Session 5: Peptides and Proteins
Hall Spectrum B+C
Session Chair
José Paulo MOTA
REQUIMTE/CQFB, FFCT, Caparica, Portugal
08:30
KL04 - Synthetic Peptide Manufacturing: Downstream Challenges and Innovations
Olivier LUDEMANN-HOMBOURGER
POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France
Olivier Ludemann-Hombourger is currently the General Director of PolyPeptide Laboratories France. He is involved in the manufacturing of synthetic peptides since 2009 : He worked during three years for Lonza in Braine l’Alleud (Belgium) as head of Operations, before joining PolyPeptide Group to Manage the French entity. The site is mainly involved in the development of new APIs.
He received his PhD in 2001 from “Institut National PolyTechnique de Lorraine” in France, in collaboration with Novasep Process, for which he was leading the R&D activity during 10 years. His core scientific expertise is related to preparative chromatography processes with a specific focus on the development of multi-column technologies. He managed the development and industrialization of the VARICOL process currently applied at manufacturing scale for the production of several APIs.
He was the chairman of several Symposia, including the 14th SPICA Event in Brussels in 2012.
09:10
OC16 - Hybrid Optimisation of Preparative Chromatography for a Difficult and Realistic Ternary Protein Mixture
Vivien FISCHER
UNIVERISTY COLLEGE LONDON / GLAXOSMITHKLINE, Stevenage , United Kingdom
Vivien Fischer graduated with a Master’s degree in Biosystems Engineering from the University of Magdeburg, Germany in 2013. She has gained more than 6 years of industrial experience in the bioprocessing arena through research collaborations at Sartorius Stedim Biotech, Germany and Domantis, UK (now part of GlaxoSmithKline). Currently, Vivien is pursuing an Engineering Doctorate in Biochemical Engineering at University College London and in collaboration with GlaxoSmithKline, UK. Her project focusses on early phase bioprocess development for the chromatographic separation of antibodies, employing experimental modelling.
09:30
OC17 - Scalability of Mini-Columns in Protein Chromatography
Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland, in 1998. The Ph.D. thesis was awarded by Polish Minister of Education.
She conducted research at Politecnico di Milano, Italy in 1997, at Max-Planck-Institute in Magdeburg, Germany in 1999-2001 and in the frame of Fulbright Grant, at University of Virginia in 2006.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany in 2003. In 2012 she was nominated as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
09:50
OC18 - Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy
Adrian SANDEN
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
08/2016 – present: PhD student at Karlsruhe Institute of Technology, Biomolecular Separation Engineering
06/2016 – 07/2016: Scientific Assistant at the Institute for Biomolecular Separation Engineering
10/2013 - 05/2016: Master of Science in Bioengineering at Karlsruhe Institute of Technology
05/2014 - 12/2015: Scientific Assistant at the Institute for Technical Biology
11/2013 - 03/2014: Internship: Student Scientist at CSL Behring in Melbourne, Department for Research and Development Albumin & IgG
10/2010 - 10/2013: Bachelor of Science in Bioengineering at Karlsruhe Institute of Technology
10:10
OC19 - Cost Effective Peptide Purification via ZEOsphere DRP Mixed-Mode Chromatography
Alessandro BUTTE
ETH ZURICH, Zurich, Switzerland
10:30
Coffee Break and Exhibition
Hall Spectrum A
Session 6: Purification of Antibodies I
Hall Spectrum B+C
Session Chair
Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland, in 1998. The Ph.D. thesis was awarded by Polish Minister of Education.
She conducted research at Politecnico di Milano, Italy in 1997, at Max-Planck-Institute in Magdeburg, Germany in 1999-2001 and in the frame of Fulbright Grant, at University of Virginia in 2006.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany in 2003. In 2012 she was nominated as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
11:00
OC20 - Continuous Biomanufacturing- Platform Alternatives for Antibody Production
Steffen ZOBEL-ROOS
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
11:20
OC21 - Antibody Aggregate Removal Using Frontal Chromatography: Performance Comparison Between Column and Membrane Adsorber
Sebastian VOGG
ETH ZURICH, Zürich, Switzerland
Sebastian Vogg obtained his Master degree in Chemical and Bioengineering at ETH Zurich in 2016. He conducted his Master thesis at MIT under the supervision of Prof. Stephanopoulos. Afterwards, he joined the group of Prof. Morbidelli to pursue a PhD working on integrated continuous downstream processing of therapeutic proteins.
11:40
OC22 - Continuous Conjugation of Antibodies By rMCSGP
Nicole ULMER
ETH ZURICH, Zurich, Switzerland
Nicole Ulmer obtained her MSc in Chemical and Bioengineering from ETH Zurich in the year 2011. She worked afterwards for six years at ChromaCon on continuous chromatography. She started her PhD in 2015 under the supervision of Prof. Morbidelli in the field of protein modification and purification.
12:00
OC23 - Temperature Dependence of Antibody Adsorption in Protein A Affinity Chromatography
Walpurga KREPPER
UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria
Walpurga Krepper obtained her Master degree in Biological Chemistry from the University of Vienna in 2016. She conducted her Master thesis in the Downstream department of Boehringer Ingelheim GmbH & Co KG and afterwards joined the group of Alois Jungbauer for her PhD. The focus of her work lies on chromatographic methods for antibody purification.
