| Thursday August 31, 2017 |
| 14:15 | Registration |
|
| 15:00 | Welcome and Opening |
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| 15:05 | The Fascinating World of Medicinal Chemistry and Drug Discovery |
Dr Christoph BOSS
(IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland) |
| YMCS Competition Presentation Session I |
|
| 15:35 | OC01 - A Novel Hydantoin-Based Series of Dpre1 Inhibitors in M.Tuberculosis: Hit-to-Lead Optimization and Biological Profiling |
Ms Olga BALABON
(UNIVERSITY OF ANTWERP, Wilrijk, Belgium) |
| 15:55 | OC02 - Target Elucidation of Novel Trypanosomatid Inhibitors
Winner of the young medicinal chemist meeting in the United Kingdom |
Mr Andrew FRASER
(UNIVERSITY OF ST ANDREWS, Ayr, United Kingdom) |
| 16:15 | OC03 - Design, Synthesis and Biological Evaluation of New Artemisinin Hybrid Molecules
Winner of the young medicinal chemist meeting in Greece |
Mr Antonios S. LETIS
(UNIVERSITY OF PATRAS, Patras, Greece) |
| 16:35 | OC04 - Development of Non-Covalent In Vivo Active Butyrylcholinesterase Inhibitors
Winner of the young medicinal chemist meeting in Slovenia |
Dr Urban KOSAK
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia) |
| 16:55 | Flash Poster Presentations |
|
| FP01- 3rd-Generation Analogs of Meiogynine A, New Multiple Inhibitors of Anti-Apoptotic Proteins of Bcl-2 Family |
Ms Alma ABOU SAMRA
(INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES, Gif-sur-Yvette, France) |
| FP02 - Slow But Steady Wins The Race: Influenza A M2/V27a Resistance Mechanism |
Dr Marta BARNIOL-XICOTA
(UNIVERSITAT DE BARCELONA, Stanford, United States) |
| FP03 - New Vistas in Lithium Halocarbenoids Mediated Homologations |
Mrs Laura CASTOLDI
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| FP04 - Synthesis of Hydroxy Lactones by Selenium-Mediated Oxidation/Cyclization of Alkenoic Acids Under Eco-Flow Conditions |
Dr Bruno CERRA
(UNIVERSITY OF PERUGIA, Perugia, Italy) |
| FP05 - Metabolite Identification and Total Synthesis of Metabolically Stabilized Analogs of The Natural Product Pironetin |
Ms Sara COULUP
(UNIVERSITY OF MINNESOTA, Minneapolis, United States) |
| FP06 - New Allosteric Modulator of The Cb2 Receptor and its Potential Application in Neuropathic Pain |
Dr Francesca GADO
(UNIVERSITÀ DI PISA, Pisa, Italy) |
| FP08 - Small Molecules for In Situ Cell Manipulation as A Regenerative Medicine Strategy |
Dr Laia JOSA CULLERE
(UNIVERSITY OF OXFORD, Barcelona, Spain) |
| FP09 - Synthesis and Biological Activity of Novel Atypical Dopamine Re-Uptake Inhibitors for The Treatment of Dementia |
Mr Predrag KALABA
(UNIVERSITY OF VIENNA, Vienna, Austria) |
| FP10 - A Multifaceted α-Enaminone: Adaptable Building Block for Synthesis of Heterocyclic Scaffolds Through Conceptually Distinct 1,2-, 1,3-, 1,4- and C-O Bond Forming Annulations |
Mr David LANKRI
(HEBREW UNIVERSITY, Jerusalem, Israel) |
| FP11 - Investigating The Impact of Covalency on Protac-Mediated Degradation of Btk |
Ms Hannah LITHGOW
(UNIVERSITY OF STRATHCLYDE & GSK, Glasgow, United Kingdom) |
| FP12 - Protein Modelling and Virtual Screening to Identify New Inhibitors Targeting The Lsrk Kinase |
Dr Prasanthi MEDARAMETLA
(UNIVERSITY OF EASTERN FINLAND, Kuopio, Finland) |
| FP13 - Towards A Pharmacological Neuroregenerative Therapy |
Dr Laura MOLA
(UNIVERSITY OF OXFORD , Oxford, United Kingdom) |
| FP14 - Novel α-Amino Diarylphosphonates as Inhibitors of E.Coli Clpp Protease |
Mr Carlos MORENO-CINOS
(UANTWERPEN, Wilrijk, Belgium) |
| FP15 - Design of Novel Imidazopyridazines as Strong Haspin Inhibitors |
Mr Matthieu PLACE
(ICOA CNRS UMR 7311, ORLEANS, France) |
| FP16 - Design of New Ezh2 Inhibitors Using Pharmacophoric Models |
Dr Filipa RAMILO-GOMES
(INSTITUTO SUPERIOR TÉCNICO -UNIVERSIDADE DE LISBOA, Lisboa, Portugal) |
| FP17 - Development of Novel Prodrug Designs Activated by Nitroreductase |
Mr Andrew TANG
(MONASH UNIVERSITY, Melbourne, Australia) |
| FP18 - Synthesis of Heterocycle-Bridged Peptidic Macrocycles Via 1,3-Diyne Transformations |
Mr Steven VERLINDEN
(VRIJE UNIVERSITEIT BRUSSEL, Elsene, Belgium) |
| FP19 - Controlling The Redox Transcription Factor Regulator Pirin: Rational Design, Activity Cliffs and Metal-Dependency |
Dr Birgit WILDING
