3rd NovAliX Conference

Biophysics in Drug Discovery 2016

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Strasbourg, France    June 7-10, 2016

Scientific Programme


13:00

Registration

14:00

Welcome Address

Session 1: Emerging Technologies

Session Chair

Dr Chun-wa CHUNG
GLAXOSMITHKLINE, Stevenage, United Kingdom

14:15

Mass Spectrometry and its Role in Drug Discovery (PL01)

Prof. Carol ROBINSON
UNIVERSITY OF OXFORD, Oxford, United Kingdom

15:00

A 5-Year Retrospective on Non-Covalent Mass Spectrometry Applied to Drug Discovery (OC01)

Dr Mathias ANTOINE
INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France

15:25

Maldi Mass Spectrometry: From Imaging to Ultra-High-Throughput-Screening (Maldi-Uhts) (OC02)

Dr Jens FUCHSER
BRUKER DALTONICS, Bremen, Germany

15:50

Coffee Break

16:20

Exploring GPCR and Membrane Protein Dynamics with Solution NMR and X-ray Free-Electron Lasers (PL02)

Prof. Gebhard F.X. SCHERTLER
PAUL SCHERRER INSTITUTE, Villigen, Switzerland

17:05

Exhibitor Short Presentation: Creoptix AG
The WAVE of the Future in Kinetics

Dr Matyas VEGH
CREOPTIX AG, Wädenswil, Switzerland

17:15

Exhibitor Short Presentation: Bruker BioSpin
Fragment Screening by Ligand Observed NMR

Dr Stefan JEHLE
BRUKER BIOSPIN, Faellanden, Switzerland

Keynote Lecture

Chair

Dr Ursula EGNER
BAYER, Berlin, Germany

17:25

The Discovery of ABL001, an Allosteric Inhibitor of BCR-ABL (KN01)

Dr Sandra JACOB
NOVARTIS, Basel, Switzerland

18:25

Welcome Reception

08:30

Registration

Session 2: Biophysics for Challenging Targets

Session Chair

Dr Geoff HOLDGATE
ASTRAZENECA, Macclesfield, United Kingdom

09:00

New Strategy for Challenging Targets: Time Resolved Molecular Interaction Analysis on Living Cells Using LigandTracer (PL03)

Dr Karl ANDERSSON
RIDGEVIEW INSTRUMENTS AB, Vänge, Sweden

09:45

Exhibitor Short Presentation: Dynamic Biosensors
Biophysical Analysis of Molecular Interactions and Enzymatic Activity with switchSENSE

Dr Duncan BORTHWICK
DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany

09:55

Combining Binding Thermodynamics and Kinetic Binding Mechanisms to Assess The Selectivity of Inhibitors of Histone Deacetylase-Like Amidohydrolases (OC03)

Mr Christian MEYNERS
UNIVERSITY OF APPLIED SCIENCES DARMSTADT, Darmstadt, Germany

10:20

Coffee Break

10:50

Thermodynamics of the Ribosome Translation Machinery (OC04)

Dr Eric ENNIFAR
CNRS, Strasbourg, France

11:15

Exhibitor Short Presentation: Molecular Sensing
Affinity Assays for GPCR ligand binding using TruBind™ Molecular Interaction Analysis

Dr Yvonne VOLZ
MOLECULAR SENSING, Idstein, Germany

11:25

Probing the Structure and Dynamics of Proteins with Single-Molecule Spectroscopy (PL04)

Prof. Ben SCHULER
UNIVERSITY OF ZURICH, Zurich, Switzerland

12:10

Lunch & Networking

13:00

Poster Session 1

Session 3: Special Focus on Cryo-EM

Session Chair

Dr Ursula EGNER
BAYER, Berlin, Germany

14:15

High-Resolution Electron Cryo-Microscopy of Membrane Protein Complexes (PL05)

Prof. Werner KÜHLBRANDT
MAX PLANCK INSTITUTE OF BIOPHYSICS, Frankfurt am Main, Germany

15:00

Cullin-Ring Ubiquitin E3 Ligase Regulation by the Cop9 Signalosome (OC05)

Dr Simone CAVADINI
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland

15:25

Coffee Break

15:55

Visualizing Dynamic Macromolecular Complexes at High Resolution by Cryo-EM (PL06)

Prof. Holger STARK
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany

16:40

EM in Industry: Expectations and Perspectives (PL07)

