Drug Analysis 2014

Pharmacometabolomics: a Tool for Drug Discovery and Personalised Medicine

Coral BARBAS

SAN PABLO - CEU UNIVERSITY, Madrid, Spain
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Coral BARBAS

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Coral Barbas has a PhD in Analytical Chemistry at Complutense University in Madrid

Current positions:
-Professor of Analytical Chemistry, Pharmacy Faculty, Universidad CEU San Pablo, Madrid (Spain) and
-Responsible for the “Centre for Metabolomics and Bioanalysis” (CEMBIO) at this Faculty.
-Vice-Chancellor for Research at Universidad CEU San Pablo
-Visiting Professor at Imperial College London

Previous appointments:
Marie Curie Fellow at Kings College London

Awards:
Angel Herrera Research award 2004-05

Main Research Areas:
-Bioanalysis:
Development of analytical methodology for in vivo assays
Study of in vivo effect of natural extracts with potential antioxidant activity in diabetic rats
Lastly, metabolomic fingerprinting of biofluids looking for biomarkers of cardiovascular diseases, diabetes, pulmonary diseases, leishmania infection, among others with GC-MS, LC-MS and CE-MS.

Others:
-Collaboration with leading groups in different countries.

-Over 130 publications in main journals of the area. 10 PhD thesis with the highest marks

-Member of Board of the Royal Spanish Society of Chemistry

Quality Control of Chinese Herbal Medicines

Rudolf BAUER

UNIVERSITY OF GRAZ, Graz, Austria
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Rudolf BAUER

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Dr. Rudolf Bauer studied pharmacy 1976 1980 at University of Munich; 1984 graduation as Ph.D. at the Institute of Pharmaceutical Biology, University of Munich, under the supervision of Prof. Dr. H. Wag¬ner; 1993 – 2002 Associate Professor at the Institute of Pharmaceutical Biology, University of Düsseldorf; since 2002 full professor of pharmacognosy at University of Graz, Austria, and since 2004 Head of the Institute of Pharmaceutical Sciences at University of Graz. Together with Professor Litscher (Medical University of Graz) he is heading the TCM Research Center Graz. Besides he is acting as a guest professor in several universities in China. He has long experience in natural product chemistry, analysis, and the bioassay-guided isolation of constituents from medicinal plants. He has published ca. 300 research papers. In 2010, he has been awarded with the Norman R. Farnsworth Excellence in Botanical Research Award of the American Botanical Council, and he is recipient of the Egon-Stahl-Award of the Society for Natural Product and Medicinal Plant Research (GA). He is former president of GA, founding president of the Good Practice in TCM Research Association, and Editor of Planta Medica. Prof Bauer has been active in the development methods for quality control of Chinese herbs for 20 years. As a member of two expert groups on herbal drugs of the European Pharmacopoeia Commission he is actively involved in the development of monographs for the European Pharmacopoeia.

State of the Art Mass Spectrometry Methods for Antibodies, Biosimilars, Bispecifics and ADCs Characterization

Alain BECK

PIERRE FABRE, St Julien-en-Genevois, France
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Alain BECK

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Dr. A. Beck is Senior Director, Antibody/ADC Physico-Chemistry and member of the board of directors of the CIPF. He contributed to the R&D of anticancer mAbs (dalotuzumab/IGF-1R with Merck, h224G11/cMet with Abbott, h515H7/CXCR4, h6F4/JAM-A), vaccines and peptides. He is inventor on 16 patents, author of near 110 publications an reports, associate editor of mAbs (www.landesbioscience.com) and guest editor for special issues on mAbs (Nat Rev Immunol, Curr Pharm Biotech, Medecine/ Sciences and Meth Mol Biol). He has contributed to near 180 scientific communications in meetings as chairman, invited speaker, panelist, moderator, advisor, and/or organizer. He is also regularly invited to boards of experts by the WHO, the EMA, the European Commission, Funding Agencies (Belgium, Czech, Dutch, France, Ontario, Poland, New Zealand) and bio-clusters (Alsace Biovalley, CLARA, Genopole, LyonBiopole).

