RICT 2016

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Conferences > Archives > RICT 2016

Scientific Programme

Wednesday July 6, 2016
08:00Registration & Welcome Coffee
09:00RICT 2016 Opening
Prof. Patrick DALLEMAGNE (UNIVERSITY OF CAEN, Caen, France)
Dr Luc VAN HIJFTE (SCT & NOVALIX, Illkirch, France)
Prof. Pierre DENISE (UNIVERSITY OF CAEN, Caen, France)
Session 1: Paul Ehrlich Award Lecture
Sponsored by Janssen Research & Development
Session Chairs
Mrs Magali MOTTE (JANSSEN R&D, Val de Rueil, France)
Dr Luc VAN HIJFTE (SCT & NOVALIX, Illkirch, France)
09:30Paul Ehrlich Prize Lecture
Trip in Drug Discovery (PL01)
Prof. Jean-Daniel BRION
(UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France)
10:30Coffee break & Exhibition
Session 2: Target Identification
Session Chair
Mr Jean-Damien CHARRIER
(VERTEX PHARMACEUTICALS, OXON, United Kingdom)
11:00Human Proteomes – from Basic Biology to Understanding Drug Action (PL02)
Prof. Bernhard KÜSTER
(TECHNICAL UNIVERSITY MUNICH, Munich, Germany)
11:45Target Deconvolution Efforts Around Wnt Pathway Screen Reveal Parallel Mechanisms of Action for 1,2,3-Thiadiazole-5-Carboxamide Series (PL03)
Dr Andrew ZHANG
(ASTRAZENECA R&D, Waltham, United States)
12:30Lunch break & Exhibition
13:30Poster Session 1
Session 3: Chemical Biology
Session Chair
Dr Gordon TANG
(ROCHE R&D CENTER (CHINA) LTD, Shanghai, China)
15:00Protein Modification: from Chemical Biology to Drug Discovery (PL04)
Prof. Edward TATE
(IMPERIAL COLLEGE LONDON, London, United Kingdom)
15:45A Role of SIRT2 in Cellular Response to Environmental Signals (PL05)
Dr Minoru YOSHIDA
(RIKEN ADVANCED SCIENCE INSTITUTE (ASI), Saitama, Japan)
16:30Coffee break & Exhibition
Session 4: Inflammation and Nociception
Session Chair
Dr Henning STEINHAGEN
(APTUIT, Verona, Italy)
17:00The Discovery and Optimization of Benzimidzoles as Selective NAV1.8 Blockers for the Treatment of Pain (PL06)
Dr Alan BROWN
(STRATIFIED MEDICAL, London, United Kingdom)
17:45Optimization and Exploration of Bradykinin 1 Receptor Antagonists for Inflammation (PL07)
Dr Sven KÜHNERT
(GRUENENTHAL GMBH, Aachen, Germany)
18:30Welcome Reception
20:30End of Day 1
Thursday July 7, 2016
Session 5: Macrocycles
Session Chair
Dr Alexis DENIS
(GSK, Courtaboeuf, France)
08:30Nanocyclix: a Chemical Biology Approach for Next Generation Kinase Inhibitors (PL08)
Dr Jan HOFLACK
(ONCODESIGN, Dijon, France)
Session 6: Case Study
Sponsored by Elsevier
Session 7: Kinases
Sponsored by Elsevier
Session Chair
Dr Alexis DENIS
(GSK, Courtaboeuf, France)
09:15Discovery of GLPG1690: a First-in-Class Autotaxin Inhibitor in Clinical Development for the Treatment of Idiopathic Pulmonary Fibrosis ( KL01)
Dr Nicolas DESROY
(GALAPAGOS, Romainville, France)
09:45Original Serotonergic Multi-Target Directed Ligands against Alzheimer's Disease (KL02)
Dr Sylvie CLAEYSEN
(INSTITUT DE GÉNOMIQUE FONCTIONNELLE / CNRS / INSERM, Montpellier , France)
Session Chair
Prof. Anne Sophie VOISIN-CHIRET
(UNIVERSITY OF CAEN, Caen, France)
09:15Development of Potent Inhibitors of the DNA-Dependent Protein Kinase (DNA-PK) (KL03)
Dr Céline CANO
(NEWCASTLE CANCER CENTRE, Newcastle upon Tyne, United Kingdom)
09:45Structure Guided Drug Discovery: Merits and Pitfalls Through the Example of Two Kinase Projects (KL04)
Dr András KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary)
10:15Coffee break & Exhibition
Session 8: CNS Targets
Session Chair
Prof. Christophe ROCHAIS
(UNIVERSITY OF CAEN, Caen, France)
10:45MT5-MMP, a New Potential Therapeutic Target in Alzheimer’s Disease (PL09)
Dr Santiago RIVERA
(CNRS / AIX-MARSEILLE UNIVERSITY, Marseille, France)
11:30Discovery of Selective Dopaminergic D3 Receptor Antagonists with Potent 5HT6 Affinity (PL10)
Dr Jean-Claude ORTUNO
(INSTITUT DE RECHERCHES SERVIER, SURESNES, France)
12:15Lunch break & Exhibition
13:15Poster Session 2
13:45Career Session
Session 9: Fragment Based Drug Design
Sponsored by Elsevier
Session 10: Breakthrough in Therapeutics
Sponsored by Elsevier
Session Chair
Dr Laure HABERKORN
(INSTITUT DE RECHERCHES SERVIER, Suresnes, France)
14:45NMR for Chemical Biology and Drug Discovery (KL05)
Dr Isabelle KRIMM
(CNRS / UNIVERSITY OF LYON 1, Villeurbanne, France)
