2nd NovAliX Virtual Conference

Program

Indicated times are in EST time zone.

Start of the scientific sessions are:

  • 10:00 am (Pacific Standard Time) 
  • 01:00 pm (Eastern Standard Time)
  • 07:00 pm (Central European Time)
  • 03:00 am + 1 day (Japan Standard Time)



Tuesday 09/03/2021
Opening
19:00Opening Address by Conference Chairman
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France)
Session 1: Hot Topic - COVID-19
19:10Introduction by the Session Chair
Dr Chaohong SUN
(ABBVIE, North Chicago, United States)
19:15Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01)
Dr Xue WANG
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands)
19:30SARS-CoV-2 3CL protease: Structure-Based Virtual Screening, Crystallographic Fragment Screening and Assay Implementation to Identify Novel Starting Points for Inhibition (OC02)
Dr Alexander METZ
(IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland)
Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.
19:45Introduction by the Session Chair
Dr Matthias FRECH
(MERCK, Darmstadt, Germany)
19:50The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01)
Dr Dirksen BUSSIERE
(ELI LILLY, San Diego, United States)
20:20Exhibitor Short Presentation - NanoImaging Services
Leading the Revolution: CryoEM-Enabled Drug Discovery
Dr Melanie ADAMS-CIOABA
(NANOIMAGING SERVICES, San Diego, United States)
20:30Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03)
Dr Dzung NGUYEN
(PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany)
20:45Exhibitor Short Presentation - Crelux, a WuXi AppTec company
Target To Hit Solutions: Drug Discovery Of Bifunctional Molecules
Dr Thomas WALDMANN
(CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany)
20:55Dissecting Protein-Protein Interaction Networks (KL01)
Prof. Michelle ARKIN
(UNIVERSITY OF CALIFORNIA, San Francisco, United States)
Networking
21:40Networking, Exhibition & Posters
23:00End of the day
Wednesday 10/03/2021
Networking
18:00Networking, Exhibition & Posters
Session 3: Integrative Structural Biology & Biophysics
19:00Introduction by the Session Chair
Dr MariJean EGGEN
(ELI LILLY, Indianapolis, United States)
19:05Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling: Stuctural Proteomics and Precision Therapeutics (IL02)
Prof. Patrick GRIFFIN
(THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States)
19:35Exhibitor Short Presentation - NovAliX
NovAliX: Drug Discovery fueled with Biophysics
Dr James TARVER
(NOVALIX, Philadelphia, United States)
19:45Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04)
Dr Ariele VIACAVA FOLLIS
(EMD SERONO R&D INSTITUTE INC, Stow, United States)
20:00Exhibitor Short Presentation - Wuxi Biortus Biosciences Co., Ltd.
Your Partner for Proteins and Structures
Dr Yujian YOU
(WUXI BIORTUS BIOSCIENCES CO., LTD., Jiangyin, China)
20:10Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05)
Dr Troy JOHNSON
(UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States)
20:25Exhibitor Short Presentation - Bruker
An Introduction to Bruker SPR Technology
Mr Cameron PARAST
(BRUKER SCIENTIFIC, Billerica, United States)
20:35Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06)
Dr Amy BONCELLA
(COLORADO SCHOOL OF MINES, Golden, United States)
20:50Identification, Characterization and Conformational Assessment of STING Modulators (IL03)
Dr Daniel WYSS
(MERCK, Morristown, United States)
Networking
21:20Networking, Exhibition & Posters
23:00End of the day
Thursday 11/03/2021
Networking
18:00Networking, Exhibition & Posters
Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference
Introduction by the Session Chair
Dr Jeffrey LENGYEL
(THERMO FISHER SCIENTIFIC, New York, United States)
19:15From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04)
Dr Corey STRICKLAND
(MERCK, Kenilworth, United States)
19:45Structural Characterization of Different TRPA1 Inhibitors (IL05)
Dr Lionel ROUGÉ
(GENENTECH, San Francisco, United States)
20:15Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06)
Dr Kenneth BORRELLI
(SCHRÖDINGER, INC., New York, United States)
20:45Using Cryo-EM for GPCR Drug Discovery and Development (IL07)
Prof. Patrick M. SEXTON
(MONASH UNIVERSITY, Parkville, Australia)
21:15Break
Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
21:20Moderator
Dr Jeffrey LENGYEL
(THERMO FISHER SCIENTIFIC, New York, United States)
Speakers
Mr Benjamin APKER
(MITEGEN, Ithaca, United States)
Dr Corey STRICKLAND
(MERCK, Kenilworth, United States)
Dr Denis ZEYER
(NOVALIX, Illkirch, France)
Networking
22:05Networking, Exhibition & Posters
23:00End of the day
Friday 12/03/2021
Networking
18:00Networking, Exhibition & Posters
Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.
19:00Introduction by the Session Chair
Dr Daniel WYSS
(MERCK, Morristown, United States)
19:05Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08)
Dr Reto HORST
(PFIZER, INC., Grotton, United States)
19:35Exhibitor Short Presentation - Dynamic Biosensors
heliX® biosensor – your structure-based drug discovery tool
Dr Joanna DEEK
(DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany)
19:45Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07)
Prof. Terence STRICK
(ECOLE NORMALE SUPERIEURE, Paris, France)
20:00Exhibitor Short Presentation - MiTeGen
Crystallography and Cryo-EM - Sample Preparation Technology Developments
Mr Benjamin APKER (MITEGEN, Ithaca, United States)
 (BIOIBÉRICA)
20:10Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08)
Dr Alessandra FEOLI
(UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy)
20:25SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09)
Prof. William POMERANTZ
(UNIVERSITY OF MINNESOTA, Minneapolis, United States)
20:55Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09)
Dr Volker GATTERDAM
(LINO BIOTECH AG, Zurich, Switzerland)
21:10Exhibitor Short Presentation - Biosensing Instruments
Cell-based SPR Introduction
Mrs Akemi UEKI
(BIOSENSING INSTRUMENT, Tempe, United States)
21:20Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10)
Ms Yuliya DUBIANOK
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)
21:35Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02)
Prof. Brent NANNENGA
(ARIZONA STATE UNIVERSITY, Tempe, United States)
22:20Closing Remarks
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France)
22:30End of the Conference

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