17th International Symposium on Preparative and Industrial Chromatography and Allied Techniques
Darmstadt, Germany October 7-10, 2018
Programme
Sunday October 7, 2018
13:00
Registration (until 19:00)
Foyer Hall Spectrum A
Workshops (subject to separate registration)
Start of parallel sessions
Workshop 1
Workshop 2
Workshop 1
14:00
Multicolumn Processes: From Historical SMB to the Latest Advances in the Purification of Biomolecules
José Paulo MOTA REQUIMTE/CQFB, FFCT, Caparica, Portugal Olivier DAPREMONT SK PHARMTECO, Rancho Cordova, United States
Workshop 2
From Development to Commercial Scale: How to Integrate QbD Tools and Data Analysis
Alessandro BUTTE ETH ZURICH, Zurich, Switzerland
15:30
Coffee Break
Start of parallel sessions
Workshop 3
Workshop 4
Workshop 3
16:00
Preparative HPLC of Peptides and Small Molecules: Phase Screening, Method Optimisation, Process Design
Michael SCHULTE MERCK KGAA, Darmstadt, Germany Jochen STRUBE CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany Ulrich EMDE MERCK KGAA, Darmstadt, Germany
Workshop 4
Real Time Monitoring and Control of
Process Chromatography
Alois JUNGBAUER UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria
Alois JUNGBAUER
Professor Alois Jungbauer received his PhD in Food Technology and Biotechnology from the University of Natural Resources and Life Sciences Vienna, Austria 1986. He serves since then as a professor at the Department of Biotechnology. He teaches Protein Technology and Downstream Processing and Bioprocess Engineering. He also acts as area head and Dep. Director of Research in the Austrian Centre of Industrial Biotechnology. He is currently working in the field of bioengineering of proteins, plasmids and viruses with special focus on expression, downstream processing and characterization of large biomolecules.
As a proliferate researcher he has more than 320 publications on recombinant protein production and bioseparation, 15 patents and 12 book contributions and recently a monograph entitled “Protein Chromatography , Process Development and Scale Up”. He is executive editor and co-founder of Biotechnology Journal, and member of editorial boards from numerous journals in the area of biochemical engineering.
17:45
Opening Ceremony
Hall Spectrum B+C
18:00
KL01 - A New View on Surface Diffusion from Molecular Dynamics Simulations of Solute Mobility at Chromatographic Interfaces
Professor Tallarek studied chemistry at the Eberhard-Karls-Universität Tübingen and obtained his Dr. rer. nat. in 1998 with an NMR imaging study of the fluid dynamics in porous media. As a Marie-Curie postdoctoral fellow from 1998 to 2000 in Wageningen (The Netherlands) he developed and applied NMR tools for the in situ characterization of transport in microfluidic devices, particularly electrokinetic microfluidics. From 2000 to 2007 he was on the faculty of the Department of Chemical and Process Engineering of the Otto-von-Guericke-Universität Magdeburg, where he completed his habilitation in 2004 (mentor: Prof. Dr.-Ing. Andreas Seidel-Morgenstern) and received a venia legendi for physical chemistry. Since 2007 he is professor of analytical chemistry and a member of the board of directors of the materials science center at the Philipps-Universität Marburg. His research focuses on the discovery and understanding of the fundamental morphology–functionality–transport relationships in functional porous materials, ranging from solute–surface interactions to macroscale transport. This approach relies on modern simulation methods to capture the involved widely different spatiotemporal scales and the precise physical reconstruction of porous media.
18:45
Welcome Reception
Hall Spectrum A
20:00
End of the Day
Monday October 8, 2018
08:00
Registration
Foyer Hall Spectrum A
08:45
Welcome
Session 1: Joachim Kinkel Symposium
Hall Spectrum B+C
Session Chair
Michael SCHULTE MERCK KGAA, Darmstadt, Germany
09:00
Opening Remarks
09:10
OC01 - Measurement, Description and Consistent Application of Adsorption Equilibria
Andreas SEIDEL-MORGENSTERN MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
Andreas SEIDEL-MORGENSTERN
Andreas Seidel-Morgenstern received in 1982 a Diplom in Chemical Engineering from Technische Hochschule Leuna-Merseburg and in 1987 a Ph.D. from the Institute of Physical Chemistry of the Academy of Sciences in Berlin-Adlershof. In 1991 and 1992 he was a postdoctoral fellow at the University of Tennessee in Knoxville. In 1994 he defended a Habilitation at the Technical University Berlin. After working for the pharmaceutical company Schering in Berlin, he became in 1995 Professor for Chemical Process Engineering at the Otto von Guericke University in Magdeburg. In 2002 he was appointed as a Director at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, where he is currently head of the “Physical and Chemical Foundations of Process Engineering” department. His research interests include heterogeneous and homogeneous catalysis, adsorption and preparative chromatography, crystallization and the development of new reactor concepts.