(THE INSTITUTE OF CANCER RESEARCH, London, United Kingdom) |
| FP20 - Indolactam V and Derivatives: Potential Tools for Contact-Independant iPSC Culture |
Dr Laurence SILPA
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
| 17:35 | YMCS Poster presentation session 1 & Networking drink |
|
| 19:00 | End of the day |
|
| Friday September 1, 2017 |
| YMCS Competition Presentation Session II |
|
| 08:30 | OC05 - Identification of potent inhibitors of the anti-infective target DXS using ligand-based virtual screening
Winner of the young medicinal chemist meeting in Germany (DPhG) |
Prof. Anna K. H. HIRSCH
(HELMHOLTZ INSTITUTE FOR PHARMACEUTICAL RESEARCH SAARLAND, Saarbrücken, Germany) |
| 08:50 | OC06 - In Situ Ugi Four-Component Reaction for the Protein-Templated Identification of Inhibitors of Endothiapepsin
Winner of the young medicinal chemist meeting in the Netherlands |
Mr M. Yagiz ÜNVER
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands) |
| 09:10 | OC07 - Design and Synthesis of Functionalized Monocyclic 3-Amino-1-Carboxymethyl-Beta-Lactams as Potential Inhibitors of Penicillin Binding Proteins of Resistant Bacteria |
Ms Lena DECUYPER
(GHENT UNIVERSITY, Gent, Belgium) |
| 09:30 | OC08 - Discovery and Optimization of Novel Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anticancer Agents
Winner of the young medicinal chemist meeting in Italy |
Prof. Sergio VALENTE
(SAPIENZA UNIVERSITY OF ROME, Rome, Italy) |
| 09:50 | OC09 - Bicyclic Constrained Peptides Targeting the EGF-EGFR Interaction
Winner of the young medicinal chemist meeting in Spain |
Mr Salvador GUARDIOLA
(INSTITUTE FOR RESEARCH IN BIOMEDICINE, Barcelona, Spain) |
| 10:10 | Coffee Break |
|
| YMCS Competition Presentation Session III |
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| 10:30 | OC10 - Discovery and Characterization of Novel Potent F508-Del Cftr Correctors |
Dr Federico SORANA
(FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, GENOVA, Italy) |
| 10:50 | OC11 - Facing Non-Alcoholic Steatohepatitis with Multitarget Compounds |
Dr Daniel MERK
(ETH ZÜRICH, Zürich, Switzerland) |
| 11:10 | OC12 - Development of Ligands for the Short-Chain Fatty Acid Receptor Ffa2
Winner of the young medicinal chemist meeting in Denmark |
Mr Anders HOJGAARD HANSEN
(UNIVERSITY OF SOUTHERN DENMARK, Odense M, Denmark) |
| 11:30 | OC13 - Fluorophore One-Atom-Controlled Recognition of DNA/RNA Secondary Structure
Winner of the young medicinal chemist meeting in Croatia |
Dr Tamara SMIDLEHNER
(RUDER BOSKOVIC INSTITUTE, Zagreb, Croatia) |
| 11:50 | Lunch & Poster session 2 |
|
| YMCS Competition Presentation Session IV |
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| 13:15 | OC14 - Building-up Molecular Complexity with Carbenoids: New Vistas in Homologation Chemistry
Winner of the young medicinal chemist meeting in Austria |
Prof. Vittorio PACE
(UNIVERSITY OF VIENNA, Turin, Italy) |
| 13:35 | OC15 - The Role of The Sulfonyl Group on The Conformational Preferences Of Bis-Aromatic Compounds ¬ 5-Ht6 Receptor Antagonists and Beyond
Winner of the young medicinal chemist meeting in Poland |
Dr Jakub STARON
(INSTITUTE OF PHARMACOLOGY PAS, Krakow, Poland) |
| 13:55 | OC16 - The Catalytic Mechanism of The Iron-dependent Sulfoxide Synthase EgtB
Winner of the young medicinal chemist meeting in Switzerland |
Dr Kristina GONCHARENKO
(UNIVERSITY OF BASEL, Basel, Switzerland) |
| 14:15 | OC17 - Modular Assembly of Reversible Multivalent Targeting Drug Conjugates
Winner of the young medicinal chemist meeting in Portugal |
Mr Fábio Miguel FIGUEIREDO SANTOS
(RESEARCH INSTITUTE FOR MEDICINES (IMED.ULISBOA), Lisboa, Portugal) |
| 14:35 | OC18 - Molecular Recognition and Activation Mechanisms of Bitter Taste Receptors
Winner of the young medicinal chemist meeting in Israel |
Dr Antonella DI PIZIO
(THE HEBREW UNIVERSITY OF JERUSALEM, Rehovot, Israel) |
| 14:55 | Voting break |
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| 15:10 | Challenging Medicinal Chemistry! |
Dr Peter NUSSBAUMER
(LEAD DISCOVERY CENTER, Dortmund, Germany) |
| 15:40 | Closing and award ceremony |
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| 16:00 | End of the Symposium |
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