Tutorial: An Analysis of the New USP Validation Guidelines

Bruno BOULANGER

ULG, Liege, Belgium
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Bruno BOULANGER

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Bruno Boulanger holds a Phd in Experimental Psychology from the University of Liège. After a post-doctorate at the Université Catholique de Louvain (Belgium) and the University of Minneapolis (USA) in Statistics applied to simulation of clinical trials, he joined Eli Lilly in Belgium in 1990. Since he gathered 20 years of experience in several areas of pharmaceutical research and industry including discovery, toxicology, CMC and early clinical phases. He holds various positions in Europe and in USA. After being the Head of European Early Phases within Eli Lilly driving an European-wide team, Bruno joined UCB Pharma as Director of Exploratory Statistics, contributing the implementation of Model-Based Drug Development strategy and applied Bayesian statistics. Bruno is also since 2000 Senior Lecturer at the Université of Liège, in the School of Pharmacy, teaching Design of Experiments and statistics. He organizes or contribute since 1998 to Non-Clinical Statistics in Europe and setup in 2010 the First Applied Bayesian Statistics conference. He is also a USP Expert, member of the Committee of Experts in Statistics. Bruno has authored or co-authored more than 70 publications in applied statistics.

Tutorial: Separation of Enantiomers of Chiral Drugs by Liquid-Phase Techniques

Bezhan CHANKVETADZE

TBILISI STATE UNIVERSITY, Tbilisi, Georgia
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Bezhan CHANKVETADZE

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Bezhan Chankvetadze is Full Professor for Physical Chemistry and director of the of the Institute of Physical and Analytical Chemistry at the Tbilisi State University in Tbilisi, Georgia. B. Chankvetadze has published over 180 research papers in peer reviewed journals, over 30 review papers and book chapters and holds several patents. B. Chankvetadze has given over 200 presentations as plenary, invited or oral speaker on the international conferences in fields of chirality, electromigration techniques and separation science. B. Chankvetadze is the Editor of the Journal of Pharmaceutical and Biomedical Analysis (Elsevier, Amsterdam, Netherlands) and a member of the editorial boards of 8 international journals. B. Chankvetadze is the recipient of “Journal of Chromatography Top Cited Article Awards” in 2005, 2006 and 2010 and the recipient of “2006 Belgian Society of Pharmaceutical Science Award of Recognition”.

New Analytical Strategies for Drug Metabolism Studies

Filip CUYCKENS

JOHNSON & JOHNSON PHARMACEUTICAL, Beerse, Belgium
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Filip CUYCKENS

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Filip Cuyckens is a Scientific Director at Janssen R&D. He has earned a pharmacist degree in 1998 at the university of Antwerp, Belgium, where he also obtained a degree in industrial pharmacy in 2002 and a Ph.D. in pharmaceutical sciences in 2003. After a short period as a production manager at Laboratoria Smeets (Wilrijk, Belgium), he started his career at Janssen R&D end of 2004 as a scientist for metabolite identification in support of the study director community for metabolism related studies. Later on, he became group leader of Biotransformations, responsible for the metabolite profiling and identification of early and late development compounds and in 2010 responsible for the Analytical Sciences group, comprising Biotransformations and non-regulated Bioanalytical Sciences, within the Drug Metabolism & Pharmacokinetics department. Evaluation and implementation of new techniques and innovations in the field are an important part of his role. Filip is an active member of the analytical chemistry community. He has (co )authored more than 40 publications, is a member of the associate editorial board of Rapid Communications in Mass Spectrometry and board member of the Belgian Society for Mass Spectrometry.

Is Modern SFC a Viable Alternative to RPLC in Pharmaceutical Analysis?

Davy GUILLARME

UNIVERSITY OF GENEVA, Geneva, Switzerland
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Davy GUILLARME

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Dr. Guillarme holds a PhD degree in analytical chemistry from the University of Lyon, France in 2004. He is now senior lecturer in the group of pharmaceutical analytical chemistry at the University of Geneva in Switzerland. Dr. Guillarme co-authored more than 90 scientific papers related to pharmaceutical analysis. His fields of expertise include liquid chromatography, UHPLC, HILIC, LC-MS, analysis of proteins and mAbs and supercritical fluid chromatography. Dr. Guillarme has also an extensive experience providing theoretical and practical training courses related to chromatographic techniques. He is an editorial advisory board member of LC-GC, American Pharmaceutical review and Journal of separation science. Finally, he has won in 2013 the Emerging leader award in chromatography from LC-GC.

