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| Wednesday July 6, 2016 |
| 08:00 | Registration & Welcome Coffee |
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| 09:00 | RICT 2016 Opening |
Prof. Patrick DALLEMAGNE (UNIVERSITY OF CAEN, Caen, France)
Dr Luc VAN HIJFTE (SCT & NOVALIX, Nijmegen, The Netherlands)
Prof. Pierre DENISE (UNIVERSITY OF CAEN, Caen, France) |
| Session 1: Paul Ehrlich Award Lecture
Sponsored by Janssen Research & Development |
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| Session Chairs |
Mrs Magali MOTTE (JANSSEN R&D, Val de Reuil, France)
Dr Luc VAN HIJFTE (SCT & NOVALIX, Nijmegen, The Netherlands) |
| 09:30 | Paul Ehrlich Prize Lecture
Trip in Drug Discovery (PL01) |
Prof. Jean-Daniel BRION
(UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France) |
| 10:30 | Coffee break & Exhibition |
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| Session 2: Target Identification |
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| Session Chair |
Mr Jean-Damien CHARRIER
(VERTEX PHARMACEUTICALS, OXON, United Kingdom) |
| 11:00 | Human Proteomes – from Basic Biology to Understanding Drug Action (PL02) |
Prof. Bernhard KÜSTER
(TECHNICAL UNIVERSITY MUNICH, Munich, Germany) |
| 11:45 | Target Deconvolution Efforts Around Wnt Pathway Screen Reveal Parallel Mechanisms of Action for 1,2,3-Thiadiazole-5-Carboxamide Series (PL03)
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Dr Andrew ZHANG
(ASTRAZENECA, Waltham, United States) |
| 12:30 | Lunch break & Exhibition |
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| 13:30 | Poster Session 1 |
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| Session 3: Chemical Biology |
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| Session Chair |
Dr Gordon TANG
(ROCHE R&D CENTER (CHINA) LTD, Shanghai, China) |
| 15:00 | Protein Modification: from Chemical Biology to Drug Discovery (PL04) |
Prof. Edward TATE
(IMPERIAL COLLEGE LONDON, London, United Kingdom) |
| 15:45 | A Role of SIRT2 in Cellular Response to Environmental Signals (PL05)
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Dr Minoru YOSHIDA
(RIKEN ADVANCED SCIENCE INSTITUTE (ASI), Saitama, Japan) |
| 16:30 | Coffee break & Exhibition |
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| Session 4: Inflammation and Nociception |
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| Session Chair |
Dr Henning STEINHAGEN
(APTUIT, Verona, Italy) |
| 17:00 | The Discovery and Optimization of Benzimidzoles as Selective NAV1.8 Blockers for the Treatment of Pain (PL06)
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Dr Alan BROWN
(STRATIFIED MEDICAL, Deal, United Kingdom) |
| 17:45 | Optimization and Exploration of Bradykinin 1 Receptor Antagonists for Inflammation (PL07) |
Dr Sven KÜHNERT
(GRUENENTHAL GMBH, Aachen, Germany) |
| 18:30 | Welcome Reception |
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| 20:30 | End of Day 1 |
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| Thursday July 7, 2016 |
| Session 5: Macrocycles |
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| Session Chair |
Dr Alexis DENIS
(GSK, Courtaboeuf, France) |
| 08:30 | Nanocyclix: a Chemical Biology Approach for Next Generation Kinase Inhibitors (PL08) |
Dr Jan HOFLACK
(ONCODESIGN, Dijon, France) |
Session 6: Case Study
Sponsored by Elsevier | Session 7: Kinases
Sponsored by Elsevier |
| Session Chair |
Dr Alexis DENIS
(GSK, Courtaboeuf, France) |
| 09:15 | Discovery of GLPG1690: a First-in-Class Autotaxin Inhibitor in Clinical Development for the Treatment of Idiopathic Pulmonary Fibrosis ( KL01)
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Dr Nicolas DESROY
(GALAPAGOS, Romainville, France) |
| 09:45 | Original Serotonergic Multi-Target Directed Ligands against Alzheimer's Disease (KL02)
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Dr Sylvie CLAEYSEN
(INSTITUT DE GÉNOMIQUE FONCTIONNELLE / CNRS / INSERM, Montpellier , France) |
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| Session Chair |
Prof. Anne Sophie VOISIN-CHIRET
(UNIVERSITY OF CAEN, Caen, France) |
| 09:15 | Development of Potent Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) (KL03) |
Dr Céline CANO
(NEWCASTLE CANCER CENTRE, Newcastle upon Tyne, United Kingdom) |
| 09:45 | Structure Guided Drug Discovery: Merits and Pitfalls Through the Example of Two Kinase Projects (KL04) |
Dr Andras KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary) |
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| 10:15 | Coffee break & Exhibition |
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| Session 8: CNS Targets |
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| Session Chair |
Prof. Christophe ROCHAIS
(UNIVERSITY OF CAEN, Caen, France) |
| 10:45 | MT5-MMP, a New Potential Therapeutic Target in Alzheimer’s Disease (PL09) |
Dr Santiago RIVERA
(CNRS / AIX-MARSEILLE UNIVERSITY, Marseille, France) |
| 11:30 | Discovery of Selective Dopaminergic D3 Receptor Antagonists with Potent 5HT6 Affinity (PL10) |
Dr Jean-Claude ORTUNO
(INSTITUT DE RECHERCHES SERVIER, SURESNES, France) |
| 12:15 | Lunch break & Exhibition |
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| 13:15 | Poster Session 2 |
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| 13:45 | Career Session |
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Session 9: Fragment Based Drug Design
