RICT 2019
Conferences > Archives > RICT 2019
Wednesday 03/07/2019
07:30Registration
08:30RICT 2019 Opening
Prof. Sebastien PAPOT (UNIVERSITY OF POITIERS, Poitiers, France)
Prof. Pascal MARCHAND (UNIVERSITY OF NANTES, Nantes, France)
Dr Patricia LEMARCHAND (UNIVERSITY OF NANTES, Nantes, France)
Inaugural Conference
Session Chair:
Prof. Sebastien PAPOT
(UNIVERSITY OF POITIERS, Poitiers, France)
09:00PL01: What Makes a Great Medicinal Chemist: Some Fresh Thoughts
Dr Mark MURCKO
(RELAY THERAPEUTICS, Boston, MA, United States)
Session 1: Recent Advances for Cancer Therapy
Session Chair:
Dr Yannick JACQUES
(INSERM/CNRS, Nantes, France)
09:45PL02: Reprogramming the Reactivity of Iron in Cancer
Dr Raphaël RODRIGUEZ
(INSTITUT CURIE, Paris, France)
10:30Coffee Break and Exhibition
11:00PL03: Quo Vadis Small Molecule Cancer Therapeutics?
Dr Ingo HARTUNG
(BAYER HEALTHCARE, Darmstadt, Germany)
11:45KL01: Therapeutic Potential of Macrocyclic ALK2 Inhibitors
Dr Pascal BENDERITTER
(ONCODESIGN, Dijon, France)
12:15Lunch
13:00Posters (Odd numbers) and Exhibition
Session 2: Artificial Intelligence in Drug Discovery
Session Chair:
Prof. Pascal BONNET
(UNIVERSITY OF ORLÉANS, Orléans, France)
14:30PL04: Massively Multi-target Profile-QSAR: IC50 Predictions Comparable to 4-Concentration Experiments for most Novartis Assays
Dr Eric MARTIN
(NOVARTIS, Emeryville, United States)
15:15PL05: Automated Syntheses Planning and its Implications for Drug Design
Dr Marwin SEGLER
(BENEVOLENTAI, Cambridge, United Kingdom)
16:00Coffee Break and Exhibition
Session 3: Mechanism Based Approaches
Session Chair:
Dr Maria DUCA
(UNIVERSITY OF CÔTE D'AZUR, Nice, France)
16:30PL06: Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
Dr Hasane RATNI
(F. HOFFMANN-LA ROCHE LTD, Basel , Switzerland)
17:15PL07: The Influence of Free Ligand Conformations on Mcl-1 PPI Inhibition
Dr Rodrigo CARBAJO
(ASTRAZENECA, Cambridge, United Kingdom)
18:00KL02: Tackling a Unique S1 Protease by SBDD - Highly Potent & Selective Factor D Inhibitors - Age-Related Macular Generation (AMD)
Dr Edwige LORTHIOIS
(NOVARTIS, Basel, Switzerland)
18:30Welcome and Networking Reception
20:30End of the day
Thursday 04/07/2019
Session 4: Paul Ehrlich Award Lecture (sponsored by Janssen Research & Development)
Session Chairs:
Dr Luc VAN HIJFTE (MERCACHEMSYNCOM, Nijmegen, The Netherlands)
Dr Jose CID (JANSSEN R&D, Toledo, Spain)
08:45PL08: Paul Ehrlich Award Lecture - Chemotype - Phenotype - Target
Prof. Herbert WALDMANN
(MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY, Dortmund, Germany)
Session 5: New Breakthrough in Antibody-based Therapy
Session Chair:
Prof. Marie-Claude VIAUD-MASSUARD
(FACULTÉ DES SCIENCES PHARMACEUTIQUES - UNIVERSITÉ DE TOURS, TOURS, France)
09:45PL09: Chemical Physiology of Antibody Conjugates and Natural Products
Prof. Gonçalo BERNARDES
(INSTITUTO DE MEDICINA MOLECULAR, PORTUGAL & UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom)
10:30Coffee Break and Exhibition
11:00PL10: Click-Cleavable Antibody-Drug Conjugates
Dr Marc ROBILLARD
(TAGWORKS PHARMACEUTICALS, Eindhoven, The Netherlands)
11:45PL11: Increasing Brain Exposure of Therapeutic Antibodies
Dr Dominique LESUISSE
(SCT & SANOFI, Chilly-Mazarin, France)
12:30Lunch
13:00Posters (Even numbers) and Exhibition
Session 6: Sugars in Drug Discovery
Session Chair:
Prof. Didier DUBREUIL
(CEISAM - UNIVERSITY OF NANTES, Nantes, France)
14:30PL12: Carbohydrate-Lectin Interactions - What Makes Them Unique?
Prof. Dr Beat ERNST
(UNIVERSITY OF BASEL, Basel, Switzerland)
15:15PL13: Complex Glycans in Health and Disease
Prof. Geert-Jan BOONS
(UTRECHT UNIVERSITY, Utrecht, The Netherlands)
16:00Coffee Break and Exhibition
Session 7: New Modalities in Drug Discovery
Session Chair:
Prof. Pascal MARCHAND
(UNIVERSITY OF NANTES, Nantes, France)
16:30PL14: Unlocking Drug Discovery Power through Collaborative Efforts between Academia and CRO : Bringing Novel Tankyrase Inhibitors towards the Clinic
Dr Anita WEGERT
(MERCACHEM-SYNCOM, Nijmegen, The Netherlands)
17:15PL15: Identification of S 64315, a Potent and Selective Mcl-1 Inhibitor through Fragment-based Drug Discovery
Dr Andras KOTSCHY
(SERVIER RESEARCH INSTITUTE OF MEDICINAL CHEMISTRY, Budapest, Hungary)
18:00KL03: Nanofitin Modules Platform: Go Multispecific, Go Multiparatopic !
Dr Anne CHEVREL
(AFFILOGIC, Nantes, France)
18:30End of the day
20:30Banquet
Friday 05/07/2019
Session 8: New Tools for Therapeutic Innovation
Session Chair:
Prof. Joachim JOSE
(UNIVERSITY OF MÜNSTER, Münster, Germany)
08:30PL16: Straightforward Conversion of Peptides into Bioactive Lactam-Based Foldamers
Prof. Muriel AMBLARD
(CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France)
09:15PL17: Chemical Biology of mRNA Modifications
Prof. Andrea RENTMEISTER
(UNIVERSITY OF MÜNSTER, Münster, Germany)
10:00Coffee Break and Exhibition
Session 9: Modifying Proteins Structures and Functions
Session Chair:
Dr Gilles GUICHARD
(UNIVERSITY OF BORDEAUX, CBMN, Bordeaux, France)
10:30PL18: Modulating Different Components of the Ubiquitin System with Small Molecules and Cyclic Peptides
Prof. Ashraf BRIK
(TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel)
11:15PL19: Cysteine Arylation to Engineer, Deliver, and Discover Proteins
Prof. Bradley Lether PENTELUTE
(MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA, United States)
Session 10: Pierre Fabre Award Lecture (Sponsored by Pierre Fabre)
Session Chairs:
Dr Serge GRISONI (CENTRE DE RECHERCHE ET DÉVELOPPEMENT PIERRE FABRE, Toulouse, France)
Dr Brigitte LESUR (SCT & INSTITUT DE RECHERCHES SERVIER, Paris, France)
12:00PL20: Pierre Fabre Award Lecture - Click Chemistry with Mesoionics: New Tools for Chemical Biology
Dr Frédéric TARAN
(CEA/SACLAY, Gif-sur-Yvette, France)
13:00Closing Remarks

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