4th NovAliX Conference

Biophysics in Drug Discovery 2017

Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs

 Strasbourg, France    June 6-9, 2017

Scientific Programme


13:00

Registration

14:00

Welcome Address

Session 1: Biophysical Techniques for the Study of Integral Membrane Proteins

Session Chair

Dr Ursula EGNER
BAYER, Berlin, Germany

14:15

Use of Mini-G Proteins to Study the Activate State of G Protein-Coupled Receptors (PL01)

Dr Chris TATE
MRC LABORATORY OF MOLECULAR BIOLOGY, Cambridge, United Kingdom

15:00

Biophysical Analysis to Aid and Complement Structure Based Drug Design for GPCRS (OC01)

Dr Carmen DREGGER
HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom

15:25

Method for Rapid Optimization of Recombinant GPCR Protein Expression and Stability Using Virus-Like Particles (OC02)

Dr Kathleen AERTGEERTS
DART NEUROSCIENCE, San Diego, United States

15:50

Coffee Break

16:20

Enabling Biophysics on Membrane Proteins Targets : Example of a Human Nucleoside Transporter (PL02)

Dr Nicolas BOCQUET
LEADXPRO AG, Villigen, Switzerland

17:05

Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics

Dr Matyas VEGH
CREOPTIX AG, Wädenswil, Switzerland

17:15

Exhibitor Short Presentation: Synthelis
Cell-free technology, expertise and services for your project in structural biology

Mrs Safia EZZINE
SYNTHELIS, La Tronche, France

Keynote Lecture

Chair

Prof. Rod HUBBARD
UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom

17:25

Allosteric Mechanisms of Signal Transduction Investigated with Pentameric Ligand Gated Ion Channels: Consequences for Drug Design (KL01)

Prof. Jean-Pierre CHANGEUX
COLLÈGE DE FRANCE & INSTITUT PASTEUR, Paris, France

18:25

Welcome Reception

20:00

End of the Day

08:30

Registration

Session 2: Recent Advances in NMR

Session Chair

Dr Chun-wa CHUNG
GLAXOSMITHKLINE, Stevenage, United Kingdom

09:00

Study of Protein Folding and Ligand Binding by Pressure Jump NMR (PL03)

Prof. Ad BAX
NATIONAL INSTITUTES OF HEALTH, Bethesda, United States

09:45

NMR as a Powerful Tool for Identifying Natural Compounds Able to Interfere with ELAV-mRNA Complexes (OC03)

Dr Francesca VASILE
UNIVERSITY OF MILANO, Milano, Italy

10:10

Coffee Break

10:40

New NMR Tools for Drug Discovery : From Validation to Structure Determination (PL04)

Dr Alvar GOSSERT
ETH ZÜRICH, Zürich, Switzerland

Session 3: Hot Topics

Session Chair

Dr Sandra JACOB
NOVARTIS, Basel, Switzerland

11:25

Biophysical Assays to Answer Evolving Questions in Drug Discovery (OC04)

Dr Derrick MEINHOLD
GLAXOSMITHKLINE, Conshohocken, United States

11:50

Exhibitor Short Presentation: Sierra Sensors
High-Throughput SPR Screening in Drug Discovery

Dr Sven MALIK
SIERRA SENSORS, Hamburg, Germany

12:00

Exhibitor Short Presentation: Biodesy
Screening with Structural Insight: High Throughput Measurement of Protein Conformational Change

Dr Tad GEORGE
BIODESY, San Francisco, United States

Session 5: Detecting Allosteric Effectors (advanced)

Session Chair

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

12:10

Surface Plasmon Resonance Based Method to Discriminate Direct Competition and Allosteric Effects in Ternary Systems (OC10)

Dr Armin RUF
F. HOFFMANN - LA ROCHE, Basel, Switzerland

12:35

Lunch & Networking

Session 4: Recent Advances in FBDD

Session Chair

Prof. Rod HUBBARD
UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom

14:00

FBLD and Biophysics: Better Together (KL02)

Dr Dan ERLANSON
CARMOT THERAPEUTICS, San Francisco, United States

15:00

XCHEM: A High Throughput in Crystallo Fragment Screening Platform (OC06)

Dr Alexandre DIAS
DIAMOND LIGHT SOURCE LTD, Didcot, Oxon, United Kingdom

15:25

Fragment Screening against DC-SIGN Identifies Multiple Druggable Secondary Sites (OC07)

Mr Hannes BAUKMANN
MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES, Potsdam-Golm, Germany

