EFMC-ISMC 2018

Programme Schedule

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Programme Schedule

Sunday September 2, 2018
13:30Registration
16:00Opening Ceremony
16:20Plenary lecture to be confirmed
16:50Title to be announced
Prof. Tatjana AVSIC-ZUPANC
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia)
17:20Award Ceremony
17:40NAUTA AWARD FOR PHARMACOCHEMISTRY
18:40Synthetic Glycoconjugate Vaccines Against Bacterial Infections Identified Using a Medicinal Chemistry Approach
Prof. Dr Peter H. SEEBERGER
(MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES, Berlin, Germany)
19:25Welcome Reception
Monday September 3, 2018
08:30UCB-EHRLICH AWARD FOR EXCELLENCE IN MEDICINAL CHEMISTRY
09:15Sugars and Proteins
Prof. Benjamin DAVIS
(OXFORD UNIVERSITY, Oxford, United Kingdom)
10:00Exhibition & Coffee
Session 1 'Technologies'

Artificial Intelligence Applications in Medicinal Chemistry
Session 2 'Chemical Biology'

Glycans in Medicinal Chemistry: Carbohydrate-Based Vaccines (EuCheMS Session)
Session 3 'Therapeutic Areas'

Immuno-Oncology: Novel Therapeutic Opportunities
10:30Session Chair
Dr Jonas BOSTRÖM
(ASTRAZENECA, Mölndal, Sweden)
10:30Session Chair
Dr Sonsoles MARTIN-SANTAMARIA
(BIOLOGICAL RESEARCH CENTER, Madrid, Spain)
10:30Session Chair
Dr Luc VAN HIJFTE
(SCT & MERCACHEMSYNCOM, Nijmegen, The Netherlands)
10:35Artificial Intelligence. Not Just Another Name for in Silico Design
Dr David E. LEAHY
(THE DISCOVERY BUS LTD, Macclesfield, United Kingdom)
10:35Breaking the Limits in Glycan Recognition by NMR
Dr Jesus JIMENEZ-BARBERO
(CIC BIOGUNE, Derio, Spain)
10:35Small Molecule Immune Checkpoint Antagonists for Cancer Therapy
Dr Murali RAMACHANDRA
(AURIGENE DISCOVERY TECHNOLOGIES LTD, Bangalore, India)
11:15Scaling De Novo Design - from Single Target to Disease Portfolio
Dr Willem VAN HOORN
(EXSCIENTIA, Dundee, United Kingdom)
11:15Cancer Vaccines and Biomarkers
Dr Hans WANDALL
(UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark)
11:15Invited speaker to be confirmed
11:35OC to be selected from submitted abstracts
11:35Infectious Diseases. Synthesis and Molecular Recognition
Dr Laurence MULARD
(INSTITUT PASTEUR, Paris, France)
11:35OC to be selected from submitted abstracts
11:55OC to be selected from submitted abstracts
11:45OC to be selected from submitted abstracts
11:55OC to be selected from submitted abstracts
12:15Exhibition & Lunch
12:15Company Workshop(s)
Session 4 'Technologies'

Timing is Everything: Target Binding Kinetics and Pharmacokinetics
Session 5 'Chemical Biology'

Recent Advances in Targeted Protein Degradation
Session 6 'Therapeutic Areas'

