Wednesday July 1, 2015 |
10:00 | Registration as of 10:00 |
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11:00 | Elsevier Reaxys Workshop: Data-Driven Approaches to Medicinal Chemistry: How Large-Scale Normalized Data Empowers Drug Discovery (duration: 90-minutes) |
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12:00 | Lunch bag (included in the fee, but subject to prior registration) |
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13:15 | Welcome Address |
Dr Christine CONTINO-PEPIN (UNIVERSITY OF AVIGNON, Avignon, France) Prof. Philippe OBERT (UNIVERSITY OF AVIGNON, Avignon, France) Prof. Janos SAPI (SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France) |
| Session 1: Paul Ehrlich Award Lecture
Sponsored by Janssen-Cilag |
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| Session Chairs |
Prof. Janos SAPI (SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France) Dr Oscar DELGADO (JANSSEN R&D, Toledo, Spain) |
13:30 | Paul Ehrlich Awardee - The Synthetic Peptide P140, a Skilled Strategist and Manipulator of the Immune System |
Dr Sylviane MULLER (IBMC-CNRS, Strasbourg, France) |
| Session 2: Kinases & Oncology
Sponsored by Servier |
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| Session Chair |
Dr Olivier MIRGUET (INSTITUT DE RECHERCHES SERVIER, Suresnes, France) |
14:30 | Discovery and Characterisation of Potent and Selective Inhibitors of ATR Kinase as Anti-cancer Agents |
Mr Jean-Damien CHARRIER (VERTEX PHARMACEUTICALS, OXON, United Kingdom) |
15:15 | Covalent Kinase Inhibitors: A Practical Guide to Molecular Trapping |
Dr Tjeerd BARF (ACERTA PHARMA BV, Oss, The Netherlands) |
16:00 | Coffee Break & Exhibition |
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| Session 3: Resistance in Infectious Diseases |
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| Session Chair |
Dr Hong SHEN (ROCHE INNOVATION CENTER, Shanghai, China) |
16:30 | Antibiotic Resistance is an Emerging Disease |
Dr Patrice COURVALIN (INSTITUT PASTEUR, Paris, France) |
17:15 | Resistance Phenotypes and SAR in HCV Drug Development |
Dr John BILELLO (MERCK, Whitehouse Station, United States) |
18:00 | Welcome Reception |
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19:30 | End of the Welcome Reception |
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Thursday July 2, 2015 |
| Session 4: Tools for Cell Therapy |
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| Session Chair |
Dr Pascal GEORGE (SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France) |
08:30 | Synthetic Molecules for Cell Biology and Cell Therapy |
Prof. Motonari UESUGI (KYOTO UNIVERSITY, Kyoto, Japan) |
Session 5: Short Communications - Targeting Apoptosis
Sponsored by SCT | Session 6: Short Communications - CNS Diseases
Sponsored by SCT |
| Session Chair |
Prof. Muriel AMBLARD (CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France) |
09:30 | How do a Proapoptotic and a Cell Penetration Peptide work Together to kill Cancer Cells? |
Dr Isabel ALVES (UNIVERSITY OF BORDEAUX, Pessac, France) |
10:00 | Allosteric Inhibitors of p38 MAPK-MK2 Pathway for Selective Cancer Cell Killing |
Dr Lenka MUNOZ (UNIVERSITY OF SYDNEY, Sydney, Australia) |
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| Session Chair |
Dr Grégory DURAND (UNIVERSITY OF AVIGNON, Avignon, France) |
09:30 | Development of Novel Multi-Target Directed Ligands for Alzheimer's Disease: Identification of Donecopride |
Prof. Christophe ROCHAIS (UNIVERSITY OF CAEN, Caen, France) |
10:00 | Development of Unnatural Basic Amino Acids Leading to Orally-Active NPFF Receptor Antagonists Preventing Opioid-Induced Hyperalgesia during the Treatment of Acute or Chronic Pains |
Dr Frédéric BIHEL (CNRS / UNIVERSITY OF STRASBOURG, Illkirch, France) |
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10:30 | Coffee Break & Exhibition |
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Session 7: Diabetes | Session 8: Tools for Target ID |
| Session Chair |
Dr Alessandra NURISSO (UNIVERSITY OF GENEVA, Genève, Switzerland) |
11:15 | From in situ Click to in vivo: Effect of Inhibition of Insulin Degrading Enzyme |
Prof. Rebecca DEPREZ-POULAIN (UNIVERSITY OF LILLE, Lille, France) |
12:00 | Revolutionary Idea Yielded SGLT2 Inhibitor Canagliflozin for Treatment of Type 2 Diabetes |
Dr Sumihiro NOMURA (MITSUBISHI TANABE PHARMA CORPORATION, Saitama, Japan) |
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| Session Chair |
Prof. Sun CHOI (EWHA WOMANS UNIVERSITY, Seoul, Korea, South) |
11:15 | Retinoids/Steroids as Ligands for Pharmacological Chaperon and Protein Knockdown Approach |
Prof. Yuichi HASHIMOTO (THE UNIVERSITY OF TOKYO, Tokyo, Japan) |
12:00 | Chemical Probes for Epigenetic Proteins |
