| Sunday February 9, 2014 |
| 14:00 | Registration |
|
| 14:30 | Sightseeing tour to Kloster Ettal
(including liquor tasting, visit of the famous church, dinner with typical Bavarian dishes) |
|
| Monday February 10, 2014 |
| 11:00 | Registration and welcome coffee |
|
| 13:30 | Opening remarks |
|
| Speakers' presentations |
|
| 14:00 | MicroScaleThermophoresis in Modern Drug Discovery Process |
Dr Alexey RAK
(SANOFI AVENTIS, Vitry-sur-Seine, France) |
| 14:30 | Eighty Targets in Four Years - Integrating MST in an Industrial Setting |
Dr Ismail MOAREFI
(CRELUX GMBH, Martinsried, Germany) |
| 15:00 | Fast and Quantitative Analysis of Aptamer-target Interactions Using MicroScale Thermophoresis |
Dr Thomas SCHUBERT
(2BIND, Regensburg, Germany) |
| 15:30 | Coffee break |
|
| Future Application Session |
|
| 16:00 | MicroScale Thermophoresis: Interaction Analysis and Beyond |
Dr Dennis BREITSPRECHER
(NANOTEMPER TECHNOLOGIES GMBH, Muenchen, Germany) |
| 16:30 | Towards Novel Antivirals for Human Hepatitis B Virus Infections |
Dr Neil FERGUSON
(UNIVERSITY COLLEGE DUBLIN, Dublin, Ireland) |
| 17:00 | The Heat of the Moment: Using MST to Access Binding Thermodynamics |
Dr Geoff HOLDGATE
(ASTRAZENECA, Macclesfield, United Kingdom) |
| 17:30 | Poster session & informal get-together |
|
| 19:00 | Conference dinner |
|
| Tuesday February 11, 2014 |
| Fragment Screening Session |
|
| 08:30 | The Use of Virtual Screening and DSF for the Rapid Identification of Fragments Active Against MEK1 |
Dr Alexey RAK
(SANOFI AVENTIS, Vitry-sur-Seine, France) |
| 08:50 | Case Study on Automated Fragment Screening |
Dr Dennis BREITSPRECHER
(NANOTEMPER TECHNOLOGIES GMBH, Muenchen, Germany) |
| 09:20 | Practical Demonstration and Handling of the NT.Automated |
|
| 10:00 | Coffee break |
|
| Speakers' presentations |
|
| 10:30 | Biophysical Methods in Drug Discovery: How MST Fits in UCB’s Toolbox ? |
Dr Nicolas BASSE
(UCB CELLTECH, Slough, United Kingdom) |
| 11:00 | Chemical Tractability Assessments with Encoded Library Technology; Probing 82 Bacterial Targets with a 2 Trillion Member DNA Encoded Library |
Dr Carl MACHUTTA
(GLAXOSMITHKLINE, Collegeville, United States) |
| 11:30 | Protein Interaction Analyses: a Basis to Understand Essential Biological Reactions, Infection and Disease Mechanisms |
Prof. Dr Peter F. ZIPFEL
(FRIEDRICH SCHILLER UNIVERSITY, Jena, Germany) |
| 12:00 | Lunch |
|
| 13:30 | MST Forum Discussion (moderated discussion) |
|
| 15:00 | Coffee break |
|
| Speakers' presentations |
|
| 15:30 | Application of MicroScale Thermophoresis in Hit Identification and Validation |
Dr Markus ZEEB
(BOEHRINGER-INGELHEIM PHARMA, Biberach an der Riß, Germany) |
| 16:00 | Biophysical Analysis on Membrane Protein Targeting and Assembly |
Dr Alexej KEDROV
(GENE CENTER MUNICH, Munich, Germany) |
| 16:30 | Using MicroScale Thermophoresis to Evaluate UHTS Hits |
Mr Edward DINUNZIO
(MERCK, New Jersey, United States) |
| Selected oral presentations |
|
| 17:00 | Structural Basis of SUFU-GLI Interaction in Human Hedgehog Signaling Regulation |
Dr Katharina GEGENSCHATZ-SCHMID
(KAROLINSKA INSTITUTET, Huddinge, Sweden) |
| 17:30 | Concluding remarks |
|
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|
| (Please note that this program still might change) |
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