| Thursday 16/11/2023 |
| 08:00 | Registration |
|
| 09:00 | Opening Ceremony |
Dr Yves P. AUBERSON (NOVARTIS & EFMC, Basel, Switzerland)
Prof. Maja KÖHN (UNIVERSITY OF FREIBURG, Freiburg, Germany) |
| 09:15 | PL01 - Moving Undruggable Discoveries into the Drug Discovery Pipeline with Chemical Biology |
Dr John TALLARICO
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States) |
| Session 1: Chemical Proteomics in Drug Discovery |
|
| Session Chair |
Dr Sebastian ESSIG
(BAYER AG, Wuppertal, Germany) |
| 10:00 | KL01 - Chemoproteomics Approaches and their Contributions to Drug Discovery |
Dr Marcus BANTSCHEFF
(CELLZOME/GSK, Heidelberg, Germany) |
| 10:45 | Coffee Break, Networking & Exhibition |
|
| 11:15 | IL01 - Towards Covalent Inhibitors Addressing Diverse Amino Acids |
Dr Stephan HACKER
(LEIDEN UNIVERSITY, Leiden, The Netherlands) |
| 11:40 | IL02 - ABPP and its Impact on Drug Discovery - Successful Examples from the MAGL Program |
Dr Uwe GRETHER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| 12:05 | OC01 - Lessons for Covalent Drug Development from Deep Chemoproteomic Profiling of Approved Covalent Drugs |
Dr Micah NIPHAKIS
(LUNDBECK, San Diego, CA, United States) |
| 12:25 | Lunch, Networking & Exhibition |
|
| 12:30 | Company Workshop by WuXi AppTec
Emerging Modalities in Drug Discovery |
Dr Tao GUO
(WUXI APPTEC, St Pauls, United States) |
| Session 2: Computational Chemical Biology (LS-EuChemS Session) |
|
| Session Chair |
Dr Sonsoles MARTIN-SANTAMARIA
(CIB-CSIC, Madrid, Spain) |
| 13:55 | KL02 - Unravelling the Molecular Mechanism of Pre-mRNA Splicing via All-atom Simulations |
Prof. Alessandra MAGISTRATO
(CNR-IOM, Trieste, Italy) |
| 14:40 | IL03 - Challenges in Simulating Molecular Recognition Using Coarse-grain Models |
Prof. Manuel MELO
(UNIVERSITY NOVA DE LISBOA, Oeiras, Portugal) |
| 15:05 | OC02 - Molecular Binding Studies in G Protein Coupled Receptors: Insights for Drug Discovery
|
Prof. Vittorio LIMONGELLI
(UNIVERSITÀ DELLA SVIZZERA ITALIANA USI, Lugano, Switzerland) |
| 15:30 | Coffee Break, Networking & Exhibition |
|
| Session 3: Chemically Induced Proximity |
|
| Session Chair |
Prof. Gonçalo BERNARDES
(UNIVERSITY OF CAMBRIDGE & IMM LISBOA, Cambridge, United Kingdom) |
| 16:00 | OC03 - Molecular Glues for the 14-3-3 Interactome |
Dr Richard DOVESTON
(UNIVERSITY OF LEICESTER, Leicester, United Kingdom) |
| 16:20 | IL04 - Tumor Targeting |
Prof. Dario NERI
(ETH ZÜRICH, Zürich, Switzerland) |
| 16:45 | IL05 - Small Molecule Therapeutics Targeting Fibroblast Activation Protein in the Tumor Microenvironment |
Dr Samuele CAZZAMALLI
(PHILOCHEM AG, Otelfingen, Switzerland) |
| 17:10 | KL03 - Chemogenetic and Optogenetic Technologies for Probing Molecular and Cellular Networks
(Virtual Lecture) |
Prof. Alice TING
(STANFORD UNIVERSITY, Stanford, United States) |
| 17:55 | Poster Session I (Odd), Networking & Exhibition |
|
| 18:30 | Welcome Reception & Poster Session I (Odd), Networking & Exhibition |
|
| 19:30 | End of the Day |
|
| Friday 17/11/2023 |
| Chair |
Prof. Gianluca SBARDELLA
(UNIVERSITY OF SALERNO, Fisciano, Italy) |
| 09:00 | PL02 - Ribozymes Meet RNA Modifications |
(SOPLVIAS AG (WAS FUJIFILM))
Prof. Claudia HÖBARTNER (UNIVERSITY OF WÜRZBURG, Würzburg, Germany) |
| Session 4: Target Engagement and Mechanism of Action Determination |
|
| Session Chair |
Dr Andrew ZHANG
(ASTRAZENECA, Waltham, United States) |
| 09:45 | KL04 - Mechanistic Insight in Drug Discovery: Past Tense of Future Direction?