09:30
OC02 - How Continuous Chromatography Moved from Craftwork to Industry. A Tribute to Passion and Creativity.
AM-PHARMA
09:50
OC03 - Modified Inorganic Sorbents for the Fast and Efficient Separation of Biomolecules
Benjamin PETERS MERCK KGAA, Darmstadt, Germany
Benjamin PETERS
Benjamin Peters is a lab manager at Merck KGaA in Darmstadt. He develops inorganic analytical HPLC column materials and designs surface bondings for various chromatographic applications. His main work is based on the synthesis of silica monoliths.
Before taking over the responsibility as a lab manager,
Benjamin worked in different laboratories focussing on
process and analytical chromatography in quality control
as well as in research and development.
He joined Merck in 2006 as an apprentice for a chemical lab technician.
10:10
OC04 - Centrifugal Partition Chromatography: new Possibilities with a Liquid Stationary Phase
Mirjana MINCEVA TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
10:30
Coffee Break sponsored by MERCK
Hall Spectrum A
Session 2: Chromatographic Media
Hall Spectrum B+C
Session Chair
Tuomo SAINIO LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
Tuomo SAINIO
Tuomo Sainio has a PhD in Chemical Engineering from Lappeenranta University of Technology (LUT), Finland. Since 2014, he has been full professor in Separation Processes at LUT. His research interests include development of process design methods as well as applications of adsorption and extraction based separations in hydrometallurgy and biomass processing.
11:00
KL02 - On the Advantage of Ordered Chromatographic Media
Gert DESMET VRIJE UNIVERSITEIT BRUSSEL (VUB), Brussels, Belgium
Gert DESMET
Gert Desmet (°1967) has a Masters degree in chemical engineering and obtained his PhD in chemical engineering (fermentation technology) from the Vrije Universiteit Brussel (VUB), Brussels, Belgium, where he currently is a full professor in chemical engineering and heads the Department of Chemical Engineering. In 2012-2015, he was the vice-dean of the Faculty of Sciences and Bioengineering.
His research focuses on the miniaturization of separation methods and on the investigation and the modeling of flow effects in chromatographic systems. He is a past co-chair and chair of the Chemistry Panel of the Belgian National Science Fund (FWO) and is an Associate Editor of the journal Analytical Chemistry from the American Chemical Society. In 2016, he was rewarded an ERC Advanced Grant. He is also a member of the permanent scientific committee of the “International Symposium on High Performance Liquid Phase Separations and Related techniques” (HPLC) and the "International Symposium on Chromatography (ISC)” conference series, as well as of the SCM and HTC conference series.
11:40
OC05 - Interplay of Mathematics and Physics of 3D Printing for Chromatography
Carlos GRANDE SINTEF, Oslo, Norway
Carlos GRANDE
Carlos A. Grande got a PhD in adsorption processs at the University of Porto in Portugal. Since 2011, he works in SINTEF in Oslo, Norway where he is now Senior Research Scientist.
He works in topics related to the digitalization of the chemical industry and is currently the coordinator of Horizon 2020 project PRINTCR3DIT and of m-era.net project NESSIE both dealing with utilization of 3D printing for chemicals and pharmaceutical industries.
12:00
OC06 - New Adsorptive Technology and its Use Within Purification Platform for Antibody-Process Related Impurities Removal
Fabien ROUSSET CHIRAL TECHNOLOGIES, Illkirch, France
Fabien ROUSSET
Rousset Fabien, Head of DAICEL Bioseparations, Dr ROUSSET started his career at PALL Corporation, where he spent 8 years as R&D manager for the development of chromatography, filtration membranes and filters for bioprocesses. Then he joined Novasep to take care of consumables technology development and BioSC continuous chromatography as technical Director. In 2016, he joined the group DAICEL and his wholly owned subsidiary Chiral Technologies Europe, worldwide leader in chiral chromatography. He is holding the position of Head of Bioseparations Business Unit.