12:20
Lunch Break and Exhibition (until 13:40)
Hall Spectrum A
12:40
Kromasil-AkzoNobel PPC
Method Development and Purification of Biotherapeutics including Peptides and Oligonucleotides (12:40-13:40)
Tosoh Bioscience GmbH
Reduce your Downstream Processing Costs and Know More About your Target Molecules (12:40-13:40)
13:40
Poster Session 2
Hall Spectrum A
Session 7: Green Purification Technologies
Hall Spectrum B+C
Session Chair
Pilar FRANCO
CHIRAL TECHNOLOGIES EUROPE, Illkirch, France
14:40
KL05 - SFC-MS in Drug Discovery: The Technology Shaping Tomorrow’s Innovation
Gerard ROSSE
DART NEUROSCIENCE, San Diego, United States
Dr Rosse is currently Scientific and Business Development Consultant at Dart Neuroscience and serves as Adjunct Associate Professor at Drexel University. Prior he was Associate Director at Dart NeuroScience and he functioned in leadership and scientific positions in medicinal and analytical chemistry with Cephalon, Sanofi and F. Hoffman-La Roche. During his industrial tenure, he led multidisciplinary teams and invented pre-clinical candidates for a wide range of therapeutic indications (CNS, Inflammation, Metabolism, Oncology, Antibacterial agents). Dr Rosse’s career is also characterized by the implementation of innovative chemical technology and analytical chemistry platforms based on SFC that accelerated the drug discovery process and reduced costs. He received the Ph.D. degree in chemistry from the University of Basel in Switzerland and postdoctoral training at Stanford University, California.
15:20
OC24 - Alternative Approaches in Preparative Chromatography for Purifying Lipophilic Compounds and the Elimination of Chlorinated Solvents
Markus JUZA
CORDEN PHARMA SWITZERLAND, Liestal, Switzerland
Dr Juza has studied in Germany and made his PhD at the university of Tübingen in the field of analytical and preparative enantioselective chromatographic methods.
After a post-doc at the federal institute of technology in Zürich with Professors Morbidelli and Mazzotti he lead for more than a decade teams dealing with preparative HPLC and SMB in Switzerland and France bevor returning to analytical development for pharmaceuticals and vitamins.
Since 2015 Dr. Juza leads the prep. HPLC-group at Corden Pharma Switzerland as “Purification Expert” dealing with the purification of lipids, carbohydrates and peptides.
He is author of more than 50 scientific publications and book chapters and teaches courses on enantioselective chromatographic methods and preparative HPLC.
15:40
OC25 - Studies on Robustness of SFC: Examples from Chiral and Peptide Separations
Torgny FORNSTEDT
KARLSTAD UNIVERSITY, Karlstad, Sweden
16:00
OC26 - Operating Mode Selection for Ternary Separations with Liquid-Liquid Chromatography
Raena MORLEY
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
• B.Sc. in Chemical Engineering, University of Rhode Island
• M.Sc. in Advanced Materials and Processes, Friedrich Alexander University Erlangen-Nuremberg
• Since 12/2015 Ph.D. Candidate in the Biothermodynamics group (Prof. Mirjana Minceva) at the Technical University of Munich.
Research focus: Model-based design approaches for preparative liquid-liquid chromatography processes
16:20
Coffee Break and Exhibition
Hall Spectrum A
Session 8: Natural Products
Hall Spectrum B+C
Session Chair
Mirjana MINCEVA
TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany
16:50
KL06 - Accessing Nature’s Chemical Diversity for Drug Discovery
Philipp KRASTEL
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland
Philipp Krastel received a bachelor degree in chemistry from the University of Kiel, Germany (1994). He then went on to obtain his masters degree majoring in organic chemistry from the University of Göttingen, Germany (1997). He received a Ph.D. from the same university (2001) specializing in natural product research. In his thesis research he investigated the metabolic profile of different endosymbionts from beetles and insects. After one year of postdoctoral training at the Institute of Biomelecular Chemistry at the University of Göttingen he started 2002 as a Research Investigator in the Natural Products Units of the Novartis Institutes of Biomedical Research in Basel focusing on the analytical and preparative characterization of secondary metabolites form microorganisms. Since 2008 he is the Group Leader of the Natural Product Chemistry group of the Natural Products Unit.
17:30
OC27 - Development of a Chromatographic Based Purification Strategy for Artemisinin from Artemisia Annua L. Extract
Fabian MESTMÄCKER
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Academic Education:
B.Sc. at Institute for Separation and Process Technology, TU Clausthal
M.Sc. at Institute for Separation and Process Technology, TU Clausthal
Ph.D student since 02/2017 at Institute for Separation and Process Technology, TU Clausthal
Ph.D supervisor: Prof. Dr.-Ing. Strube
Topic: continuous chromatography
17:50
OC28 - Chromatographic Recovery of Hydroxy Acids, Lignin, and Pulping Chemicals from Spent Alkaline Pulping Liquors
Jari HEINONEN
LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland
20:00