EFMC-YMCS 2016

3rd EFMC Young Medicinal Chemists' Symposium

 Manchester, UK    September 1-2, 2016

Programme


14:15

Registration

15:00

Welcome and opening

15:00

Session Chair

Prof. Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium

15:05

Case Histories of Fragment-Based Drug Discovery.

Dr David REES
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom

15:35

Heterocycles and Medicinal Chemistry: the Importance of Innovative Synthesis

Dr Anthony WOOD
PFIZER, Waltham, United States

YMCS Competition Presentation Session I

16:05

New Avenues in Protein Labeling - Exploiting Dna for Directing Chemical Reactions
Winner of the young medicinal chemist meeting in Denmark (CP01)

Dr Anne Louise Bank KODAL
NOVO NORDISK, Bagsværd, Denmark

16:25

Drug Design, Synthesis and Biological Evaluation of Antiretroviral and Anticancer Agents
Winner of the young medicinal chemist meeting in Italy (CP02)

Dr Valeria FAMILGLINI
UNIVERSITY OF ROME, Rome, Italy

16:45

Development of Potent, Cell-Active Inhibitors of the Mycobacterium Tuberculosis Cholesterol Oxidase Cyp125 (OC01)

Ms Madeline KAVANAGH
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

17:05

Flash Poster Presentations

FP01- Toward Libraries of Artificial Macrocycles

Mrs Eman ABD ELRAHEEM
GRONINGEN UNIVERSITY, Groningen, The Netherlands

FP02 - Discovery, Structural Exploration and Biological Profiling of a Novel Class of Antimycobacterial Dpre1 Inhibitors

Ms Olga BALABON
UNIVERSITY OF ANTWERP, Wilrijk, Belgium

FP03 - Orally Bioavailable Antimalarial 4(1h)-Quinolone Prodrugs with Single-Dose Cures

Dr Fabian BROCKMEYER
NORTHEASTERN UNIVERSITY, Germany

FP04 - Developement of Synthesis Methodology for Dna-Encoded Small Molecule Screening Libraries

Dr Mateja KLIKA SKOPIC
TECHNISCHE UNIVERSITÄT DORTMUND, Dortmund, Germany

FP05 - Fishing for an Off-Target": Deconvoluting the Molecular Mechanism of Gpcr-Induced Macrophage Chemotaxis"

Dr Maria CHATZOPOULOU
UNIVERSITY OF OXFORD, Oxford, United Kingdom

FP06 - Design, Synthesis and Pharmacological Evaluation of Fluorescent Tools for Studying Cannabinoid Type 2 Receptor

Ms Anna COOPER
UNIVERSITY OF OTAGO, Dunedin, New Zealand

FP07 - Development of Novel, Selective and Irreversible Pi3kδ Inhibitors

Mr Sam DALTON
UNIVERSITY OF STRATHCLYDE, Glasgow, United Kingdom

FP08 - Identification of Novel Non-Natural Supramolecular Ligands as Stabilizers of 14-3-3? Protein-Protein Interactions

Dr Alba GIGANTE
DUISBURG ESSEN UNIVERSITY, Tres Cantos-Madrid, Spain

FP09 - Targets in Orphan Diseases and Their Repurposing Candidates - Analysis with a Knime Workflow Using Open Phacts

Ms Jana GURINOVA
UNIVERSITY OF VIENNA, Vienna, Austria

FP10 - Selectivity Profiling of the Human Monoamine Transporters: A Case Study on Cathinone Analogs

Ms Eva HELLSBERG
UNIVERSITY OF VIENNA, Vienna, Austria

FP11 - Photoswitchable 4-(Piperidin-4-Yl)-1-Hydroxypyrazole Analogues for the Gaba Type A Receptors

Ms Henriette KIHL
UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark

FP12 - Extending Sar of Bile Acids as Fxr/Tgr5 Modulators: Synthesis and Biological Activity of Ring C Modified Cdca Derivatives

Ms Serena MOSTARDA
UNIVERSITÀ DEGLI STUDI DI PERUGIA, Perugia, Italy

FP13 - Lead Optimisation of a Novel Class of Trypanosomacidal Agents

Ms Harriet NEWSON
UNIVERSITY OF WESTERN AUSTRALIA, Australia

FP14 - Synthesis and Biological Evaluation of Diaromatic Guanidinium-Like Derivatives as Protein Kinase Inhibitors for the Treatment of Cancer

Ms Viola PREVITALI
TRINITY COLLEGE DUBLIN, Dublin, Ireland

FP15 - Development of Novel 1,4-Benzodiazepines as Antitrypanosomal Agents

Dr Santo PREVITI
UNIVERSITY OF MESSINA, Messina, Italy

FP16 - Determining the Binding Mode of 3-(1-Alkyl-1h-Imidazol-5-Yl)-1h-Indoles

Dr Adam HOGENDORF
MAJ INSTITUTE OF PHARMACOLOGY, POLISH ACADEMY OF SCIENCES, Krakow, Poland

FP17 - Targeting the Human Dihydroorotate Dehydrogenase (Hdhodh) by a Scaffold Hopping Bioisosteric Approach Using Hydroxylated Pentaatomic Heterocycles