Spatially-Resolved Analysis of Metallopharmaceuticals by Elemental Bioimaging

Uwe KARST

UNIVERSITY OF MUENSTER, Muenster, Germany
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Uwe KARST

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Uwe Karst received his PhD at the University of Münster, Germany in the group of Karl Cammann and moved to the University of Colorado in Boulder for a postdoctoral fellowship with Robert E. Sievers. After finishing his Habilitation in Münster, he was appointed as Full Professor of Chemical Analysis at the University of Twente, The Netherlands. In 2005, he took over his current position as Chair of Analytical Chemistry in Münster. His research main interests include hyphenated techniques, with particular focus on pharmaceutical analysis, elemental speciation and bioimaging as well as metallomics. He has contributed to the current strong development of on-line electrochemistry/liquid chromatography/mass spectrometry to simulate the oxidative metabolism of xenobiotics. Recently, he has additionally focused on the combination of speciation analysis and elemental bioimaging to unravel the fate of heteroatom-containing drugs in the body, including cytostatics (platinum), antibacterial agents (mercury, silver) and contrast agents (gadolinium, iodine).

The Nanoliter Lab: Using Droplet Microfluidics to Screen Enzymes and Protein-Protein Interactions

Robert KENNEDY

UNIVERSITY OF MICHIGAN, Michigan, United States
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Robert KENNEDY

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Robert Kennedy is the Willard Professor of Chemistry and Professor of Pharmacology at the University of Michigan. Prof. Kennedy’s research interests are analytical chemistry especially separations, microfluidics, and mass spectrometry. He is also interested in applying these tools to neuroscience, endocrinology, biotechnology, and drug discovery. His group has developed instrumentation based on microfluidics and mass spectrometry for monitoring neurotransmitters in vivo. These methods have been used for studying changes in neurotransmitter concentrations associated with behavior and diseases. His group has developed sensors for monitoring insulin secretion from pancreatic -cells. These methods are coupled with metabolomics to understand the biochemical mechanism of insulin secretion and perturbations associated with diabetes. An emerging area of research is use of rapid electrophoretic and mass spectrometric assays as novel approaches to high-throughput screening. His work has been recognized by several awards including two MERIT awards from the NIH, a Presidential Faculty Fellowship, a Sloan Foundation Fellowship, and Golay Award for Achievements in Chromatography. He is presently Associate Editor of Analytical Chemistry and Director of the Analytical Core of the Metabolomics Research Center at Michigan.

Analytical Quality by Design

David LLOYD

BRISTOL-MYERS SQUIBB, New Brunswick, United States
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David LLOYD

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David Lloyd obtained his PhD from the Department of Chemistry, University of York, UK, working with Prof. David Goodall on the development of laser-based polarimetry. He then completed postdoctoral research on bioanalytical capillary electrophoresis (CE) with Prof. Irving Wainer at St. Jude Children’s Research Hospital in Memphis, TN. He has since worked both in academia (McGill University, Departments of Oncology and Experimental Medicine) and the pharmaceutical industry (DuPont Pharmaceuticals and Bristol-Myers Squibb). Whilst at McGill, Dr. Lloyd’s analytical research focused on microscale bioanalysis by CE and on chiral CE. Since moving to the pharmaceutical industry, his responsibilities have been in analytical R&D for projects ranging from the late discovery stage through worldwide registrational filings. His current research interests are related to separation science and analytical QbD. From 1995 – 2002 Dr. Lloyd was Contributing Editor of TrAC - Trends in Analytical Chemistry, and from 1999 - 2011 he was Editor of the Journal of Chromatography B.

