| Wednesday 13/06/2018 |
| 12:30 | Registration |
|
| 13:45 | Welcome Address |
|
| Session 1: Hot Topics |
|
| Session Chair |
Dr Chaohong SUN
(ABBVIE, North Chicago, United States) |
| 14:00 | OC01 - Making Off-Rate Screening in FBDD More Amenable For Fast Dissociating Compounds |
Dr Menachem GUNZBURG
(MONASH UNIVERSITY, Parkville, Australia) |
| 14:15 | OC02 - Novel Active Site and Allosteric Site Binders Identified for FPPS Of T. cruzi |
Ms Joy PETRICK
(NOVARTIS, Basel, Switzerland) |
| 14:30 | OC03 - Dynamic Single-Molecule Approaches to Accelerate the Development of More Efficient Drugs |
Dr Gerrit SITTERS
(LUMICKS, Amsterdam, The Netherlands) |
| 14:45 | OC04 - Quantitative Irreversible Tethering (QIT) for Covalent Ligand Discovery |
Dr Gregory CRAVEN
(IMPERIAL COLLEGE LONDON, London, United Kingdom) |
| 15:00 | OC05 - Large Protein Conformational Changes in Pi3kgamma Linked to the Binding of a New Class of Highly Selective Inhibitors |
Dr Göran DAHL
(ASTRAZENECA, Mölndal, Sweden) |
| 15:15 | IL01 - Binding Kinetics and Thermodynamics in Drug Discovery |
Dr Chaohong SUN
(ABBVIE, North Chicago, United States) |
| 15:45 | Coffee Break |
|
| Session 2 : Target Engagement |
|
| Session Chair |
Dr Daniel WYSS
(MERCK, Morristown, United States) |
| 16:25 | IL02 - Chemical Probes for Epigenetic Targets |
Prof. Masoud VEDADI
(STRUCTURAL GENOMICS CONSORTIUM, Toronto, Canada) |
| 16:55 | Exhibitor Short Presentation: Bruker
Development and Proof-of-Concept of a New Flow-through System for High Resolution NMR to Evaluate Biologics-producing Cell Lines and Their Growth Environments |
Dr Jason S. WOOD
(BRUKER BIOSPIN, Billerica, United States) |
| 17:05 | Exhibitor Short Presentation: Creoptix
The Wave of the Future in Kinetics |
Dr Matyas VEGH
(CREOPTIX AG, Wädenswil, Switzerland) |
| 17:15 | OC06 - Quantification of Target Occupancy in Cells and Tumor Tissue Using FCCS |
Dr Frank BECKER
(INTANA BIOSCIENCE GMBH, Planegg, Germany) |
| 17:30 | IL03 - How to Be Selectively Promiscuous |
Prof. Jack TAUNTON
(UNIVERSITY OF CALIFORNIA, San Francisco, United States) |
| Keynote Lecture |
|
| Session Chair |
Dr Daniel WYSS
(MERCK, Morristown, United States) |
| 18:00 | KL01 - From Simulations of Biomolecules to Fighting Diseases |
Prof. Martin KARPLUS
(UNIVERSITY OF STRASBOURG, FRANCE & HARVARD UNIVERSITY, Cambridge, United States) |
| 19:00 | Welcome Reception |
|
| 20:30 | End of the Day |
|
| Thursday 14/06/2018 |
| 08:30 | Registration |
|
| Session 3 : Cryo-EM |
|
| Session Chair |
Dr Bridget CARRAGHER
(NEW YORK STRUCTURAL BIOLOGY CENTER, New York, United States) |
| 09:00 | IL04 - How Low Can You Go? Size and Resolution Limits Using Conventional Cryo-EM |
Dr Gabriel LANDER
(THE SCRIPPS RESEARCH INSTITUTE, San Diego, United States) |
| 09:30 | IL05 - Cryo-EM for Characterization and Structure Based Drug Design |
Dr Bridget CARRAGHER
(NEW YORK STRUCTURAL BIOLOGY CENTER, New York, United States) |
| 10:00 | Coffee Break |
|
| Session 3 (continued) : Cryo-EM |
|
| 10:30 | OC07 - Cryo-EM to Address Intractable Targets in Drug Discovery |
Dr Hervé REMIGY
(THERMO FISHER SCIENTIFIC, Eindhoven, The Netherlands) |
| 10:45 | OC08 - Strength of Cryo-EM in Drug Discovery: One Could Always See Something |
Dr Wen-ti LIU
(NOVALIX, Illkirch, France) |
| 11:00 | IL06 - Single Particle Cryo-EM Structure of the Insulin Receptor:Insulin Complex |