Life Science at the Interface of Agro and Pharma
13:15Session Chair
Prof. Ad P. IJZERMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
13:15Session Chair
Dr Gregory HOLLINGWORTH
(NOVARTIS PHARMA AG, Basel, Switzerland)
13:15Session Chair
Dr Franz VON NUSSBAUM
(BAYER, Lyon, France)
13:20Micro-pharmacokinetics”: How Local Drug Concentration Influences Observed Binding Kinetics
Prof. Steven CHARLTON
(UNIVERSITY OF NOTTINGHAM, Nottingham, United Kingdom)
13:20Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook
Dr Mikihiko NAITO
(NATIONAL INSTITUTE OF HEALTH SCIENCES, Tokyo, Japan)
13:20A New Target in Fungal Protein Biosynthesis: Shared Learnings for AgChem and MedChem
Dr David BERNIER
(BAYER S.A.S. - CROPSCIENCE DIVISION, Lyon, France)
14:00Title to be announced
Dr Laura HEITMAN
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
14:00Targeting Transcription and Translation Factors for Degradation with Low Molecular Weight Cereblon Modulators
Dr Philip CHAMBERLAIN
(CELGENE, Alameda, United States)
14:00Natural Products as Leads in Agrochemistry
Dr Joachim RHEINHEIMER
(BASF, Ludwigshafen am Rhein, Germany)
14:20Title to be announced
Dr Liesbeth DE LANGE
(UNIVERSITY OF LEIDEN, Leiden, The Netherlands)
14:20The CRBN/IMiD Degrome
Dr Nicolas THOMÄ
(FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland)
14:20Synthesis and Fungicidal Activity of Novel Inhibitors of Oxysterol Binding Protein
Dr Sarah SULZER
(SYNGENTA AG, Basel, Switzerland)
14:40OC to be selected from submitted abstracts
14:40OC to be selected from submitted abstracts
14:40OC to be selected from submitted abstracts
15:00Exhibition & Coffee
Session 7

First Time Disclosures
15:30Session Chair
Dr Emmanuel PINARD
(F. HOFFMANN-LA ROCHE, Basel, Switzerland)
15:35Discovery of RG7916, a Selective SMN2 Splicing Modifier for the Treatment of Spinal Muscular Atrophy
Dr Hasane RATNI
(F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland)
16:05Discovery of LOU064, a BTK Inhibitor with Best in Class Selectivity
Dr Robert PULZ
(NOVARTIS PHARMA, Basel, Switzerland)
16:35Discovery of a Novel Oral NO- and Haem-Independent sGC Activator BAY 1101042
Dr Michael G. HAHN
(BAYER HEALTHCARE, Wuppertal, Germany)
17:05First Time Disclosure of BI 409306, a First in Class PDE9 Inhibitor for the Treatment of CNS Diseases
Dr Riccardo GIOVANNINI
(BOHERINGER INGELHEIM, Biberach, Germany)
17:35Poster Session 1 & Networking
19:30End of the Day
Tuesday September 4, 2018
08:30PROUS INSTITUTE-OVERTON AND MEYER AWARD FOR NEW TECHNOLOGIES IN DRUG DISCOVERY
09:15EFMC Prize Ceremony
09:20EFMC Prize for a Young Medicinal Chemist in Industry
09:40EFMC Prize for a Young Medicinal Chemist in Academia
10:00Exhibition & Coffee
Session 8 'Technologies'

New Chemical Modalities in Medicinal Chemistry
Session 9 'Therapeutic Areas'

Targeting Aggregated Proteins in Neurodegenerative Diseases with Small Molecules
Sessions 10 'Chemical Biology'

Targeting the STING Pathway (Stimulator of Interferon Genes)
10:30Session Chair
Dr Eric VALEUR
(ASTRAZENECA, Västra Frölunda, Sweden)
10:30Session Chair
Dr Laurent PROVINS
(UCB, Braine-l'Alleud, Belgium)
10:30Session Chair
Dr Thorsten OOST
(BOEHRINGER INGELHEIM PHARMA GMBH & CO KG, Biberach, Germany)
10:35New Modalities for Complex and Unprecedented Biological Targets
Dr Eric VALEUR
(ASTRAZENECA, Västra Frölunda, Sweden)
10:35Understanding Aggregation Inhibition of Alpha-Synuclein and Tau by Small Molecules
Prof. Markus ZWECKSTETTER
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)
10:35Innate Immune Sensing and Signaling of Cytosolic DNA
Dr Zhijian CHEN
(UNIVERSITY OF TEXAS, Dallas, United States)
11:15Cell Permeability with Beyond ‘Rule of 5’ Modalities – Do We Understand How This Works?
Dr Nick TERRETT
(MERCK SHARP & DOHME RESEARCH GMBH (MSD), Kriens, Switzerland)
11:15Discovery of Peptidomimetics Targeting Protein-Protein Interactions of Alpha- Synuclein
Dr Wolfgang WRASIDLO
(UNIVERSITY OF CALIFORNIA SAN DIEGO, La Jolla, United States)
11:15Modification of Cyclic Dinucleotides to Enhance Modulation of the Innate Immune Response
Dr Diane COE
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
11:35Development of a Novel Hybrid Macrocyclic New Modalities Class for Structure-Based Protein Mimetics
Dr Stephanie GUERET
(ASTRAZENECA-MAX PLANCK INSTITUTE SATELLITE UNIT, Dortmund, Germany)
11:35Targeting the Monomeric Intrinsically Disordered Structural State of Tau and Alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Alzheimer's and Parkinson’s Disease.
Dr Gergely TOTH
(CANTABIO PHARMACEUTICALS INC., Sunnyvale, United States)
11:35Use of Cyclic Dinucleotides (CDNs) to Induce Stimulator of Interferon Genes (STING)-Dependent Antitumor Immunity
Dr Cedric BOULARAN
(INVIVOGEN, Toulouse, France)
11:55OC to be selected from submitted abstracts
11:55OC to be selected from submitted abstracts
11:55OC to be selected from submitted abstracts
12:15Exhibition & Lunch
12:15Company Workshop(s)
13:15Flash Poster Presentations
Flash Poster 1Flash Poster 2 Flash Poster 3
10 opportunities for young scientists to present a summary of their poster
10 opportunities for young scientists to present a summary of their poster
10 opportunities for young scientists to present a summary of their poster
Session 11 'Technologies'