Nanoimmunoaffinity Extraction and Analysis of Biomarkers of Oxidative Stress

Michael LÄMMERHOFER

EBERHARD KARLS UNIVERSITY TÜBINGEN, Tübingen, Germany
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Michael LÄMMERHOFER

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Michael Lämmerhofer is Professor for Pharmaceutical (Bio)Analysis at the University of Tuebingen, Germany. He graduated in Pharmaceutical Sciences in 1992 and earned his PhD in Pharmaceutical Chemistry in 1996 both at the University of Graz, Austria. Between 1997 and 2011 he was coworker of Prof. Wolfgang Lindner at the University of Vienna, Department of Analytical Chemistry first as an assistant professor and since 2002 as associate professor. In 1999-2000 he was post-doc at the Department of Chemistry of the University of California, Berkeley with Prof. Frantisek Svec. His research interests include the development of functionalized separation materials, monoliths, and nanoparticles. Recently, he shifted his focus to bioanalysis working on metabolomics and plasmid DNA analysis. Another topic of current interest is the analysis of oxidative stress biomarkers, in particular oxidized phospholipids. Michael has published more than 120 papers and 6 book chapters, and edited a book on metabolomics. He holds 7 patents and is associate editor of Journal of Separation Science.

Analytical Armamentarium for the Structural Characterization of Neo-Glycoproteins

Gabriella MASSOLINI

UNIVERSITY OF PAVIA, Pavia, Italy
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Gabriella MASSOLINI

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Professor Gabriella Massolini is Full Professor of Pharmaceutical Analysis at Pavia University. Visiting scientist at Bradford University (UK) and in 1992 associated professor at McGill University in Montreal (Canada). From 2002 Prof. Massolini is one of the members of the PhD Teaching Council in “Chimica e Tecnologia Farmaceutiche” and from 2007 she is the director of the PhD School. She is Editor of Chromatographia since 2006 Since November 2009 she is Director of the Department of Drug Scieces of Pavia University Professor Massolini is author of more than 100 publications. Her main scientific interests involve the development of stationary phases based on immobilized proteins/enzymes. In particular, she carried out innovative researches on the exploitation of immobilized enzymes as bioreactors in liquid chromatography and on the comprehension of interaction mechanisms for protein-based stationary phases. Recently, she is involved in the development of frontal affinity chromatography -MS methods for drug discovery. She has developed new on-line HPLC-MS systems for the digestion/purification/identification of proteins and their post-translational modifications.

SPME-LC-MS for Drug Bioanalysis, a New Tool for in vivo Sampling and High Throughput Determinations

Janusz PAWLISZYN

UNIVERSITY OF WATERLOO, Waterloo Ontario, Canada
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Janusz PAWLISZYN

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Janusz Pawliszyn, University Professor and Canada Research Chair
Department of Chemistry, University of Waterloo, Waterloo, Ontario N2K 3G1
Tel: (519) 888-4641 Fax: (519) 746-0435
e-mail: janusz@uwaterloo.ca
Home page: http://www.spme.uwaterloo.ca/

The primary focus of Professor Pawliszyn's research program is the design of highly automated and integrated instrumentation for the isolation of analytes from complex matrices and the subsequent separation, identification and determination of these species. The primary separation tools used by his group are Gas Chromatography, Liquid Chromatography and Capillary Electrophoresis coupled to variety of detections systems, including range of mass spectrometry techniques. Currently his research is focusing on elimination of organic solvents from the sample preparation step to facilitate on-site monitoring and in-vivo analysis. Several alternative techniques to solvent extraction are investigated including use of coated fibers, packed needles, membranes and supercritical fluids. Dr. Pawliszyn is exploring application of the computational and modeling techniques to enhance performance of sample preparation, chromatographic separations and detection. The major area of his interest involves the development and application of imaging detection techniques for microcolumn chromatography, capillary electrophoresis and micro chip separation devices.