Dr Denis ZEYER
NOVALIX, Illkirch, France

Keynote Lecture

Chair

Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany

17:10

X-ray Crystallography: an Ever-Reemerging Technology (KN02)

Dr Gerard BRICOGNE
GLOBAL PHASING LTD., Cambridge, United Kingdom

Session 4: Computational Biophysics

Session Chair

Prof. Rod HUBBARD
UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom

09:00

Structural Stability of Protein-Ligand Complexes: Applications in Virtual Screening (PL08)

Prof. Xavier BARRIL
BARCELONA UNIVERSITY, Barcelona, Spain

09:45

Exhibitor Short Presentation: BioSolveIT
A Visual Approximation to On-the-Fly Computational Thermodynamic Profiling

Dr Marcus GASTREICH
BIOSOLVEIT, St. Augustin, Germany

09:55

Diverse Applications of Free Energy Calculations in Drug Discovery (OC06)

Dr David RINALDO
SCHRÖDINGER, Mannheim, Germany

10:20

Coffee Break

10:50

Uncoupling the Structure-Activity Relationships of Beta-2 Adrenergic Receptor Ligands from Membrane Binding (OC07)

Dr Callum DICKSON
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States

11:15

Exhibitor Short Presentation: Biodesy
Real-time, Solution-based Measurement of Protein Conformational Change

Dr Tad GEORGE
BIODESY, San Francisco, United States

11:25

Computational Exploration of Protein Dynamics for Ligand Design (PL09)

Prof. Rebecca WADE
HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES AND HEIDELBERG UNIVERSITY, Heidelberg, Germany

12:10

Lunch & Networking

12:55

Poster Session 2

Session 5: Cellular Biophysics

Session Chair

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

14:00

The Life and Death of Cells: Cellular Bioenergetics for Better Phenotype Based Drug Discovery (PL10)

Dr Magnus JANSSON
SYMCEL SVERIGE AB, Spanga, Sweden

14:45

Exhibitor Short Presentation: Sierra Sensors
Introducing MASS-2 for High Performance, High Throughput SPR Analysis

Dr Sven MALIK
SIERRA SENSORS, Hamburg, Germany

14:55

Exhibitor Short Presentation: NovAliX
Balancing Standard and Unique Services for Drug Discovery

Dr Frank MOFFATT
NOVALIX, Illkirch, France

15:05

Insulin Degrading Enzyme: Drug Target Engagement in Hela Cells by Cellular Thermal Shift Assay (OC08)

Dr Adrien HERLEDAN
INSTITUT PASTEUR DE LILLE, Lille, France

15:30

Coffee Break

16:00

Imaging of G-protein Coupled Receptors while Quantifying their Ligand-binding Free Energy Landscape to Mutiple Ligands (PL11)

Prof. Daniel MÜLLER
ETH ZÜRICH, Basel, Switzerland

16:45

Poster Prizes

20:00

Conference Dinner

Session 6: Biophysics for Biotherapeutics

Session Chair

Dr Johannes OTTL
NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland

09:00

The Neonatal Fc Receptor (FcRn) Binds Independently to Both Sites of the IgG Homodimer with Identical Affinities (PL12)

Dr Yasmina ABDICHE
RINAT-PFIZER, San Francisco, United States

09:45

Exhibitor Short Presentation: Malvern Instruments
Innovative Solutions for Biosimilars

Mr Michel TERRAY
MALVERN INSTRUMENTS, Orsay Cedex, France

09:55

Analysis of Bispecific Interactions with the Switchsense Biosensor (OC09)

Dr Ulrich RANT
DYNAMIC BIOSENSORS GMBH, Martinsried/Planegg, Germany

10:20

Coffee Break

10:50

Kinetic Excursion Analysis (Kinexa) of Avidity Enhancement of a Multi-Valent Adnectin Binding to Clustered Receptors on Cho Cells (OC10)

Dr Lumelle SCHNEEWEIS
BRISTOL-MYERS SQUIBB, Princeton, NJ, United States

11:15

Exhibitor Short Presentation: NanoTemper Technologies
Prometheus NT.48 - The Stability Expert

Dr François-Xavier OGI
NANOTEMPER TECHNOLOGIES, Karlsruhe, Germany

11:25

Combinatorial SEC, AUC and TEM Approach for the Characterization of mAb Dimers (PL13)

Dr Arne RUFER
F. HOFFMANN-LA ROCHE LTD., Basel, Switzerland

12:10

Closing Remarks and Departure