Dr Giovanna SCAPIN
(MERCK & CO. INC (MSD), Whitehouse Station, United States) |
| 11:30 | Poster Session |
|
| 12:30 | Lunch & Networking
|
|
| Session 4 : Membrane Proteins |
|
| Session Chair |
Dr Dan ERLANSON
(CARMOT THERAPEUTICS, South San Francisco, United States) |
| 14:00 | IL07 - New Tools Reveal Mechanisms of Allosteric Coupling in Human GPCRs |
Dr Matthew EDDY
(UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, United States) |
| 14:30 | Exhibitor Short Presentation: Pall ForteBio
Dissecting Biomolecular Interactions - Pall ForteBio’s Next Gen SPR and BLI Label-Free Platforms: Providing Faster and Easier Solutions to Your Emerging Applications |
Mr Bob DASS
(PALL FORTEBIO, Menlo Park, United States) |
| 14:40 | OC09 - Enabling NMR-Based Fragment Screening Using Stabilized Native GPCR: Case Study of Adenosine Receptor |
Dr Anass JAWHARI
(CALIXAR, Lyon, France) |
| 14:55 | OC10 - Crystal Structures of Human Glycine Receptor Alpha3 Bound to a Novel Class of Analgesic Potentiators |
Dr Xin HUANG
(AMGEN, Cambridge, United States) |
| 15:10 | IL08 - Structural Insight into Allosteric Modulation of GPCRs |
Dr Miles CONGREVE
(HEPTARES, Welwyn Garden City, United Kingdom) |
| 15:40 | Coffee Break |
|
| Session 5 : Protein-Protein Interactions |
|
| Session Chair |
Dr MariJean EGGEN
(ELI LILLY, Indianapolis, United States) |
| 16:20 | IL09 - Design Considerations for Synthetic Macrocycles in Drug Discovery |
Prof. Adrian WHITTY
(BOSTON UNIVERSITY, Boston, United States) |
| 16:45 | OC11 - Use of Complementary Biophysical Methods to Characterize Ligand Binding to IL-17A |
Dr Parag SAHASRABUDHE
(PFIZER, Groton, United States) |
| 17:00 | OC12 - Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of α-Synuclein Aggregation in Parkinson’s Disease |
Ms Roxine STAATS
(UNIVERSITY OF CAMBRIDGE, Cambridge, United Kingdom) |
| 17:15 | IL10 - Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein–Protein Interaction |
Dr Shilin XU
(UNIVERSITY OF MICHIGAN, Michigan, United States) |
| 18:00 | Posters & Drinks |
|
| 19:30 | End of the Day |
|
| 20:00 | Conference Dinner |
|
| Friday 15/06/2018 |
| 08:30 | Registration |
|
| Session 6 : Biotherapeutics |
|
| Session Chair |
Dr Jim BRYSON
(BRISTOL-MYERS-SQUIBB, Princeton, United States) |
| 09:00 | IL11 - Attacking the Cancer Cell Surface-ome with Recombinant Antibodies |
Prof. Jim WELLS
(UCSF, San Francisco, United States) |
| 09:30 | Exhibitor Short Presentation: Sierra Sensors
Controlling Throughput for SPR |
Dr Christopher WHALEN
(SIERRA SENSORS, Greenville, United States) |
| 09:40 | IL12 - Multi-Specific Designer Proteins for Tumor Therapeutics |
Dr Karyn T. O'NEIL
(ARō BIOTHERAPEUTICS, Philadelphia, United States) |
| 10:10 | Coffee Break |
|
| Session 6 (continued) : Biotherapeutics |
|
| 10:40 | Exhibitor Short Presentation: WuXi AppTec
Crelux – A Fully Integrated Offering, from Protein to Screen, Through Crystallography Confirmation and Beyond. |
Dr Thomas WALDMANN
(CRELUX, A WUXI APPTEC COMPANY, Martinsried, Germany) |
| 10:50 | IL13 - Emerging Higher Order Structure Techniques in Biotherapeutics Development |
Dr Tapan K. DAS
(BRISTOL-MYERS SQUIBB, New York, United States) |
| 11:20 | Poster Prizes and Closing Remarks |
|
| 11:45 | Farewell Lunch & Networking |
|
| 13:00 | End of the Conference |
|