Professor Pawliszyn has supervised 41 PhD and 62 MS students and he is an author of over 450 scientific publications and a book on Solid Phase Microextraction. His Hirsch Index (H-index) is 78. He is a Fellow of Royal Society of Canada and Chemical Institute of Canada, editor of Analytica Chimica Acta, Trends in Analytical Chemistry and a member of the Editorial Board of Journal of Separation Science and Journal of Pharmaceutical Analysis. He initiated a conference, “ExTech”, focusing on new advances in sample preparation and disseminates new scientific developments in the area, which meets every year in different part of the world. He received the 1995 McBryde Medal, the 1996 Tswett Medal, the 1996 Hyphenated Techniques in Chromatography Award, the 1996 Caledon Award, the Jubilee Medal 1998 from the Chromatographic Society, U.K., the 2000 Maxxam Award from Canadian Society for Chemistry, the 2000 Varian Lecture Award from Carleton University, the Alumni Achievement Award for 2000 from Southern Illinois University, the Humboldt Research Award for 2001, 2002 COLACRO Medal, 2003 Canada Research Chair, in 2006 he has been elected to the most cited chemists by ISI, in 2008 he received A.A. Benedetti-Pichler Award from Eastern Analytical Symposium, 2008 Andrzej Waksmundzki Medal from Polish Academy of Sciences, 2008 Manning Principal Award, 2010 Torbern Bergman Medal from the Swedish Chemical Society, 2010 Ontario Premier’s Innovation Award, 2010 Marcel Golay Award, 2010 ACS Award in Separation Science and Technology, 2011 PittCon Dal Nogare Award, 2012 E.W.R. Steacie Award, 2013 CIC Environmental Research and Development Award and 2013 CIC LeSueur Memorial Award. He presently holds the University Professor, Canada Research Chair and Natural Sciences and Engineering Research Council of Canada Industrial Research Chair in New Analytical Methods and Technologies.
B.Sc./Chem.Eng., 1977, Technical University of Gdansk
M.Sc., 1978, Technical University of Gdansk
Ph.D., 1982, Southern Illinois University
PDF., 1984, University of Toronto

Analytical Microextraction Across Supported Liquid Membranes - Principles, Applications and Recent Developments

Stig PEDERSEN BJERGAARD

UNIVERSITY OF OSLO, Oslo, Norway
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Stig PEDERSEN BJERGAARD

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Stig Pedersen-Bjergaard (SPB) was born in Copenhagen in 1966. SPB graduated with a Master of Science degree in Chemistry from The Technical University of Denmark (Lyngby, Denmark) in 1990. SPB was then engaged as PhD-student at Department of Chemistry, University of Oslo (Oslo, Norway) under the supervision of Professor Tyge Greibrokk, and defended the PhD-thesis entitled “Development and Applications of Atomic Emission Detection in Capillary Gas Chromatography” in 1995. In 1996, SPB was appointed as Associate Professor at the School of Pharmacy, University of Oslo (Oslo, Norway), and from year 2000 as full Professor at the same institution. In 2008, SPB was appointed as full Professor (part time) at Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen (Copenhagen, Denmark). SPB has specialized in analytical micro extraction technologies, on development and applications of artificial liquid membranes, and on electrokinetic separation methods. SPB has published more than 130 papers in international journals (H-index=36), given more than 80 presentations at international symposia, authored 7 patent applications, and is a member of the Editorial board for Journal of Chromatography A, Analytica Chimica Acta, Journal of Pharmaceutical Analysis, and International Journal of Analytical Chemistry.

Development of Selective Extraction Sorbents from the Macro- to the Microscale for the Trace Analysis in Complex Media

Valerie PICHON

ESPCI, Paris, France
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Valerie PICHON

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Valérie Pichon is full professor at the University Pierre and Marie Curie (UPMC, Paris, France) and she leads since 2009 the Department of Analytical, Bioanalytical Sciences and Miniaturization, part of the UMR CBI (CNRS-EPSCI), i.e. a group of 30 researchers (permanents, postdoctoral and PhD students) located at the ESPCI ParisTech. She graduated PhD in Analytical Chemistry from the UPMC in 1995 and became Lecturer at the Analytical Chemistry Laboratory at the ESPCI ParisTech, and then Professor at the UPMC in 2010. Her major research interests include developing stationary phases based on antibodies or aptamers and molecularly imprinted polymers to selectively extract organic, and more recently inorganic molecules in complex samples, always trying to miniaturize these tools. She is author of more than 90 publications (h factor= 31), 5 book chapters, holds a patent and attended as guest lecturer to more than 80 lectures. She was rewarded in 2001 with the Analytical Chemistry Department of the French Society of Chemistry Prize. She is currently Vice-President of AfSep (Association Française des Sciences Séparatives).

