EFMC-ISMC 2018

Programme Schedule

The Programme is available here!


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Confirmed Speakers


Plenary Lectures


Prof. Tatjana AVSIC-ZUPANC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

Title to be announced

Prof. Benjamin DAVIS
Prof. Benjamin DAVIS
OXFORD UNIVERSITY, Oxford, United Kingdom
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Sugars and Proteins

Prof. Cristina NEVADO
Prof. Cristina NEVADO
UNIVERSITY OF ZURICH, Zurich, Switzerland

Title to be announced

Prof. Dr Peter H. SEEBERGER
Prof. Dr Peter H. SEEBERGER
MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES, Berlin, Germany
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Synthetic Glycoconjugate Vaccines Against Bacterial Infections Identified Using a Medicinal Chemistry Approach

Invited Speakers


Dr Alexander ADIBEKIAN
THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States

Title to be announced

Dr Hassan AL-ALI
Dr Hassan AL-ALI
THE MIAMI PROJECT TO CURE PARALYSIS, Miami, United States
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Exploiting Kinase Polypharmacology to Promote Nerve Regeneration

Dr David BERNIER
Dr David BERNIER
BAYER S.A.S. - CROPSCIENCE DIVISION, Lyon, France
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A New Target in Fungal Protein Biosynthesis: Shared Learnings for AgChem and MedChem

Dr Jonas BOSTRÖM
Dr Jonas BOSTRÖM
ASTRAZENECA, Mölndal, Sweden
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Stuck in a Rut with Old Chemistry

Dr Giovanni BOTTEGONI
Dr Giovanni BOTTEGONI
HEPTARES THERAPEUTICS, Welwyn Garden City, United Kingdom
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In silico Polypolpharmacology

Dr Cedric BOULARAN
Dr Cedric BOULARAN
INVIVOGEN, Toulouse, France
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Use of Cyclic Dinucleotides (CDNs) to Induce Stimulator of Interferon Genes (STING)-Dependent Antitumor Immunity

Prof. Christina CHAI
Prof. Christina CHAI
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, Singapore
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Towards the Development of Small Molecule Therapy for Chikungunya

Dr Philip CHAMBERLAIN
Dr Philip CHAMBERLAIN
CELGENE, Alameda, United States
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Targeting Transcription and Translation Factors for Degradation with Low Molecular Weight Cereblon Modulators


Prof. Steven CHARLTON
UNIVERSITY OF NOTTINGHAM, Nottingham, United Kingdom

Micro-pharmacokinetics”: How Local Drug Concentration Influences Observed Binding Kinetics


Prof. Fener CHEN
FUDAN UNIVERSITY, China

Asymmetric Aldol Reactions of Heterocyclic Dienolsilanes and α,β-Unsaturated Carbonyl Derived Dienolsilanes


Dr Zhijian CHEN
UNIVERSITY OF TEXAS, Dallas, United States

Innate Immune Sensing and Signaling of Cytosolic DNA

Dr Liesbeth DE LANGE
Dr Liesbeth DE LANGE
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

Title to be announced

Prof. Bernard FLYNN
Prof. Bernard FLYNN
MONASH UNIVERSITY, Parkville, Australia
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Unravelling the Mysteries of the Sphinx: New Therapeutic Targets and Drug Leads from the Phenotypic Screening of Non-Lipid Sphingolipid Mimetics

Prof. Karl GADEMANN
Prof. Karl GADEMANN
UNIVERSITY OF ZURICH, Zurich, Switzerland
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Capturing Biological Activity in Natural Product Fragments by Chemical Synthesis

Dr Antony GEE
Dr Antony GEE
KING'S COLLEGE LONDON, London, United Kingdom
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PET Molecular Imaging – An Overview


Dr Riccardo GIOVANNINI
BOHERINGER INGELHEIM, Biberach, Germany

First Time Disclosure of BI 409306, a First in Class PDE9 Inhibitor for the Treatment of CNS Diseases

Prof. Stanislav GOBEC
Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia
Read more

Nonpeptidic Selective Inhibitors of Immunoproteasome

Dr Stephanie GUERET
Dr Stephanie GUERET
ASTRAZENECA-MAX PLANCK INSTITUTE SATELLITE UNIT, Dortmund, Germany
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Development of a Novel Hybrid Macrocyclic New Modalities Class for Structure-Based Protein Mimetics