12:20
OC07 - A New Cation Exchange Resin Designed for the Removal of Monoclonal Antibody Aggregates Using Flow-Through Frontal Chromatography
Romas SKUDAS MERCK KGAA, Darmstadt, Germany
Romas SKUDAS
Dr Romas Skudas is currently a Senior Scientist/Lab Head within Merck KGaA, Darmstadt, Germany Process Solutions Chromatography R&D group. He has worked at Merck KGaA, Darmstadt, Germany since 2004 on a variety of topics, including the synthesis, characterization and modelling of separation materials and their use in economics biopharmaceutical molecule purification and characterization process. The most recent topic is biopharmaceutical molecule purification process optimization. Dr Skudas has authored several dozen journal articles, book chapters and patent publications, and he was invited to present at a range of conferences. He holds a doctorate degree in analytical and inorganic chemistry from Johannes Gutenberg University in Germany.
12:40
Lunch and Exhibition (until 14:00)
Hall Spectrum A
Start of parallel sessions
Vendor Seminar 1
Vendor Seminar 2
Vendor Seminar 1
13:00
Agilent Technologies
The New Benchmark for Preparative LC Workflows - Pathways to Achieve Exceptional Accuracy and Flexibility (13:00-14:00)
Vendor Seminar 2
Osaka Soda Co., Ltd.
Taming the Devil (Advances in the Understanding of CIP in RP HPLC Processes) (13:00-14:00)
Session 3: Theory and Simulations
Hall Spectrum B+C
Session Chair
Andreas SEIDEL-MORGENSTERN MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
Andreas SEIDEL-MORGENSTERN
Andreas Seidel-Morgenstern received in 1982 a Diplom in Chemical Engineering from Technische Hochschule Leuna-Merseburg and in 1987 a Ph.D. from the Institute of Physical Chemistry of the Academy of Sciences in Berlin-Adlershof. In 1991 and 1992 he was a postdoctoral fellow at the University of Tennessee in Knoxville. In 1994 he defended a Habilitation at the Technical University Berlin. After working for the pharmaceutical company Schering in Berlin, he became in 1995 Professor for Chemical Process Engineering at the Otto von Guericke University in Magdeburg. In 2002 he was appointed as a Director at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, where he is currently head of the “Physical and Chemical Foundations of Process Engineering” department. His research interests include heterogeneous and homogeneous catalysis, adsorption and preparative chromatography, crystallization and the development of new reactor concepts.
14:00
KL03 - Computational Fluid Dynamics to Understand Process Chromatography
Alois JUNGBAUER UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria
Alois JUNGBAUER
Professor Alois Jungbauer received his PhD in Food Technology and Biotechnology from the University of Natural Resources and Life Sciences Vienna, Austria 1986. He serves since then as a professor at the Department of Biotechnology. He teaches Protein Technology and Downstream Processing and Bioprocess Engineering. He also acts as area head and Dep. Director of Research in the Austrian Centre of Industrial Biotechnology. He is currently working in the field of bioengineering of proteins, plasmids and viruses with special focus on expression, downstream processing and characterization of large biomolecules.
As a proliferate researcher he has more than 320 publications on recombinant protein production and bioseparation, 15 patents and 12 book contributions and recently a monograph entitled “Protein Chromatography , Process Development and Scale Up”. He is executive editor and co-founder of Biotechnology Journal, and member of editorial boards from numerous journals in the area of biochemical engineering.
14:40
OC08 - When Adsorption Models or Intuition Fail at Describing Ion-Exchange Chromatography
Speaker to be confirmed YPSO-FACTO
Speaker to be confirmed
EDUCATION:
• Chemical Engineer at CPE LYON (France)
• PhD Chemical Engineering at University Claude BERNARD Lyon (France)
EXPERIENCE:
• R&D Engineer at NOVASEP (France), 2005-2011.
• Scientific Calculation Manager at PROCESSIUM (France), 2011-2016
• Innovation Manager at PROESSIUM (France), 2016-2018
• Currently, Head of Biotech Modeling at YPSO-FACTO (France)
15:00
OC09 - Improvement of Multicapillary Packing Efficiency by Diffusional Bridging: A Theoretical and Dynamic Simulation Study
Francois PARMENTIER SEPARATIVE, Solaize, France
Francois PARMENTIER
François Parmentier is chemical engineer. He graduated in chemistry from Bordeaux Engineering School and in Chemical Engineering from ENSIC in Nancy whit honours.