Analytical Needs within Innovative Manufacturing of Future Pharmaceuticals

Jukka RANTANEN

UNIVERSITY OF COPENHAGEN, Kobenhavn, Denmark
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Jukka RANTANEN

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Jukka Rantanen is professor of pharmaceutical technology and engineering at the Department of Pharmacy (University of Copenhagen). He received his Ph.D. from the University of Helsinki in 2001, completed postdoctoral visit at the Department of Industrial and Physical Pharmacy (Purdue University, USA) in 2003, and joined the faculty at the University of Copenhagen in 2006 as a full professor. Jukka has supervised or is currently supervising 25 post doc researchers and Ph.D. students. He has published 160+ scientific papers (h-index 26, ISI Web of Science) and is an editorial board member of four leading scientific journals within pharmaceutical sciences and chemical engineering. Jukka is a member of the Process Analytical Technology Working Party of the European Pharmacopoeia Commission as well as a member of the National Pharmacopoeia Council in Denmark (Farmakopenævnet). He is currently a chairman of the Steering Committee of the EUFEPS QbD and PAT Sciences Network (EUFEPS, European Federation for Pharmaceutical Sciences). Jukka is a board member of Danish Council for Independent Research (DFF) within Technology and Production Sciences. He has been consulting several international companies in the field of process analytical technologies (PAT) and Quality by Design (QbD). Jukka is the past chairman of the committee of the Finnish Society of Physical Pharmacy and a founding member of the Pharmaceutical Solid State Research Cluster (PSSRC).

Utility of CE-MS and HILIC-MS for Untargeted Analysis of the Anionic Urinary Metabolome

Govert SOMSEN

VU UNIVERSITY AMSTERDAM, Amsterdam, The Netherlands
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Govert SOMSEN

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Prof. Govert Somsen studied Chemistry at VU University in Amsterdam with a specialization in Analytical Chemistry and Applied Spectroscopy. He obtained his doctorate at the VU with professors Brinkman and Velthorst on the coupling of liquid chromatography with vibrational spectroscopy for the identification of compounds in complex mixtures. In 1996, Somsen was appointed assistant professor at the University of Groningen, where he performed research on the development and biomedical application of capillary electrophoretic (CE) techniques. He switched in 2001 to Utrecht University, where he became associate professor. There he focused on integration of CE with mass spectrometry, optical spectroscopy and sample pre-treatment techniques for drug impurity profiling, characterization of therapeutic proteins, and human metabolomics. From 2008 to 2011, he was also reader in Analytical Techniques in the Life Sciences at the Avans University for Applied Sciences in Breda. In 2013, Somsen was appointed full professor Biomolecular Analysis/Analytical Chemistry at VU University. His current research interests include compositional and conformational characterization of intact biomacromolecules, bioactivity screening of compounds in complex samples, and metabolite analysis in biofluids with particular attention for compound chirality.

Proteomics, Bioinformatics and Biopharmaceuticals

Alain VAN DORSSELAER

UNIVERSITY OF STRASBOURG, Strasbourg, France
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Alain VAN DORSSELAER

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Born 1948, CNRS Research Director at the University of Strasbourg Director of the Analytical Sciences Department (Institut Pluridisciplinaire Hubert Curien, UMR 7178)
During his career at the University of Strasbourg, he developed new analytical methods and strategies based on mass spectrometry, first for characterization of peptides, and then for proteins with posttranslational modifications. He was involved in the development of proteomics since1993 and since then, his laboratory has widely collaborated with biologists in the field of proteomics applications. He has used also the proteomic methodologies for to the characterization of many recombinant or natural proteins used in human therapy in collaboration with a series of pharmaceutical companies. In parallel, he also developed the mass spectrometry of large noncovalent complexes and used it for the study of protein/protein and protein/ligand interactions, and recently for the characterization of monoclonal antibodies. Proteomics is the main research theme of the laboratory and covers plants, micro-organisms and human diseases. Most studies are made in tight collaboration with biologists and pharmaceutical companies. The last five years he his team developed a series of bioinformatics to improve the interpretation of proteomic data.
Publications: More than 440 publications in international journals. H-index 59 ( 2013)

