| Sunday October 5, 2014 |
| 13:00 | Registration |
|
| Workshop 1 | Workshop 2 | Workshop 3 |
| 14:00 | Preparative HPLC:
Phase Screening, Method Optimisation, Process Development. Troubleshooting a Preparative Chromatographic Device |
Michael SCHULTE
(MERCK KGAA, Darmstadt, Germany) |
|
| 14:00 | From Development to Commercial Scale:
Rules to Scale up, QbD, Regulatory, Process Validation |
Alessandro BUTTE
(ETH ZURICH, Zurich, Switzerland) |
|
| 14:00 | Multicolumn Processes:
From Historical SMB to the Latest Advances in the Purification of Biomolecules |
Arvind RAJENDRAN
(UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
|
|
| 15:30 | Coffee Break |
|
| Workshop 4 | Workshop 5 | Workshop 6 |
| 16:00 | Solving a Purification Process:
Choice of the Appropriate Process (Centrifugal Partition Chromatography vs Countercurrent Chromatography, Batch vs Continuous, Low Pressure vs High Pressure, Liquid vs SFC) |
Eric VALERY
(NOVASEP CDMO, AN AXPLORA COMPANY, Pompey, France) |
|
| 16:00 | Process Design for Purification of Small Molecules and Peptides |
Jochen STRUBE
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
|
| 16:00 | Process Design for Purification of Biomolecules |
Alois JUNGBAUER
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) |
|
|
| 18:00 | Welcome Reception |
|
| 19:30 | End of Day 1 |
|
| Monday October 6, 2014 |
| 08:45 | Welcome |
|
| Session 1: Process Modeling and Optimization 1 |
|
| Session Chair |
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| Session Co-Chair |
Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 09:00 | Keynote Lecture
Chromatographer: What Could Modeling Do for You? |
Roger-Marc NICOUD
(FOUNDER AND FORMER CEO NOVASEP, CONSULTANT, Nancy, France) |
| 09:40 | Advances in Model-Based Inline Peak Deconvolution: Process-Data-Based Model Calibration and Real-Time Pooling Decisions |
Nina BRESTRICH
(KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) |
| 10:00 | Modeling and Optimization of the Twin Column Capture SMB Process |
Daniel BAUR
(ETH ZÜRICH, Zurich, Switzerland) |
| 10:20 | Coffee Break sponsored by LABOMATIC AG |
|
| Session 2: Process Modeling and Optimization 2 |
|
| Session Chair |
Jochen STRUBE
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| Session Co-Chair |
Mirjana MINCEVA
(TECHNISCHE UNIVERSITÄT MÜNCHEN, Freising, Germany) |
| 10:50 | Implementation of Model-Based Approach for Chromatography Development |
Bertrand GUELAT
(NOVARTIS PHARMA AG, Basel, Switzerland) |
| 11:10 | Modelling and Simulation of the Purification of Cell Culture-Derived Influenza Virus Via Continuous Size Exclusion Chromatoghraphy |
Laura M. FISCHER
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 11:30 | Unified Design of Chromatographic Separation Processes |
Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 11:50 | Modelling and Optimization of Preparative Chromatography Separation of Rare Earth Elements |
Bernt NILSSON
(LUND UNIVERSITY, Lund, Sweden) |
| 12:10 | Lunch Break
Vendor Seminars by AkzoNobel, LEWA and Waters Corporation (12:20-13:20) |
|
| Session 3: Purification and Resolution of Small Molecules |
|
| Session Chair |
José Paulo MOTA
(REQUIMTE/CQFB, FFCT, Caparica, Portugal) |
| Session Co-Chair |
António E. RIBEIRO
(POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal) |
| 13:20 | Keynote Lecture
Pharmaceutical Small Molecule Purification: Where Are We and Where Do We Need to Be?
