: Total Synthesis, Structure-Activity and Target Elucidation Studies of Mycolactones |
Prof. Matthias GEHRINGER
(UNIVERSITY OF TUEBINGEN, Tuebingen, Germany) |
| FP03 - The Development of New Treatments for Multi-Drug Resistant Tuberculosis |
Ms Lisa BARBARO
(MONASH UNIVERSITY, Reservoir, Australia) |
| FP04 - Synthesis and Characterisation of Psoralen Derivates as Inhibitors of The β5i Subunit of the Immunoproteasome |
Ms Eva Shannon SCHIFFRER
(UNIVERSITY OF LJUBLJANA, FACULTY OF PHARMACY, Zirovnica, Slovenia) |
| FP05 - Fragment-Based Approach Applied to The Discovery of Protein-Protein Interaction Stabilisers |
Mr Dario VALENTI
(TAROS CHEMICALS GMBH & CO. KG, Dortmund, Germany) |
| FP06 - The Use of Irreversible Ligands in the Quest to Obtain the First Ligand-Bound X-Ray Structures of The Adenosine A1 Receptor |
Dr Manuela JORG
(MONASH UNIVERSITY, Parkville, Australia) |
| FP07 - Inhibitors of Human Sialyltransferases as Novel Anti-Metastatic Agents |
Mr Chris DOBIE
(UNIVERSITY OF WOLLONGONG, Gwynneville, Australia) |
| FP08 - 3-Oxabicyclo[4.1.0]Heptane: A Bioisostere for Morpholine as a Kinase Hinge Binding Moiety |
Mr Declan SUMMERS
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| FP09 - Development of Small-Molecule Inhibitors of Adipose Triglyceride Lipase (ATGL) |
Ms Anna MIGGLAUTSCH
(TU GRAZ, Graz, Austria) |
| FP10 - Covalent Fragment-Based Discovery of New Mura Inhibitors |
Dr Martina HRAST
(FAKULTETA ZA FARMACIJO, Ljubljana, Slovenia) |
| 16:25 | Coffee Break |
|
| YMCS competition presentation session II |
|
| Session Chair |
Dr Kristina GONCHARENKO
(SPIROCHEM AG, Basel, Switzerland) |
| 16:40 | OC04 - The Design and Synthesis of Bromodomain Photoaffinity Probes
Winner of the young medicinal chemist meeting in the United Kingdom |
Mr David FALLON
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 17:00 | OC05 - Gemini-Type Protacs: a Small Molecule-Based Strategy for Self-directed Inactivation of Cereblon |
Dr Christian STEINEBACH
(UNIVERSITY OF BONN, Bonn, Germany) |
| 17:20 | OC06 - Investigation of Direct Effect of Psychoactive Compounds on Invertebrate Neurons in Real Time
Winner of the young medicinal chemist meeting in Hungary |
Dr Gabor MAASZ
(HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary) |
| 17:40 | OC07 - Hydrogen peroxide sensitive prodrugs of methotrexate and aminopterin for the treatment of rheumatoid arthritis
Winner of the young medicinal chemist meeting in Denmark |
Dr Jorge PEIRO CADAHIA
(NUEVOLUTION A/S, Copenhagen, Denmark) |
| 18:00 | Flash poster presentations (10-20) |
|
| FP11 - Rational Design of Optimized Allosteric Effectors of Cathepsins K and S Based on Succinimide-Glycinate Scaffold |
Ms Tjasa GORICAN
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| FP12 - Covalent Inhibition with Terminal Alkyne As ‘Inert’ Electrophile |
Mrs Elma MONS
(LEIDEN UNIVERSITY MEDICAL CENTER, Leiden, The Netherlands) |
| FP13 - Exploration of Chemical Space of Two Classes of INHA Inhibitors |
Dr Izidor SOSIC
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| FP14 - Late-Stage Functionalization of Peptides: Novel Site-Selective Modification & Bioconjugation |
Dr Anaïs NOISIER
(ASTRAZENECA, Mölndal, Sweden) |
| FP15 - Identification of A GSK-3β/CK-1δ Inhibitor: Dual Target and Dual Mechanisms of Action as Possible Strategy for The Treatment of Parkinson’s Disease. |
Prof. Stephanie FEDERICO
(UNIVERSITY OF TRIESTE, Trieste, Italy) |
| FP16 - Discovery of Benzothiazole-Based DNA Gyrase and Topoisomerase IV Inhibitors with Broad Spectrum Antibacterial Activity |
Ms Martina DURCIK
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| FP17 - Development of Peptides as Therapeutics for Pharmacological Intervention in Vital Protein Cascades |
Dr Christina LAMERS
(UNIVERSITY OF BASEL, Leipzig, Germany) |
| FP18 - Deep Learning Applications in The Design and Identification of Antibacterial Compounds |
Dr Marko JUKIC
(FAKULTETA ZA FARMACIJO, UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| FP19 - The Design and Synthesis of Novel Inhibitors of the Notch Activation Complex Kinase for Notch Mediated Tumorigenesis |
Ms Tanya KELLEY
(UNIVERSITY OF MIAMI, miami, United States) |
| 18:20 | Poster presentation session 1 (Odd numbers) & Networking drink |
|