Sponsored by Elsevier | Session 10: Breakthrough in Therapeutics
Sponsored by Elsevier |
| Session Chair |
Dr Laure HABERKORN
(INSTITUT DE RECHERCHES SERVIER, Suresnes, France) |
| 14:45 | NMR for Chemical Biology and Drug Discovery (KL05)
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Dr Isabelle KRIMM
(CNRS / UNIVERSITY OF LYON 1, Lyon, France) |
| 15:15 | Fragment-Based Design of ITK Inhibitors (KL06) |
Dr Steven DURRANT
(VERTEX PHARMACEUTICALS (EUROPE) LTD, Abingdon, United Kingdom) |
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| Session Chair |
Dr Olivier BARBERAN
(ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany) |
| 14:45 | Inhibiting Chromatin Assembly by Targeting Histone Chaperones (KL07)
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Dr Françoise OCHSENBEIN
(CEA SACLAY, Gif-sur-Yvette, France) |
| 15:15 | E.coli Anti-Adhesives, Potential Therapeutics for Crohn's Disease? (KL08) |
Dr Sébastien GOUIN
(UNIVERSITY OF NANTES, Nantes, France) |
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| Session 11: Mechanism Based Approaches | Session 10 (cont'd): Breakthrough in Therapeutics
Sponsored by Elsevier |
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| Session Chair |
Dr Olivier BARBERAN
(ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany) |
| 15:45 | Development of Novel Antiangiogenic Agents for the Treatment of Retinal Neovascularization via Integration of Chemistry and Biology (PL12) |
Prof. Young-Ger SUH
(SEOUL NATIONAL UNIVERSITY, Seoul, Korea, South) |
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| 16:30 | Coffee break & Exhibition |
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Session 12: Structure Based Drug Design
Sponsored by IPSEN | Session 13: CNS Disorders mGluR |
| Session Chair |
Dr Olivier LAVERGNE
(, Palaiseau, France) |
| 17:00 | Design of Chemical Probes Acting on Emerging Targets Assisted by Online Computational Tools (PL13) |
Dr Bruno VILLOUTREIX
(INSERM/UNIVERSITY PARIS DIDEROT, Paris, France) |
| 17:45 | Advances in Structure Based Drug Discovery of Membrane Protein Targets (PL14) |
Dr Michael HENNIG
(LEADXPRO, Villigen, Switzerland) |
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| Session Chair |
Dr Pascal GEORGE
(SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France) |
| 17:00 | Innovative Approaches to Control Metabotropic Glutamate Receptor Activity in the Brain (PL15) |
Dr Jean-Philippe PIN
(CNRS-UNIVERSITY OF MONTPELLIER, Montpellier, France) |
| 17:45 | The Design of mGluR Modulators for CNS Disorders (PL16) |
Dr Michiel VAN GOOL
(JANSSEN R&D, Toledo, Spain) |
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| 18:30 | End of Day 2 |
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| 20:00 | Symposium Banquet |
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| Friday July 8, 2016 |
| Session 14: Imaging | Session 15: Molecular Diversity and Drug Efficiency
Sponsored by Galapagos |
| Session Chair |
Prof. Ronan BUREAU
(UNIVERSITY OF CAEN, Caen, France) |
| 08:30 | Molecular Imaging Agents Based on Lanthanide Complexes (PL17) |
Dr Eva JAKAB-TOTH
(CNRS, Orléans, France) |
| 09:15 | Novel Fluorogenic Probes for In Vivo Imaging of Tiny Tumors and Super-Resolution Imaging in Living Cells (PL18) |
Prof. Yasuteru URANO
(THE UNIVERSITY OF TOKYO, Tokyo, Japan) |
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| Session Chair |
Dr Pierre DEPREZ
(GALAPAGOS, Romainville, France) |
| 08:30 | The Realisation of Activity-Directed Synthesis (PL19) |
Prof. Adam NELSON
(UNIVERSITY OF LEEDS, Leeds, United Kingdom) |
| 09:15 | Towards an Understanding of Cellular Drug Efficiency as a Way to Control Molecular Obesity (PL20) |
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| 10:00 | Coffee break & Exhibition |
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| Session 16: Case Study - Cancer
Sponsored by Idenix, an MSD Company |
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| Session Chair |
Dr Christophe PARSY
(IDENIX SARL, AN MSD COMPANY, MONTPELLIER, France) |
| 10:30 | Conquering the p53-MDM2 Protein-Protein Interaction Target at Novartis (PL21)
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Dr Pascal FURET
(NOVARTIS, Basel, Switzerland) |
| 11:15 | Discovery of the Type II Kinase Inhibitor LY3009120; a Pan-RAF Inhibitor Showing Minimal Paradoxical Activation and Anti-Cancer Activity Against BRAF or RAS Mutant Tumor Cells (PL22) |
Dr James R. HENRY
(ELI LILLY & CO., Indianapolis, United States) |
| Session 17: Pierre Fabre Award Lecture |
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| Session Chair |
Dr Frédéric MARION
(INSTITUT DE RECHERCHE PIERRE FABRE, Toulouse, France) |
| 12:00 | Pierre Fabre Award for Therapeutic Innovation
A Scien-trepreneur Journey From Digital to In-vivo Organic Chemistry (PL23) |
Dr Alain WAGNER
(CNRS/UNIVERSITY OF STRASBOURG, Illkirch, France) |
| Session 18: RICT 2016 Prizes, Future Event & Closing Remarks |
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| 13:00 | RICT 2016 Closing remarks & Prizes |
Prof. Janos SAPI
(SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France) |
| 13:15 | Introduction to RICT 2017 |
Dr Michel BALTAS
(CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France) |
| 13:30 | End of Day 3 & Lunch box |
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