|
Larry MILLER
(AMGEN, Thousand Oaks, United States) |
| 14:00 | Preparative Chiral Chromatography. Summa Chiralogica |
Pilar FRANCO
(CHIRAL TECHNOLOGIES EUROPE, Illkirch, France) |
| 14:20 | Implementation of Continuous Chromatography Under cGMP for the Pharmaceutical Industry |
Olivier DAPREMONT
(SK PHARMTECO, Rancho Cordova, United States) |
| 14:40 | Highly Active Small Molecules and Peptides: Intrinsic Reduction of Risks by the Use of Preparative Chromatography and Flow Technologies |
Ulf ALTENHOENER
(LONZA AG, Aarau , Switzerland) |
| 15:00 | Coffee Break |
|
| Session 4: Counter Current Chromatography |
|
| Session Chair |
Joachim KINKEL
(GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany) |
| Session Co-Chair |
Alain BERTHOD
(UNIVERSITÉ DE LYON 1 - CNRS, Villeurbanne, France) |
| 15:30 | Keynote Lecture
Continuous Processing by CCC/CPC: Where to Plug and How to Play When Everything is Fluid
|
Svetlana IGNATOVA
(BRUNEL UNIVERSITY, Uxbridge, United Kingdom) |
| 16:10 | From Molecule to Process: Model-Based Design of Continuous Centrifugal Partition Chromatography |
Mirjana MINCEVA
(TECHNISCHE UNIVERSITÄT MÜNCHEN, Freising, Germany) |
| 16:30 | Methodology for Scale-Up in Countercurrent Chromatography |
Karine FAURE
(INSTITUT DES SCIENCES ANALYTIQUES, Villeurbanne, France) |
| 16:50 | pH Zone Refining in Centrifugal Partition Extraction. A Step Change in Productivity for Liquid-Liquid Chromatography Processes? |
Paul HELLIER
(INSTITUT DE RECHERCHE PIERRE FABRE, GAILLAC, France) |
| 17:10 | A New Dynamic Fractionation Method and Column Design for Size Separation of Bio-Polymer Particles |
Peter HEWITSON
(BRUNEL INSTITUTE FOR BIOENGINEERING, Uxbridge, United Kingdom) |
| 17:30 | Poster Session #1 and Beer Party
(presentation of posters with even numbers) |
|
| 19:00 | End of Day 2 |
|
| Tuesday October 7, 2014 |
| Session 5: Protein and Peptide Purification |
|
| Session Chair |
Olivier LUDEMANN-HOMBOURGER
(POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France) |
| Session Co-Chair |
Jeannie HORAK
(UNIVERSITY OF TUEBINGEN, Tuebingen, Germany) |
| 08:30 | Keynote Lecture
Peptide Purification: State-of-the-Art and Challenges |
Thomas MEIER
(BACHEM AG, Bubendorf, Switzerland) |
| 09:10 | High Yeld Protein Refolding by Integrating Single-Column Chromatoghraphy and Membrane Filtration |
Sebastian NIMMIG
( FRIEDRICH-ALEXANDER-UNIVERSITY, Hanau, Germany) |
| 09:30 | Saturation Capacity for Proteins in Ion Exchange Chromatoghraphy |
Fabian STEINEBACH
(ETH ZÜRICH, Zurich, Switzerland) |
| 09:50 | HTS Chromatographic Platforms: Small is Beautiful |
David DELVAILLE
(MERCKSERONO, Martillac, France) |
| 10:10 | Peptide Purification Via Ion-Exchange Doped Reversed Phase Chromatography: a Combined Experimental and Modeling Approach |
Gianluca BUFFOLINO
(ZEOCHEM AG, Uetikon am See, Switzerland) |
| 10:30 | Coffee Break |
|
| Session 6: Purification of Biopharmaceuticals |
|
| Session Chair |
Michael SCHULTE
(MERCK KGAA, Darmstadt, Germany) |
| Session Co-Chair |
Kathleen MIHLBACHLER
(LEWA GMBH, Leonberg, Germany) |
| 11:00 | Integration of Continuous Precipitation and Flow Through Chromatography with Monoliths for Purification of Recombinant Antibodies |
Alois JUNGBAUER
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) |
| 11:20 | Purification of Antibody Conjugates by MCSGP Chromatography |
Thomas MÜLLER-SPÄTH
(CHROMACON AG, Zurich, Switzerland) |
| 11:40 | Implementation of a Negative Mode Platform for Virus Purification |
Ricardo SILVA
(IBET - INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal) |
| 12:00 | Optimizing the Separation of MAB Charge Variants Using Model-Based Approaches |
Rushd KHALAF
(ETH ZÜRICH, Zurich, Switzerland) |
| 12:20 | Lunch Break sponsored by AMPAC FINE CHEMICALS
Vendor Seminars by Novasep, Merck Millipore, Chiral Technologies Europe and Agilent Technologies (12:30-13:30) |
|
| 13:30 | Poster Session #2
(presentation of posters with odd numbers) |
|
