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Program
Indicated times are in EST time zone.
Start of the scientific sessions are:
- 10:00 am (Pacific Standard Time)
- 01:00 pm (Eastern Standard Time)
- 07:00 pm (Central European Time)
- 03:00 am + 1 day (Japan Standard Time)
| Tuesday 09/03/2021 |
| Opening |
| 19:00 | Opening Address by Conference Chairman |
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France) |
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| Session 1: Hot Topic - COVID-19 |
| 19:10 | Introduction by the Session Chair |
Dr Chaohong SUN
(ABBVIE, North Chicago, United States) |
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| 19:15 | Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01) |
Dr Xue WANG
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands) |
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| 19:30 | SARS-CoV-2 3CL protease:
Structure-Based Virtual Screening, Crystallographic Fragment Screening and Assay Implementation to Identify Novel Starting Points for Inhibition (OC02) |
Dr Alexander METZ
(IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland) |
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| Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc. |
| 19:45 | Introduction by the Session Chair |
Dr Matthias FRECH
(MERCK, Darmstadt, Germany) |
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| 19:50 | The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01) |
Dr Dirksen BUSSIERE
(ELI LILLY, San Diego, United States) |
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| 20:20 | Exhibitor Short Presentation - NanoImaging Services
Leading the Revolution: CryoEM-Enabled Drug Discovery
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Dr Melanie ADAMS-CIOABA
(NANOIMAGING SERVICES, San Diego, United States) |
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| 20:30 | Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03) |
Dr Dzung NGUYEN
(PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany) |
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| 20:45 | Exhibitor Short Presentation - Crelux, a WuXi AppTec company
Target To Hit Solutions: Drug Discovery Of Bifunctional Molecules |
Dr Thomas WALDMANN
(CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany) |
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| 20:55 | Dissecting Protein-Protein Interaction Networks (KL01) |
Prof. Michelle ARKIN
(UNIVERSITY OF CALIFORNIA, San Francisco, United States) |
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| Networking |
| 21:40 | Networking, Exhibition & Posters |
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| Wednesday 10/03/2021 |
| Networking |
| 18:00 | Networking, Exhibition & Posters |
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| Session 3: Integrative Structural Biology & Biophysics |
| 19:00 | Introduction by the Session Chair |
Dr MariJean EGGEN
(ELI LILLY, Indianapolis, United States) |
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| 19:35 | Exhibitor Short Presentation - NovAliX
NovAliX: Drug Discovery fueled with Biophysics |
Dr James TARVER
(NOVALIX, Philadelphia, United States) |
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| 19:45 | Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04) |
Dr Ariele VIACAVA FOLLIS
(EMD SERONO R&D INSTITUTE INC, Stow, United States) |
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| 20:00 | Exhibitor Short Presentation - Wuxi Biortus Biosciences Co., Ltd.
Your Partner for Proteins and Structures
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Dr Yujian YOU
(WUXI BIORTUS BIOSCIENCES CO., LTD., Jiangyin, China) |
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| 20:10 | Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05) |
Dr Troy JOHNSON
(UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States) |
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| 20:25 | Exhibitor Short Presentation - Bruker
An Introduction to Bruker SPR Technology |
Mr Cameron PARAST
(BRUKER SCIENTIFIC, Billerica, United States) |
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| 20:35 | Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06) |
Dr Amy BONCELLA
(COLORADO SCHOOL OF MINES, Golden, United States) |
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| 20:50 | Identification, Characterization and Conformational Assessment of STING Modulators (IL03) |
Dr Daniel WYSS
(MERCK & CO., INC., Morristown, United States) |
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| Networking |
| 21:20 | Networking, Exhibition & Posters |
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| Thursday 11/03/2021 |
| Networking |
| 18:00 | Networking, Exhibition & Posters |
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Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference |
| Introduction by the Session Chair |
Dr Jeffrey LENGYEL
(THERMO FISHER SCIENTIFIC, New York, United States) |
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| 19:15 | From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04) |
Dr Corey STRICKLAND
(MERCK, Kenilworth, United States) |
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| 19:45 | Structural Characterization of Different TRPA1 Inhibitors (IL05) |
Dr Lionel ROUGÉ
(GENENTECH, San Francisco, United States) |
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| 20:15 | Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06) |
Dr Kenneth BORRELLI
(SCHRÖDINGER, INC., New York, United States) |
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| 20:45 | Using Cryo-EM for GPCR Drug Discovery and Development (IL07) |
Prof. Patrick M. SEXTON
(MONASH UNIVERSITY, Parkville, Australia) |
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| Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets |
| 21:20 | Moderator |
Dr Jeffrey LENGYEL
(THERMO FISHER SCIENTIFIC, New York, United States) |
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| Speakers |
Mr Benjamin APKER
(MITEGEN, Ithaca, United States) |
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Dr Corey STRICKLAND
(MERCK, Kenilworth, United States) |
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Dr Denis ZEYER
(NOVALIX, Illkirch, France) |
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| Networking |
| 22:05 | Networking, Exhibition & Posters |
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| Friday 12/03/2021 |
| Networking |
| 18:00 | Networking, Exhibition & Posters |
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| Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc. |
| 19:00 | Introduction by the Session Chair |
Dr Daniel WYSS
(MERCK & CO., INC., Morristown, United States) |
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| 19:05 | Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08) |
Dr Reto HORST
(PFIZER, INC., Grotton, United States) |
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| 19:35 | Exhibitor Short Presentation - Dynamic Biosensors
heliX® biosensor – your structure-based drug discovery tool |
Dr Joanna DEEK
(DYNAMIC BIOSENSORS, Martinsried/Planegg, Germany) |
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| 19:45 | Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07) |
Prof. Terence STRICK
(ECOLE NORMALE SUPERIEURE, Paris, France) |
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| 20:00 | Exhibitor Short Presentation - MiTeGen
Crystallography and Cryo-EM - Sample Preparation Technology Developments |
Mr Benjamin APKER (MITEGEN, Ithaca, United States)
(BIOIBÉRICA) |
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| 20:10 | Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08) |
Dr Alessandra FEOLI
(UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy) |
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| 20:25 | SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09) |
Prof. William POMERANTZ
(UNIVERSITY OF MINNESOTA, Minneapolis, United States) |
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| 20:55 | Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09) |
Dr Volker GATTERDAM
(LINO BIOTECH AG, Zurich, Switzerland) |
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| 21:10 | Exhibitor Short Presentation - Biosensing Instruments
Cell-based SPR Introduction |
Mrs Akemi UEKI
(BIOSENSING INSTRUMENT, Tempe, United States) |
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| 21:20 | Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10) |
Ms Yuliya DUBIANOK
(UNIVERSITY OF OXFORD, Oxford, United Kingdom) |
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| 21:35 | Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02) |
Prof. Brent NANNENGA
(ARIZONA STATE UNIVERSITY, Tempe, United States) |
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| 22:20 | Closing Remarks |
Dr Jean-Paul RENAUD
(URANIA THERAPEUTICS, Ostwald, France) |
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| 22:30 | End of the Conference |
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