After 10 years in research and operational functions at Rhone Poulenc in France, he directed his career toward numerical simulation and joined RSI company in Grenoble, subsidiary of IFPEN, where he passed 15 years as head of the chemical engineering modelling department.
In 2014 he founded Separative company, devoted to the development of innovative solutions in chromatography .
15:20
OC10 - Chromatographic Separations with Focusing of Both the Weak and the Strong Component
Tuomo SAINIO LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
Tuomo SAINIO
Tuomo Sainio has a PhD in Chemical Engineering from Lappeenranta University of Technology (LUT), Finland. Since 2014, he has been full professor in Separation Processes at LUT. His research interests include development of process design methods as well as applications of adsorption and extraction based separations in hydrometallurgy and biomass processing.
15:40
Coffee Break sponsored by AMPAC FINE CHEMICALS
Hall Spectrum A
Session 4: Continuous Chromatography
Hall Spectrum B+C
Session Chair
Olivier DAPREMONT SK PHARMTECO, Rancho Cordova, United States
16:10
OC11 - Design and Optimization of a Continuous Separation of Tartronic and Glyceric Acids by Simulated Moving Bed
Lucas Coêlho has a Bachelor and a Master degree in Pharmaceutical Science from the Federal University of Pernambuco (UFPE), in Brazil since 2010. After the Master, he has become Project Manager and, later on, Industrial Director of a Brazilian company that develops products and processes for sugar mills and water treatment sectors. In 2013, returned to academic studies at UFPE and in 2017 obtained his PhD degree in Chemical Engineering, in collaboration with the Faculty of Engineering of University of Porto (Portugal). Lucas also has a Specialization in Innovation Management and Technology Diffusion and always has been involved with themes related to research, development and Innovation. Currently, he is a Post-Doc researcher, at the Laboratory of Separation and Reaction Engineering (LSRE-LCM) working with Prof. Alírio Rodrigues, aiming the production and purification of added value compounds of industrial interest from waste raw materials.
& FEDERAL UNIVERSITY OF PERNAMBUCO, Recife, Brazil
16:30
OC12 - Strategies for the Global Multicomponent Separation of Nadolol Stereoisomers by Chiral and Achiral Fixed-Bed and Simulated Moving Bed Chromatography
António E. RIBEIRO POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal
António E. RIBEIRO
Dr. António Ribeiro has a PhD in Chemical and Biological Engineering obtained in University of Porto. Is now teaching Chemical and Biological Engineering in the Polytechnic Institute of Bragança and divides his investigation between the two Institutions (Porto and Bragança). The main interest area is the development of separation and extraction of pharmaceutical and natural high-added-value products by means of continuous adsorptive separation processes, such as the simulated moving bed and related techniques.
16:50
OC13 - Inexiotech - This Disruptive Technology Allows for the Resolution of Multicomponent Mixtures in a Serial Continuous Process
Alexandre MACIUK UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France
Alexandre MACIUK
- Pharmacist, Strasbourg University, France;
- PhD in Reims, France, (Dr Renault), methodology development in centrifugal partition chromatography, especially in preparative displacement modes;
- Visiting fellow in Danish Pharmaceutical University, Copenhagen (Dr Jarosewski), development of LC-SPE-NMR applications on natural products;
- Post-doctoral fellow in National Institute of Aging, NIH, Baltimore (Dr Wainer), development of immobilized receptor chromatography for drug screening;
- Associate Professor in Pharmacy school, Paris-South University, France, screening of natural products for bioactive compounds using bioanalytical method development on MS;
- Expert on French and European Food Safety Agencies
- Consultant for Fauquet Innovation for chromatographic development.
- 40 publications, 3 patents.
