4th NovAliX Conference

Media Partner

Scientific Programme

Tuesday June 6, 2017
13:00Registration
14:00Welcome Address
Session 1: Biophysical Techniques for the Study of Integral Membrane Proteins
Session Chair
Dr Ursula EGNER
(BAYER, Berlin, Germany)
14:15Use of Mini-G Proteins to Study the Activate State of G Protein-Coupled Receptors (PL01)
Dr Chris TATE
(MRC LABORATORY OF MOLECULAR BIOLOGY, Cambridge, United Kingdom)
15:00Biophysical Analysis to Aid and Complement Structure Based Drug Design for GPCRS (OC01)
Dr Carmen DREGGER
(HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom)
15:25Method for Rapid Optimization of Recombinant GPCR Protein Expression and Stability Using Virus-Like Particles (OC02)
Dr Kathleen AERTGEERTS
(DART NEUROSCIENCE, San Diego, United States)
15:50Coffee Break
16:20Enabling Biophysics on Membrane Proteins Targets : Example of a Human Nucleoside Transporter (PL02)
Dr Nicolas BOCQUET
(LEADXPRO AG, Villigen, Switzerland)
17:05Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics
Dr Matyas VEGH
(CREOPTIX AG, Wädenswil, Switzerland)
17:15Exhibitor Short Presentation: Synthelis
Cell-free technology, expertise and services for your project in structural biology
Mrs Safia EZZINE
(SYNTHELIS, La Tronche, France)
Keynote Lecture
Chair
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
17:25Allosteric Mechanisms of Signal Transduction Investigated with Pentameric Ligand Gated Ion Channels: Consequences for Drug Design (KL01)
Prof. Jean-Pierre CHANGEUX
(COLLÈGE DE FRANCE & INSTITUT PASTEUR, Paris, France)
18:25Welcome Reception
20:00End of the Day
Wednesday June 7, 2017
08:30Registration
Session 2: Recent Advances in NMR
Session Chair
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
09:00Study of Protein Folding and Ligand Binding by Pressure Jump NMR (PL03)
Prof. Ad BAX
(NATIONAL INSTITUTES OF HEALTH, Bethesda, United States)
09:45NMR as a Powerful Tool for Identifying Natural Compounds Able to Interfere with ELAV-mRNA Complexes (OC03)
Dr Francesca VASILE
(UNIVERSITY OF MILANO, Milano, Italy)
10:10Coffee Break
10:40New NMR Tools for Drug Discovery : From Validation to Structure Determination (PL04)
Dr Alvar GOSSERT
(ETH ZÜRICH, Zürich, Switzerland)
Session 3: Hot Topics
Session Chair
Dr Sandra JACOB
(NOVARTIS, Basel, Switzerland)
11:25Biophysical Assays to Answer Evolving Questions in Drug Discovery (OC04)
Dr Derrick MEINHOLD
(GLAXOSMITHKLINE, Conshohocken, United States)
11:50Exhibitor Short Presentation: Sierra Sensors
High-Throughput SPR Screening in Drug Discovery
Dr Sven MALIK
(SIERRA SENSORS, Hamburg, Germany)
12:00Exhibitor Short Presentation: Biodesy
Screening with Structural Insight: High Throughput Measurement of Protein Conformational Change
Dr Tad GEORGE
(BIODESY, San Francisco, United States)
Session 5: Detecting Allosteric Effectors (advanced)
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
12:10Surface Plasmon Resonance Based Method to Discriminate Direct Competition and Allosteric Effects in Ternary Systems (OC10)
Dr Armin RUF
(F. HOFFMANN - LA ROCHE, Basel, Switzerland)
12:35Lunch & Networking
Session 4: Recent Advances in FBDD
Session Chair
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
14:00FBLD and Biophysics: Better Together (KL02)
Dr Dan ERLANSON
(CARMOT THERAPEUTICS, San Francisco, United States)
15:00XCHEM: A High Throughput in Crystallo Fragment Screening Platform (OC06)
Dr Alexandre DIAS
(DIAMOND LIGHT SOURCE LTD, Didcot, Oxon, United Kingdom)
15:25Fragment Screening against DC-SIGN Identifies Multiple Druggable Secondary Sites (OC07)
Mr Hannes BAUKMANN
(MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES, Potsdam-Golm, Germany)
15:50Coffee Break
16:20Fragment Based Lead Generation – What Drives Success? (PL05)