15:15Fragment-Based Design of ITK Inhibitors (KL06)
Dr Steven DURRANT
(VERTEX PHARMACEUTICALS (EUROPE) LTD, Abingdon, United Kingdom)
Session Chair
Dr Olivier BARBERAN
(ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany)
14:45Inhibiting Chromatin Assembly by Targeting Histone Chaperones (KL07)
Dr Françoise OCHSENBEIN
(CEA SACLAY, Gif-sur-Yvette, France)
15:15E.coli Anti-Adhesives, Potential Therapeutics for Crohn's Disease? (KL08)
Dr Sébastien GOUIN
(CNRS / UNIVERSITY OF NANTES, Nantes, France)
Session 11: Mechanism Based ApproachesSession 10 (cont'd): Breakthrough in Therapeutics
Sponsored by Elsevier
Session Chair
Dr Francine ACHER
(CNRS - UNIVERSITY PARIS DESCARTES, Paris, France)
15:45Protein Total Synthesis and the Challenge of Understanding MET Tyrosine Kinase Receptor Activation (PL11)
Dr Oleg MELNYK
(CNRS / UNIVERSITY OF LILLE / PASTEUR INSTITUTE OF LILLE, Lille, France)
Session Chair
Dr Olivier BARBERAN
(ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany)
15:45Development of Novel Antiangiogenic Agents for the Treatment of Retinal Neovascularization via Integration of Chemistry and Biology (PL12)
Prof. Young-Ger SUH
(SEOUL NATIONAL UNIVERSITY, Seoul, Korea, South)
16:30Coffee break & Exhibition
Session 12: Structure Based Drug Design
Sponsored by IPSEN
Session 13: CNS Disorders mGluR
Session Chair
Dr Olivier LAVERGNE
(, Les Ulis, France)
17:00Design of Chemical Probes Acting on Emerging Targets Assisted by Online Computational Tools (PL13)
Dr Bruno VILLOUTREIX
(INSERM / UNIVERSITY PARIS DIDEROT, Paris, France)
17:45Advances in Structure Based Drug Discovery of Membrane Protein Targets (PL14)
Dr Michael HENNIG
(LEADXPRO AG, Villigen, Switzerland)
Session Chair
Dr Pascal GEORGE
(SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France)
17:00Innovative Approaches to Control Metabotropic Glutamate Receptor Activity in the Brain (PL15)
Dr Jean-Philippe PIN
(CNRS / INSERM / UNIVERSITY OF MONTPELLIER, Montpellier, France)
17:45The Design of mGluR Modulators for CNS Disorders (PL16)
Dr Michiel VAN GOOL
(JANSSEN R&D, Toledo, Spain)
18:30End of Day 2
20:00Symposium Banquet
Friday July 8, 2016
Session 14: ImagingSession 15: Molecular Diversity and Drug Efficiency
Sponsored by Galapagos
Session Chair
Prof. Ronan BUREAU
(UNIVERSITY OF CAEN, Caen, France)
08:30Molecular Imaging Agents Based on Lanthanide Complexes (PL17)
Dr Eva JAKAB-TOTH
(CNRS, Orléans, France)
09:15Novel Fluorogenic Probes for In Vivo Imaging of Tiny Tumors and Super-Resolution Imaging in Living Cells (PL18)
Prof. Yasuteru URANO
(THE UNIVERSITY OF TOKYO, Tokyo, Japan)
Session Chair
Dr Pierre DEPREZ
(GALAPAGOS, Romainville, France)
08:30The Realisation of Activity-Directed Synthesis (PL19)
Prof. Adam NELSON
(UNIVERSITY OF LEEDS, Leeds, United Kingdom)
09:15Towards an Understanding of Cellular Drug Efficiency as a Way to Control Molecular Obesity (PL20)
Dr Mike HANN
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
10:00Coffee break & Exhibition
Session 16: Case Study - Cancer
Sponsored by Idenix, an MSD Company
Session Chair
Dr Christophe PARSY
(IDENIX SARL, AN MSD COMPANY, MONTPELLIER, France)
10:30Conquering the p53-MDM2 Protein-Protein Interaction Target at Novartis (PL21)
Dr Pascal FURET
(NOVARTIS, Basel, Switzerland)
11:15Discovery of the Type II Kinase Inhibitor LY3009120; a Pan-RAF Inhibitor Showing Minimal Paradoxical Activation and Anti-Cancer Activity Against BRAF or RAS Mutant Tumor Cells (PL22)
Dr James R. HENRY
(ELI LILLY & CO., Indianapolis, United States)
Session 17: Pierre Fabre Award Lecture
Session Chair
Dr Frédéric MARION
(INSTITUT DE RECHERCHE PIERRE FABRE, Toulouse, France)
12:00Pierre Fabre Award for Therapeutic Innovation
A Scien-trepreneur Journey From Digital to In-vivo Organic Chemistry (PL23)
Dr Alain WAGNER
(CNRS / UNIVERSITY OF STRASBOURG, Illkirch, France)
Session 18: RICT 2016 Prizes, Future Event & Closing Remarks
13:00RICT 2016 Closing remarks & Prizes
Prof. Janos SAPI
(SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France)
13:15Introduction to RICT 2017
Dr Michel BALTAS
(CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France)
13:30End of Day 3 & Lunch box

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