Expanding Medicinal Chemists’ Synthetic Toolbox
Session 12 'Therapeutic Areas'

Breakthroughs in Polypharmacology Towards Neurological Disorders (ACS Session)
Session 13 'Chemical Biology'

Chemical Biology Approaches to Target Identification
13:45Session Chair
Prof. Gyorgy KESERU
(RESEARCH CENTRE FOR NATURAL SCIENCES, HUNGARIAN ACADEMY OF SCIENCES, Budapest, Hungary)
13:45Session Chair
Prof. Maria Laura BOLOGNESI
(UNIVERSITY OF BOLOGNA, Bologna, Italy)
13:45Session Chair
Prof. Herbert WALDMANN
(MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany)
13:50Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis
Prof. Karl GADEMANN
(UNIVERSITY OF ZURICH, Zurich, Switzerland)
13:50Multi-Functional Treatment Strategies for Multi-Factorial Neurodegenerative Disorders: Challenges and Prospects
Dr Mark J. MILLAN
(INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France)
13:50Activity-Based Glycosidase Profiling in Biomedicine and Biotechnology
Prof. Hermen OVERKLEEFT
(LEIDEN UNIVERSITY, Leiden, The Netherlands)
14:30Stuck in a Rut with Old Chemistry
Dr Jonas BOSTRÖM
(ASTRAZENECA, Mölndal, Sweden)
14:30Exploiting Kinase Polypharmacology to Promote Nerve Regeneration
Dr Hassan AL-ALI
(THE MIAMI PROJECT TO CURE PARALYSIS, Miami, United States)
14:30Reprogramming the Reactivity of Metals in Persister Cancer Cells
Dr Raphaël RODRIGUEZ
(INSTITUT CURIE, Paris, France)
14:50New Chemical Libraries in Exploration of Chemical Space
Prof. Jurij SVETE
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia)
14:50In silico Polypolpharmacology
Dr Giovanni BOTTEGONI
(HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom)
14:50Title to be announced
Dr Alexander ADIBEKIAN
(THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States)
15:10OC to be selected from submitted abstracts
15:10OC to be selected from submitted abstracts
15:10OC to be selected from submitted abstracts
15:30Exhibition & Coffee
16:00Flash Poster Presentations
Flash Poster 4Flash Poster 5Flash Poster 6
15 opportunities for young scientists to present a summary of their poster
15 opportunities for young scientists to present a summary of their poster
15 opportunities for young scientists to present a summary of their poster
16:45Poster Session 2 & Networking
18:45Close Poster Session
20:00Concert/Public Event
Wednesday September 5, 2018
08:30Title to be announced
Dr Helga RÜBSAMEN-SCHAEFF
(AICURIS GMBH & CO. KG, Wuppertal, Germany)
09:15Plenary lecture to be confirmed
10:00Exhibition & Coffee
Session 14 'Technologies'

Development of New Synthetic Methodologies for Drug Discovery (CPA Session)
Session 15 'Therapeutic Areas'

