8th NovAliX Conference | Hybrid Event
Monday 09/05/2022
12:00Registration
8th NovAliX Conference - DAY 1
13:15Opening & Welcome Address by NovAliX Conference Chairman
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France)

SESSION 1:
BIOPHYSICAL APPROACHES FOR RNAS AS THERAPEUTICS AND THERAPEUTIC TARGETS
Session Chair
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden)
13:25Fluorescent Nucleobase Analogues - minimally Perturbing Labels in Nucleic Acid Biophysics and Bioimaging as well as Drug Discovery (IL01)
Prof. Marcus WILHELMSSON
(CHALMERS UNIVERSITY OF TECHNOLOGY, Gothenburg, Sweden)
13:55Structure-based Design of RNA-Binding Small Molecules and their Binding Characterization via MST, (kin)ITC and SwitchSENSE Assays (OC01)
Dr Christian KERSTEN
(JOHANNES GUTENBERG UNIVERSITY, Mainz, Germany)
14:10Exhibitor Short Presentation by Fida Biosystems
Mr Stephan KOETZNER
(FIDABIO, Austria)
14:20Binding of Small Molecules to Oligonucleotides in Drug Discovery (OC02)
 (SANOFI-AVENTIS DEUTSCHLAND GMBH)
Dr Nina GROSSMANN (MERCK HEALTHCARE, Darmstadt, Germany)
14:35Exhibitor Short Presentation by Bruker Daltonics
Dr Cyrill BRUNNER
(BRUKER DALTONICS GMBH & CO. KG , Fällanden, Switzerland)
14:45Manipulating RNA Function by Structural Dynamics (IL02)
Prof. Katja PETZOLD
(KAROLINSKA INSTITUTET, Stockholm, Sweden)
15:15Coffee Break

SESSION 2:
EMERGING TECHNIQUES FOR THE MEASUREMENT OF IN-CELL INTERACTIONS
Session Chair
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden)
15:45Measuring Ligand Binding in Cells Using CETSA® (IL03)
Dr Joseph SHAW
(ASTRAZENECA, Cambridge, United Kingdom)
16:15NovAliX Workshop:
Combining Biophysics to Enable Drug Discovery: Showcasing Structural MS and SPR
Dr Francois DEBAENE (NOVALIX, strasbourg, France)
Dr Renaud MORALES (NOVALIX, Strasbourg, France)
16:45In-cell NMR to study RNA Structure and Folding (IL04)
Prof. Harald SCHWALBE
(J.W. GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany)
17:15Observing Reversible Engagement of KRAS Hotspot Mutants at the Switch-2 Pocket in Cells (OC03)
Mr Matthew ROBERS
(PROMEGA, Madison, United States)

KEYNOTE LECTURE
17:30In-cell NMR: a Powerful Approach for Drug Discovery (KL01)
Prof. Lucia BANCI
(UNIVERSITY OF FLORENCE, Sesto Fiorentino, Italy)
18:30Welcome Reception for on-site participants
19:30End of the Day
Tuesday 10/05/2022
08:00Registration
8th NovAliX Conference - DAY 2
SESSION 3:
HOT TOPICS
Session Chair
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
09:00The Use of Dual Targeted Bicycles® to Induce Localised CD137 Agonism (OC04)
Dr Peter BROWN
(BICYCLE THERAPEUTICS, Cambridge, United Kingdom)
09:15Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (OC05)
Dr Michael HENNIG
(LEADXPRO AG, Villigen, Switzerland)
09:30Exhibitor Short Presentation by Refeyn
Dr James WILKINSON
(REFEYN, Oxford, United Kingdom)
09:40Applying Biophysical Interaction Methods to Characterize Binary and Ternary Complex Formation (OC06)
Dr Daniel SCHWARZ
(MERCK KGAA, Darmstadt, Germany)
09:55Discovery and Characterization of Active Small Molecule Ligands Targeting the Function of Ubiquitin Specific Protease USP7 by a Catalytic Site Independent Mechanism (OC07)
Prof. Till MAURER
(IDEAYA BIOSCIENCES, South San Francisco, United States)
10:10Coffee Break
10:40The Biophysics in the Discovery of Potent cGAS Inhibitors (OC08)
Dr Manuel HILBERT
(F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland)
10:55Exhibitor Short Presentation by Collaborative Drug Discovery
Mr Mark HARDING
(COLLABORATIVE DRUG DISCOVERY, Toulouse, France)
11:05Positioning Biophysics on the Drug Discovery Map (IL05)
Dr Christine GENICK
(NOVARTIS PHARMA AG, Basel, Switzerland)