(Virtual Lecture) |
Dr Rachel GRIMLEY
(CANCER RESEARCH HORIZONS (CANCER RESEARCH UK), Cambridge, United Kingdom) |
| 10:30 | Coffee Break, Networking & Exhibition |
|
| 11:00 | IL06 - Biophysical Proteomics |
Dr Mikhail SAVITSKY
(EUROPEAN MOLECULAR BIOLOGY LABORATORY, Heidelberg, Germany) |
| 11:25 | IL07 - Proteomics Profiling of PROTACs and E3 Modulators to Identify Mechanistic Biomarkers and Substrates |
Dr Meha SINGH
(ASTRAZENECA, Waltham, United States) |
| 11:50 | OC04 - Morphological Profiling of Small Molecules Using the Cell Painting Assay |
Dr Slava ZIEGLER
(MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany) |
| 12:10 | Lunch, Networking & Exhibition |
|
| Session 5: Protein Conformations: Beyond the Ground State |
|
| Session Chair |
Dr Wolfgang JAHNKE
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 13:40 | KL05 - Evolution of Energy Landscapes and its Exploitation for Drug and Enzyme Design |
Prof. Dorothee KERN
(BRANDEIS UNIVERSITY, Waltham, United States) |
| 14:25 | IL08 - Low Molecular Weight Inhibitors of IL-1β: from a 19F NMR Fragment Hit to a Cellular Proof of Concept |
Dr Anna VULPETTI
(NOVARTIS, Basel, Switzerland) |
| 14:50 | IL09 - NMR Provides Unique Insight into the Role of Disorder in Highly Dynamic Viral Replication Assemblies |
Prof. Martin BLACKLEDGE
(INSTITUT DE BIOLOGIE STRUCTURALE (IBS), Grenoble, France) |
| 15:15 | OC05 - Spatiotemporally Controlled Generation of NTPs as A Versatile Tool for Single-Molecule Studies |
Prof. Sebastian DEINDL
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
| 15:35 | Coffee Break, Networking & Exhibition |
|
| Session 6: Targeting Metabolism (ICBS Session) |
|
| Session Chair |
Prof. Zaneta NIKOLOVSKA-COLESKA
(UNIVERSITY OF MICHIGAN, Ann Arbor, United States) |
| 16:05 | KL06 - Understanding the Role of Metabolism in Cancer |
Prof. Matthew G. VANDER HEIDEN
(MIT, Cambridge, United States) |
| 16:50 | IL10 - Chemical Biology of Sterol-mediated Processes |
Dr Luca LARAIA
(TECHNICAL UNIVERSITY OF DENMARK, Kgs. Lyngby, Denmark) |
| 17:15 | OC06 - The Hidden Activator Within the Inhibitor: Regulated Tissue-Selective Inhibition and Activation of the Sugar Tolerance Transcription Factor ChREBP |
Dr Maren HEIMHALT
(LUDWIG MAXIMILIAN UNIVERSITÄT, Planegg-Martinsried, Germany) |
| 17:35 | Poster Session II (Even), Networking & Exhibition |
|
| 19:10 | End of the Day |
|
| 20:15 | Symposium Banquet |
|
| Saturday 18/11/2023 |
| Chair |
Prof. Dennis GILLINGHAM
(UNIVERSITY OF BASEL, Basel, Switzerland) |
| 09:00 | PL03 - The Second Dimension of the Genetic Code |
Prof. Thomas CARELL