& FAUQUET INNOVATION, Montmagny, France
17:10
OC14 - Model Predictive Control of 4-Zone Simulated Moving Bed Chromatography for the Separation of Bicalutamide Enantiomers: Experimental Validation
Ju Weon LEE MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany
Ju Weon LEE
Education
• Feb. 1997. Bachelor, Department of Chemical Engineering, Inha University, Republic of Korea
• Feb. 1999. Master, Department of Chemical Engineering, Inha University, Republic of Korea
• Aug. 2007. Ph.D., Department of Chemical Engineering, Inha University, Republic of Korea
Job History
• Dec. 2009– Present. Postdoctoral associate, Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany -
Supervisor: Prof. Andreas Seidel-Morgenstern
• Sept. 2007– Nov. 2009. Postdoctoral associate, School of Chemical Engineering, Purdue University, West Lafayette, IN, U.S.A. Supervisor: Prof. Phillip C. Wankat
17:30
OC15 - Evaluation of Continuous Purification of Therapeutic Extracellular Vesicles
Mafalda MOLEIRINHO INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal
Mafalda MOLEIRINHO
Mafalda Moleirinho is a Biological Engineer from Instituto Superior Técnico in Lisbon, Portugal. Since 2015, Mafalda is working in the Downstream Lab at Animal Cell Technology at Instituto de Biologia Experimental e Tecnológica (iBET), in Oeiras. In 2016, Mafalda enrolled the MIT-Portugal PhD program in Bioengineering and her investigation has been focused in the development of new purification strategies for viral particles and nanovesicles.
17:50
Poster Session 1 & Beer Party
Hall Spectrum A
18:50
End of the Day
Tuesday October 9, 2018
Session 5: Peptides and Proteins
Hall Spectrum B+C
Session Chair
José Paulo MOTA REQUIMTE/CQFB, FFCT, Caparica, Portugal
08:30
KL04 - Synthetic Peptide Manufacturing: Downstream Challenges and Innovations
Olivier LUDEMANN-HOMBOURGER POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France
Olivier LUDEMANN-HOMBOURGER
Olivier Ludemann-Hombourger is currently the General Director of PolyPeptide Laboratories France. He is involved in the manufacturing of synthetic peptides since 2009 : He worked during three years for Lonza in Braine l’Alleud (Belgium) as head of Operations, before joining PolyPeptide Group to Manage the French entity. The site is mainly involved in the development of new APIs.
He received his PhD in 2001 from “Institut National PolyTechnique de Lorraine” in France, in collaboration with Novasep Process, for which he was leading the R&D activity during 10 years. His core scientific expertise is related to preparative chromatography processes with a specific focus on the development of multi-column technologies. He managed the development and industrialization of the VARICOL process currently applied at manufacturing scale for the production of several APIs.
He was the chairman of several Symposia, including the 14th SPICA Event in Brussels in 2012.
09:10
OC16 - Hybrid Optimisation of Preparative Chromatography for a Difficult and Realistic Ternary Protein Mixture
Vivien FISCHER UNIVERISTY COLLEGE LONDON / GLAXOSMITHKLINE, Stevenage , United Kingdom
Vivien FISCHER
Vivien Fischer graduated with a Master’s degree in Biosystems Engineering from the University of Magdeburg, Germany in 2013. She has gained more than 6 years of industrial experience in the bioprocessing arena through research collaborations at Sartorius Stedim Biotech, Germany and Domantis, UK (now part of GlaxoSmithKline). Currently, Vivien is pursuing an Engineering Doctorate in Biochemical Engineering at University College London and in collaboration with GlaxoSmithKline, UK. Her project focusses on early phase bioprocess development for the chromatographic separation of antibodies, employing experimental modelling.
09:30
OC17 - Scalability of Mini-Columns in Protein Chromatography
Dorota ANTOS RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota ANTOS
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland, in 1998. The Ph.D. thesis was awarded by Polish Minister of Education.
She conducted research at Politecnico di Milano, Italy in 1997, at Max-Planck-Institute in Magdeburg, Germany in 1999-2001 and in the frame of Fulbright Grant, at University of Virginia in 2006.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany in 2003. In 2012 she was nominated as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
09:50
OC18 - Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy
Adrian SANDEN KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
Adrian SANDEN
08/2016 – present: PhD student at Karlsruhe Institute of Technology, Biomolecular Separation Engineering
06/2016 – 07/2016: Scientific Assistant at the Institute for Biomolecular Separation Engineering
10/2013 - 05/2016: Master of Science in Bioengineering at Karlsruhe Institute of Technology
05/2014 - 12/2015: Scientific Assistant at the Institute for Technical Biology
11/2013 - 03/2014: Internship: Student Scientist at CSL Behring in Melbourne, Department for Research and Development Albumin & IgG
10/2010 - 10/2013: Bachelor of Science in Bioengineering at Karlsruhe Institute of Technology
Dorota ANTOS RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota ANTOS
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland, in 1998. The Ph.D. thesis was awarded by Polish Minister of Education.
