7th NovAliX Conference
Wednesday 13/11/2019
13:00Registration
13:45Welcome Address
Session 1: Recent Advances in FBDD
Session Chair
Dr Mike HANN
(GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom)
14:00PhABits – Shining New Light on Fragments Approaches for Assessing Targets Tractability (IL01)
Dr Mike HANN
(GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom)
14:30Fast Molecular Interaction Screening and Affinity Determination in Biophysical Drug Discovery Projects with Dianthus NT.23 and Tycho NT.6 (OC01)
Mr Andreas LANGER
(NANOTEMPER TECHNOLOGIES GMBH, Munich, Germany)
14:45Targeting TIR Domain Assemblies in TLR Signaling Pathways to Design Anti-Inflammatory Compounds (OC02)
Mr Md Habibur RAHAMAN
(UNIVERSITY OF QUEENSLAND, Brisbane, Australia)
15:00Ligand-Based Fluorine NMR Screening in Drug Discovery (IL02)
Dr Anna VULPETTI
(NOVARTIS, Basel, Switzerland)
15:30Coffee Break & Exhibition
16:05Exhibitor Short Presentation: Crelux – A WuXi AppTec company
A Fragment-Based Approach to Leverage Challenging Targets: Human STING
16:1519F NMR Screening Applied to Multiple Cancer Target (OC03)
Dr Kenneth CAMERON
(CRUK BEATSON INSTITUTE, Glasgow, United Kingdom)
16:30Enabling Drug Discovery with Crude Reaction Mixture Screening (IL03)
Dr Ben DAVIS
(VERNALIS RESEARCH, Cambridge, United Kingdom)
Academia Keynote Lecture
Session Chair
17:00Structure-biophysics Driven PROTAC Design for Degrading Undruggable Cancer Targets (KL01)
Prof. Alessio CIULLI
(UNIVERSITY OF DUNDEE, Dundee, United Kingdom)
18:00Welcome Reception
19:30End of the Day
Thursday 14/11/2019
09:00Registration
Session 2: Challenging Targets (GPCRs, Ion Channels...)
Session Chair
Dr Junichi SAITO
(KYOWA KIRIN CO., LTD., Shizuoka, Japan)
09:30Structural Biology of Seven-Transmembrane Receptors Toward Drug Discovery (IL04)
Prof. Shigeyuki YOKOYAMA
(RIKEN, Yokohama City, Japan)
10:00Venturing into the Untapped: Discovery of Small-Molecule Drugs Targeting Messenger RNAs Using Biophysical and Computational Methods (OC04)
Dr Ella MORISHITA
(VERITAS IN SILICO, Tokyo, Japan)
10:15Coffee Break & Exhibition
10:45Cryo-EM Structures Capturing the Transport Cycle of the P4-ATPase Flippase (OC05)
Mr Masahiro HIRAIZUMI (MITSUBISHI TANABE PHARMA CORPORATION, Yokohama, Japan)
11:00Advancing Cryo-EM for Determination of G Protein-Coupled Receptor Structure (IL05)
Prof. Patrick M. SEXTON
(MONASH UNIVERSITY, Parkville, Australia)
11:30Poster Session
12:30Lunch Break, Exhibition & Networking
Session 3: Cryo-EM in Drug Discovery
Session Chair
Dr Midori KAMIMURA
(TEIJIN PHARMA LIMITED, Tokyo, Japan)
14:00Cryo-EM Structural Studies of The Human TRPV4 Ion-Channel: Insights and Characterization of a Novel Open-Conformation (OC06)
Dr Simon HOLTON
(BAYER, Berlin, Germany)
14:15Cryo-EM Application for Drug Discovery (OC07)
Dr Wen-ti LIU
(NOVALIX, Illkirch, France)
14:30Advancing Drug Discovery in Pharma Using Cryo-EM (IL06)
Dr Claudio CIFERRI
(GENENTECH, South San Francisco, United States)
15:00Exhibitor Short Presentation: Thermo Fisher Scientific
Cryo-EM Single Particle Analysis Productivity: the State of the Art
15:10Coffee Break & Exhibition
Session 4: X-ray Crystallography / Cryo-EM Complementarity
Session Chair
Dr Denis ZEYER
(NOVALIX, Illkirch, France)
15:45Increased Performance in High-Throughput Compound and Fragment Screening Campaigns by the Use of "Club Class" Data Collection (IL07)
Dr Gerard BRICOGNE
(GLOBAL PHASING LTD., Cambridge, United Kingdom)
16:15Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase (IL08)
Prof. Holger STARK
(MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY, Göttingen, Germany)
16:45Applying Hybrid Biophysical and Structural Methods to Study Allosteric Regulation of GTP Cyclohydrolase I - A Target for Treating Inflammatory and Neuropathic Pain (IL09)
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
17:15Posters & Drinks
18:30End of the Day
20:00Conference Dinner
Friday 15/11/2019
08:30Registration
Session 5: Hot Topics
Session Chair
Dr Herbert NAR
(BOEHRINGER INGELHEIM, Biberach, Germany)
09:00Re-energizing Small Molecule Drug Discovery by Centaur Chemist™ (IL10)
Dr Daisuke TANAKA
(EXSCIENTIA, Osaka, Japan)
Industry Keynote Lecture
Session Chair
Dr Mike HANN
(GSK MEDICINES RESEARCH CENTRE, Stevenage, United Kingdom)
09:30From Fragments to Pharmaceuticals (KL02)
Dr Harren JHOTI
(ASTEX PHARMACEUTICALS, Cambridge, United Kingdom)
Session 5: Hot Topics (continued)
Session Chair
10:30Coffee Break & Exhibition
11:00Exhibitor Short Presentation: NanoTemper Technologies
Biophysical Tools for Measuring Binding Affinity, Protein Stability or Protein Quality with just a Tiny Amount of Sample
11:10Exhibitor Short Presentation: NovAliX
Single Particle Cryo-EM a Cutting Edge Service for Drug Discovery
11:20Uncovering a Ligand-Induced Twisted State of a Homodimeric Enzyme by Pulsed Electron-Electron Double Resonance (OC08)
Dr Dzung NGUYEN
(PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany)
11:35Structural Mechanisms of and Drug Discovery Targeting Substrate of Gamma-Secretase in Alzheimer's Disease (OC09)
Prof. Chunyu WANG
(RENSSELAER POLYTECHNIC INSTITUTE, Latham, United States)
11:50Poster Prize and Closing Remarks
12:05End of the Conference

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