1st Alpine Winter Conference on Medicinal and Synthetic Chemistry

Oral Communications have been selected!

Abstract submission for poster is still open. Deadline is November 20, 2017

Spread the word with #AlpineWinterConference

Sunday January 28, 2018
17:00Opening Remarks
17:15Recent Developments in Strategies and Tactics Towards the Synthesis of Complex Secondary Metabolites as Enabling Tools for the Study of Biology and Medicine
Erick M. CARREIRA
(ETH ZÜRICH, Zürich, Switzerland)
18:15Poster Session
20:15End of Day 1
Monday January 29, 2018
Session 1: Advances in Synthetic Methods
Session Chair
Nuno MAULIDE
(UNIVERSITY OF VIENNA, Vienna, Austria)
08:30Assembly Line Synthesis
Varinder K. AGGARWAL
(UNIVERSITY OF BRISTOL, Bristol, United Kingdom)
09:00Photochemical Reactions en route to Structurally Complex Molecules
Thorsten BACH
(TECHNISCHE UNIVERSITÄT MÜNCHEN, Garching, Germany)
09:30Coffee Break
10:00Small Ring Chemistry
Ilan MAREK
(ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel)
10:30Open Slot for an Oral Communication selected from submitted Abstracts (OC01)
11:00End of the morning session
Session 2: Addressing Preclinical Toxicity – Approaches and Lessons Learned
Session Chair
Andy PEAT
(GLAXOSMITHKLINE, United States)
17:30Mechanism-Based Toxicities Associated With NAMPT Inhibition and Related Mitigation Strategies
Peter DRAGOVICH
(GENENTECH INC., San Francisco, United States)
18:00Utilizing in Depth Understanding of a Molecules Off Target Profile to Tailor Clinical and Preclinical Safety Assessments
Douglas THOMSON
(CELLZOME GMBH, Heidelberg, Germany)
18:30Coffee Break
19:00Overcoming Drug Bioactivation in Lead Optimization: Case Studies
Axel PÄHLER
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)
19:30Small Structural Changes Leading to Major Impact on Safety: Developing Safety Strategies in Medicinal Chemistry (OC2)
Martin PETTERSSON
(PFIZER, Cambridge, United States)
20:00Panel Discussion
20:45End of Day 2
Tuesday January 30, 2018
Session 3: Advances in Lead Generation
Session Chair
Doris RIETHER
(BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG, Biberach an der Riss, Germany)
08:30ADAS (Affinity Directed Automated Synthesis): A New Technology to Accelerate Lead Generation
Eva Maria MARTIN
(ELI LILLY, Madrid, Spain)
09:00A Chemist’s Guide to Modern Phenotypic Drug Discovery
Monika ERMANN
(EVOTEC LTD, Oxfordshire, United Kingdom)
09:30Coffee Break
10:00CDK8 Inhibitors with Pre-Engineerd Long Residence Time, Exhibiting Efficacy in Tumor Xenograft Models (OC03)
Koen HEKKING
(MERCACHEM B.V. , Nijmegen, The Netherlands)
10:30From Multiple Hit Series to (Pre)Clinical Candidates Using DNA Encoded Library Technology
Sanne SCHRODER GLAD
(NUEVOLUTION A/S, Copenhagen, Denmark)
11:00End of the morning session
Session 4: Chemical Biology in Drug and Target Discovery
Session Chair
Matthew HAYWARD
(PFIZER, Groton, United States)
17:30Biosensors for Measuring Metabolite and Drug Concentrations in Living Cells
Kai JOHNSSON
(SWISS FEDERAL INSTITUTE OF TECHNOLOGY IN LAUSANNE (EPFL), Lausanne, Switzerland)
18:00Chemical Physiology of Antibody Conjugates and Natural Products (OC04)
Gonçalo BERNARDES
(INSTITUTO DE MEDICINA MOLECULAR, LISBON, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
18:30Coffee Break
19:00Activity-based proteomics – Protein and Ligand Discovery on a Global Scale
Benjamin CRAVATT
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States)
20:00End of Day 3
Wednesday January 31, 2018
Session 5: Alternative Modalities
Session Chair
Philippe NANTERMET
(MERCK, SHARP & DOHME, West Point, United States)
08:30Discovery Chemistry Modalities: Chemistry on the Macromolecular Scale
David TELLERS
(MERCK & CO. INC (MSD), West Point, United States)
09:00New Modalities for Challenging Targets in Drug Discovery
Eric VALEUR
(ASTRAZENECA, Västra Frölunda, Sweden)
09:30Coffee Break
10:00Messenger RNA as a Novel Therapeutic Approach
Kerry BENENATO
(MODERNA THERAPEUTICS, Cambridge, United States)
10:30Proteolysis Targetting Chimera: A New Frontier in Medicinal Chemistry (OC05)
Niall ANDERSON
(GLAXOSMITHKLINE, Hertfordshire, United Kingdom)
11:00End of the morning session
Session 6: Late Stage Functionalization
Session Chair
Guido KOCH
(NOVARTIS PHARMA AG, Basel, Switzerland)
17:30Title to be announced
Matthew GAUNT
(UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
18:00Title to be announced
Nicolai CRAMER
(ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland)
18:30Coffee Break
19:00Catalytic Approaches to Simplifying Synthesis
Darren J. DIXON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)
19:30Synthetic Routes to Oxindoles via Metal Catalysis (OC06)
Mark LAUTENS
(UNIVERSITY OF TORONTO, Toronto, ON, Canada)
20:00End of the Scientific Programme on Day 4
21:00Conference Dinner
23:00End of Day 4
Thursday February 1, 2018
Session 7: Challenges and Opportunities in Fragment Based Drug Discovery
Session Chair
Alison WOOLFORD
(ASTEX PHARMACEUTICALS, Cambridge, United Kingdom)
08:30Drug Discovery for Challenging Targets by X-ray Crystallographic Fragment Screening
Tom HEIGHTMAN
(ASTEX THERAPEUTICS, Cambridge, United Kingdom)
09:00The Impact of Fragments on Drug Discovery
Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
09:30Coffee Break
10:00Fragment Based Discovery of Small Molecule MRCK Inhibitors
Mairi SIME
(BEATSON INSTITUTE FOR CANCER RESEARCH, Bearsden Glasgow , United Kingdom)
10:30Open Slot for an Oral Communication selected from submitted Abstracts (OC07)
11:00End of the morning session
Session 8: Drug Discovery Tales
Session Chair
Sarah SKERRATT
(VERTEX PHARMACEUTICALS, Oxon, United Kingdom)
17:10Discovery of Allosteric Malt1 Protease Inhibitors with High in Vivo Efficacy (OC08)
Jean QUANCARD
(NOVARTIS PHARMA, Basel, Switzerland)
17:30Discovery of Tak-041: A Potent and Selective Gpr139 Agonist for the Treatment of Negative Symptoms Associated with Schizophrenia
Holger MONENSCHEIN
(TAKEDA CALIFORNIA, INC, San Diego, United States)
17:50Open Slot for an Oral Communication selected from submitted Abstracts (OC10)
18:10Discovery of a Ketohexokinase Inhibitor for the Treatment of Nafld/Nash: Fragment-to-Candidate via Structure-Based Drug Design and Parallel Chemistry
Brian RAYMER
(PFIZER, Cambridge, United States)
18:30Coffee Break
19:00Novel Approaches in the Design of CNS Drug Candidates and PET Ligands
Anabella VILLALOBOS
(BIOGEN, Cambridge, United States)
19:45Closing Remarks
20:00End of Symposium

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