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| Monday 09/05/2022 |
| 12:00 | Registration |
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| 8th NovAliX Conference - DAY 1 |
| 13:15 | Opening & Welcome Address by NovAliX Conference Chairman |
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France) |
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SESSION 1:
BIOPHYSICAL APPROACHES FOR RNAS AS THERAPEUTICS AND THERAPEUTIC TARGETS |
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| Session Chair |
Dr Stefan GESCHWINDNER
(ASTRAZENECA, Mölndal, Sweden) |
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| 13:25 | Fluorescent Nucleobase Analogues - minimally Perturbing Labels in Nucleic Acid Biophysics and Bioimaging as well as Drug Discovery (IL01) |
Prof. Marcus WILHELMSSON
(CHALMERS UNIVERSITY OF TECHNOLOGY, Gothenburg, Sweden) |
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| 13:55 | Structure-based Design of RNA-Binding Small Molecules and their Binding Characterization via MST, (kin)ITC and SwitchSENSE Assays (OC01) |
Dr Christian KERSTEN
(JOHANNES GUTENBERG UNIVERSITY, Mainz, Germany) |
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| 14:10 | Exhibitor Short Presentation by Fida Biosystems |
Mr Stephan KOETZNER
(FIDABIO, Austria) |
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| 14:20 | Binding of Small Molecules to Oligonucleotides in Drug Discovery (OC02) |
(SANOFI-AVENTIS DEUTSCHLAND GMBH)
Dr Nina GROSSMANN (MERCK HEALTHCARE, Darmstadt, Germany) |
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| 14:35 | Exhibitor Short Presentation by Bruker Daltonics |
Dr Cyrill BRUNNER
(BRUKER DALTONICS GMBH & CO. KG , Fällanden, Switzerland) |
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| 14:45 | Manipulating RNA Function by Structural Dynamics (IL02) |
Prof. Katja PETZOLD
(KAROLINSKA INSTITUTET, Stockholm, Sweden) |
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SESSION 2:
EMERGING TECHNIQUES FOR THE MEASUREMENT OF IN-CELL INTERACTIONS |
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| Session Chair |
Prof. Helena DANIELSON
(UPPSALA UNIVERSITY, Uppsala, Sweden) |
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| 15:45 | Measuring Ligand Binding in Cells Using CETSA® (IL03) |
Dr Joseph SHAW
(ASTRAZENECA, Cambridge, United Kingdom) |
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| 16:15 | NovAliX Workshop:
Combining Biophysics to Enable Drug Discovery: Showcasing Structural MS and SPR |
Dr Francois DEBAENE (NOVALIX, strasbourg, France)
Dr Renaud MORALES (NOVALIX, Strasbourg, France) |
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| 16:45 | In-cell NMR to study RNA Structure and Folding (IL04) |
Prof. Harald SCHWALBE
(J.W. GOETHE UNIVERSITY FRANKFURT, Frankfurt am Main, Germany) |
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| 17:15 | Observing Reversible Engagement of KRAS Hotspot Mutants at the Switch-2 Pocket in Cells (OC03) |
Mr Matthew ROBERS
(PROMEGA, Madison, United States) |
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| 17:30 | In-cell NMR: a Powerful Approach for Drug Discovery (KL01) |
Prof. Lucia BANCI
(UNIVERSITY OF FLORENCE, Sesto Fiorentino, Italy) |
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| 18:30 | Welcome Reception for on-site participants |
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| Tuesday 10/05/2022 |
| 08:00 | Registration |
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| 8th NovAliX Conference - DAY 2 |
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| Session Chair |
Dr Chun-wa CHUNG
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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| 09:00 | The Use of Dual Targeted Bicycles® to Induce Localised CD137 Agonism (OC04) |
Dr Peter BROWN
(BICYCLE THERAPEUTICS, Cambridge, United Kingdom) |
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| 09:15 | Biophysical Methods Enabling Structure-Based Drug Discovery on Membrane Protein Targets (OC05) |
Dr Michael HENNIG
(LEADXPRO AG, Villigen, Switzerland) |
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| 09:30 | Exhibitor Short Presentation by Refeyn |
Dr James WILKINSON
(REFEYN, Oxford, United Kingdom) |
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| 09:40 | Applying Biophysical Interaction Methods to Characterize Binary and Ternary Complex Formation (OC06) |
Dr Daniel SCHWARZ
(MERCK KGAA, Darmstadt, Germany) |
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| 09:55 | Discovery and Characterization of Active Small Molecule Ligands Targeting the Function of Ubiquitin Specific Protease USP7 by a Catalytic Site Independent Mechanism (OC07) |
Prof. Till MAURER
(IDEAYA BIOSCIENCES, South San Francisco, United States) |
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| 10:40 | The Biophysics in the Discovery of Potent cGAS Inhibitors (OC08) |
Dr Manuel HILBERT
(F. HOFFMANN-LA ROCHE LTD, Basel, Switzerland) |