Dr Jenny SANDMARK
(ASTRAZENECA, Gothenburg, Sweden)
17:05A New Heuristic to Predict 3D Ligand Bound Conformation by Mining PDB Subpockets (OC08)
Mr Olivier BEQUIGNON
(JANSSEN R&D, Val de Reuil Cedex, France)
17:30Exhibitor Short Presentation: Domainex
The MST Approach to Fragment Screening
Prof. Trevor PERRIOR
(DOMAINEX LIMITED, Cambridge, United Kingdom)
17:40Navigating Biophysical Space in Search of Medicines (PL06)
Dr Glyn WILLIAMS
(ASTEX PHARMACEUTICALS, Cambridge, United Kingdom)
Thursday June 8, 2017
Session 5: Detecting Allosteric Effectors
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
09:00Large Scale Protein Conformational Motions : From Fundamental Biophysics to Functional Dynamics (PL07)
Prof. Martin BLACKLEDGE
(IBS - INSTITUT DE BIOLOGIE STRUCTURALE, Grenoble, France)
09:45Identifying Allosteric Modifiers of K-RAS Using Second Harmonic Generation (OC09)
Dr Elizabeth VO
(UCSF, San Francisco, United States)
10:10Coffee Break
10:40Analysis of Allosteric Modulators with Kinetic Fret (OC11)
Dr Martin REDHEAD
(UCB, Slough, United Kingdom)
11:05Spectroscopic Adventures in Orthosteric and Allosteric Inhibition (PL08)
Dr Richard TAYLOR
(UCB, Slough, United Kingdom)
Session 3: Hot Topics (continued)
Session Chair
Dr Sandra JACOB
(NOVARTIS, Basel, Switzerland)
11:50Precision of Biophysical Techniques that Determine Protein? Compound Dissociation Constants, Lessons from our Database of over 700 Ligand Kds Determined by ITC, FTSA(DSF), SPR, and SFA (OC05)
Prof. Daumantas MATULIS
(INSTITUTE OF BIOTECHNOLOGY, Vilnius, Lithuania)
12:15Lunch & Networking
13:15Poster Session
Session 6: IDPs and the Dark Proteome
Session Chair
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom)
14:30Mechanistic Insights into TSPO and IDPs through NMR (PL09)
Prof. Markus ZWECKSTETTER
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)
Roundtable Discussion
15:15Increasing Success in Science by Increasing Diversity: From Methods to Gender
Session 6: IDPs and the Dark Proteome (continued)
Session Chair
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom)
16:00Finding Small-Molecules Inhibitors of the Interaction between the Intrinsically Disordered Androgen Receptor N-Terminal Domain and its Globular Partner RAP74 C-Terminal Domain (OC12)
Mrs Marta FRIGOLE-VIVAS
(INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA), Barcelona, Spain)
16:25Coffee Break
16:55Systematic Development of Small Molecules Against Aβ Aggregation (PL10)
Prof. Michele VENDRUSCOLO
(UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
17:40Poster Prizes
17:50End of the Day
20:00Conference Dinner
Friday June 9, 2017
Session 7: Antibodies and Relatives
Session Chair
Dr Jim BRYSON
(BRISTOL-MYERS-SQUIBB, Princeton, United States)
09:00Cutting-Edge Mass Spectrometry Methods for the Multi-Level Structural Characterization of mAbs and ADCs (KL03)
Dr Alain BECK
(PIERRE FABRE, St Julien-en-Genevois, France)
10:00Adnectin Bioconjugates for PET Imaging and Targeted Drug Conjugates (PL11)
Dr Jim BRYSON
(BRISTOL-MYERS-SQUIBB, Princeton, United States)
10:45Coffee Break
11:15Exhibitor Short Presentation: Pall ForteBio
Our Label-Free, Real-Time Kinetics Technologies with Microplate Sampling Allow for High-Throughput in Screening & Characterisation of Drug Candidates Including Challenging Matrixes Like Crude Biologicals or Fragments in DMSO
Mr Attila ARANYOS
(PALL CORPORATION, Saint-Germain-en-Laye, France)
11:25Thermal Stabilization and Conformational Trapping of Membrane Transporters by in Vitro Selected Synthetic Nanobodies (PL12)
Prof. Markus SEEGER
(UNIVERSITY OF ZURICH, Zürich, Switzerland)
12:10Closing Remarks and Departure

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