ROUNDTABLE DISCUSSION 1
11:35Roundtable set-up
11:40Big Data Management in Biophysics
moderated by
Dr Engi HASSAAN
(NATURE COMMUNICATIONS, Berlin, Germany)
with the participation of
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom)
Dr Matthias FRECH (MERCK, Darmstadt, Germany)
Dr Christine GENICK (NOVARTIS PHARMA AG, Basel, Switzerland)
Dr Stefan GESCHWINDNER (ASTRAZENECA, Mölndal, Sweden)
12:25Lunch & Networking on-site
13:25Poster Session for on-site delegates
Virtual Meet & Greet for online delegates

SESSION 4:
BIOPHYSICS IN COVALENT DRUG DISCOVERY
14:25Session Chair
Dr Sandra JACOB
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland)
14:25Reactive Fragment Platforms for Covalent Hit ID (IL06)
Dr Emma GRANT
(GLAXOSMITHKLINE, Stevenage, United Kingdom)
14:55Exhibitor Short Presentation by Thermo Fisher Scientific
Dr Igor NEDERLOF
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands)
15:05Functionalizing Covalent Binders (IL07)
 (SANOFI-AVENTIS DEUTSCHLAND GMBH)
Dr Nir LONDON (THE WEIZMANN INSTITUTE OF SCIENCE, Rehovot, Israel)
15:35Coffee Break
16:05Dynamic Biosensors workshop:
switchSENSE® heliX®: Measuring Interactions from Small Molecules to Cells
Dr Daisy PAIVA (DYNAMIC BIOSENSORS GMBH, Planegg, Germany)
Dr Alice SOLDA (DYNAMIC BIOSENSORS GMBH, Planegg, Germany)
16:35Exhibitor Short Presentation by Crelux, a WuXi AppTec Company
Dr Tobias DEIMLING
(CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany)
16:45Structure-Based Design of a Phosphotyrosine-Masked, Cell Penetrant Small Molecule Covalently Targeting the E3 Ligase SOCS2 (IL08)
Dr Sarath RAMACHANDRAN
(UNIVERSITY OF DUNDEE, Scotland, United Kingdom)
17:15Poster Session 2 for on-site delegates
Virtual Meet & Greet for online delegates
18:15End of the Day
20:00Conference Dinner at the Paulaner am Nockherberg
sponsored by Dynamic Biosensors
Wednesday 11/05/2022
8th NovAliX Conference - DAY 3
SESSION 5:
USE OF BIOPHYSICAL TOOLS AND STRUCTURAL BIOLOGY TO UNDERSTAND THE MOLECULAR MECHANISM OF INDUCED-PROXIMITY AGENTS
Session Chair
Prof. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
09:00Towards Regulation of MDM2 via Stabilisation of a Complex Protein-Protein Interaction (OC09)
Mr Jake WARD
(UNIVERSITY OF LEICESTER, Leicester, United Kingdom)
09:15Exhibitor Short Presentation by Promega
Dr Stephan KIRCHMAIER
(PROMEGA, Walldorf, Germany)
09:25Molecular Glues Stabilizing 14-3-3 Protein-Protein Interactions (IL09)
Dr Christian OTTMANN
(EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands)
09:55Coffee break
10:25MOSBRI Presentation
Dr Patrick ENGLAND
(MOSBRI - INSTITUT PASTEUR PARIS, Paris, France)
10:35Exploration of Orthogonal E3 Ligases for Targeted Protein Degradation (IL10)
Dr Lena MÜNZKER
(BOEHRINGER INGELHEIM, Wien, Austria)

ROUND TABLE DISCUSSION 2
11:05Roundtable set-up
11:10Use of Biophysical Tools and Structural Biology to Understand the Molecular Mechanism of Induced-proximity Agents
moderated by
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
Dr Engi HASSAAN (NATURE COMMUNICATIONS, Berlin, Germany)
with the participation of
Dr Christian OTTMANN (EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands)
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany)
11:55Poster Prizes & Closing Remarks
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France)
12:05Departure

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