15:50

Coffee Break

16:20

Fragment Based Lead Generation – What Drives Success? (PL05)

Dr Jenny SANDMARK
ASTRAZENECA, Gothenburg, Sweden

17:05

A New Heuristic to Predict 3D Ligand Bound Conformation by Mining PDB Subpockets (OC08)

Mr Olivier BEQUIGNON
JANSSEN R&D, Val de Reuil Cedex, France

17:30

Exhibitor Short Presentation: Domainex
The MST Approach to Fragment Screening

Prof. Trevor PERRIOR
DOMAINEX LIMITED, Cambridge, United Kingdom

17:40

Navigating Biophysical Space in Search of Medicines (PL06)

Dr Glyn WILLIAMS
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom

Session 5: Detecting Allosteric Effectors

Session Chair

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

09:00

Large Scale Protein Conformational Motions : From Fundamental Biophysics to Functional Dynamics (PL07)

Prof. Martin BLACKLEDGE
IBS - INSTITUT DE BIOLOGIE STRUCTURALE, Grenoble, France

09:45

Identifying Allosteric Modifiers of K-RAS Using Second Harmonic Generation (OC09)

Dr Elizabeth VO
UCSF, San Francisco, United States

10:10

Coffee Break

10:40

Analysis of Allosteric Modulators with Kinetic Fret (OC11)

Dr Martin REDHEAD
UCB, Slough, United Kingdom

11:05

Spectroscopic Adventures in Orthosteric and Allosteric Inhibition (PL08)

Dr Richard TAYLOR
UCB, Slough, United Kingdom

Session 3: Hot Topics (continued)

Session Chair

Dr Sandra JACOB
NOVARTIS, Basel, Switzerland

11:50

Precision of Biophysical Techniques that Determine Protein? Compound Dissociation Constants, Lessons from our Database of over 700 Ligand Kds Determined by ITC, FTSA(DSF), SPR, and SFA (OC05)

Prof. Daumantas MATULIS
INSTITUTE OF BIOTECHNOLOGY, Vilnius, Lithuania

12:15

Lunch & Networking

13:15

Poster Session

Session 6: IDPs and the Dark Proteome

Session Chair

Dr Geoff HOLDGATE
ASTRAZENECA, Macclesfield, United Kingdom

14:30

Mechanistic Insights into TSPO and IDPs through NMR (PL09)

Prof. Markus ZWECKSTETTER
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany

Roundtable Discussion

15:15

Increasing Success in Science by Increasing Diversity: From Methods to Gender

Session 6: IDPs and the Dark Proteome (continued)

Session Chair

Dr Geoff HOLDGATE
ASTRAZENECA, Macclesfield, United Kingdom

16:00

Finding Small-Molecules Inhibitors of the Interaction between the Intrinsically Disordered Androgen Receptor N-Terminal Domain and its Globular Partner RAP74 C-Terminal Domain (OC12)

Mrs Marta FRIGOLE-VIVAS
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA), Barcelona, Spain

16:25

Coffee Break

16:55

Systematic Development of Small Molecules Against Aβ Aggregation (PL10)

Prof. Michele VENDRUSCOLO
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

17:40

Poster Prizes

17:50

End of the Day

20:00

Conference Dinner

Session 7: Antibodies and Relatives

Session Chair

Dr Jim BRYSON
BRISTOL-MYERS-SQUIBB, Princeton, United States

09:00

Cutting-Edge Mass Spectrometry Methods for the Multi-Level Structural Characterization of mAbs and ADCs (KL03)

Dr Alain BECK
PIERRE FABRE, St Julien-en-Genevois, France

10:00

Adnectin Bioconjugates for PET Imaging and Targeted Drug Conjugates (PL11)

Dr Jim BRYSON
BRISTOL-MYERS-SQUIBB, Princeton, United States

10:45

Coffee Break

11:15

Exhibitor Short Presentation: Pall ForteBio
Our Label-Free, Real-Time Kinetics Technologies with Microplate Sampling Allow for High-Throughput in Screening & Characterisation of Drug Candidates Including Challenging Matrixes Like Crude Biologicals or Fragments in DMSO

Mr Attila ARANYOS
PALL CORPORATION, Saint-Germain-en-Laye, France

11:25

Thermal Stabilization and Conformational Trapping of Membrane Transporters by in Vitro Selected Synthetic Nanobodies (PL12)

Prof. Markus SEEGER
UNIVERSITY OF ZURICH, Zürich, Switzerland

12:10

Closing Remarks and Departure