08:00
08:30
Introduction and Welcoming Words
Prof. Bertrand DÉCAUDIN
DEAN OF THE FACULTY OF PHARMACY, UNIVERSITY OF LILLE, Lille, France
Prof. Damien CUNY
VICE PRESIDENT, UNIVERSITY OF LILLE, Lille, France
Session 1 - Electrically Driven Analytical Methods
Session Chairs
Prof. Debby MANGELINGS
VRIJE UNIVERSITEIT BRUSSEL, Brussels, Belgium
Debby Mangelings graduated as pharmacist and is appointed as associate professor at the department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling of the Vrije Universiteit Brussel.
Her main research interest are chiral separations, in which she focuses on the definition of generic chiral method development strategies using liquid chromatography, supercritical fluid chromatography, among other techniques. Furthermore, she is also involved in projects on miniaturized separation techniques, drug impurity profiling, metabolomics and skin permeability determinations.
Prof. Osamu NIWA
SAITAMA INSTITUTE OF TECHNOLOGY, Fukaya, Japan
Osamu Niwa received his B. Eng. degree in 1981 and PhD in 1990 from Kyushu University. He joined NTT Laboratories in 1983 and worked in research and development on electrochemical and optical biosensors. In 2004, he worked as a deputy director and group leader in Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Japan. From October 2015, he is a professor of Advanced Science Research Laboratory and also Dean of The Graduate School of Engineering, Saitama Institute of Technology. His current research interests are electrochemistry of nanocarbons, metal nanoparticles embedded carbon electrodes and their application for clinical, pharmaceutical and environmental fields. From 2015 to 2017, he was a vice-president of Japan Society for Analytical Chemistry and now president of Japan Society of Chemical Sensors and will be an associate editor for Sensors and Actuators B. He published about 230 peer reviewed papers and contributed to about 10 book chapters.
08:50
PL01 - Capillary Electrochromatographic Column Technology for Pharmaceutical Analysis
Prof. Zilin CHEN
WUHAN UNIVERSITY, Wuhan, China
Dr. Zilin Chen now works as Luojia Chair Professor, vice dean of School of Pharmaceutical Sciences and director of Institute for Pharmaceutical Analysis and Drug Screening in Wuhan University. Prof. Chen received his Ph.D. degree in applied chemistry in 2000 from Tokyo Metropolitan University (TMU), Japan. He then worked as a postdoctoral fellow of Japan Society for the Promotion of Science (JSPS) at TMU, a postdoctoral fellow at NTT Microsystem Integration Labs, Japan and a research assistant professor at University of Notre Dame, USA. He joined in Wuhan University as Luojia Chair Professor in 2007. He has over 120 peer-reviewed research papers published in international journals. His research interests include the micro-column chromatography, capillary electrophoresis and mass spectrometry for biological and pharmaceutical analysis. He initiated and organized first international symposium on Advances in Pharmaceutical Analysis (APA) in 2017 at Wuhan.
09:35
KL01 - Electrodriven Methodologies for the Screening of New Antithrombotic Drugs
Prof. Marianne FILLET
UNIVERSITY OF LIÈGE, Liege, Belgium
EDUCATION, TRAINING AND PROFESSIONAL EXPERIENCE
- 1993: Master's degree in Pharmaceutical Sciences at the University of Liège
- 1998: PhD in Pharmaceutical Sciences at the University of Liège
- 1998-2010: Postdoctoral Researcher F.R.S.-FNRS (National Funds for Scientific Research)
- 2010-now: Professor at the University of Liège; Head of the Laboratory for the Analysis of Medicines (www.lam-ulg.com)
- 2014-now: Director of the CIRM (Center for Interdisciplinary Research on Medicines, ULiège)
MAIN RESEARCH AREA
- Development of analytical methods for drug characterization and quantitation (synthetic drugs and biopharmaceuticals) by HPLC, CE coupled with UV, LIF or MS
- Discovery and quantification of new disease biomarkers in biological fluids by proteomic and metabolomic approaches
- Optimization of microsampling and microfluidic approaches for PK studies on individual living animals
- Study of ligand-target interactions in physiological conditions
10:05
KL02 - Single-Stranded Nucleic Acid Molecules as Chiral Selectors: Mechanisms and Applications
Prof. Eric PEYRIN
GRENOBLE ALPES UNIVERSITY, St Martin d'Heres, France
Current title and position
Professor in analytical sciences at the Grenoble Alpes University, France
Head of the team “New tools for drug delivery and analysis”, Departement de Pharmacochimie Moléculaire, UMR 5063 CNRS, Université Grenoble Alpes
Research field
Bioanalytical chemistry, miniaturized separation systems, optical biosensors, selection and applications of nucleic acid aptamers, chiral recognition mechanisms, enantioselective separation and sensing platforms.