Analysis of Large Biomolecules: New Strategies

Jean-Luc VEUTHEY

UNIVERSITY OF GENEVA, Geneva, Switzerland
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Jean-Luc VEUTHEY

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Jean-Luc Veuthey is professor at the School of Pharmaceutical Sciences, University of Geneva, Switzerland since 1992. His research domain is dedicated to the development of separation techniques in pharmaceutical sciences and more precisely: sample-preparation procedures; fundamental studies in liquid chromatography, supercritical fluid chromatography and capillary electrophoresis; hyphenation of these techniques with mass spectrometry; analysis of drugs and drugs abuse in different matrices. Professor Veuthey is author of more than 300 scientific refereed publications and an h-index of 40. He is also active in different both national and international scientific committees and in editorial boards. Since January 2011, Jean-Luc Veuthey is vice-rector of the University of Geneva in charge of: Human Resources; Building and Logistics, Technology Transfer.

Building on Success - Metabolic Profiling for Patients and Populations

Ian D. WILSON

IMPERIAL COLLEGE LONDON, London, United Kingdom
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Ian D. WILSON

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Ian Wilson trained as a biochemist at the University of Manchester Institute of Science and Technology, going on to a PhD at Keele University on insect moulting hormones. After this he worked in the Pharmaceutical industry, most recently as a Senior Principal Scientist in the Dept of Drug Metabolism and Pharmacokinetics at the AstraZeneca Research site at Alderley Park in Cheshire (UK). Since September 2012 he has been at Imperial College in London. He is the author, or co-author, of some 480 papers or reviews, and has received a number of awards in separation and analytical science from the Royal Society of Chemistry, including the Gold Medal of the Analytical Division (2005) and the Knox Medal of the RSC Separation Science Group (2012). He received the Jubilee Medal of the Chromatographic Society in 1994 and gave the inaugural Desty Memorial lecture for Innovation in Separation Science in1996. His research is directed towards the development of hyphenated techniques in chromatography and their application to problems in drug metabolism, toxicology and metabonomics.

Towards Personalised Medicine Based on Metabolomics with Mass Spectrometry

Guowang XU

DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES, Dalian, China
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Guowang XU

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http://www.402.dicp.ac.cn

Prof. Dr. Guowang Xu is a professor in Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences since 1997. In 2004 he obtained the foundation for distinguished young scientists from National Natural Science Foundation of China. Since 2005 he has become the director of Metabonomics Research Center in DICP. Now he is also the deputy-president and general-secretary of Chinese chromatographic society and trustee of Chinese Mass spectrometry Society. Prof. Xu has published more than 300 peer-reviewed papers in journals and holds 20 China patents, co-written 4 books. He was also the co-Chairman of 30th ISCC in China, 33rd HPLC in Japan and 37th HPLC in Dalian, China and member of permanent scientific committee of HPLC. His main research field is in chromatography, mass spectrometry and the metabolomics applications in disease biomarker discovery, traditional Chinese medicines and food safety.

Full Evaporation Headspace Gas Chromatography for Analysis of High Boiling Organic Compounds

Determination of Drug-Albumin Binding Modes by Induced CD Spectroscopy and TD-DFT Calculations

Antibody-Free Bioanalysis of Proteins and Peptides in Complex Body Fluids at The PM Level By LC-MS/MS

Rainer BISCHOFF

UNIVERSITY OF GRONINGEN, Groningen, The Netherlands

Highly Enantioselective Mip-Based Porous Ultra-Thin Film in The Fabrication of an Electrochemical Sensor for the Chiral Analysis of beta-Blockers

Surface Acoustic Wave Biosensor as an Analytical Tool in Pharmaceutics: A Quality by Design Approach

Supporting Analytical Quality by Design with Informatics - A Silent Enabler

Cell Culture Monitoring by Near Infrared Spectroscopy

Validation of the Analytical Procedure for the Determination of the Underivatized Neurotoxin Beta-N-Methylamino-L-Alanine by LC/MS-MS in Environmental Samples and in Human Brain

