FMC 2015

The programme of the Frontiers in Medicinal Chemistry Symposium is now available!

Conferences > Archives > FMC 2015
Sunday September 13, 2015
15:00Optional excursions
18:30Welcome reception with Belgian Beers
Monday September 14, 2015
08:00Registration
08:45Welcome address
Plenary Session
Session Chair
Prof. Koen AUGUSTYNS
(UNIVERSITY OF ANTWERP, Antwerp, Belgium)
09:00Discovery and Development of Bedaquiline: A Rocky Road
Prof. Koen ANDRIES
(JANSSEN PHARMACEUTICA NV, Beerse, Belgium)
09:45Regulated Necrosis: Disease Relevance and Therapeutic Opportunities
Prof. Peter VANDENABEELE
(UNIVERSITY OF GHENT, Ghent, Belgium)
10:30Coffee break and Exhibition
11:00The Role of CXCR4 Modulators in Controlling HIV Entry, Stem Cell Mobilisation and Certain Types of Cancer
Prof. Dennis LIOTTA
(EMORY UNIVERSITY, Atlanta, United States)
11:45Lunch and Exhibition
Session 1 - Molecular Chaperones and their Therapeutic Potential
Session Chair
Prof. Brian S. J. BLAGG
(UNIVERSITY OF KANSAS, Lawrence, United States)
13:00Story of the Hsp27 Inhibitor Apatorsen
Dr Palma ROCCHI
(MARSEILLE CANCEROLOGY RESEARCH CENTER, Marseille, France)
13:30Targeting Protein-Protein Interactions in the Heat Shock Protein 70 (Hsp70) Complex
Prof. Jason GESTWICKI
(UNIVERSITY OF CALIFORNIA, San Francisco, United States)
14:00Update on Hsp90 Inhibitors as Cancer Therapeutics
Dr Weiwen YING
(SYNTA PHARMACEUTICALS, Lexington, United States)
Oral Communications
14:30The Discovery of Chemical Probes for Bromodomain Containing Proteins
Prize winner EFMC-YMCS 2014
Dr Duncan HAY
(EVOTEC, Abingdon, United Kingdom)
14:45The Discovery Of A New Validated Target For Tuberculosis Via Phenotypic Screening
Ms Raquel FERNANDEZ
(GLAXOSMITHKLINE, Tres Cantos, Spain)
15:00Measuring The Dynamics Of Target Engagement Inside Cells Using Bret
Dr Matthew ROBERS
(PROMEGA, Madison, United States)
15:15Outcome EFMC video competition
15:30Coffee break and Exhibition
16:00Poster Session 1
(posters with odd numbers)
17:30City Tour
Tuesday September 15, 2015
Session 2 - Unexplored Chemical Space: Experiences from the European Lead Factory and the NIH
Session Chair
Dr Peter MOLENVELD
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands)
08:30Sanford-Burnham’s Experience with the NIH’s Molecular Libraries Program
Dr Anthony PINKERTON
(SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, La Jolla, United States)
09:00Sharing Compound Collections: UCB's First Experiences from the European Lead Factory
Dr Jeremy DAVIS
(UCB, Slough, United Kingdom)
09:30Privileged Structures Unlocking Therapeutic Target Families
Dr Gerhard MÜLLER
(MERCACHEM, Martinsried, Germany)
10:00Coffee break and Exhibition
Session 3 - Emerging Advances in GPCR Research
Session Chair
Dr Laurent PROVINS
(UCB, Braine-l'Alleud, Belgium)
10:30Revealing The Structural Basis for GPCR Drug Action through Atomic-Level Simulation
Prof. Ron DROR
(STANFORD UNIVERSITY, Stanford, United States)
11:00Towards 3rd Generation Antihistamines: Fact or Fiction?
Prof. Rob LEURS
(VU UNIVERSITY AMSTERDAM, Amsterdam, The Netherlands)
11:30The Design of mGlu2 Negative Allosteric Modulators for the Treatment of Neuropsychiatric Disorders
Dr Michiel VAN GOOL
(JANSSEN R&D, Toledo, Spain)
12:00Lunch and Exhibition
12:45Poster Session 2
(posters with even numbers)
Session 4 - Novel Strategies for Anti-Thrombotic Therapy
Session Chairs
Dr Amjad ALI (MERCK, SHARP & DOHME, Kenilworth, United States)
Dr Amy RIPKA (WUXI APPTEC, Cambridge, United States)
14:15Targeting Factor XII in Thrombosis and Inflammation
Prof. Thomas RENNE
(KAROLINSKA INSTITUTET, Stockholm, Sweden)
14:45Structure-Based Design of Inhibitors of Factor XIa
Dr James CORTE
(BRISTOL MYERS SQUIBB, Princeton, United States)