Dr Stefano SAINAS
UNIVERSITY OF TORINO, Torino, Italy

FP18 - Towards the Elucidation of the Mechanism of Action of Small Molecule Upregulators of Utrophin Using Chemical Proteomics

Dr Aini VUORINEN
UNIVERSITY OF OXFORD, Oxford, United Kingdom

FP19 - Development of an Albumin-Binding Ligand for Prolonging the Plasma Half-Life of Peptide Therapeutics

Mr Alessandro ZORZI
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE , Lausanne, Switzerland

FP20 - Near-Infrared (Nir) Photothermal Therapy Using Biocompatible Palladium Nanoparticles

Dr Belen RUBIO RUIZ
UNIVERSITY OF EDINBURGH, Edinburgh, United Kingdom

17:45

YMCS Poster presentation session & Networking drink

19:00

End of the day

YMCS Competition Presentation Session II

08:30

Antimalarial Drug Discovery: Exploring the Mep Pathway
Winner of the young medicinal chemist meeting in the United Kingdom (CP03)

Ms Kathryn PRICE
UNIVERSITY OF LIVERPOOL, Liverpool, United Kingdom

08:50

Drugging the Undrugguble: Targeting Challenging E3 Ligases
Winner of the young medicinal chemist meeting in Spain (CP04)

Dr Carles GALDEANO
UNIVERSITAT DE BARCELONA, Barcelona, Spain

09:10

Development of Highly Selective and Reversible Diacylglycerol Lipase Inhibitors
Winner of the young medicinal chemist meeting in The Netherlands (CP05)

Dr Freek JANSSEN
LEIDEN UNIVERSITY, Nijmegen, The Netherlands

09:30

Functional Lipidomics-Based Lead Discovery Reveals Novel Role of Phospholipids in Vitamin A Signaling
Winner of the young medicinal chemist meeting in Germany (CP06)

Dr Andreas KOEBERLE
UNIVERSITY OF JENA, Jena, Germany

09:50

Design, Synthesis and Biological Evaluation of Selective CDK Inhibitors based on Flavopiridol Structure
Winner of the young medicinal chemist meeting in Greece (CP07)

Dr Nikitia MEXIA
UNIVERSITY OF ATHENS, Leeds, United Kingdom

10:10

Coffee break

YMCS Competition Presentation Session III

10:35

Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex Dna Structures
Winner of the young medicinal chemist meeting in Sweden (CP08)

Dr Madeleine LIVENDAHL
UMEA UNIVERSITY, Umeå, Sweden

10:55

Stable, Effective, and Selective Anticancer Phenolato Titanium(Iv) Complexes
Winner of the young medicinal chemist meeting in Israel (CP09)

Dr Sigalit MEKER
THE HEBREW UNIVERSITY OF JERUSALEM, Kfar Yona, Israel

11:15

Glyco-Conjugated Photosensitizers: From Synthesis to Validation in Cancer Photodynamic Therapy
Winner of the young medicinal chemist meeting in Portugal (CP10)

Ms Patricia PEREIRA
UNIVERSIDADE DE AVEIRO, Aveiro, Portugal

11:35

Discovery of Cct251921: A Potent, Selective and Orally Bioavailable Small Molecule Modulator of the Mediator Complex-Associated Kinases Cdk8 and Cdk19 (OC02)

Dr Aurelie MALLINGER
INSTITUTE OF CANCER RESEARCH, London, United Kingdom

11:55

Lunch

YMCS Competition Presentation Session IV

13:15

How to Design Cell Permeable Non-Peptidic Macrocycles (OC03)

Dr Björn OVER
MACROCYCLE ADME, BEYOND RO5 AND NATURAL PRODUCT-FRAGMENTS, Landvetter, Sweden

13:35

New 3d-Scaffolds for Fragment-Based Lead Discovery (Fbld): Exploration of Chemical Space Using Functionalized Spirohydantoins
Winner of the young medicinal chemist meeting in France (CP11)

Mr Hugues PREVET
LABORATORY U1177 - UNIVERSITY OF LILLE, Lille, France

13:55

Discovery Of Novel Atpase Inhibitors Of Dna Gyrase And Topoisomerase Iv Starting From Marine Sponge Alkaloid Oroidin
Winner of the young medicinal chemist meeting in Slovenia (CP12)

Dr Tihomir TOMASIC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

14:15

Purine Mimicking 3'-Ethynylribofuranose Nucleosides: New Opportunities for an Old Sugar Modification
Winner of the young medicinal chemist meeting in Belgium (KVCV) (CP13)

Dr Fabian HULPIA
UGENT, Ghent, Belgium

14:35

Experimental Platform for Characterization and High-Throughput Screening of Acetylcholinesterase Inhibitors
Winner of the young medicinal chemist meeting in Poland (CP14)

Dr Piotr DRACZKOWSKI
UNIVERSITY OF LUBLIN, Lublin, Poland

14:55

Novel Derivatives of the Tspo Ligand Dpa-714 For in Vivo Pet Imaging of Neuroinflammation (OC04)

Mrs Fanny CACHEUX
CEA, Orsay, France

15:15

Voting Break

15:30

Closing and award ceremony