| Sunday October 7, 2018 |
| 13:00 | Registration (until 19:00) |
|
| Foyer Hall Spectrum A |
| Workshops (subject to separate registration) |
|
| Workshop 1 | Workshop 2 |
| Palladium 2.05 | Platinum 2.08 |
| 14:00 | Multicolumn Processes: From Historical SMB to the Latest Advances in the Purification of Biomolecules |
José Paulo MOTA (REQUIMTE/CQFB, FFCT, Caparica, Portugal)
Olivier DAPREMONT (SK PHARMTECO, Rancho Cordova, United States) |
|
| From Development to Commercial Scale: How to Integrate QbD Tools and Data Analysis |
Alessandro BUTTE
(ETH ZURICH, Zurich, Switzerland) |
|
|
| 15:30 | Coffee Break |
|
| Workshop 3 | Workshop 4 |
| Palladium 2.05 | Platinum 2.08 |
| 16:00 | Preparative HPLC of Peptides and Small Molecules: Phase Screening, Method Optimisation, Process Design |
Michael SCHULTE (MERCK KGAA, Darmstadt, Germany)
Jochen STRUBE (CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany)
Ulrich EMDE (MERCK KGAA, Darmstadt, Germany) |
|
| Real Time Monitoring and Control of
Process Chromatography |
Alois JUNGBAUER
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) |
|
|
| 17:45 | Opening Ceremony |
|
| Hall Spectrum B+C |
| 18:00 | KL01 - A New View on Surface Diffusion from Molecular Dynamics Simulations of Solute Mobility at Chromatographic Interfaces |
Ulrich TALLAREK
(PHILIPPS-UNIVERSITÄT MARBURG, Marburg, Germany) |
| 18:45 | Welcome Reception |
|
| Hall Spectrum A |
| 20:00 | End of the Day |
|
| Monday October 8, 2018 |
| 08:00 | Registration |
|
| Foyer Hall Spectrum A |
| 08:45 | Welcome |
|
| Session 1: Joachim Kinkel Symposium |
|
| Hall Spectrum B+C |
| Session Chair |
Michael SCHULTE
(MERCK KGAA, Darmstadt, Germany) |
| 09:00 | Opening Remarks |
|
| 09:10 | OC01 - Measurement, Description and Consistent Application of Adsorption Equilibria |
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 09:30 | OC02 - How Continuous Chromatography Moved from Craftwork to Industry. A Tribute to Passion and Creativity.
|
(AM-PHARMA) |
| 09:50 | OC03 - Modified Inorganic Sorbents for the Fast and Efficient Separation of Biomolecules
|
Benjamin PETERS
(MERCK KGAA, Darmstadt, Germany) |
| 10:10 | OC04 - Centrifugal Partition Chromatography: new Possibilities with a Liquid Stationary Phase
|
Mirjana MINCEVA
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 10:30 | Coffee Break sponsored by MERCK |
|
| Hall Spectrum A |
| Session 2: Chromatographic Media |
|
| Hall Spectrum B+C |
| Session Chair |
Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 11:00 | KL02 - On the Advantage of Ordered Chromatographic Media |
Gert DESMET
(VRIJE UNIVERSITEIT BRUSSEL (VUB), Brussels, Belgium) |
| 11:40 | OC05 - Interplay of Mathematics and Physics of 3D Printing for Chromatography |
Carlos GRANDE
(SINTEF, Oslo, Norway) |
| 12:00 | OC06 - New Adsorptive Technology and its Use Within Purification Platform for Antibody-Process Related Impurities Removal |
Fabien ROUSSET
(CHIRAL TECHNOLOGIES, Illkirch, France) |
| 12:20 | OC07 - A New Cation Exchange Resin Designed for the Removal of Monoclonal Antibody Aggregates Using Flow-Through Frontal Chromatography |
Romas SKUDAS
(MERCK KGAA, Darmstadt, Germany) |
| 12:40 | Lunch and Exhibition (until 14:00) |
|
| Hall Spectrum A |
| Vendor Seminar 1 | Vendor Seminar 2 |
| Palladium 2.05 | Platinum 2.08 |
| 13:00 | Agilent Technologies
The New Benchmark for Preparative LC Workflows - Pathways to Achieve Exceptional Accuracy and Flexibility (13:00-14:00) |
|
|
| Osaka Soda Co., Ltd.
