| Sunday 03/09/2023 |
| 15:30 | Registration |
|
| 17:10 | Opening Ceremony |
Dr Vesna GABELICA MARKOVIC (CROATIAN CHEMICAL SOCIETY, MEDICINAL & PHARMACEUTICAL CHEMISTRY SECTION, Zagreb, Croatia)
Prof. Karl GADEMANN (UNIVERSITY OF ZÜRICH, Zürich, Switzerland)
Dr Ingo HARTUNG (MERCK HEALTHCARE, Darmstadt, Germany)
Prof. Rui MOREIRA (UNIVERSITY OF LISBON, Lisbon, Portugal) |
| 17:30 | Opening Lecture
Synthetic and Medicinal Chemistry for Biologics (IL01) |
Prof. Jeffrey BODE
(ETH ZURICH, Zürich, Switzerland) |
| 18:30 | Welcome Reception |
|
| Monday 04/09/2023 |
| 08:00 | Registration |
|
| Session 1 |
|
| Session Chair |
Dr Luc VAN HIJFTE
(SYMERES, Nijmegen, The Netherlands) |
| 08:30 | Innovation in Synthetic Fluorine Chemistry through Use of Flow (IL02) |
Prof. Timothy NOËL
(UNIVERSITY OF AMSTERDAM, Amsterdam, The Netherlands) |
| 09:15 | MicroCycle: A Machine Learning Driven, Automated and Integrated Platform for Drug Discovery (IL03) |
Dr Cara BROCKLEHURST
(NOVARTIS, Basel, Switzerland) |
| 10:00 | Divergent Synthesis as an Emergent Tool for Drug Discovery (OC01) |
Prof. Alexandros ZOGRAFOS
(ARISTOTLE UNIVERSITY OF THESSALONIK, THESSALONIKI, Greece) |
| 10:15 | Coffee-break and Exhibition |
|
| 10:45 | Synthesis of Fluorinated Molecules Using Modern Synthetic Tools (IL04) |
Dr Tatiana BESSET
(INSA OF ROUEN, Mont-Saint-Aignan, France) |
| 11:30 | Chemical Probes and their Relevance for Drug Discovery Programs – Examples from the Endocannabinoid System (IL05) |
Dr Uwe GRETHER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| 12:15 | Isolation and Biological Activities of Natural Products and Analogues from the Adriatic Coral Eunicella Cavolini (OC02) |
Prof. Dean MARKOVIC
(UNIVERSITY OF RIJEKA, Rijeka, Croatia) |
| 12:30 | Lunch and Exhibition |
|
| 13:15 | Poster Session 1 |
|
| Session 2 |
|
| Session Chair |
Dr Sanja KOSTRUN
(SELVITA LTD., Zagreb, Croatia) |
| 14:30 | New Catalytic Approaches for Simplifying Complex Amine Synthesis (IL06) |
Prof. Darren J. DIXON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 15:15 | Challenges and Opportunities in CNS Drug Discovery (IL07) |
Dr Frauke POHLKI
(ABBVIE, Ludwigshafen, Germany) |
| 16:00 | Design and Optimization of High Performance KSPi ADCs With Increased Tumor Selectivity: Enhancing the Therapeutic Window by Legumain-Mediated ADC Activation (OC03) |
Dr Anne-Sophie REBSTOCK
(VINCERX, Monheim am Rhein, Germany) |
| 16:15 | Coffee-break and Exhibition |
|
| 16:45 | Enabling Technologies to Drive the MSD Portfolio (IL08) |
Dr Rebecca RUCK
(MERCK, SHARP & DOHME, Rahway, United States) |
| 17:30 | Empowering Organic Synthesis: From Unique Methods to Complex Natural Products (IL09) |
Prof. David SARLAH
(UNIVERSITY OF ILLINOIS, Urbana, United States) |
| 18:15 | Closing of the day |
|
| Tuesday 05/09/2023 |
| 08:30 | Session 3 |
|
| Session Chair |
Prof. Maria Laura BOLOGNESI
(UNIVERSITY OF BOLOGNA, Bologna, Italy) |
| 08:30 | Making Difficult-to-Make Molecules: Photochemistry as an Enabling Tool (IL25) |
