2nd NovAliX Virtual Conference

Confirmed Speakers


Keynote Speakers

Dissecting Protein-Protein Interaction Networks (KL01)
Prof. Michelle ARKINProf. Michelle ARKIN
(UNIVERSITY OF CALIFORNIA, San Francisco, United States)

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Microcrystal Electron Diffraction (MicroED): Methodology and Applications (KL02)
Prof. Brent NANNENGAProf. Brent NANNENGA
(ARIZONA STATE UNIVERSITY, Tempe, United States)

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Session 1: Hot Topics - COVID-19

SARS-CoV-2 3CL protease: Structure-Based Virtual Screening, Crystallographic Fragment Screening and Assay Implementation to Identify Novel Starting Points for Inhibition (OC02)
Dr Alexander METZDr Alexander METZ
(IDORSIA PHARMACEUTICALS LTD, Allschwil, Switzerland)

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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (OC01)
Dr Xue WANGDr Xue WANG
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands)

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Session 2: Induced-Proximity Drug Discovery : Selective Protein Degraders, PPI Stabilizers, etc.

The Structural Basis of Indisulam-Mediated Recruitment of RBM39 to the DCAF15-DDB1-DDA1 E3 Ligase Complex (IL01)
Dr Dirksen BUSSIEREDr Dirksen BUSSIERE
(ELI LILLY, San Diego, United States)

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Targeting a Cryptic Binding Pocket by Disulfide-Induced Rupture of a Homodimeric Protein-Protein Interface (OC03)
Dr Dzung NGUYENDr Dzung NGUYEN
(PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany)

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Session 3: Integrative Structural Biology & Biophysics

Inhibition of the Cysteine Desulfurase in the SUF Pathway of Iron-Sulfur Cluster Biogenesis Towards Development of Novel Antibacterials (OC06)
Dr Amy BONCELLADr Amy BONCELLA
(COLORADO SCHOOL OF MINES, Golden, United States)

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Hijacking Molecular Plasticity to Fine Tune Nuclear Receptor Signaling: Stuctural Proteomics and Precision Therapeutics (IL02)
Prof. Patrick GRIFFINProf. Patrick GRIFFIN
(THE SCRIPPS RESEARCH INSTITUTE, Jupiter, United States)

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Fragment Screening Reveals a Novel Pocket in Cysteine Protease ATG4B (OC05)
Dr Troy JOHNSONDr Troy JOHNSON
(UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER, Houston, United States)

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Synergistic Use of Ligand Based NMR and Crystallography to Elucidate Small Molecules Interactions with Challenging Targets (OC04)
Dr Ariele VIACAVA FOLLISDr Ariele VIACAVA FOLLIS
(EMD SERONO R&D INSTITUTE INC, Stow, United States)

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Identification, Characterization and Conformational Assessment of STING Modulators (IL03)
Dr Daniel WYSSDr Daniel WYSS
(MERCK, Morristown, United States)

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Session 4: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets
a full day session organized by Thermo Fisher Scientific, Platinum Sponsor of the NovAliX Conference

Improving Protein-Ligand Modeling into Cryo-EM Data and the use of those Models in Drug Discovery Efforts (IL06)
Dr Kenneth BORRELLIDr Kenneth BORRELLI
(SCHRÖDINGER, INC., New York, United States)

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Structural Characterization of Different TRPA1 Inhibitors (IL05)
Dr Lionel ROUGÉDr Lionel ROUGÉ
(GENENTECH, San Francisco, United States)

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Using Cryo-EM for GPCR Drug Discovery and Development (IL07)
Prof. Patrick M. SEXTONProf. Patrick M. SEXTON
(MONASH UNIVERSITY, Parkville, Australia)

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From Concept to Reality: CryoEM as an Integral Part of Drug Discovery and Development (IL04)
Dr Corey STRICKLANDDr Corey STRICKLAND
(MERCK, Kenilworth, United States)

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Session 5: Advances in Biophysical Techniques : Single-Molecule Techniques, Label-Free Technologies, Surface-Immobilized Techniques beyond SPR, etc.

Too Weak for Biophysics: Concentration-Dependent Crystallographic Soaking as Tool for Fragment Hit Prioritisation (OC10)
Ms Yuliya DUBIANOKMs Yuliya DUBIANOK
(UNIVERSITY OF OXFORD, Oxford, United Kingdom)

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Development of a Microscale Thermophoresis-Based Method for Screening Inhibitors of the Methyl-Lysine Reader Protein MRG15 (OC08)
Dr Alessandra FEOLIDr Alessandra FEOLI
(UNIVERSITÀ DEGLI STUDI DI SALERNO, Fisciano (Salerno), Italy)

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Focal Molography - A New Bioanalytical Tool to Eliminate Guess Work in Pharma Research (OC09)
Dr Volker GATTERDAMDr Volker GATTERDAM
(LINO BIOTECH AG, Zurich, Switzerland)

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Ligand-Dependent Structural Plasticity of TrkA Kinase Studied by NMR Spectroscopy (IL08)
Dr Reto HORSTDr Reto HORST
(PFIZER, INC., Grotton, United States)

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SAR by 19F NMR: Using Protein-Observed Fluorine NMR for Targeting Protein Complexes (IL09)
Prof. William POMERANTZProf. William POMERANTZ
(UNIVERSITY OF MINNESOTA, Minneapolis, United States)

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Real-Time Single-Molecule Detection of Drug-Protein Interactions Using a Novel DNA-Based Nanoscale Actuator (OC07)
Prof. Terence STRICKProf. Terence STRICK
(ECOLE NORMALE SUPERIEURE, Paris, France)

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Panel Discussion: Cryo-EM in Drug Discovery - Accelerating Drug Design for Intractable Targets

Speakers
Mr Benjamin APKERMr Benjamin APKER
(MITEGEN, Ithaca, United States)

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Dr Corey STRICKLANDDr Corey STRICKLAND
(MERCK, Kenilworth, United States)

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Dr Denis ZEYERDr Denis ZEYER
(NOVALIX, Illkirch, France)

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