| 20:00 | End of the day |
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| 20:15 | Optional Networking Event (until 21:30) |
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| Friday September 7, 2018 |
| YMCS competition presentation session III |
|
| Session Chair |
Dr Ziga JAKOPIN
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| 08:30 | OC08 - Fosmidomycin Analogs as Antimalarial and Antitubercular Agents - a Prodrug Approach
Winner of the young medicinal chemist meeting in Belgium (KVCV) |
Ms Charlotte COURTENS
(UGENT, Gent, Belgium) |
| 08:50 | OC09 - Metal-Chelating Acetohydroxamic Acids against Hepatitis C Virus and Flaviviruses
Winner of the young medicinal chemist meeting in Greece |
Ms Erofili GIANNAKOPOULOU
(NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS, Athens, Greece) |
| 09:10 | OC10 - Elucidation of the Antifungal Mechanism of Action of Bis-Guanylhydrazones
Winner of the young medicinal chemist meeting in Serbia |
Ms Jelena LAZIC
(UNIVERSITY OF BELGRADE, FACULTY OF CHEMISTRY, Belgrade, Serbia) |
| 09:30 | OC11 - Discovery and Optimisation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors
Winner of the young medicinal chemist meeting in Slovenia |
Dr Nace ZIDAR
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| 09:50 | OC12 - The Effect of Singlet Oxygen Production and Lipophylicity of the Photosensitizer in Photodynamic Activity of N-Methylated and N-Oxsidised Pyridylporphyrins
Winner of the young medicinal chemist meeting in Croatia |
Ms Martina MUSKOVIC
(UNIVERSITY OF RIJEKA, Rijeka, Croatia) |
| 10:10 | Coffee Break |
|
| YMCS competition presentation session IV |
|
| Session Chair |
Mr Roman SINK
(UNIVERSITY OF LJUBLJANA FACULTY OF PHARMACY, Ljubljana, Slovenia) |
| 10:30 | OC13 - Synthesis and Biological Evaluation of Bia 10-2474: an Irreversible and Aspecific Faah Inhibitor
Winner of the young medicinal chemist meeting in The Netherlands |
Dr Anthe JANSSEN
(LEIDEN UNIVERSITY, Leiden, The Netherlands) |
| 10:50 | OC14 - Methylene - Cycloalkylacetate (mca) as Novel Neurotropic Agents
Winner of the young medicinal chemist meeting in Israel |
Mr David LANKRI
(HEBREW UNIVERSITY, Jerusalem, Israel) |
| 11:10 | OC15 - Development of Release-and-Report Kinase Inhibitors as Molecular Tools for Investigating Neurodegenerative Disorders
Winner of the young medicinal chemist meeting in Sweden |
Dr Cassandra LEE FLEMING
(UNIVERSITY OF GOTHENBURG, Gothenburg, Sweden) |
| 11:30 | OC16 - Piperazine Derivatives as a Novel, Active Histamine h3 Receptor Ligands
Winner of the young medicinal chemist meeting in Poland |
Dr Katarzyna SZCZEPANSKA
(JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE, Krakow, Poland) |
| 11:50 | Lunch & Poster presentation session 2 (Even numbers) |
|
| YMCS competition presentation session V |
|
| Session Chair |
Prof. Emmanouil FOUSTERIS
(UNIVERSITY OF PATRAS, Patras, Greece) |
| 13:15 | OC17 - Development of Aminoxyrone as the First-in-Class hsp90 C-Terminal Domain Dimerization Inhibitor
Winner of the young medicinal chemist meeting in Germany |
Prof. Finn HANSEN
(UNIVERSITÄT LEIPZIG, Leipzig, Germany) |
| 13:35 | OC18 - How Can We Inhibit a Protein that is Intrinsically Disordered? Androgen Receptor – epi-001 a Case Study
Winner of the young medicinal chemist meeting in Spain |
Dr Marta FRIGOLE-VIVAS
(INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA), Dresden, Germany) |
| 13:55 | OC19 - Kinase Templated Abiotic Reaction: from Promiscuity to Selectivity
Winner of the young medicinal chemist meeting in Switzerland |
Mr Jacques SAARBACH
(UNIVERSITÉ DE GENÈVE, Geneve 4, Switzerland) |
| 14:15 | OC20 - The Best of Three Worlds: Tackling Multidrug Resistance through Phytochemical, Biological and Computational Approaches
Winner of the young medicinal chemist meeting in Portugal |
Dr Ricardo FERREIRA
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
| 14:35 | OC21 - Targeting Zinc-Finger Proteins in Cancer and Viral Infections
Winner of the young medicinal chemist meeting in Italy |
Dr Mattia MORI
(UNIVERSITY OF SIENA, Siena, Italy) |
| 14:55 | Voting break |
|
| 15:10 | KL02 - My Lessons in Drug Discovery |
Dr Marton CSEKEI
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary) |
| 15:40 | Closing and award ceremony |
|