Dr Michael G. HAHN
Dr Michael G. HAHN
BAYER HEALTHCARE, Wuppertal, Germany
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Discovery of a Novel Oral NO- and Haem-Independent sGC Activator BAY 1101042

Dr Laura HEITMAN
Dr Laura HEITMAN
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

Title to be announced

Dr Jinbo HU
Dr Jinbo HU
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, China
Read more

Sulfur- and Silicon-Based Fluorination Reagents for Medicinal Chemistry

Dr Jesus JIMENEZ-BARBERO
Dr Jesus JIMENEZ-BARBERO
CIC BIOGUNE, Derio, Spain
Read more

Breaking the Limits in Glycan Recognition by NMR

Dr Jesper LAU
Dr Jesper LAU
NOVO NORDISK, Maaloev, Denmark
Read more

From Ala Scan to Structural Design of GLP-1 Analogues

Prof. Stefan LAUFER
Prof. Stefan LAUFER
UNIVERSITY OF TÜBINGEN, Tübingen, Germany
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EGFR Triple Mutant - Recent Set-Backs and New Hopes in Fighting Mutant Non-Small Cell Lung Cancer

Dr David E. LEAHY
Dr David E. LEAHY
THE DISCOVERY BUS LTD, Macclesfield, United Kingdom
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Artificial Intelligence. Not Just Another Name for in Silico Design

Dr Mark J. MILLAN
Dr Mark J. MILLAN
INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France
Read more

Multi-Functional Treatment Strategies for Multi-Factorial Neurodegenerative Disorders: Challenges and Prospects

Dr Laurence MULARD
Dr Laurence MULARD
INSTITUT PASTEUR, Paris, France

Infectious Diseases. Synthesis and Molecular Recognition

Dr Mikihiko NAITO
Dr Mikihiko NAITO
NATIONAL INSTITUTE OF HEALTH SCIENCES, Tokyo, Japan
Read more

Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook

Prof. Hermen OVERKLEEFT
Prof. Hermen OVERKLEEFT
LEIDEN UNIVERSITY, Leiden, The Netherlands
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Activity-Based Glycosidase Profiling in Biomedicine and Biotechnology

Prof. Roberto PELLICCIARI
Prof. Roberto PELLICCIARI
TES PHARMA SRL, Corciano, Italy
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Obeticholic Acid, Leading in the NASH Race. History and Perspectives

Dr Robert PULZ
Dr Robert PULZ
NOVARTIS PHARMA, Basel, Switzerland
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Discovery of LOU064, a BTK Inhibitor with Best in Class Selectivity

Dr Murali RAMACHANDRA
Dr Murali RAMACHANDRA
AURIGENE DISCOVERY TECHNOLOGIES LTD, Bangalore, India
Read more

Small Molecule Immune Checkpoint Antagonists for Cancer Therapy

Dr Hasane RATNI
Dr Hasane RATNI
F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland
Read more

Discovery of RG7916, a Selective SMN2 Splicing Modifier for the Treatment of Spinal Muscular Atrophy


Dr Joachim RHEINHEIMER
BASF, Ludwigshafen am Rhein, Germany

Natural Products as Leads in Agrochemistry

Dr Raphaël RODRIGUEZ
Dr Raphaël RODRIGUEZ
INSTITUT CURIE, Paris, France
Read more

Reprogramming the Reactivity of Metals in Persister Cancer Cells

Dr Webster L. SANTOS
Dr Webster L. SANTOS
VIRGINIA TECH, Blacksburg, United States
Read more

Controlling Sphingosine-1-Phosphate Levels as a Therapeutic Strategy

Dr Laurent SCHIO
Dr Laurent SCHIO
SANOFI, Vitry sur Seine, France
Read more

From Pan Kinase to (Ultra) Selective Kinase Inhibitors

Dr Magnus SCHOU
Dr Magnus SCHOU
KAROLINSKA INSTITUTE, Stockholm, Sweden
Read more

PET in Neuroscience Drug Discovery and Development

Dr Zhang-Jie SHI
Dr Zhang-Jie SHI
FUNDAN UNIVERSITY, Shanghai, China
Read more

Direct Transformation of Unreactive Chemical Bonds

Prof. Satoshi SHUTO
Prof. Satoshi SHUTO
HOKKAIDO UNIVERSITY, Sapporo, Japan
Read more

Design and Synthesis of Stable Congeners of Cyclic ADP-Ribose, a Ca2+-Mobilizing Second Messenger, Toward Identification of the Target Protein