(LUDWIG-MAXIMILIANS-UNIVERSITY, München, Germany) |
| Session 7: Chemical Immunology & Checkpoint Inhibitors |
|
| Session Chair |
Prof. Nina HARTRAMPF
(UNIVERSITY OF ZURICH, Zürich, Switzerland) |
| 09:45 | KL07 - Fluorescent Amino Acids and Peptides for Translational Imaging of Infection and Inflammation in Humans |
Prof. Marc VENDRELL
(UNIVERSITY OF EDINBURGH, Edinburgh, United Kingdom) |
| 10:30 | Coffee Break, Networking & Exhibition |
|
| 11:00 | IL11 - Chemoenzymatic and Metabolic Protein Labeling Strategies |
Dr Kimberly BONGER
(RADBOUD UNIVERSITY, Nijmegen, The Netherlands) |
| 11:25 | IL12 - Chemical Immunology Tools for Synthetic Adjuvant and Vaccine Development |
Dr Alberto FERNÁNDEZ-TEJADA
(CIC BIOGUNE, Derio (Bizkaia), Spain) |
| 11:50 | OC07 - Collectin-11 Antagonists in a Therapeutic Approach to Minimize Complement-Mediated Immune Injury |
Dr Rachel HEVEY
(UNIVERSITY OF BASEL, Basel, Switzerland) |
| 12:10 | Lunch, Networking & Exhibition |
|
| Session 8: New Understandings of Post-translational Protein Modifications |
|
| Session Chair |
Prof. Christian A. OLSEN
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark) |
| 13:40 | KL08 - Chemical Approaches to Studying Chromatin |
Prof. Tom MUIR
(PRINCETON UNIVERSITY, Princeton, United States) |
| 14:25 | IL13 - Beyond Phosphorylation – Protein Pyrophosphorylation by Inositol Pyrophosphate Messengers |
Prof. Dorothea FIEDLER
(LEIBNIZ-FORSCHUNGSINSTITUT FÜR MOLEKULARE PHARMAKOLOGIE (FMP), Berlin, Germany) |
| 14:50 | IL14 - Decoding PTM Signaling from Chromatin to the Cytoskeleton |
Prof. Beat FIERZ
(ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland) |
| 15:15 | OC08 - PhotoCrot: a Precise Photo-Chemical Approach to Selectively Identify Crotonylated Proteins
|
Dr Rita PETRACCA
(UTRECHT UNIVERSITY, Utrecht, The Netherlands) |
| 15:35 | Coffee Break, Networking & Exhibition |
|
| Session 9: EFMC-WuXi AppTec Award for Excellence in Chemical Biology |
|
| Session Chair |
Prof. Rui MOREIRA
(UNIVERSITY OF LISBON, Lisbon, Portugal) |
| 16:05 | Award Ceremony |
Prof. Rui MOREIRA (UNIVERSITY OF LISBON, Lisbon, Portugal)
Dr Tao GUO (WUXI APPTEC, St Pauls, United States) |
| 16:20 | PL04 - EFMC-WuXi AppTec Award for Excellence in Chemical Biology Lecture:
Translational Chemical Biology |
Prof. Gonçalo BERNARDES
(UNIVERSITY OF CAMBRIDGE & IMM LISBOA, Cambridge, United Kingdom) |
| 17:05 | Poster Prizes Ceremony |
Prof. Yimon AYE
(ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL), Lausanne, Switzerland) |
| 17:20 | Closing Remarks |
Dr Yves P. AUBERSON
(NOVARTIS & EFMC, Basel, Switzerland) |
| 17:25 | End of the Symposium |
|
