Wednesday March 20, 2019 |
12:00 | Registration |
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13:15 | Welcome Address |
Dr Jean-Paul RENAUD (NOVALIX & RIBOSTRUCT, Illkirch, France) |
| Session 1: Hot Topics |
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| Session Chair |
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom) |
13:30 | The Way Home: Molecular Recognition Path of L-TRP to IDO1 (OC01) |
Prof. Antonio MACCHIARULO (UNIVERSITY OF PERUGIA, Perugia, Italy) |
13:45 | Fragment Based Screening: Critical Aspects of its Performance and Evaluation Screening a Diverse Set of Cancer Target Classes (OC02) |
Dr Andrea GOHLKE (BEATSON INSTITUTE FOR CANCER RESEARCH, Glasgow, United Kingdom) |
14:00 | High-Throughput, Automated Crystallography Pipelines for Drug Discovery (OC03) |
Dr Irina CORNACIU (EMBL GRENOBLE, Grenoble, France) |
14:15 | Exhibitor Short Presentation: ForteBio
Integrated Solutions for Early Stage Biologics Discovery |
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14:25 | Structure of an Essential Inner Membrane Protein-LPS Complex (OC04) |
Dr Thomas CLAIRFEUILLE (GENENTECH, INC., South San Francisco, United States) |
14:40 | Fragment Based Target Sreening to Prioritise Novel Antimicrobial Targets (OC05) |
Dr Peter CANNING (LIFEARC, Stevenage, United Kingdom) |
14:55 | Biophysics as a Key Element in the Early Phase of Drug Discovery (IL01) |
Dr Matthias FRECH (MERCK, Darmstadt, Germany) |
15:25 | Coffee Break & Exhibition |
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| Session 2: X-ray Crystallography − Cryo-EM Complementarity |
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| Session Chair |
Dr Michael HENNIG (LEADXPRO, Villigen, Switzerland) |
15:55 | High-Resolution Structure Determination of Dynamic Macromolecular Complexes by Cryo-EM (IL02) |
Prof. Holger STARK (MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany) |
16:25 | Using X-ray and Cryo-EM Approaches to Study Allosteric Regulation of GTP Cyclohydrolase I (OC06) |
Dr Rebecca EBENHOCH (BOEHRINGER INGELHEIM, Biberach, Germany) |
16:40 | Structural Studies of Chromatin Remodellers by Cryo-EM: Challenges and Opportunities for Drug Development (IL03) |
Prof. Karl-Peter HOPFNER (LUDWIG-MAXIMILIANS UNIVERSITY, München, Germany) |
17:10 | Exhibitor Short Presentation: ThermoFisher Scientific
New Optical Modes to Improve Cryo-EM Throughput |
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17:20 | Cryo-EM, a New Tool for Drug Discovery at Novartis (IL04) |
Dr Christian WIESMANN (NOVARTIS, Basel, Switzerland) |
| Keynote Lecture |
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| Chair |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
17:50 | Integrative Structural Biology of GPCRs (KL01) |
Prof. Kurt WÜTHRICH (THE SCRIPPS RESEARCH INSTITUTE, USA & ETH ZURICH, Zurich, Switzerland) |
18:50 | Welcome Reception |
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20:00 | End of the Day |
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Thursday March 21, 2019 |
08:30 | Registration |
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| Session 3: Chemical Biology Meets Biophysics for Drug Discovery |
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| Session Chair |
Dr Sandra JACOB (NOVARTIS, Basel, Switzerland) |
09:00 | Illuminating the Path to New E3-Ligases for Targeted Protein Degradation (IL05) |
Ms Hannah LITHGOW (UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom)  (BIOIB‚RICA) |
09:30 | The Development and Biophysical Characterisation of Click-Tagged, Reversible Probes to Measure Target Occupancy of ERK1/2 Kinase Inhibitors (OC07) |
Dr Chiara Rosa VALENZANO (ASTEX PHARMACEUTICALS, Cambridge, United Kingdom) |
09:45 | Biophysical and Structural Principles of PROTAC Mechanism of Action (IL06) |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
10:15 | Coffee Break & Exhibition |
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10:45 | The PROTAC Design Toolbox: Biophysically Enabling the Optimisation of a Potent SMARCA Degrader (OC08) |
Dr David ZOLLMAN (UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
11:00 | Exhibitor Short Presentation: Creoptix
Pushing Boundaries in Kinetics Analysis |
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11:10 | Rational Design of Kinase Inhibitors Using Structure and Biophysical Data (IL07) |
Prof. Stefan KNAPP (GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany) |