Dr Richard B SILVERMAN
Dr Richard B SILVERMAN
NORTHWESTERN UNIVERSITY, Evanston, United States
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Design, Synthesis, and Mechanism of β-Glucocerebrosidase Activators for Gaucher’s and Parkinson’s Diseases

Dr Sarah SULZER
Dr Sarah SULZER
SYNGENTA AG, Basel, Switzerland
Read more

Synthesis and Fungicidal Activity of Novel Inhibitors of Oxysterol Binding Protein

Prof. Jurij SVETE
Prof. Jurij SVETE
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia
Read more

New Chemical Libraries in Exploration of Chemical Space

Dr Nick TERRETT
Dr Nick TERRETT
MERCK SHARP & DOHME RESEARCH GMBH (MSD), Kriens, Switzerland
Read more

Cell Permeability with Beyond ‘Rule of 5’ Modalities – Do We Understand How This Works?

Dr Nicolas THOMÄ
Dr Nicolas THOMÄ
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland
Read more

The CRBN/IMiD Degrome


Dr Jan Willem THURING
JANSSEN PHARMACEUTICA NV, Beerse, Belgium

Discovery of JNJ-64619178 as a Potent and Selective PRMT5 Inhibitor for the Treatment of Lung and Hematologic Cancers

Prof. Matthew TODD
Prof. Matthew TODD
UNIVERSITY OF SYDNEY, Sydney, Australia
Read more

All Bugs are Shallow: Open Source Drug Discovery

Dr Gergely TOTH
Dr Gergely TOTH
CANTABIO PHARMACEUTICALS INC., Sunnyvale, United States
Read more

Targeting the Monomeric Intrinsically Disordered Structural State of Tau and Alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Alzheimer's and Parkinson’s Disease.


Dr Wesley TROTTER
MSD, Boston, United States

Cyclic Dinucleotide STING Agonists as Anti-tumor Agents


Dr David TULLY
NOVARTIS, Emeryville, United States

Discovery of LJN452, a Highly Potent, Non-Bile Acid FXR Agonist for the Treatment of Cholestasis and NASH


Dr Sean C. TURNER
ABBVIE, Ludwigshafen am Rhein, Germany

Allosteric Modulators of the GABA-B Receptor

Dr Anne VALADE
Dr Anne VALADE
UCB, Braine-l'Alleud, Belgium
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The Value of Orthogonal Techniques for Elucidating Binding Site(s) of GPCR Allosteric Modulators: a Case Study With Positive Allosteric Modulators of Dopamine Receptors

Dr Eric VALEUR
Dr Eric VALEUR
ASTRAZENECA, Västra Frölunda, Sweden
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New Modalities for Complex and Unprecedented Biological Targets

Dr Willem VAN HOORN
Dr Willem VAN HOORN
EXSCIENTIA, Dundee, United Kingdom
Read more

Scaling De Novo Design - from Single Target to Disease Portfolio


Dr Hans WANDALL
UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark

Cancer Vaccines and Biomarkers

Dr Sven WEILER
Dr Sven WEILER
BASILEA PHARMACEUTICA INTERNATIONAL LTD., Basel, Switzerland
Read more

Active Site Inhibitors of Sphingosine 1-Phosphate Lyase – Exploring Novel Biology With Tool Compounds


Prof. Bert WINDHORST
VU UNIVERSITY MEDICAL CENTER, AMSTERDAM, The Netherlands

PET for Oncology Drug Discovery and Development

Dr Wolfgang WRASIDLO
Dr Wolfgang WRASIDLO
UNIVERSITY OF CALIFORNIA SAN DIEGO, La Jolla, United States
Read more

Discovery of Peptidomimetics Targeting Protein-Protein Interactions of Alpha- Synuclein

Prof. Hang YIN
Prof. Hang YIN
TSINGHUA UNIVERSITY, Beijing, China
Read more

Small-Molecule Immunomodulators of Toll-Like Receptors

Prof. Xumu ZHANG
Prof. Xumu ZHANG
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, Guangdong, China
Read more

Practical Asymmetric Hydrogenation

Prof. Markus ZWECKSTETTER
Prof. Markus ZWECKSTETTER
MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany
Read more

Understanding Aggregation Inhibition of Alpha-Synuclein and Tau by Small Molecules


Gold Sponsors

Silver Sponsor

Bronze Sponsors

Award & Prize Sponsors

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