15:15Vorapaxar Discovery and Clinical Benefits
Dr Patrick ANDRE
(MERCK & CO., Kenilworth, United States)
15:45Coffee break and Exhibition
Session 5 - Academic Drug Discovery (+ Panel discussion)
Session Chair
Prof. Henk TIMMERMAN
(VU UNIVERSITY AMSTERDAM, Oegstgeest, The Netherlands)
16:15Translating Medicinal Chemistry Research into Targeted Therapeutics. Building on Academic Knowledge
Prof. Roberto PELLICCIARI
(UNIVERSITY OF PERUGIA, Corciano, Italy)
16:45Science, Business & Innovation in Medicinal Chemistry
Prof. Iwan DE ESCH
(VU UNIVERSITY AMSTERDAM, Amsterdam, The Netherlands)
17:15Panel Discussion - Introduction by the moderator
Panellist 1
Prof. Christa MÜLLER
(UNIVERSITY OF BONN, Bonn, Germany)
Panellist 2
Prof. Chas BOUNTRA
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)
Panellist 3
Prof. Dennis LIOTTA
(EMORY UNIVERSITY, Atlanta, United States)
Panel Discussion with Roberto Pellicciari, Iwan de Esch, Christa Müller, Chas Bountra and Dennis Liotta, and discussion with the audience
18:15End of Panel Discussion
20:00Banquet at Grand Café Horta
Wednesday September 16, 2015
Session 6 - Non-Small Molecules
Session Chair
Prof. Steven FIRESTINE
(WAYNE STATE UNIVERSITY, Detroit, United States)
08:30High Affinity Bicyclic Peptides: Application to Payloads in Oncology
Dr Gavin BENNETT
(BICYCLE THERAPEUTICS , Cambridge, United Kingdom)
09:00Exploring Macrocycles for Protein-protein Interaction Targets: the Discovery of Novel Bifunctional XIAP Antagonists
Dr Nick TERRETT
(ENSEMBLE THERAPEUTICS CORPORATION, Kriens, Switzerland)
09:30Discovery and Optimisation of Bioactive Macrocycles from DNA-Encoded Libraries
Dr Patrick MCENANEY
(THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States)
10:00Coffee break and Exhibition
Session 7 - Emerging Topics
Session Chair
Dr Pascal GEORGE
(SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France)
10:30Discovery of Highly Efficacious Potentiators for the Treatment of Cystic Fibrosis
Dr Steven VAN DER PLAS
(GALAPAGOS, Mechelen, Belgium)
10:55Discovery & Optimisation of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders: From Hit to Clinic
Dr Hamid HOVEYDA
(EUROSCREEN, Woluwe-Saint-Lambert, Belgium)
11:20Selective JAK1 Inhibitor for the Treatment of Autoimmune Diseases
Dr Michael L. VAZQUEZ
(PFIZER, Cambridge, United States)
11:45Discovering A Potent Allosteric Kinase Modulator Employing A Computational And Synthetic Toolbox
Mr Edwin KROON
(UNIVERSITY OF GRONINGEN, Groningen, The Netherlands)
12:10Lunch and Exhibition
Session 8 - Kinetics and Thermodynamics of Ligand Binding
Session Chair
Dr Matthias FRECH
(MERCK, Darmstadt, Germany)
13:15Kinetics in Drug discovery - A Case for the Adenosine Receptors
Mr Dong GUO
(LEIDEN UNIVERSITY, Leiden , The Netherlands)
13:45Drug Target Residence Time: HSP90, a Model to Gain Insight into the Molecular Mechanism of Binding
Dr Matthias FRECH
(MERCK, Darmstadt, Germany)
14:15Novel JAK Inhibitors for Inhaled and Topical Delivery
Dr Peter JONES
(PFIZER, Cambridge, United States)
14:45Coffee break and Exhibition
Session 9 - Rational Design of Non-Oral Drugs
Session Chair
Dr Jordi GRACIA
(ALMIRALL, Barcelona, Spain)
15:15Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD
Dr Chris DE SAVI
(ASTRAZENECA R&D, Boston, United States)
15:45A Novel Retinoic Acid Receptor Agonist for Dermatological Indications with Specific Design Parameters for Topical Administration to Manage Safety
Dr Claire BOUIX-PETER
(GALDERMA R&D, Sophia-Antipolis, France)
16:15Locally-acting ROCK Inhibitors for the Treatment of Eye Diseases
Dr Olivier DEFERT
(AMAKEM, Diepenbeek, Belgium)
16:45Closing remarks

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