3rd NovAliX Conference

VENUE CHANGE!
The NovAliX Conference will now take place at HILTON STRASBOURG - More info here.

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Read the Testimonials of the 2015 Conference attendees now!

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Accommodation - important notice

During the same week of June a session of the European Parliament will take place in Strasbourg, we therefore recommend you to book your accommodation well in advance!

Scientific Programme

Tuesday June 7, 2016
13:00Registration
14:00Welcome Address
Session 1: Emerging Technologies
Session Chair
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
14:15Mass Spectrometry and its Role in Drug Discovery (PL01)
Prof. Carol ROBINSON
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)
15:00A 5-Year Retrospective on Non-Covalent Mass Spectrometry Applied to Drug Discovery (OC01)
Dr Mathias ANTOINE
(INSTITUT DE RECHERCHES SERVIER, Croissy-sur-Seine, France)
15:25Maldi Mass Spectrometry: From Imaging to Ultra-High-Throughput-Screening (Maldi-Uhts) (OC02)
Dr Jens FUCHSER
(BRUKER DALTONICS, Bremen, Germany)
15:50Coffee Break
16:20Exploring GPCR and Membrane Protein Dynamics with Solution NMR and X-ray Free-Electron Lasers (PL02)
Prof. Gebhard F.X. SCHERTLER
(PAUL SCHERRER INSTITUTE, Villigen, Switzerland)
17:05Exhibitor Short Presentation: Creoptix AG
The WAVE of the Future in Kinetics
Dr Matyas VEGH
(CREOPTIX AG, Wädenswil, Switzerland)
17:15Exhibitor Short Presentation: Bruker BioSpin
Fragment Screening by Ligand Observed NMR
Dr Stefan JEHLE
(BRUKER BIOSPIN, Faellanden, Switzerland)
Keynote Lecture
Chair
Dr Ursula EGNER
(BAYER, Berlin, Germany)
17:25The Discovery of ABL001, an Allosteric Inhibitor of BCR-ABL (KN01)
Dr Sandra JACOB
(NOVARTIS, Basel, Switzerland)
18:25Welcome Reception
Wednesday June 8, 2016
08:30Registration
Session 2: Biophysics for Challenging Targets
Session Chair
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom)
09:00New Strategy for Challenging Targets: Time Resolved Molecular Interaction Analysis on Living Cells Using LigandTracer (PL03)
Dr Karl ANDERSSON
(RIDGEVIEW INSTRUMENTS AB, Vänge, Sweden)
09:45Exhibitor Short Presentation: Dynamic Biosensors
Biophysical Analysis of Molecular Interactions and Enzymatic Activity with switchSENSE
Dr Duncan BORTHWICK
(DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany)
09:55Combining Binding Thermodynamics and Kinetic Binding Mechanisms to Assess The Selectivity of Inhibitors of Histone Deacetylase-Like Amidohydrolases (OC03)
Mr Christian MEYNERS
(UNIVERSITY OF APPLIED SCIENCES DARMSTADT, Darmstadt, Germany)
10:20Coffee Break
10:50Thermodynamics of the Ribosome Translation Machinery (OC04)
Dr Eric ENNIFAR
(CNRS, Strasbourg, France)
11:15Exhibitor Short Presentation: Molecular Sensing
Affinity Assays for GPCR ligand binding using TruBind™ Molecular Interaction Analysis
Dr Yvonne VOLZ
(MOLECULAR SENSING, Idstein, Germany)
11:25Probing the Structure and Dynamics of Proteins with Single-Molecule Spectroscopy (PL04)
Prof. Ben SCHULER
(UNIVERSITY OF ZURICH, Zurich, Switzerland)
12:10Lunch & Networking
13:00Poster Session 1
Session 3: Special Focus on Cryo-EM
Session Chair
Dr Ursula EGNER
(BAYER, Berlin, Germany)
14:15High-Resolution Electron Cryo-Microscopy of Membrane Protein Complexes (PL05)
Prof. Werner KÜHLBRANDT
(MAX PLANCK INSTITUTE OF BIOPHYSICS, Frankfurt am Main, Germany)
15:00Cullin-Ring Ubiquitin E3 Ligase Regulation by the Cop9 Signalosome (OC05)
Dr Simone CAVADINI
(FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH, Basel, Switzerland)
15:25Coffee Break
15:55Visualizing Dynamic Macromolecular Complexes at High Resolution by Cryo-EM (PL06)
Prof. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)