Prof. Paul BRENNAN (UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
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12:45 | Lunch & Exhibition |
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13:30 | Poster Session 1
(posters with odd numbers) |
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13:45 | Career Session |
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Session 9: Cardiac Diseases | Session 10: Structure Based Approaches
Sponsored by 'Fondation de la Maison de la Chimie' |
| Session Chair |
Prof. Joachim MITTENDORF (BAYER PHARMA AG, Wuppertal, Germany) |
14:45 | Phenotypic Screening for the Discovery of Novel Molecules for Therapeutic Cardiac Regeneration |
Dr Alleyn T. PLOWRIGHT (ASTRAZENECA, Cambridge, United Kingdom) |
15:30 | BAY 1067197 - Discovery of a Partial Adenosine A1 Agonist for the Treatment of Heart Failure |
Dr Daniel MEIBOM (BAYER PHARMA, Wuppertal, Germany) |
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| Session Chair |
Dr Jean-Paul RENAUD (RIBOSTRUCT, Ostwald, France) |
14:45 | Drugs, Targets, Diseases and the Druggable Proteome |
Prof. Tudor I. OPREA (UNIVERSITY OF NEW MEXICO, Albuquerque, United States) |
15:30 | Shedding Light on Protein Kinase Plasticity |
Prof. Pascal BONNET (UNIVERSITY OF ORLÉANS, Orléans, France) |
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16:15 | Coffee Break & Exhibition |
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Session 11: Neglected/Rare Diseases | Session 12: GPCRs |
| Session Chair |
Dr Anne VALADE (UCB, Braine-l'Alleud, Belgium) |
16:45 | Lessons learned in TB Drug Discovery |
Dr Jan JIRICEK (NOVARTIS INSTITUTE FOR TROPICAL DISEASES, Singapore, Singapore) |
17:30 | Cerdelga, an Oral Therapy for Gaucher’s Disease; from Discovery to Launch |
Dr David J HARRIS (SANOFI, Waltham, United States) |
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| Session Chair |
Dr Manuel CASES-THOMAS (ELI LILLY & COMPANY, United Kingdom) |
16:45 | Two Steps Forward, One Step Back: Successes and Failures in Structure-based Discovery of GPCR Ligands
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Prof. Jens CARLSSON (STOCKHOLM UNIVERSITY, Stockholm, Sweden) |
17:30 | Fragment and Structure-Based Drug Discovery for a Family C GPCR: Discovery of the mGlu5 NAM Pre-clinical Candidate HTL14242 |
Dr John CHRISTOPHER (HEPTARES, Hertfordshire, United Kingdom) |
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20:00 | Symposium Banquet |
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Friday July 3, 2015 |
| Session 13: Viral Diseases
Sponsored by IDENIX an MSD Company |
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| Session Chair |
Dr Sylvie POCHET (INSTITUT PASTEUR, Paris, France) |
08:30 | Sofosbuvir: A Breakthrough Curative Therapy for HCV |
Dr Michael SOFIA (TEKMIRA/ONCORE BIOPHARMA, Doylestown, PA, United States) |
09:15 | Discovery of HIV Integrase Inhibitors |
Dr John WAI (WUXI APPTEC, Shanghai, China) |
10:00 | Coffee Break & Exhibition |
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10:30 | Poster Session 2
(posters with even numbers) |
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| Session 14: Pierre Fabre Award Lecture
Sponsored by Pierre Fabre |
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| Session Chair |
Dr Serge GRISONI (CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France) |
11:45 | Pierre Fabre Awardee - Small Molecules, Big Players |
Dr Raphaël RODRIGUEZ (INSTITUT CURIE, Paris, France) |
12:30 | Lunch & Exhibition |
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| Session 15: Immuno/Inflammatory Diseases
Sponsored by GSK |
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| Session Chair |
Dr Alexis DENIS (GSK, Courtaboeuf, France) |
13:30 | Novel Triazolopyridine Compounds as Selective JAK1 Inhibitors: From Target Discovery to Filgotinib |
Dr Christel MENET (GALAPAGOS, Brussels, Belgium) |
14:15 | Locking the Bioactive Conformation – Discovery of BAY 85-8501, a Potent Inhibitor of Human Neutrophil Elastase |
Dr Franz VON NUSSBAUM (BAYER PHARMA, Berlin, Germany) |
| Session 16: Poster Prizes and Closing Remarks |
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| Session Chair |
Dr Luc VAN HIJFTE (SCT & NOVALIX, Nijmegen, The Netherlands) |
15:00 | Poster Prizes & Closing Remarks |
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| Session 17: Future Event and Closing |
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| Session Chair |
Prof. Patrick DALLEMAGNE (UNIVERSITY OF CAEN, Caen, France) |
15:15 | Introduction to RICT 2016 |
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15:30 | End of the symposium |
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