Taming the Devil (Advances in the Understanding of CIP in RP HPLC Processes) (13:00-14:00) |
|
|
|
| Session 3: Theory and Simulations |
|
| Hall Spectrum B+C |
| Session Chair |
Andreas SEIDEL-MORGENSTERN
(MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany) |
| 14:00 | KL03 - Computational Fluid Dynamics to Understand Process Chromatography |
Alois JUNGBAUER
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) |
| 14:40 | OC08 - When Adsorption Models or Intuition Fail at Describing Ion-Exchange Chromatography |
Speaker to be confirmed
(YPSO-FACTO) |
| 15:00 | OC09 - Improvement of Multicapillary Packing Efficiency by Diffusional Bridging: A Theoretical and Dynamic Simulation Study |
Francois PARMENTIER
(SEPARATIVE, Solaize, France) |
| 15:20 | OC10 - Chromatographic Separations with Focusing of Both the Weak and the Strong Component |
Tuomo SAINIO
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 15:40 | Coffee Break sponsored by AMPAC FINE CHEMICALS |
|
| Hall Spectrum A |
| Session 4: Continuous Chromatography |
|
| Hall Spectrum B+C |
| Session Chair |
Olivier DAPREMONT
(SK PHARMTECO, Rancho Cordova, United States) |
| 16:10 | OC11 - Design and Optimization of a Continuous Separation of Tartronic and Glyceric Acids by Simulated Moving Bed |
Lucas COELHO (UNIVERSITY OF PORTO, Porto, Portugal)
& (FEDERAL UNIVERSITY OF PERNAMBUCO, Recife, Brazil) |
| 16:30 | OC12 - Strategies for the Global Multicomponent Separation of Nadolol Stereoisomers by Chiral and Achiral Fixed-Bed and Simulated Moving Bed Chromatography |
António E. RIBEIRO
(POLYTECHNIC INSTITUTE OF BRAGANÇA, Braganca, Portugal) |
| 16:50 | OC13 - Inexiotech - This Disruptive Technology Allows for the Resolution of Multicomponent Mixtures in a Serial Continuous Process |
Alexandre MACIUK (UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France)
& (FAUQUET INNOVATION, Montmagny, France) |
| 17:10 | OC14 - Model Predictive Control of 4-Zone Simulated Moving Bed Chromatography for the Separation of Bicalutamide Enantiomers: Experimental Validation |
Ju Weon LEE
(MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany) |
| 17:30 | OC15 - Evaluation of Continuous Purification of Therapeutic Extracellular Vesicles |
Mafalda MOLEIRINHO
(INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal) |
| 17:50 | Poster Session 1 & Beer Party |
|
| Hall Spectrum A |
| 18:50 | End of the Day |
|
| Tuesday October 9, 2018 |
| Session 5: Peptides and Proteins |
|
| Hall Spectrum B+C |
| Session Chair |
José Paulo MOTA
(REQUIMTE/CQFB, FFCT, Caparica, Portugal) |
| 08:30 | KL04 - Synthetic Peptide Manufacturing: Downstream Challenges and Innovations |
Olivier LUDEMANN-HOMBOURGER
(POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France) |
| 09:10 | OC16 - Hybrid Optimisation of Preparative Chromatography for a Difficult and Realistic Ternary Protein Mixture |
Vivien FISCHER
(UNIVERISTY COLLEGE LONDON / GLAXOSMITHKLINE, Stevenage , United Kingdom) |
| 09:30 | OC17 - Scalability of Mini-Columns in Protein Chromatography |
Dorota ANTOS
(RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland) |
| 09:50 | OC18 - Process Analysis for Preparative Protein Chromatography Using In-Line Attenuated Total Reflection Fourier Transform Infrared Spectroscopy |
Adrian SANDEN
(KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany) |
| 10:10 | OC19 - Cost Effective Peptide Purification via ZEOsphere DRP Mixed-Mode Chromatography |
Alessandro BUTTE
(ETH ZURICH, Zurich, Switzerland) |
| 10:30 | Coffee Break and Exhibition |
|
| Hall Spectrum A |
| Session 6: Purification of Antibodies I |
|
| Hall Spectrum B+C |
| Session Chair |
Dorota ANTOS
(RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland) |
| 11:00 | OC20 - Continuous Biomanufacturing- Platform Alternatives for Antibody Production |
Steffen ZOBEL-ROOS
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 11:20 | OC21 - Antibody Aggregate Removal Using Frontal Chromatography: Performance Comparison Between Column and Membrane Adsorber |
Sebastian VOGG
(ETH ZURICH, Zürich, Switzerland) |
| 11:40 | OC22 - Continuous Conjugation of Antibodies By rMCSGP |
Nicole ULMER
(ETH ZURICH, Zurich, Switzerland) |
| 12:00 | OC23 - Temperature Dependence of Antibody Adsorption in Protein A Affinity Chromatography |
Walpurga KREPPER
(UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, Vienna, Austria) |
| 12:20 | Lunch Break and Exhibition (until 13:40) |
|
| Hall Spectrum A |
| Vendor Seminar 3 | Vendor Seminar 4 |
| Palladium 2.05 | Platinum 2.08 |
| 12:40 | Kromasil-AkzoNobel PPC
Method Development and Purification of Biotherapeutics including Peptides and Oligonucleotides (12:40-13:40) |
|
|
| Tosoh Bioscience GmbH
Reduce your Downstream Processing Costs and Know More About your Target Molecules (12:40-13:40)
|
|
|
|
| 13:40 | Poster Session 2 |
|
| Hall Spectrum A |
| Session 7: Green Purification Technologies |
|
| Hall Spectrum B+C |
| Session Chair |
Pilar FRANCO
(CHIRAL TECHNOLOGIES EUROPE, Illkirch, France) |
| 14:40 | KL05 - SFC-MS in Drug Discovery: The Technology Shaping Tomorrow’s Innovation |
Gerard ROSSE
(DART NEUROSCIENCE, San Diego, United States) |
| 15:20 | OC24 - Alternative Approaches in Preparative Chromatography for Purifying Lipophilic Compounds and the Elimination of Chlorinated Solvents |
Markus JUZA
(CORDEN PHARMA SWITZERLAND, Liestal, Switzerland) |
| 15:40 | OC25 - Studies on Robustness of SFC: Examples from Chiral and Peptide Separations |
Torgny FORNSTEDT
(KARLSTAD UNIVERSITY, Karlstad, Sweden) |
| 16:00 | OC26 - Operating Mode Selection for Ternary Separations with Liquid-Liquid Chromatography |
Raena MORLEY
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 16:20 | Coffee Break and Exhibition |
|
| Hall Spectrum A |
| Session 8: Natural Products |
|
| Hall Spectrum B+C |
| Session Chair |
Mirjana MINCEVA
(TECHNICAL UNIVERSITY OF MUNICH, Freising, Germany) |
| 16:50 | KL06 - Accessing Nature’s Chemical Diversity for Drug Discovery |
Philipp KRASTEL
(NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland) |
| 17:30 | OC27 - Development of a Chromatographic Based Purification Strategy for Artemisinin from Artemisia Annua L. Extract |
Fabian MESTMÄCKER
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 17:50 | OC28 - Chromatographic Recovery of Hydroxy Acids, Lignin, and Pulping Chemicals from Spent Alkaline Pulping Liquors |
Jari HEINONEN
(LAPPEENRANTA UNIVERSITY OF TECHNOLOGY, Lappeenranta, Finland) |
| 20:00 | Gala Dinner |
|
| Wednesday October 10, 2018 |
| Session 9: Antibodies and Proteins II |
|
| Hall Spectrum B+C |
| Session Chair |
Olivier LUDEMANN-HOMBOURGER
(POLYPEPTIDE LABORATORIES FRANCE, Strasbourg, France) |
| 08:30 | OC29 - Visualization and Quantification of Protein Bind and Elute Processes to the IEX Hydrogel of a Membrane Adsorber |
Adrian LEY
(SARTORIUS STEDIM BIOTECH GMBH / INSTITUTE OF PHYSICAL CHEMISTRY, GEORG-AUGUST UNIVERSITY GOETTINGEN, Goettingen, Germany) |
| 08:50 | OC30 - Water on Hydrophobic Surfaces - Mechanistic Modeling of Polyethylene Glycol-Induced Protein Precipitation |
Steffen GROSSHANS
(KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Karlsruhe, Germany) |
| 09:10 | OC31 - Membrane Based Separation of Aqueous Two-Phase Systems for the Purification of Monoclonal Antibodies |
Thomas KRUSE
(SARTORIUS STEDIM BIOTECH & CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Göttingen, Germany) |
| 09:30 | SPICA 2018 Poster Prizes |
|
| 09:50 | Coffee Break and Exhibition |
|
| Hall Spectrum A |
| Session 10: Process Optimization Chromatography and Case Studies |
|
| Hall Spectrum B+C |
| Session Chair |
Jochen STRUBE
(CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany) |
| 10:20 | KL07 - Efficient Simulation and Control of Chromatographic Processes |
Achim KIENLE
(OTTO VON GUERICKE UNIVERSITY MAGDEBURG, Magdeburg, Germany) |
| 11:00 | OC32 - Automatic Determination of Optimum Operating Concepts and Process Variables for Multi-Component Separations |
Johannes SCHMÖLDER
(FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, Erlangen, Germany) |
| 11:20 | OC33 - Optimization of Processes Combining Chemistry & Purification - Strategies & Case Studies |
Jérome BONI
(NOVASEP FINORGA, Chasse-sur-Rhone, France) |
| 11:40 | OC34 - Continuous Centrifugal Partition Chromatography: Using a Mass Transfer Model for Process Optimization and Various Mode Comparison |
Luc MARCHAL
(UNIVERSITÉ DE NANTES, Saint Nazaire, France) |
| 12:00 | OC35 - Model-Based Quality by Design: Challenges, Pitfalls and Best Practices |
Maria CASALS PERAVAREZ
(GOSILICO, Karlsruhe, Germany) |
| 12:20 | Kinkel Symposium Award |
|
| 12:25 | Closing Remarks |
|