Author or co-author of more than 110 international publications, 3 patents, 4 book chapters; more than 20 invited conferences and seminars
Education and former professional experience
Clinical Chemist, PharmD, PhD, HDRD
10:35
OC01 - CE-MS Analysis of Derivatized D- and L-Amino Acids for Targeted Neurometabolomics
Prof. Jacques CROMMEN
UNIVERSITY OF LIEGE, Liege, Belgium
Jacques Crommen is currently Professor Emeritus at the University of Liege, Belgium and Guest Professor at Jinan University, Guangzhou, China. He was Full Professor and Head of the Laboratory of Analytical Pharmaceutical Chemistry at the University of Liege from 1991 to 2010. He was also Guest Professor at the Catholic University of Louvain (UCL), Belgium, from 1997 to 2003. He was Editor of the Journal of Pharmaceutical and Biomedical Analysis from 1999 to 2003 and member of the Editorial Board of the Journal of Chromatography A from 1995 to 1999. He is Vice President of the Belgian Royal Academy of Medicine, and Honorary Member of the Hungarian Pharmaceutical Society and the Belgian Society of Pharmaceutical Sciences. He was awarded the degree of Doctor honoris causa from the Iuliu Hatieganu University, Cluj-Napoca, Romania. His current research interests include chiral separations and analysis of counterfeit drugs by HPLC and CE, and quantification of biomarkers by miniaturized separation techniques coupled to mass spectrometry.
10:55
Session 2 - Phytopharmaceutical Analysis
Session Chairs
Prof. Marianne FILLET
UNIVERSITY OF LIÈGE, Liege, Belgium
EDUCATION, TRAINING AND PROFESSIONAL EXPERIENCE
- 1993: Master's degree in Pharmaceutical Sciences at the University of Liège
- 1998: PhD in Pharmaceutical Sciences at the University of Liège
- 1998-2010: Postdoctoral Researcher F.R.S.-FNRS (National Funds for Scientific Research)
- 2010-now: Professor at the University of Liège; Head of the Laboratory for the Analysis of Medicines (www.lam-ulg.com)
- 2014-now: Director of the CIRM (Center for Interdisciplinary Research on Medicines, ULiège)
MAIN RESEARCH AREA
- Development of analytical methods for drug characterization and quantitation (synthetic drugs and biopharmaceuticals) by HPLC, CE coupled with UV, LIF or MS
- Discovery and quantification of new disease biomarkers in biological fluids by proteomic and metabolomic approaches
- Optimization of microsampling and microfluidic approaches for PK studies on individual living animals
- Study of ligand-target interactions in physiological conditions
Prof. Zhengjin JIANG
JINAN UNIVERSITY, Guangzhou, China
Dr. Zhengjin Jiang received his PhD degree in the Institute of Elemento-Organic Chemistry, Nankai University in 2001. After graduation, he worked for one year in Unimicro (Tianjin) Technologies, Inc, followed as postdoctoral researcher or research fellow in The University of Tuebingen in Germany, King‘s College London, Pfizer (Sandwich) Research Centre, Novartis Horsham Research Centre, respectively. In 2011, he returned to China and became a full professor of pharmacy at Jinan University, China. His research has been focused on separation science and their applications in pharmaceutical analysis. So far, he has published over 90 scientific publications in international peer-reviewed journals and given more than 20 oral presentations at international conferences. He is also the holder of 5 patens. He also served as co-chair (with Prof. Su Zeng, Zhejiang University) of the 27th International Symposium on Pharmaceutical and Biomedical Analysis in 2016.
11:15
KL03 - Challenges for Quality Control of Chinese Medicines
Prof. Shaoping LI
UNIVERSITY OF MACAU, Macau, China
Dr. Shao-ping Li is a Professor on Quality Control of Chinese Medicine and Deputy Director at the State Key Laboratory of Quality Research in Chinese Medicine, University of Macau.