She conducted research at Politecnico di Milano, Italy in 1997, at Max-Planck-Institute in Magdeburg, Germany in 1999-2001 and in the frame of Fulbright Grant, at University of Virginia in 2006.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany in 2003. In 2012 she was nominated as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
11:00
OC20 - Continuous Biomanufacturing- Platform Alternatives for Antibody Production
Steffen ZOBEL-ROOS CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
11:20
OC21 - Antibody Aggregate Removal Using Frontal Chromatography: Performance Comparison Between Column and Membrane Adsorber
Sebastian VOGG ETH ZURICH, Zürich, Switzerland
Sebastian VOGG
Sebastian Vogg obtained his Master degree in Chemical and Bioengineering at ETH Zurich in 2016. He conducted his Master thesis at MIT under the supervision of Prof. Stephanopoulos. Afterwards, he joined the group of Prof. Morbidelli to pursue a PhD working on integrated continuous downstream processing of therapeutic proteins.
11:40
OC22 - Continuous Conjugation of Antibodies By rMCSGP
Nicole ULMER ETH ZURICH, Zurich, Switzerland
Nicole ULMER
Nicole Ulmer obtained her MSc in Chemical and Bioengineering from ETH Zurich in the year 2011. She worked afterwards for six years at ChromaCon on continuous chromatography. She started her PhD in 2015 under the supervision of Prof. Morbidelli in the field of protein modification and purification.
12:00
OC23 - Temperature Dependence of Antibody Adsorption in Protein A Affinity Chromatography
Walpurga KREPPER UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria
Walpurga KREPPER
Walpurga Krepper obtained her Master degree in Biological Chemistry from the University of Vienna in 2016. She conducted her Master thesis in the Downstream department of Boehringer Ingelheim GmbH & Co KG and afterwards joined the group of Alois Jungbauer for her PhD. The focus of her work lies on chromatographic methods for antibody purification.
12:20
Lunch Break and Exhibition (until 13:40)
Hall Spectrum A
Start of parallel sessions
Vendor Seminar 3
Vendor Seminar 4
Vendor Seminar 3
12:40
Kromasil-AkzoNobel PPC
Method Development and Purification of Biotherapeutics including Peptides and Oligonucleotides (12:40-13:40)
Vendor Seminar 4
Tosoh Bioscience GmbH
Reduce your Downstream Processing Costs and Know More About your Target Molecules (12:40-13:40)
13:40
Poster Session 2
Hall Spectrum A
Session 7: Green Purification Technologies
Hall Spectrum B+C
Session Chair
Pilar FRANCO CHIRAL TECHNOLOGIES EUROPE, Illkirch, France
KL05 - SFC-MS in Drug Discovery: The Technology Shaping Tomorrow’s Innovation
Gerard ROSSE DART NEUROSCIENCE, San Diego, United States
Gerard ROSSE
Dr Rosse is currently Scientific and Business Development Consultant at Dart Neuroscience and serves as Adjunct Associate Professor at Drexel University. Prior he was Associate Director at Dart NeuroScience and he functioned in leadership and scientific positions in medicinal and analytical chemistry with Cephalon, Sanofi and F. Hoffman-La Roche. During his industrial tenure, he led multidisciplinary teams and invented pre-clinical candidates for a wide range of therapeutic indications (CNS, Inflammation, Metabolism, Oncology, Antibacterial agents). Dr Rosse’s career is also characterized by the implementation of innovative chemical technology and analytical chemistry platforms based on SFC that accelerated the drug discovery process and reduced costs. He received the Ph.D. degree in chemistry from the University of Basel in Switzerland and postdoctoral training at Stanford University, California.
15:20
OC24 - Alternative Approaches in Preparative Chromatography for Purifying Lipophilic Compounds and the Elimination of Chlorinated Solvents
Markus JUZA CORDEN PHARMA SWITZERLAND, Liestal, Switzerland
Markus JUZA
Dr Juza has studied in Germany and made his PhD at the university of Tübingen in the field of analytical and preparative enantioselective chromatographic methods.
After a post-doc at the federal institute of technology in Zürich with Professors Morbidelli and Mazzotti he lead for more than a decade teams dealing with preparative HPLC and SMB in Switzerland and France bevor returning to analytical development for pharmaceuticals and vitamins.
Since 2015 Dr. Juza leads the prep. HPLC-group at Corden Pharma Switzerland as “Purification Expert” dealing with the purification of lipids, carbohydrates and peptides.
