New Opportunities in GPCR Drug Discovery
Oegstgeest (near Leiden), The Netherlands May 8-11, 2022
Registration
Dinner and Get Together
Breakfast
Opening
General Introduction to GPCRs: Pharma Relevance, Indications, Molecular Pharmacology
Coffee Break
Structural Biology of GPCRs in the Era of Cryo-EM – Implications for Drug Design and Discovery
Lunch
GPCR Ligands: Molecular Recognition, Kinetics and Allosteric Modulation
Coffee Break
Partial Agonism/Biased Signalling and its Therapeutical Relevance
Day End
Walking tour through Leiden
Dinner in Leiden
Breakfast
A General Introduction into GPCRdb & Hands-on with the GPCRdb
Coffee Break
Lunch
GPCR Ligand Design: Cheminformatics and Modelling
Coffee Break
Tutorials and Excercises
Day End
Dinner and Get Together
Breakfast
Discovery of Cariprazine, A Dopamine D3 Receptor Prefering Third Generation Antipsychotics
Coffee break
Binding and Modulating GPCRs by Inside/Outside Binding Nanobodies
Wrap up and Lunch