5th NovAliX Conference

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Cryo-EM

(Special Feature of the Conference)

Keynote Speaker

Professor Martin Karplus - Nobel Prize in Chemistry 2013

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EFMC-ISMC

Wednesday June 13, 2018
12:30Registration
13:45Welcome Address
Session 1: Hot Topics
Session Chair
Dr Chaohong SUN
(ABBVIE, North Chicago, United States)
14:00OC01 - Making Off-Rate Screening in FBDD More Amenable For Fast Dissociating Compounds
Dr Menachem GUNZBURG
(MONASH UNIVERSITY, Parkville, Australia)
14:15OC02 - Novel Active Site and Allosteric Site Binders Identified for FPPS Of T. cruzi
Ms Joy PETRICK
(NOVARTIS, Basel, Switzerland)
14:30OC03 - Dynamic Single-Molecule Approaches to Accelerate the Development of More Efficient Drugs
Dr Gerrit SITTERS
(LUMICKS, Amsterdam, The Netherlands)
14:45OC04 - Quantitative Irreversible Tethering (QIT) for Covalent Ligand Discovery
Dr Gregory CRAVEN
(IMPERIAL COLLEGE LONDON, London, United Kingdom)
15:00OC05 - Large Protein Conformational Changes in Pi3kgamma Linked to the Binding of a New Class of Highly Selective Inhibitors
Dr Göran DAHL
(ASTRAZENECA, Mölndal, Sweden)
15:15IL01 - Binding Kinetics and Thermodynamics in Drug Discovery
Dr Chaohong SUN
(ABBVIE, North Chicago, United States)
15:45Coffee Break
Session 2 : Target Engagement
Session Chair
Dr Daniel WYSS
(MERCK, Kenilworth, United States)
16:25IL02 - Chemical Probes for Epigenetic Targets
Prof. Masoud VEDADI
(STRUCTURAL GENOMICS CONSORTIUM, Toronto, Canada)
16:55Exhibitor Short Presentation: Bruker
Development and Proof-of-Concept of a New Flow-through System for High Resolution NMR to Evaluate Biologics-producing Cell Lines and Their Growth Environments
Dr Jason S. WOOD
(BRUKER BIOSPIN, Billerica, United States)
17:05Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics
Dr Matyas VEGH
(CREOPTIX AG, Wädenswil, Switzerland)
17:15OC06 - Quantification of Target Occupancy in Cells and Tumor Tissue Using FCCs
Dr Frank BECKER
(INTANA BIOSCIENCE GMBH, Planegg, Germany)
17:30IL03 - How to Be Selectively Promiscuous
Prof. Jack TAUNTON
(UNIVERSITY OF CALIFORNIA, San Francisco, United States)
Keynote Lecture
Session Chair
Dr Daniel WYSS
(MERCK, Kenilworth, United States)
18:00KL01 - From Simulations of Biomolecules to Fighting Diseases
Prof. Martin KARPLUS
(UNIVERSITY OF STRASBOURG, FRANCE & HARVARD UNIVERSITY, Cambridge, United States)
19:00Welcome Reception
20:30End of the Day
Thursday June 14, 2018
08:30Registration
Session 3 : Cryo-EM
Session Chair
Dr Bridget CARRAGHER
(NEW YORK STRUCTURAL BIOLOGY CENTER, New York, United States)
09:00IL04 - How Low Can You Go? Size and Resolution Limits Using Conventional Cryo-EM
Dr Gabriel LANDER
(THE SCRIPPS RESEARCH INSTITUTE, San Diego, United States)
09:30IL05 - Cryo-EM for Characterization and Structure Based Drug Design
Dr Bridget CARRAGHER
(NEW YORK STRUCTURAL BIOLOGY CENTER, New York, United States)
10:00Coffee Break
Session 3 (continued) : Cryo-EM
10:30OC07 - Cryo-EM to Address Intractable Targets in Drug Discovery
Dr Hervé REMIGY
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands)
10:45OC08 - Strength of Cryo-EM in Drug Discovery: One Could Always See Something