Dr Susannah COOTE
(UNIVERSITY OF BATH, Bath, United Kingdom) |
| 09:15 | Structure Based Identification of Novel Albumin Binders for Half-Life Extensions of Proteins and Peptides (IL11) |
Dr Maria MÉNDEZ PÉREZ
(SANOFI-AVENTIS DEUTSCHLAND GMBH, Frankfurt, Germany) |
| 10:00 | High-Throughput Protac Synthesis and Direct to Biology Assaying for Rapidly Evaluating Targeted Protein Degradation (OC04) |
Dr Afjal MIAH
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
| 10:15 | Coffee-break and Exhibition
|
|
| 10:45 | Phenotypic Screen to NLRP3 lead (IL12) |
Dr Daniel OEHLRICH
(JANSSEN RESEARCH AND DEVELOPMENT, Beerse, Belgium) |
| 11:30 | Genochemetic Diversification of Natural Products (IL13) |
Prof. Rebecca GOSS
(UNIVERSITY OF ST ANDREWS, St Andrews, United Kingdom) |
| 12:15 | Development of Selective mTOR Inhibitors for the Treatment of Cancer and Neurological Disorders (OC05) |
Dr Chiara BORSARI
(UNIVERSITY OF MILAN, Milan, Italy) |
| 12:30 | Lunch and Exhibition
|
|
| 13:15 | Poster Session 2 |
|
| 14:30 | Session 4 |
|
| Session Chair |
Dr Ingo HARTUNG
(MERCK HEALTHCARE, Darmstadt, Germany) |
| 14:30 | Next Generation Design-Make-Test-Analysis-Cycles (IL14) |
Dr Clara CHRIST
(BAYER, Berlin, Germany) |
| 15:15 | Making and Breaking of C-S Bonds Using Metal Catalysis (IL15) |
Dr Ivana FLEISCHER
(UNIVERSITY OF TÜBINGEN, Tuebingen, Germany) |
| 16:00 | Discovery of Imidazo[1,2-a]Pyridine Carboxamide BAY 1165747, a Long-Acting Soluble Guanylate Cyclase Stimulator for Resistant Hypertension (OC06) |
Dr Alexandros VAKALOPOULOS
(BAYER, Wuppertal, Germany) |
| 16:15 | Coffee-break and Exhibition
|
|
| 16:45 | From BRD4 to KRAS: 12 Years of Oncology Small Molecules (IL16) |
Dr Darryl MCCONNELL
(BOEHRINGER INGELHEIM, Austria) |
| 17:30 | Synthesis of Glycosylated Natural Products or Analogues of Biological Interest (IL17) |
Dr Stéphanie NORSIKIAN
(INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France) |
| 18:15 | Closing of the day
|
|
| Wednesday 06/09/2023 |
| 08:30 | Session 5 |
|
| Session Chair |
Dr Werngard CZECHTIZKY
(ASTRAZENECA, Mölndal, Sweden) |
| 08:30 | Machine Learning to Accelerate Design-Make-Test Cycles (IL18) |
Dr Marwin SEGLER
(MICROSOFT RESEARCH, Cambridge, United Kingdom) |
| 09:15 | Covalent Chemical Biology with Natural Products and Novel Synthetic Warheads (IL19) |
Prof. Thomas POULSEN
(AARHUS UNIVERSITY, Aarhus C, Denmark) |
| 10:00 | Direct Access to Unnatural Drug-Like Molecules by Photocatalytic Late-Stage Functionalization (OC07) |
Prof. Olga GARCIA MANCHENO
(UNIVERSITY OF MÜNSTER, Münster, Germany) |
| 10:15 | Coffee-break and Exhibition
|
|
| 10:45 | Multicomponent Alkene Cross-Coupling by Base Metal Catalysis (IL20) |
Dr Ming Joo KOH
(NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore) |
| 11:30 | Novel, Reversible DCAF1 Ligands Expand the TPD-Toolbox (IL21) |
Dr Martin SCHRÖDER (NOVARTIS, Basel, Switzerland)
Dr Anna VULPETTI (NOVARTIS, Basel, Switzerland) |