Upcoming Treatment for NASH and Other Fibrotic Diseases
Session 16 'Chemical Biologies'

Recent Developments in Kinase Inhibitors
10:30Session Chair
Dr Ming-Qiang ZHANG
(AMGEN, Shanghai City, China)
10:30Session Chair
Prof. Roberto PELLICCIARI
(TES PHARMA SRL, Corciano, Italy)
10:30Session chair
Prof. Stefan LAUFER
(UNIVERSITY OF TÜBINGEN, Tübingen, Germany)
10:35Sulfur- and Silicon-Based Fluorination Reagents for Medicinal Chemistry
Dr Jinbo HU
(SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, China)
10:35Obeticholic Acid, Leading in the NASH Race. History and Perspectives
Prof. Roberto PELLICCIARI
(TES PHARMA SRL, Corciano, Italy)
10:35EGFR Triple Mutant - Recent Set-Backs and New Hopes in Fighting Mutant Non-Small Cell Lung Cancer
Prof. Stefan LAUFER
(UNIVERSITY OF TÜBINGEN, Tübingen, Germany)
11:15Direct Transformation of Unreactive Chemical Bonds
Dr Zhang-Jie SHI
(FUNDAN UNIVERSITY, Shanghai, China)
11:15Discovery of LJN452, a Highly Potent, Non-Bile Acid FXR Agonist for the Treatment of Cholestasis and NASH
Dr David TULLY
(NOVARTIS, Emeryville, United States)
11:15From Pan Kinase to (Ultra) Selective Kinase Inhibitors
Dr Laurent SCHIO
(SANOFI, Vitry sur Seine, France)
11:35Practical Asymmetric Hydrogenation
Prof. Xumu ZHANG
(SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, Guangdong, China)
11:35OC to be selected from submitted abstracts
11:35OC to be selected from submitted abstracts
11:55Asymmetric Aldol Reactions of Heterocyclic Dienolsilanes and α,β-Unsaturated Carbonyl Derived Dienolsilanes
Prof. Fener CHEN
(FUDAN UNIVERSITY, China)
11:55OC to be selected from submitted abstracts
11:55OC to be selected from submitted abstracts
12:15Exhibition & Lunch
12:15Company Workshop(s)
Session 17

Emerging topics
Session 18 'Therapeutic Areas'

Addressing Infectious Diseases in the Developing Countries (AFMC Session)
Session 19 'Chemical Biology'

The Spingosine-1-Phosphate Axis: Therapeutic Potential in Inflammation, Cancer, and More (ACS Session)
13:15Session Chair to be confirmed
13:15Session Chair
Dr Renate GRIFFITH
(UNIVERSITY OF NEW SOUTH WALES, UNSW Sydney, Australia)
13:15Session Chair
Dr Tony LEE
(GILEAD SCIENCES, Seattle, United States)
13:20OC to be selected from submitted abstracts
13:20All Bugs are Shallow: Open Source Drug Discovery
Prof. Matthew TODD
(UNIVERSITY OF SYDNEY, Sydney, Australia)
13:20Invited speaker to be confirmed
14:00OC to be selected from submitted abstracts
14:00Towards the Development of Small Molecule Therapy for Chikungunya
Prof. Christina CHAI
(NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore)
14:00Unravelling the Mysteries of the Sphinx: New Therapeutic Targets and Drug Leads from the Phenotypic Screening of Non-Lipid Sphingolipid Mimetics
Prof. Bernard FLYNN
(MONASH UNIVERSITY, Parkville, Australia)
14:20OC to be selected from submitted abstracts
14:20OC to be selected from submitted abstracts
14:20Active Site Inhibitors of Sphingosine 1-Phosphate Lyase – Exploring Novel Biology With Tool Compounds
Dr Sven WEILER
(BASILEA PHARMACEUTICA INTERNATIONAL LTD., Basel, Switzerland)
14:40OC to be selected from submitted abstracts
14:40OC to be selected from submitted abstracts
14:40Controlling Sphingosine-1-Phosphate Levels as a Therapeutic Strategy
Dr Webster L. SANTOS
(VIRGINIA TECH, Blacksburg, United States)
15:00End of the Day
15:30Excursions
20:00Banquet
Thursday September 6, 2018
Session 20 'Technologies'