He is author of more than 50 scientific publications and book chapters and teaches courses on enantioselective chromatographic methods and preparative HPLC.
15:40
OC25 - Studies on Robustness of SFC: Examples from Chiral and Peptide Separations
Torgny FORNSTEDT KARLSTAD UNIVERSITY, Karlstad, Sweden
16:00
OC26 - Operating Mode Selection for Ternary Separations with Liquid-Liquid Chromatography
Raena MORLEY TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
Raena MORLEY
• B.Sc. in Chemical Engineering, University of Rhode Island
• M.Sc. in Advanced Materials and Processes, Friedrich Alexander University Erlangen-Nuremberg
• Since 12/2015 Ph.D. Candidate in the Biothermodynamics group (Prof. Mirjana Minceva) at the Technical University of Munich.
Research focus: Model-based design approaches for preparative liquid-liquid chromatography processes
16:20
Coffee Break and Exhibition
Hall Spectrum A
Session 8: Natural Products
Hall Spectrum B+C
Session Chair
Mirjana MINCEVA TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
16:50
KL06 - Accessing Nature’s Chemical Diversity for Drug Discovery
Philipp KRASTEL NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland
Philipp KRASTEL
Philipp Krastel received a bachelor degree in chemistry from the University of Kiel, Germany (1994). He then went on to obtain his masters degree majoring in organic chemistry from the University of Göttingen, Germany (1997). He received a Ph.D. from the same university (2001) specializing in natural product research. In his thesis research he investigated the metabolic profile of different endosymbionts from beetles and insects. After one year of postdoctoral training at the Institute of Biomelecular Chemistry at the University of Göttingen he started 2002 as a Research Investigator in the Natural Products Units of the Novartis Institutes of Biomedical Research in Basel focusing on the analytical and preparative characterization of secondary metabolites form microorganisms. Since 2008 he is the Group Leader of the Natural Product Chemistry group of the Natural Products Unit.
17:30
OC27 - Development of a Chromatographic Based Purification Strategy for Artemisinin from Artemisia Annua L. Extract
Fabian MESTMÄCKER CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Fabian MESTMÄCKER
Academic Education:
B.Sc. at Institute for Separation and Process Technology, TU Clausthal
M.Sc. at Institute for Separation and Process Technology, TU Clausthal
Ph.D student since 02/2017 at Institute for Separation and Process Technology, TU Clausthal
Ph.D supervisor: Prof. Dr.-Ing. Strube
Topic: continuous chromatography
17:50
OC28 - Chromatographic Recovery of Hydroxy Acids, Lignin, and Pulping Chemicals from Spent Alkaline Pulping Liquors
Jari HEINONEN LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
20:00
Gala Dinner
Wednesday October 10, 2018
Session 9: Antibodies and Proteins II
Hall Spectrum B+C
Session Chair
Olivier LUDEMANN-HOMBOURGER POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France
Olivier LUDEMANN-HOMBOURGER
Olivier Ludemann-Hombourger is currently the General Director of PolyPeptide Laboratories France. He is involved in the manufacturing of synthetic peptides since 2009 : He worked during three years for Lonza in Braine l’Alleud (Belgium) as head of Operations, before joining PolyPeptide Group to Manage the French entity. The site is mainly involved in the development of new APIs.
He received his PhD in 2001 from “Institut National PolyTechnique de Lorraine” in France, in collaboration with Novasep Process, for which he was leading the R&D activity during 10 years. His core scientific expertise is related to preparative chromatography processes with a specific focus on the development of multi-column technologies. He managed the development and industrialization of the VARICOL process currently applied at manufacturing scale for the production of several APIs.
He was the chairman of several Symposia, including the 14th SPICA Event in Brussels in 2012.