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| 10:55 | Exhibitor Short Presentation by Collaborative Drug Discovery |
Mr Mark HARDING
(COLLABORATIVE DRUG DISCOVERY, Toulouse, France) |
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| 11:05 | Positioning Biophysics on the Drug Discovery Map (IL05) |
Dr Christine GENICK
(NOVARTIS PHARMA AG, Basel, Switzerland) |
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| 11:40 | Big Data Management in Biophysics
moderated by |
Dr Engi HASSAAN
(NATURE COMMUNICATIONS, Berlin, Germany) |
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| with the participation of |
Dr Chun-wa CHUNG (GLAXOSMITHKLINE, Stevenage, United Kingdom)
Dr Matthias FRECH (MERCK, Darmstadt, Germany)
Dr Christine GENICK (NOVARTIS PHARMA AG, Basel, Switzerland)
Dr Stefan GESCHWINDNER (ASTRAZENECA, Mölndal, Sweden) |
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| 12:25 | Lunch & Networking on-site |
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| 13:25 | Poster Session for on-site delegates
Virtual Meet & Greet for online delegates |
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SESSION 4:
BIOPHYSICS IN COVALENT DRUG DISCOVERY |
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| 14:25 | Session Chair |
Dr Sandra JACOB
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
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| 14:25 | Reactive Fragment Platforms for Covalent Hit ID (IL06) |
Dr Emma GRANT
(GLAXOSMITHKLINE, Stevenage, United Kingdom) |
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| 14:55 | Exhibitor Short Presentation by Thermo Fisher Scientific |
Dr Igor NEDERLOF
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands) |
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| 15:05 | Functionalizing Covalent Binders (IL07) |
(SANOFI-AVENTIS DEUTSCHLAND GMBH)
Dr Nir LONDON (THE WEIZMANN INSTITUTE OF SCIENCE, Rehovot, Israel) |
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| 16:05 | Dynamic Biosensors workshop:
switchSENSE® heliX®: Measuring Interactions from Small Molecules to Cells |
Dr Daisy PAIVA (DYNAMIC BIOSENSORS GMBH, Planegg, Germany)
Dr Alice SOLDA (DYNAMIC BIOSENSORS GMBH, Planegg, Germany) |
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| 16:35 | Exhibitor Short Presentation by Crelux, a WuXi AppTec Company |
Dr Tobias DEIMLING
(CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany) |
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| 16:45 | Structure-Based Design of a Phosphotyrosine-Masked, Cell Penetrant Small Molecule Covalently Targeting the E3 Ligase SOCS2 (IL08) |
Dr Sarath RAMACHANDRAN
(UNIVERSITY OF DUNDEE, Scotland, United Kingdom) |
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| 17:15 | Poster Session 2 for on-site delegates
Virtual Meet & Greet for online delegates |
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| 20:00 | Conference Dinner at the Paulaner am Nockherberg
sponsored by Dynamic Biosensors |
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| Wednesday 11/05/2022 |
| 8th NovAliX Conference - DAY 3 |
| SESSION 5:
USE OF BIOPHYSICAL TOOLS AND STRUCTURAL BIOLOGY TO UNDERSTAND THE MOLECULAR MECHANISM OF INDUCED-PROXIMITY AGENTS |
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| Session Chair |
Prof. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom) |
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| 09:00 | Towards Regulation of MDM2 via Stabilisation of a Complex Protein-Protein Interaction (OC09) |
Mr Jake WARD
(UNIVERSITY OF LEICESTER, Leicester, United Kingdom) |
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| 09:15 | Exhibitor Short Presentation by Promega |
Dr Stephan KIRCHMAIER
(PROMEGA, Walldorf, Germany) |
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| 09:25 | Molecular Glues Stabilizing 14-3-3 Protein-Protein Interactions (IL09) |
Dr Christian OTTMANN
(EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands) |
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| 10:25 | MOSBRI Presentation |
Dr Patrick ENGLAND
(MOSBRI - INSTITUT PASTEUR PARIS, Paris, France) |
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| 10:35 | Exploration of Orthogonal E3 Ligases for Targeted Protein Degradation (IL10) |
Dr Lena MÜNZKER
(BOEHRINGER INGELHEIM, Wien, Austria) |
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| 11:10 | Use of Biophysical Tools and Structural Biology to Understand the Molecular Mechanism of Induced-proximity Agents
moderated by |
Prof. Alessio CIULLI (UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
Dr Engi HASSAAN (NATURE COMMUNICATIONS, Berlin, Germany) |
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| with the participation of |
Dr Christian OTTMANN (EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands)
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
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| 11:55 | Poster Prizes & Closing Remarks |
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France) |
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