Recent Developments in Nucleoside Medicinal Chemistry
Session 21 'Therapeutic Areas'

Inflammatory and Autoimmune Diseases
Session 22 'Chemical Biology'

Enzyme Activators and Positive Allosteric Modulators
08:30Session Chair
Dr Jared CUMMING
(MSD, Boston, United States)
08:30Session Chair
Prof. Stanislav GOBEC
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia)
08:30Session Chair
Prof. Joachim MITTENDORF
(BAYER AG, Wuppertal, Germany)
08:35Cyclic Dinucleotide STING Agonists as Anti-tumor Agents
Dr Wesley TROTTER
(MSD, Boston, United States)
08:35Keynote speaker to be confirmed
08:35Design, Synthesis, and Mechanism of β-Glucocerebrosidase Activators for Gaucher’s and Parkinson’s Diseases
Dr Richard B SILVERMAN
(NORTHWESTERN UNIVERSITY, Evanston, United States)
09:15Discovery of JNJ-64619178 as a Potent and Selective PRMT5 Inhibitor for the Treatment of Lung and Hematologic Cancers
Dr Jan Willem THURING
(JANSSEN PHARMACEUTICA NV, Beerse, Belgium)
09:15Small-Molecule Immunomodulators of Toll-Like Receptors
Prof. Hang YIN
(TSINGHUA UNIVERSITY, Beijing, China)
09:15Allosteric Modulators of the GABA-B Receptor
Dr Sean C. TURNER
(ABBVIE, Ludwigshafen am Rhein, Germany)
09:35Design and Synthesis of Stable Congeners of Cyclic ADP-Ribose, a Ca2+-Mobilizing Second Messenger, Toward Identification of the Target Protein
Prof. Satoshi SHUTO
(HOKKAIDO UNIVERSITY, Sapporo, Japan)
09:35Nonpeptidic Selective Inhibitors of Immunoproteasome
Prof. Stanislav GOBEC
(UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia)
09:35The Value of Orthogonal Techniques for Elucidating Binding Site(s) of GPCR Allosteric Modulators: a Case Study With Positive Allosteric Modulators of Dopamine Receptors
Dr Anne VALADE
(UCB, Braine-l'Alleud, Belgium)
09:55OC to be selected from submitted abstracts
09:55OC to be selected from submitted abstracts
09:55OC to be selected from submitted abstracts
10:15Exhibition & Coffee (brunch)
Session 23 'Technologies'

PET Imaging as a Tool in for in Vivo Drug Evaluation and Development (EANM Session)
Session 24 'Therapeutic Areas'

Cardiometabolic Diseases
Session 25

Late Breaking News
10:45Session Chair
Dr Antony GEE
(KING'S COLLEGE LONDON, London, United Kingdom)
10:45Session Chair
Dr Karin CONDE-KNAPE
(NOVO NORDISK, Bagsvaerd, Denmark)
10:45Session Chair to be confirmed
10:50PET Molecular Imaging – An Overview
Dr Antony GEE
(KING'S COLLEGE LONDON, London, United Kingdom)
10:50Keynote speaker to be confirmed
10:50OC to be selected from submitted abstracts
11:30PET in Neuroscience Drug Discovery and Development
Dr Magnus SCHOU
(KAROLINSKA INSTITUTE, Stockholm, Sweden)
11:30Invited speaker to be confirmed
11:30OC to be selected from submitted abstracts
11:50PET for Oncology Drug Discovery and Development
Prof. Bert WINDHORST
(VU UNIVERSITY MEDICAL CENTER, AMSTERDAM, The Netherlands)
11:50From Ala Scan to Structural Design of GLP-1 Analogues
Dr Jesper LAU
(NOVO NORDISK, Maaloev, Denmark)
11:50OC to be selected from submitted abstracts
12:10OC to be selected from submitted abstracts
12:10OC to be selected from submitted abstracts
12:10OC to be selected from submitted abstracts
12:30Title to be announced
Prof. Cristina NEVADO
(UNIVERSITY OF ZURICH, Zurich, Switzerland)
Chair
13:15Closing Remarks, Poster Prizes and Welcome to EFMC-ISMC 2020

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