08:30
OC29 - Visualization and Quantification of Protein Bind and Elute Processes to the IEX Hydrogel of a Membrane Adsorber
Adrian LEY SARTORIUS STEDIM BIOTECH GMBH / INSTITUTE OF PHYSICAL CHEMISTRY, GEORG-AUGUST UNIVERSITY GOETTINGEN, Goettingen, Germany
Adrian LEY
Highschool Degree in Dieburg (near Darmstadt) in 2010 B. Sc and M.Sc in Chemistry at the University of Göttingen between 2010 and 2015 PhD Student in Polymer Chemistry since 2016 at the University of Göttingen in collaboration with the Sartorius Stedim Biotech GmbH
08:50
OC30 - Water on Hydrophobic Surfaces - Mechanistic Modeling of Polyethylene Glycol-Induced Protein Precipitation
Steffen GROSSHANS KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Karlsruhe, Germany
09:10
OC31 - Membrane Based Separation of Aqueous Two-Phase Systems for the Purification of Monoclonal Antibodies
Thomas KRUSE SARTORIUS STEDIM BIOTECH & CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Göttingen, Germany
Thomas KRUSE
July 2009: High school diploma (Johann Georg Lingemann Gymnasium, Heilbad Heiligenstadt)
September 2013: B.Sc. Biochemistry/ Molecular Biology at the Friedrich Schiller University Jena (Center for Molecular Biomedicine, Jena)
September 2015: M.Sc. Biochemistry at the Friedrich Schiller University Jena (Fritz Lipmann Institute, Jena)
from June 2016: PhD at the Institute for Separation and Process Technology (Clausthal University of Technology) in cooperation with Sartorius Stedim Biotech GmbH (Göttingen)
09:30
SPICA 2018 Poster Prizes
09:50
Coffee Break and Exhibition
Hall Spectrum A
Session 10: Process Optimization Chromatography and Case Studies
Hall Spectrum B+C
Session Chair
Jochen STRUBE CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
10:20
KL07 - Efficient Simulation and Control of Chromatographic Processes
Achim KIENLE OTTO VON GUERICKE UNIVERSITY MAGDEBURG, Magdeburg, Germany
Achim KIENLE
Achim Kienle is Professor for Automation/Modelling at the Otto von Guericke University in Magdeburg. In parallel he is leading a reserch group at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg as an external scientific member. He has studied Chemical Engineeering at Stuttgart University, where he also did his PhD and his Habilitation.
Main research interest are:
+Dynamics and control of chemical processes including
- chromatographic processes
- particulate processes
- integrated chemical processes
+Mixed integer nonlinear optimization of novel process concepts
+Modeling and dynamics of vaccine and biopolymer production processes
11:00
OC32 - Automatic Determination of Optimum Operating Concepts and Process Variables for Multi-Component Separations
Johannes SCHMÖLDER FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany
Johannes SCHMÖLDER
Johannes Schmölder studied Life Science Engineering, graduating at the Friedrich-Alexander-University Erlangen-Nuremberg (FAU).
Since January 2016, he has been a Scientific Assistant in the group of Professor Kaspereit at the Institute of Separation Science & Technology at the FAU. His work focuses on building simulation and optimization frameworks for chromatographic processes.
11:20
OC33 - Optimization of Processes Combining Chemistry & Purification - Strategies & Case Studies
Jérome BONI NOVASEP FINORGA, Chasse-sur-Rhone, France
Jérome BONI
Graduated in Organic Chemistry, I joined NovaSep in 1999 as R&D Engineer and took several positions as Project Manager, R&D Manager, Production Manager, Industrialization Manager and then Head of R&D and Pilotting department (in 2013) at Novasep Pompey site (CDMO & Equipment supplier site).
Since 2017, I took the position of Technologies manager at Novasep Chasse sur Rhône site (near to Lyon, dedicated to manufacturing small molecules/Chemistry), for which I am involving at implementing/developing technologies such as Flow chemistry, Batch and Continuous Preparative Chromatography, filtrration (Batch and continuous), ....
My expertise is mainly in the downstream processes field (batch and continuous chromatography using Low and High pressure for biomolecules and synthetic, filtration (micro, nano, viral, ...) using batch or continuous mode, etc) I also used to use modeling and simulation for designing chromato. processes.
11:40
OC34 - Continuous Centrifugal Partition Chromatography: Using a Mass Transfer Model for Process Optimization and Various Mode Comparison
Luc MARCHAL UNIVERSITÉ DE NANTES, Saint Nazaire, France
12:00
OC35 - Model-Based Quality by Design: Challenges, Pitfalls and Best Practices
Maria CASALS PERAVAREZ GOSILICO, Karlsruhe, Germany
Maria CASALS PERAVAREZ
Maria Casals Peralvarez studied biotechnology and bioengineering in Barcelona and Delft, graduating from TU Delft in 2017 with a master’s degree in "Life science & technology". She specialized in process design and optimization, working on both upstream and downstream projects, for example with BOKU and ACIB Vienna. Maria joined GoSilico in 2017 where she performs consultancy services and contract development for industrial downstream processes.