Excursions - Tour 1

Excursions - Tour 2

Registration

Opening

Opening Lecture
The Art and Science of Total Synthesis and its Impact on Biology and Medicine: From the Fundamentals to the Translational (T01)

Welcome Reception

End of the Day

Registration

Session Chair

Nature’s Medicine Chest: Opportunities for Synthesis and Drug Discovery (T02)

Drug Discovery in Academia (T03)

Practical and Asymmetric Gilman-Speeter Synthesis of B-Lactams (OC01)

Coffee Break and Exhibition

Discovery of First in Class, Orally Bioavailable p300/CBP HAT Domain Inhibitors (T04)

Novel Bacterial Topoisomerase Inhibitors (NBTI) with Potent Gram-Negative Activity (T05)

Rapid Exploration of Synthetically Tractable Chemical Space and Lead Optimization Using a Combination of Reaction-Based Enumeration, Active Learning, and Free Energy Calculations (OC02)

Lunch and Exhibition

Schrödinger Workshop: Using LiveDesign for Collaborative and Data Driven Drug Design

Session Chair

Catalytic Chirality Generation: New Strategies for Organic Synthesis (T06)

Nucleophilic Boron for the Synthesis of Functionalized Small Rings (T07)

A Radical Approach for the Late-Stage Functionalization of Phosphinic Peptides (OC03)

Coffee Break and Exhibition

EFMC Prize Winner EFMC-YMCS 2018
Development of Release-And-Report Kinase Inhibitors as Molecular Tools for Investigating Neurodegenerative Disorders (OC04)

Photoinduced Assembly of C–N Bonds (T08)

Practical Heteroatom- and Group-Transfer Reactions (T09)

Closing of the Day

Session Chair

Design and Synthesis of Chemical Probes for Bromodomains (T10)

A Medicinal Chemist's Perspective on Solute Carriers: Avoiding or Targeting them (T11)

Stabilizing Inactive Conformations of MALT1 AS an Effective Strategy to Inhibit its Protease Activity (OC05)

Coffee Break and Exhibition

A Chemical Approach to Map Protein Interactions at the Cell Surface (T12)

From Fragments to Antibody Drug Conjugates in Emerging Oncology Targeted Therapies (T13)

Macrocyclic Modalities for Modulation of Protein-Protein Interactions (OC06)

Lunch and Exhibition

Poster Session 1 (odd numbers)

Session Chair

Awareness of PAINS (Pan Assay Interference Compounds) can Accelerate the Drug Discovery Process (T14)

Artificial Intelligence in ADMET Modeling and Compound Profiling (T15)

Antimicrobial Activity of Curcumin Analog PGV-6, HGV-6 and GVT-6 (OC07)

Coffee Break and Exhibition

Sustainable by Design Anti-Trypanosomatid Small Molecules: an Aspirational Goal for Medicinal Chemistry (T16) - ChemMedChem Lecture

Artificial Intelligence in de Novo Molecular Design (T17)

Closing of the Day

Session Chair

Amides and Chemical Education as Vehicles for Innovation (T18)

Discovery of AZD5718, a Novel 5-lipoxygenase Activating Protein (FLAP) Inhibitor (T19)

Discovery of GSK701, a Novel Orally Effective Preclinical Drug Candidate for the Treatment of Malaria (OC08)

Coffee Break and Exhibition

Design and Implementation of de Novo Biosynthetic Cascades (T20)

Catalysis for Total Synthesis (T21)

Developing a ‘Reverse-Biomimetic’ Synthesis of Arogenate and its Analogues (OC09)

Lunch and Exhibition

Poster Session 2 (even numbers)

Session Chair

Development and Application in Flow of Sustainable Synthetic Methodologies that Use Singlet Oxygen as Green Oxidant and Cascade Reaction Facilitator (T22)

Prize Ceremony

EFMC Prize for a Young Medicinal Chemist in Academia
From the Elucidation of the Mechanism of Vitamin E to the Design of Innovative Drugs that Limit Inflammation and Enhance Resolution (OC10)

EFMC Prize for a Young Medicinal Chemist in Industry
Cipargamin-Biocatalysis in the Discovery and Development of an Antimalarial Drug (OC11)

Coffee Break and Exhibition

Flow Chemistry and Photochemistry as a Tool for Drug Discovery (T23)

Closing of the Day

Symposium Banquet

Session Chair

Start Selective and Rigidify: The Discovery Path Towards the Next Generation of EGFR Tyrosine Kinase Inhibitors (T24)

RNA Therapeutics: New Chemical Modalities Becoming a Therapeutic Reality (T25)

Removable Directing Groups for Late-Stage Functionalisation (OC12)

Coffee Break and Exhibition

TLR7/8 Antagonists: from Screening to in vivo Potency (T26)

Allosteric Activation of a Master Metabolic Regulator AMPK: Drug Discovery Opportunities and Challenges (T27)

Closing Remarks & Prize Ceremony

End of the Symposium