Session Chair
Dr Gilles GUICHARD
CBMN & IECB, UNIVERSITY OF BORDEAUX, CNRS, BORDEAUX INP, Pessac, France
10:00
Targeting Protein-Protein Interactions in Receptor Complexes (PL13)
Prof. Kristian STROMGAARD
UNIVERSITY OF COPENHAGEN, Copenhagen, Denmark
Professor Kristian Strømgaard graduated from the Royal Danish School of Pharmacy (1999), with part of the studies carried out at the Danish pharmaceutical company H. Lundbeck A/S and previous studies at University College London. He did his postdoctoral training at Columbia University (USA) and was subsequently appointed assistant professor at University of Copenhagen, and thereafter promoted to full professor in chemical biology 2006. His research spans chemistry and biology with focus on protein-protein interactions, including inlcuding peptide and protein engineering. In 2014 he was appointed Director of Center for Biopharmaceuticals at University of Copenhagen and 2016-17 he was a visting professor at Harvard Medical School. He is co-founder of the biotechnology company Avilex Pharma.
10:30
Selecting Targets to Harness the Therapeutic Opportunities Afforded by PROTAC-mediated Protein Degradation (PL14)
Dr John HARLING
GLAXOSMITHKLINE, Stevenage, United Kingdom
I conducted both my B.Sc and Ph.D at Imperial followed by two years as a Postdoctoral Researcher at the University of Texas at Austin. Joined GlaxoSmithKline (then SmithKlineBeecham) as a Medicinal Chemist in 1991. During my >25 years at GSK I have worked in programs spanning Neurosciences, Cardiovascular and Respiratory therapeutic areas. In 2007 I was appointed as a Medicinal Chemistry Department Head in the Respiratory therapeutic area. In 2012 I became involved in the initiation of an exploratory effort to assess the potential of a new protein degradation technology through collaboration with Professor Craig Crews at Yale. My current position is Senior Scientific Director within Medicinal Chemistry at GSK where I have a remit to develop protein degradation capability at GSK.
11:00
Networking & Exhibition break
Session Chair
Prof. Dominique BONNET
CNRS-UNIVERSITY OF STRASBOURG, Illkirch, France
11:30
Proteomimetics as Inhibitors of Transcription Factor Complexes (PL15)
Prof. Tom GROSSMANN
VU UNIVERSITY AMSTERDAM, Amsterdam, The Netherlands
Tom Grossmann holds the Chair of Biomimetic Chemistry at the VU University Amsterdam. He studied chemistry at the Humboldt University Berlin, including undergraduate research with Peter Vollhardt at the University of California Berkeley. In 2008, he received his PhD with Oliver Seitz at the Humboldt University Berlin. After postdoctoral research in the group of Gregory Verdine at Harvard University, he became group leader at the Technical University and the Chemical Genomics Centre in Dortmund. Since 2016, he is full professor at the VU University Amsterdam, currently being supported by an ERC Starting Grant.
12:00
Drugging KRAS with Medchem 2.0 (PL16)
Dr Darryl MCCONNELL
BOEHRINGER INGELHEIM RCV, Vienna, Austria
Darryl McConnell is currently Senior Vice President and Research Site Head at Boehringer-Ingelheim Regional Centre Vienna, Austria. His goal is to discover new chemical therapeutics for cancer’s so-called undruggable targets together with the team at BI.
Darryl’s interests lie in drugging protein-protein interactions, kinases and pushing the frontiers of PROTACs for cancer patients. Fragment screening, protein crystallography, protein NMR, drug resistance, agile methods in drug discovery and natural product inspired medicinal chemistry are some of his areas of scientific interest.
Darryl commenced his career with Boehringer-Ingelheim in 2002 as a Research Laboratory Head and is in his current role since 2015. Prior to this Darryl has worked for Intervet in Vienna from 2001, for Biota Holdings Ltd in Melbourne, Australia from 1999 in the area of respiratory viruses and Chiron Technologies in Melbourne from 1997.
Darryl McConnell received his Bachelor of Science with First Class Honours in 1991 with Professor John Elix at the Australian National University in Canberra. He performed his PhD at the University of New South Wales in Sydney with Professor David Black for which he was awarded the Cornforth Medal for the best chemistry PhD thesis in Australia for that year. Following this he performed a 2 year Postdoctoral study at the University of Sydney with Professor Leslie Field in organometallic chemistry.
12:30
End of morning session