| Session 7: Industrial Purification Processes |
|
| Session Chair |
Eric VALERY
(NOVASEP CDMO, AN AXPLORA COMPANY, Pompey, France) |
| Session Co-Chair |
Galatea PAREDES
(NOVARTIS PHARMA, Basel, Switzerland) |
| 14:30 | Keynote Lecture
Industrial Preparative HPLC for Production of API Including Most Common Unit Operations; Membrane Operations, Evaporation, Crystallization |
Roman BURJA
(LEK PHARMACEUTICALS D.D., Menges, Slovenia) |
| 15:10 | Overcoming Challenges in the Industrial Production of OMEGA-3S |
Jean BLEHAUT
(NOVASEP GROUP, Pompey, France) |
| 15:30 | Design of an Agarose Based Platform for Large Scale Chromatography |
Hans JOHANSSON
(PUROLITE, Uppsala, Sweden) |
| 15:50 | Continuous Manufacturing in Biopharmaceutical Industries |
Holger FROEHLICH
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 16:10 | Coffee Break |
|
| Session 8: Multicolumn Chromatography |
|
| Session Chair |
Massimo MORBIDELLI
(ETH ZÜRICH, Milano, Italy) |
| Session Co-Chair |
Ernst FREUND
(NOVARTIS PHARMA AG, Basel, Switzerland) |
| 16:30 | Keynote Lecture
Multi-Column Chromatography: Challenges and Opportunities |
Yoshiaki KAWAJIRI
(GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States) |
| 17:10 | Three Column Intermittent Simulated Moving BED (3C-ISMB) Cromatoghraphy: Cascade Operation for Center-Cut Separations |
Simon JERMANN
(ETH ZÜRICH, Zurich, Switzerland) |
| 17:30 | Purification of an Intermediately Eluting Component from a Complex Mixture |
Kiara KOCHENDOERFER
(BASF SE, Ludwigshafen, Germany) |
| 17:50 | Continuous Processing of Self-Cleaving Fusion Proteins by Matrix-Assisted Refolding Separation Using SMB Size Exclusion Chromatography with Buffer Recycling |
Martin WELLHÖFER
(CELONIC AG, Basel, Switzerland) |
| 18:10 | Panel discussion: Bridging Purification and Flow Chemistry?
Discussion animated by Berthold SCHENKEL (Novartis, Switzerland), Andreas SEIDEL-MORGENSTERN (MPI for Dynamics of Complex Technical Systems, Germany) and Olivier DAPREMONT (AMPAC Fine Chemicals, United States) |
|
| 19:00 | End of Day 3 |
|
| 20:00 | Symposium Banquet |
|
| Wednesday October 8, 2014 |
| Session 9: Supercritical Fluid Chromatography |
|
| Session Chair |
Arvind RAJENDRAN
(UNIVERSITY OF ALBERTA, Edmonton, AB, Canada) |
| Session Co-Chair |
Antoine PRADINES
(SANOFI-AVENTIS, Toulouse Cedex 1, France) |
| 08:30 | Separation of Lignans by Supercritical Fluid Simulated Moving BED |
Ming-Tsai LIANG
(I-SHOU UNIVERSITY, Kaohsiung, Taiwan) |
| 08:50 | Scale-Up in Supercritical Fluid Chromatography |
Abhijit TARAFDER
(WATERS CORPORATION, Boston, United States) |
| 09:10 | Reliable Scale-Up from Analytical to Large Scale Instrumentation in Chiral Supercritical Fluid Chromatography |
Torgny FORNSTEDT
(KARLSTAD UNIVERSITY, Karlstad, Sweden) |
| 09:30 | Extraction-Injection: an Alternative Sample Introduction Method for SFC |
Geoffroy COX
(PIC SOLUTION, Media, United States) |
| 09:50 | Poster Prize |
|
| 10:10 | Coffee Break |
|
| Session 10: Integrated Continuous Processes |
|
| Session Chair |
Olivier DAPREMONT
(SK PHARMTECO, Rancho Cordova, United States) |
| Session Co-Chair |
Martin WELLHÖFER
(CELONIC AG, Basel, Switzerland) |
| 10:40 | Keynote Lecture
Chromatography and Crystallization: Good Partners in Separating Enantiomers |
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 11:20 | Implementing Integrated Continuous Downstream Processing |
Kathleen MIHLBACHLER
(LEWA GMBH, Leonberg, Germany) |
| 11:40 | Integrated Reaction/Separation Process for High-Yield Pegylation |
David PFISTER
(ETH ZÜRICH, Zürich, Switzerland) |
| 12:00 | Hardware Solutions Enabling Continuous Biomanufacturing |
Roger NORDBERG
(GE HEALTHCARE, Uppsala, Sweden) |
| 12:20 | Integrated Counetr Current Chromatography (ICCC) - From SMB to a Fully Integrated Process |
Steffen ZOBEL-ROOS
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 12:40 | Closing Remarks |
|
| 13:00 | End of Day 4 |
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