16:40EM in Industry: Expectations and Perspectives (PL07)
Dr Denis ZEYER
(NOVALIX, Illkirch, France)
Keynote Lecture
Chair
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
17:10X-ray Crystallography: an Ever-Reemerging Technology (KN02)
Prof. Gerard BRICOGNE
(GLOBAL PHASING LTD., Cambridge, United Kingdom)
Thursday June 9, 2016
Session 4: Computational Biophysics
Session Chair
Prof. Rod HUBBARD
(UNIVERSITY OF YORK & VERNALIS, Cambridge, United Kingdom)
09:00Structural Stability of Protein-Ligand Complexes: Applications in Virtual Screening (PL08)
Prof. Xavier BARRIL
(BARCELONA UNIVERSITY, Barcelona, Spain)
09:45Exhibitor Short Presentation: BioSolveIT
A Visual Approximation to On-the-Fly Computational Thermodynamic Profiling
Dr Marcus GASTREICH
(BIOSOLVEIT, St. Augustin, Germany)
09:55Diverse Applications of Free Energy Calculations in Drug Discovery (OC06)
Dr David RINALDO
(SCHRÖDINGER, Mannheim, Germany)
10:20Coffee Break
10:50Uncoupling the Structure-Activity Relationships of Beta-2 Adrenergic Receptor Ligands from Membrane Binding (OC07)
Dr Callum DICKSON
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, United States)
11:15Exhibitor Short Presentation: Biodesy
Real-time, Solution-based Measurement of Protein Conformational Change
Dr Tad GEORGE
(BIODESY, San Francisco, United States)
11:25Computational Exploration of Protein Dynamics for Ligand Design (PL09)
Prof. Rebecca WADE
(HEIDELBERG INSTITUTE FOR THEORETICAL STUDIES AND HEIDELBERG UNIVERSITY, Heidelberg, Germany)
12:10Lunch & Networking
12:55Poster Session 2
Session 5: Cellular Biophysics
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
14:00The Life and Death of Cells: Cellular Bioenergetics for Better Phenotype Based Drug Discovery (PL10)
Dr Magnus JANSSON
(SYMCEL SVERIGE AB, Spanga, Sweden)
14:45Exhibitor Short Presentation: Sierra Sensors
Introducing MASS-2 for High Performance, High Throughput SPR Analysis
Dr Sven MALIK
(SIERRA SENSORS, Hamburg, Germany)
14:55Exhibitor Short Presentation: NovAliX
Balancing Standard and Unique Services for Drug Discovery
Dr Frank MOFFATT
(NOVALIX, Illkirch, France)
15:05Insulin Degrading Enzyme: Drug Target Engagement in Hela Cells by Cellular Thermal Shift Assay (OC08)
Dr Adrien HERLEDAN (INSTITUT PASTEUR DE LILLE, Lille, France)
15:30Coffee Break
16:00Imaging of G-protein Coupled Receptors while Quantifying their Ligand-binding Free Energy Landscape to Mutiple Ligands (PL11)
Prof. Daniel MÜLLER
(ETH ZÜRICH, Basel, Switzerland)
16:45Poster Prizes
20:00Conference Dinner
Friday June 10, 2016
Session 6: Biophysics for Biotherapeutics
Session Chair
Dr Johannes OTTL
(NOVARTIS INSTITUTE OF BIOMEDICAL RESEARCH, Basel, Switzerland)
09:00The Neonatal Fc Receptor (FcRn) Binds Independently to Both Sites of the IgG Homodimer with Identical Affinities (PL12)
Dr Yasmina ABDICHE
(RINAT-PFIZER, San Francisco, United States)
09:45Exhibitor Short Presentation: Malvern Instruments
Innovative Solutions for Biosimilars
Mr Michel TERRAY
(MALVERN INSTRUMENTS, Orsay Cedex, France)
09:55Analysis of Bispecific Interactions with the Switchsense Biosensor (OC09)
Dr Ulrich RANT
(DYNAMIC BIOSENSORS GMBH, Martinsried/Planegg, Germany)
10:20Coffee Break
10:50Kinetic Excursion Analysis (Kinexa) of Avidity Enhancement of a Multi-Valent Adnectin Binding to Clustered Receptors on Cho Cells (OC10)
Dr Lumelle SCHNEEWEIS
(BRISTOL-MYERS SQUIBB, Princeton, NJ, United States)
11:15Exhibitor Short Presentation: NanoTemper Technologies
Prometheus NT.48 - The Stability Expert
Dr François-Xavier OGI
(NANOTEMPER TECHNOLOGIES, Karlsruhe, Germany)
11:25Combinatorial SEC, AUC and TEM Approach for the Characterization of mAb Dimers (PL13)
Dr Arne RUFER
(F. HOFFMANN-LA ROCHE LTD., Basel, Switzerland)
12:10Closing Remarks and Departure

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