Synthesis and Degradation Impurities in Peptide Drugs

Development of a Multiplexed Surface-Enhanced Raman Scattering Quantitatve Approach for Bisphenol Detection

Capillary Electrophoresis - Mass Spectrometry for Characterization of Protein Drugs and Determination of Protein-Protein Interactions

NMR in the Pharmaceutical and Biomedical Areas for Identification and Quantification of Drugs and Metabolomic Applications

Residual Solvents: A Potential Threat Present In Counterfeit Medicines

In-Line Mammalian Cells Culture Monitoring: Comparison of Predictive Performances Offered by NIR and Raman Spectroscopies

Quantitative Performances of UHPSFC AND UHPLC: A Comparative Study

LC-SPE-NMR Identification and NMR Quantification of Salvia Fruticosa Phytochemicals with Antifungal Activity

Mass Spectrometric Approach for the Characterization of Inhibitors of Amiloyd Aggregation Process

Parallel Artificial Liquid Membrane Extraction (Palme) – An Innovative Implementation of Supported Liquid Membrane Extractions into a Multiwell Plate

Preparation of Molecularly Imprinted Polymers for Hydrophilic Compounds by Modified Precipitation Polymerization

Immunoaffinity + LC-MS/MS: An Alternative Approach for Antibody Selectivity Evaluation?

In-Depth Glycan Analysis of the Biotherapeutic Enbrel (Etanercept) Using HILIC UPLC/FLR and Mass Spectrometry

Quantitation of Hepcidin in Dried Blood Spots by Microfluidic LC-CHIP/MS-MS

HPLC Chiral Separation of N-Fluorenylmetoxycarbonyl Alpha-Amino Acids Using Polysaccharide Based Chiral Stationary Phase

Functionalized Polymeric Monolithic Columns in Micro-Hplc for Pharmaceutical Analysis

Zhengjin JIANG

JINAN UNIVERSITY, Guangzhou, China

Microflow LC-MS/MS of Human Osteopontin Using an Extended Peptide Internal Standard to Track Digestion and Immunocapture Variability

The Medium-Throughput Determination of Hydrophobicity and Dissociation Constant by LC-MS

Expanding the Role of Capillary Electrophoresis with Mass Spectrometry Detection (CESI-MS) for the Development, Characterization & Control of Biologics

In Vivo Monitoring of Neuropeptides In the Rat Hippocampus Using Nano UPLC-ESI-MS/MS

Definition of a Generic Chiral Separation Strategy on Polysaccharide-Based Chiral Stationary Phases in Supercritical Fluid Chromatography

Debby MANGELINGS

VRIJE UNIVERSITEIT BRUSSEL, Brussels, Belgium

Determination of the Enantiomeric Ratio of Drugs Using New SFC-MS/MS Instruments

Development of Analytical Methodology to Support a QBD Approach to Formulation Design: A Case Study

Sheathless Capillary Electrophoresis-Mass Spectrometry: An Enabling Technology for Small-Volume Metabolomics Studies

Rawi RAMAUTAR

LEIDEN UNIVERSITY, Leiden, The Netherlands

Gas Pressure Assisted Micro-Liquid-Liquid-Extraction-nanoESI-DI-MS: A New Fully-Automated Platform for Bionanalysis

In-Vitro Phenotyping for Toxicological Purposes: New Insights with the Cocktail Approach

Serge RUDAZ

UNIVERSITY OF GENEVA, Geneva, Switzerland

Development of Highly Selective LC/MS Assay for Vitamin D Metabolites

Study of Virus-Like Particles of Human Papillomavirus (HPV-VLP) by Capillary Electrophoresis

Anne-Catherine SERVAIS

UNIVERSITY OF LIÈGE, Liege, Belgium

Why Capillary Electrophoresis is an Ideal Tool for Drug Screening

Possibilities of Retention Modeling for HILIC and SFC Separations

Hyphenated Techniques for the Bioanalytical Study of Enzymes

Investigations of Metalloproteins and their Interactions by Affinity Capillary Electrophoresis (ACE)