3rd NovAliX Conference

Biophysics in Drug Discovery 2016

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Strasbourg, France    June 7-10, 2016

Keynote Lectures

X-ray Crystallography: an Ever-Reemerging Technology (KN02)

Dr Gerard BRICOGNE
Dr Gerard BRICOGNE
GLOBAL PHASING LTD., Cambridge, United Kingdom
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The Discovery of ABL001, an Allosteric Inhibitor of BCR-ABL (KN01)

Dr Sandra JACOB
Dr Sandra JACOB
NOVARTIS, Basel, Switzerland
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Session 1: Emerging Technologies

A 5-Year Retrospective on Non-Covalent Mass Spectrometry Applied to Drug Discovery (OC01)

Dr Mathias ANTOINE
Dr Mathias ANTOINE
INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France
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Maldi Mass Spectrometry: From Imaging to Ultra-High-Throughput-Screening (Maldi-Uhts) (OC02)

Dr Jens FUCHSER
Dr Jens FUCHSER
BRUKER DALTONICS, Bremen, Germany
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Mass Spectrometry and its Role in Drug Discovery (PL01)

Prof. Carol  ROBINSON
Prof. Carol ROBINSON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Exploring GPCR and Membrane Protein Dynamics with Solution NMR and X-ray Free-Electron Lasers (PL02)

Prof. Gebhard F.X. SCHERTLER
Prof. Gebhard F.X. SCHERTLER
PAUL SCHERRER INSTITUTE, Villigen, Switzerland
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Session 2: Biophysics for Challenging Targets

New Strategy for Challenging Targets: Time Resolved Molecular Interaction Analysis on Living Cells Using LigandTracer (PL03)

Dr Karl  ANDERSSON
Dr Karl ANDERSSON
RIDGEVIEW INSTRUMENTS AB, Vänge, Sweden
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Thermodynamics of the Ribosome Translation Machinery (OC04)

Dr Eric ENNIFAR
Dr Eric ENNIFAR
CNRS, Strasbourg, France
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Combining Binding Thermodynamics and Kinetic Binding Mechanisms to Assess The Selectivity of Inhibitors of Histone Deacetylase-Like Amidohydrolases (OC03)

Mr Christian MEYNERS
Mr Christian MEYNERS
UNIVERSITY OF APPLIED SCIENCES DARMSTADT, Darmstadt, Germany
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Probing the Structure and Dynamics of Proteins with Single-Molecule Spectroscopy (PL04)

Prof. Ben SCHULER
Prof. Ben SCHULER
UNIVERSITY OF ZURICH, Zurich, Switzerland
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Session 3: Special Focus on Cryo-EM

Cullin-Ring Ubiquitin E3 Ligase Regulation by the Cop9 Signalosome (OC05)

Dr Simone CAVADINI
Dr Simone CAVADINI
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland
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High-Resolution Electron Cryo-Microscopy of Membrane Protein Complexes (PL05)

Prof. Werner KÜHLBRANDT
Prof. Werner KÜHLBRANDT
MAX PLANCK INSTITUTE OF BIOPHYSICS, Frankfurt am Main, Germany
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Visualizing Dynamic Macromolecular Complexes at High Resolution by Cryo-EM (PL06)

Prof. Holger STARK
Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany
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EM in Industry: Expectations and Perspectives (PL07)

Dr Denis ZEYER
Dr Denis ZEYER
NOVALIX, Illkirch, France
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Session 4: Computational Biophysics

Structural Stability of Protein-Ligand Complexes: Applications in Virtual Screening (PL08)

Prof. Xavier BARRIL
Prof. Xavier BARRIL
BARCELONA UNIVERSITY, Barcelona, Spain
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Uncoupling the Structure-Activity Relationships of Beta-2 Adrenergic Receptor Ligands from Membrane Binding (OC07)

Dr Callum DICKSON
Dr Callum DICKSON
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States
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Diverse Applications of Free Energy Calculations in Drug Discovery (OC06)

Dr David RINALDO
Dr David RINALDO
SCHRÖDINGER, Mannheim, Germany
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Computational Exploration of Protein Dynamics for Ligand Design (PL09)

Prof. Rebecca WADE
Prof. Rebecca WADE
HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES AND HEIDELBERG UNIVERSITY, Heidelberg, Germany
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Session 5: Cellular Biophysics

Insulin Degrading Enzyme: Drug Target Engagement in Hela Cells by Cellular Thermal Shift Assay (OC08)

Dr Adrien HERLEDAN
Dr Adrien HERLEDAN
INSTITUT PASTEUR DE LILLE, Lille, France
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The Life and Death of Cells: Cellular Bioenergetics for Better Phenotype Based Drug Discovery (PL10)

Dr Magnus JANSSON
Dr Magnus JANSSON
SYMCEL SVERIGE AB, Spanga, Sweden
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Imaging of G-protein Coupled Receptors while Quantifying their Ligand-binding Free Energy Landscape to Mutiple Ligands (PL11)

Prof. Daniel MÜLLER
Prof. Daniel MÜLLER
ETH ZÜRICH, Basel, Switzerland
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Session 6: Biophysics for Biotherapeutics

The Neonatal Fc Receptor (FcRn) Binds Independently to Both Sites of the IgG Homodimer with Identical Affinities (PL12)

Dr Yasmina ABDICHE
Dr Yasmina ABDICHE
RINAT-PFIZER, San Francisco, United States
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Analysis of Bispecific Interactions with the Switchsense Biosensor (OC09)

Dr Ulrich RANT
Dr Ulrich RANT
DYNAMIC BIOSENSORS GMBH, Martinsried/Planegg, Germany
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Combinatorial SEC, AUC and TEM Approach for the Characterization of mAb Dimers (PL13)

Dr Arne RUFER
Dr Arne RUFER
F. HOFFMANN-LA ROCHE LTD., Basel, Switzerland
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Kinetic Excursion Analysis (Kinexa) of Avidity Enhancement of a Multi-Valent Adnectin Binding to Clustered Receptors on Cho Cells (OC10)

Dr Lumelle SCHNEEWEIS
Dr Lumelle SCHNEEWEIS
BRISTOL-MYERS SQUIBB, Princeton, NJ, United States
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