Dr Wen-ti LIU
(NOVALIX, Illkirch, France)
11:00IL06 - Single Particle Cryo-EM Structure of the Insulin Receptor:Insulin Complex
Dr Giovanna SCAPIN
(MERCK & CO. INC (MSD), Whitehouse Station, United States)
11:30Poster Session
12:30Lunch & Networking
Session 4 : Membrane Proteins
Session Chair
Dr Dan ERLANSON
(CARMOT THERAPEUTICS, San Francisco, United States)
14:00IL07 - New Tools Reveal Mechanisms of Allosteric Coupling in Human GPCRs
Dr Matthew EDDY
(UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, United States)
14:30Exhibitor Short Presentation: Pall ForteBio
Dissecting Biomolecular Interactions - Pall ForteBio’s Next Gen SPR and BLI Label-Free Platforms: Providing Faster and Easier Solutions to Your Emerging Applications
Mr Bob DASS
(PALL FORTEBIO, Menlo Park, United States)
14:40OC09 - Enabling NMR-Based Fragment Screening Using Stabilized Native GPCR: Case Study of Adenosine Receptor
Dr Anass JAWHARI
(CALIXAR, Lyon, France)
14:55OC10 - Crystal Structures of Human Glycine Receptor Alpha3 Bound to a Novel Class of Analgesic Potentiators
Dr Xin HUANG
(AMGEN, Cambridge, United States)
15:10IL08 - Structural Insight into Allosteric Modulation of GPCRs
Dr Miles CONGREVE
(HEPTARES, Welwyn Garden City, United Kingdom)
15:40Coffee Break
Session 5 : Protein-Protein Interactions
Session Chair
Dr MariJean EGGEN
(ELI LILLY, Indianapolis, United States)
16:20IL09 - Design Considerations for Synthetic Macrocycles in Drug Discovery
Prof. Adrian WHITTY
(BOSTON UNIVERSITY, Boston, United States)
16:45OC11 - Use of Complementary Biophysical Methods to Characterize Ligand Binding to IL-17A
Dr Parag SAHASRABUDHE
(PFIZER, Groton, United States)
17:00OC12 - Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of α-Synuclein Aggregation in Parkinson’s Disease
Ms Roxine STAATS
(UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
17:15IL10 - Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction
Dr Shilin XU
(UNIVERSITY OF MICHIGAN, Michigan, United States)
18:00Posters & Drinks
19:30End of the Day
20:00Conference Dinner
Friday June 15, 2018
08:30Registration
Session 6 : Biotherapeutics
Session Chair
Dr Jim BRYSON
(BRISTOL-MYERS-SQUIBB, Princeton, United States)
09:00IL11 - Attacking the Cancer Cell Surface-ome with Recombinant Antibodies
Prof. Jim WELLS
(UCSF, San Francisco, United States)
09:30Exhibitor Short Presentation: Sierra Sensors
Controlling Throughput for SPR
Dr Christopher WHALEN
(SIERRA SENSORS, Greenville, United States)
09:40IL12 - Multi-Specific Designer Proteins for Tumor Therapeutics
Dr Karyn T. O'NEIL
(ARō BIOTHERAPEUTICS, Philadelphia, United States)
10:10Coffee Break
Session 6 (continued) : Biotherapeutics
10:40Exhibitor Short Presentation: WuXi AppTec
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond.
Dr Thomas WALDMANN
(CRELUX, A WUXI APPTEC COMPANY, St. Paul, United States)
10:50IL13 - Emerging Higher Order Structure Techniques in Biotherapeutics Development
Dr Tapan K. DAS
(BRISTOL-MYERS SQUIBB, New York, United States)
11:20Poster Prizes and Closing Remarks
11:45Farewell Lunch & Networking
13:00End of the Conference

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