1st Alpine Winter Conference on Medicinal and Synthetic Chemistry

Confirmed Speakers


Keynote Speakers

 Benjamin CRAVATT
Benjamin CRAVATT
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States
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Activity-based proteomics – Protein and Ligand Discovery on a Global Scale

 Anabella VILLALOBOS
Anabella VILLALOBOS
BIOGEN, Cambridge, United States

Title to be announced

Addressing Preclinical Toxicity – Approaches and Lessons Learned

 Peter DRAGOVICH
Peter DRAGOVICH
GENENTECH INC., San Francisco, United States
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Mechanism-Based Toxicities Associated With NAMPT Inhibition and Related Mitigation Strategies

 Axel PÄHLER
Axel PÄHLER
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Overcoming Drug Bioactivation in Lead Optimization: Case Studies

 Douglas THOMSON
Douglas THOMSON
CELLZOME GMBH, Heidelberg, Germany
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Utilizing in Depth Understanding of a Molecules Off Target Profile to Tailor Clinical and Preclinical Safety Assessments

Advances in Lead Generation

 Monika ERMANN
Monika ERMANN
EVOTEC LTD, Oxfordshire, United Kingdom
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A Chemist’s Guide to Modern Phenotypic Drug Discovery

 Eva Maria MARTIN
Eva Maria MARTIN
ELI LILLY, Madrid, Spain
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ADAS (Affinity Directed Automated Synthesis): A New Technology to Accelerate Lead Generation

 Sanne SCHRØDER GLAD
Sanne SCHRØDER GLAD
NUEVOLUTION A/S, Copenhagen, Denmark
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From Multiple Hit Series to (Pre)Clinical Candidates Using DNA Encoded Library Technology

Advances in Synthetic Methods

 Varinder K. AGGARWAL
Varinder K. AGGARWAL
UNIVERSITY OF BRISTOL, Bristol, United Kingdom
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Assembly Line Synthesis

 Thorsten BACH
Thorsten BACH
TECHNISCHE UNIVERSITÄT MÜNCHEN, Garching, Germany
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Photochemical Reactions en route to Structurally Complex Molecules

 Ilan MAREK
Ilan MAREK
ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel
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Small Ring Chemistry

Alternative Modalities

 Matthew STANTON
Matthew STANTON
MODERNA THERAPEUTICS, Cambridge, United States
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Messenger RNA as A Novel Therapeutic Approach

 David TELLERS
David TELLERS
MERCK & CO. INC (MSD), West Point, United States
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Discovery Chemistry Modalities: Chemistry on the Macromolecular Scale

 Eric VALEUR
Eric VALEUR
ASTRAZENECA R&D GOTHENBURG, Mölndal, Sweden
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New Modalities for Challenging Targets in Drug Discovery

Challenges and Opportunities in Fragment Based Drug Discovery

 Tom HEIGHTMAN
Tom HEIGHTMAN
ASTEX PHARMACEUTICALS, Cambridge, United Kingdom

Drug Discovery for Challenging Targets by X-ray Crystallographic Fragment Screening

 Rod HUBBARD
Rod HUBBARD
UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom
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The Impact of Fragments on Drug Discovery

 Mairi SIME
Mairi SIME
BEATSON INSTITUTE FOR CANCER RESEARCH, Bearsden Glasgow , United Kingdom
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Fragment Based Discovery of Small Molecule MRCK Inhibitors

Chemical Biology in Drug and Target Discovery

 Kai JOHNSSON
Kai JOHNSSON
SWISS FEDERAL INSTITUTE OF TECHNOLOGY IN LAUSANNE (EPFL), Lausanne, Switzerland
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Biosensors for Measuring Metabolite and Drug Concentrations in Living Cells

Late Stage Functionalization

 Nicolai CRAMER
Nicolai CRAMER
ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland

Title to be announced

 Darren J. DIXON
Darren J. DIXON
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Catalytic Approaches to Simplifying Synthesis


Matthew GAUNT
UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom

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Title to be announced


EFMC Sponsored Event

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