| 12:15 | Cocktails For 19F NMR Fragment Screening: From Theory to Applications Using Enamine’s Stock Chemical Space (OC08) |
Prof. Dmytro VOLOCHNYUK
(ENAMINE LTD, Kyiv, Ukraine) |
| 12:30 | Lunch and Exhibition
|
|
| 13:15 | Poster Session 3
|
|
| 14:30 | Session 6 |
|
| Session Chair |
Prof. Rui MOREIRA
(UNIVERSITY OF LISBON, Lisbon, Portugal) |
| 14:30 | Disrupting the YAP-TEAD Protein-Protein Interaction with Small Molecules - Discovery of Drug Candidate NVP-IAG933 (IL22) |
Dr Nicolas SOLDERMANN
(NOVARTIS, Basel, Switzerland) |
| 15:15 | EFMC Prizes Session - Ceremony & Lectures |
|
| 15:20 | EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Academia
Targeted Protein Degradation via Molecular Glues (PR01) |
Dr Georg WINTER
(RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES, Vienna, Austria) |
| 15:35 | EFMC Prize for a Young Medicinal Chemist or Chemical Biologist in Industry
Discovery and Characterization of Potent, Efficacious and Orally Available Antimalarial Plasmepsin X Inhibitors (PR02) |
Dr Teresa DE HARO GARCIA
(UCB, Braine l'Alleud, Belgium) |
| 15:50 | EFMC-YMCS 2022 Best Oral Communication (OC09)
Epitope Identification Using In-Silico Approaches, a Case Study: Nanobodies Binding to MGlu5 Receptor |
Ms Floriane ESHAK
(UNIVERSITY PARIS CITÉ, Paris, France) |
| 16:05 | EFMC Best Practices Working Group |
Prof. Anders BACH
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark) |
| 16:15 | Coffee-break and Exhibition
|
|
| 16:45 | First time disclosure
Discovery of the clinical candidate BI 1810631 (Zongertinib), a Selective HER2 Inhibitor for the Treatment of
HER2 Exon 20 Insertion Driven Tumors (OC10) |
Dr Birgit WILDING
(BOEHRINGER INGELHEIM, Vienna, Austria) |
| 17:10 | Will Chemputers Dream of Electric Drugs (IL23) |
Prof. Leroy CRONIN
(UNIVERSITY OF GLASGOW, Glasgow, United Kingdom) |
| 17:55 | Closing of the day
|
|
| 20:00 | Symposium Banquet sponsored by Selvita
|
|
| Thursday 07/09/2023 |
| 08:30 | Session 7 |
|
| Session Chair |
Prof. Karl GADEMANN
(UNIVERSITY OF ZÜRICH, Zürich, Switzerland) |
| 08:30 | Taking Molecular Glue Degraders to New Heights (IL24) |
Dr Etienne DONCKELE
(MONTE ROSA THERAPEUTICS, Basel, Switzerland) |
| 09:15 | The beautiful simplicity of rearrangements – towards ideal reactions? (IL10)
Chemistry Europe Speaker |
Prof. Nuno MAULIDE
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| 10:00 | RSC Medicinal Chemistry Lectureship
Time to Shine for Constrained Peptides in Medicinal Chemistry (OC11) |
Prof. Christoph NITSCHE
(AUSTRALIAN NATIONAL UNIVERSITY, Canberra, Australia) |
| 10:15 | Coffee-break and Exhibition
|
|
| 10:45 | Novel Modes of Enzyme Inhibition (IL26) |
Dr Anders JOHANSSON
(ASTRAZENECA, Molndal, Sweden) |
| 11:30 | Natural Product Synthesis Through the Lens of Informatics (IL27) |
Prof. Ryan SHENVI
(SCRIPPS RESEARCH, La Jolla, United States) |
| 12:15 | Closing Remarks & Prize Ceremony
|
Prof. Karl GADEMANN
(UNIVERSITY OF ZÜRICH, Zürich, Switzerland) |
| 12:30 | End of the symposium
|
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