11:40 | Poster Session |
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12:40 | Lunch, Exhibition & Networking |
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| Session 4: MS-Based Methods |
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| Session Chair |
Dr Stefan GESCHWINDNER (ASTRAZENECA, Mölndal, Sweden) |
14:00 | Advances in Structural Mass Spectrometry for Drug Discovery and Therapeutic Protein Characterization (IL08) |
Dr Sarah CIANFERANI (UNIVERSITY OF STRASBOURG, Strasbourg, France) |
14:30 | Identifying an Escape Route from Adverse Effects of the Liver X Receptor Ligands Using HDX-MS (OC09) |
Dr Anna BELORUSOVA (ASTRAZENECA, Molndal, Sweden) |
14:45 | Sugars in the Gas Phase? Novel Techniques to Unravel the Glycocode (IL09) |
Prof. Kevin PAGEL (FREIE UNIVERSITÄT BERLIN, Berlin, Germany) |
15:15 | Exhibitor Short Presentation: Bruker Daltonics
High-Throughput SPR Screening in Drug Discovery |
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15:25 | Use of Mass Spectrometry in Small Molecule Lead Discovery (IL10) |
Dr Jörg HOERNSCHEMEYER (F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
15:55 | Coffee Break & Exhibition |
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| Session 5: Characterisation of Small Molecules Binding to RNA |
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| Session Chair |
Dr Ursula EGNER (BAYER, Berlin, Germany) |
16:25 | Hit Discovery for Riboswitch Ligands (IL11) |
Prof. Ruth BRENK (UNIVERSITY OF BERGEN, Bergen, Norway) |
16:55 | Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation (OC10) |
Dr Margaret BUTKO (BIODESY, South San Francisco, United States) |
17:10 | Structural Basis for Gene-Specific RNA Splicing Correction Induced by a Small Molecule (IL12) |
Prof. Frédéric ALLAIN (ETH ZURICH, Zurich, Switzerland) |
17:40 | Exhibitor Short Presentation: 2bind
Work with the Experts in Biophysics – A Quick Dive into 2bind’s Tailor-made Services for Drug Discovery |
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17:50 | Ribosomal Translation and Human Diseases (IL13) |
Prof. Eric WESTHOF (INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, Strasbourg, France) |
18:20 | Poster Session & Drinks |
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19:20 | End of the Day |
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20:00 | Conference Dinner |
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Friday March 22, 2019 |
| Session 6: Enabling Tools for Biophysical and Structural Studies |
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| Session Chair |
Prof. Helena DANIELSON (UPPSALA UNIVERSITY, Uppsala, Sweden) |
09:00 | Innovating Drug Discovery by Locking GPCRs in Functional Conformations (IL14) |
Dr Christel MENET (CONFO THERAPEUTICS, Brussels, Belgium) |
09:30 | New Biophysical Approaches to Study IRES RNA/Ribosomes Interactions (OC11) |
Dr Eric ENNIFAR (CNRS, Strasbourg, France) |
09:45 | Exhibitor Short Presentation: Synthelis
From Gene to Structure (FGTS) |
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09:55 | Strategies to Enable Challenging Biophysical and Structural Studies (IL15) |
Dr Stefan GESCHWINDNER (ASTRAZENECA, Mölndal, Sweden) |
10:25 | Coffee Break & Exhibition |
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10:55 | SPR-Based Approaches to Enable Direct Binding Assays for Membrane Proteins (IL16) |
Dr Sylwia HUBER (F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
11:25 | Impact of Mechanistic Enzymology and Bio-Structural Mass Spectrometry on the Progression of a Serine Hydrolase Inhibitor Discovery Project (OC12) |
Dr Mathias ANTOINE (INSTITUT DE RECHERCHES SERVIER, Croissy-Sur-Seine, France) |
11:40 | An Integrated Molecular-Scale Biophysics Approach to Drug Discovery: the Contribution of the ARBRE-MOBIEU European Network (IL17) |
Dr Patrick ENGLAND (INSTITUT PASTEUR, Paris, France) |
12:10 | Exhibitor Short Presentation: Crelux
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond |
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12:20 | Wave-Guided Interferometry and Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (IL18) |
Dr Nicolas BOCQUET (LEADXPRO AG, Villigen, Switzerland) |
12:50 | Poster Prizes and Closing Remarks |
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13:00 | Departure |
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