Prof. Li is an Editor of Journal of Pharmaceutical and Bioanalytical Analysis, an Associate Editor of Journal of Separation Science, and Chinese Medicine. He is also Editorial Board member of Journal of Function Foods, Journal of Food and Drug Analysis, American Journal of Chinese Medicine, International Journal of Analytical Chemistry, Journal of Pharmaceutical Analysis, etc.
Professor Li is an advisor of American Herbal Pharmacopoeia and a member of Chinese Pharmacopoeia Commission. He is also the author of over 300 peer refereed journal papers and book chapters, and holder of ten items of China patent and 1 US patent.
11:45
OC02 - Cell Membrane Affinity Materials for Recognition and Preconcentration Active Components from TCM
Prof. Sicen WANG
XI'AN JIAOTONG UNIVERSITY, Xi'an, China
Sicen Wang is a full professor of Pharmaceutical Analysis, Research & Engineering Center for Natural Medicine, School of Pharmacy, Xi'an Jiaotong University, since January 2011. He studied pharmaceutical analysis and received his Ph. D. from Xi'an Jiaotong University in 2006 under the supervision of Prof. Langchong He. Then he joined the Research & Engineering Center for Natural Medicine, School of Pharmacy, Xi'an Jiaotong University a lecturer (2006–2007) and an associate professor (2008–2010). His research interests include the screening the active components from natural medicines and developing new drugs, and pharmaceutical quality control using various analytical techniques. He has published approximately 110 manuscripts, cited over 1300 times.
He received the Outstanding Young Scientist Award (2013), the National Invention Award (2012). He is an editor of the Journal of Pharmaceutical Analysis from 2016 and Journal of Chinese Biology from 2013.
12:05
OC03 - Methods for Measuring Protein-Protein Interactions and Discovery of Potent Inhibitors
Prof. Joachim JOSE
UNIVERSITY OF MÜNSTER, Münster, Germany
12:25
Exhibitor Short Presentation - Shimadzu
The Art of Growing the Difference in SFC Analysis
Dr Johanna DUVAL
SHIMADZU, Marne La Vallée Cedex 2, France
12:40
Exhibitor Short Presentation - Waters
Benefits of Mass Detection - Solutions for Pharma, Cosmetics and Botanical Applications
Dr Eric VAN BEELEN
WATERS, The Netherlands
12:55
Walking Lunch & Poster Session (Main Hall)
Session 3 - New Trends in Liquid Chromatography
Session Chairs
Prof. Bezhan CHANKVETADZE
TBILISI STATE UNIVERSITY, Tbilisi, Georgia
Bezhan Chankvetadze is Full Professor for Physical Chemistry and director of the Institute of Physical and Analytical Chemistry at the Tbilisi State University in Tbilisi, Georgia. Between 1991-2005 B. Chankvetadze held research and teaching positions at the Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, Germany and at the Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Japan. B. Chankvetadze is the Editor of the Journal of Pharmaceutical and Biomedical Analysis (Elsevier, Amsterdam, Netherlands) and Full Member of the Georgian National Academy of Sciences. B. Chankvetadze has published over 200 research papers in peer reviewed journals and given over 250 presentations on international conferences in fields of chirality, electromigration techniques and separation science.
Prof. Bart DE SPIEGELEER
UNIVERSITY OF GHENT, Ghent, Belgium
14:00
KL04 - Routine Use of HILIC Applications in Food Analyses and in Biomolecule Development
Dr Tivadar FARKAS
PHENOMENEX, Torrance, United States
Tivadar Farkas has over 20 years of experience in chromatography. He received his Ph.D. degree from the University of Tennessee at Knoxville in Analytical Chemistry in 1997 under the guidance of Georges Guiochon. The topic of his thesis was the investigation of HPLC column heterogeneity with electrochemical and with laser induced fluorescence detection.
Tivadar Farkas started his career in fragrance and food analysis by GC. He joined Phenomenex in 1997 as a Senior Scientist and worked first on column packing technology. For several years he managed the Analytical Support and Development group within R&D, focusing on the development of novel stationary phases, column formats, and applications for both analytical and prep HPLC, including chiral LC. Currently he acts as the Senior Managing Scientist of the R&D department at Phenomenex overseeing all major research projects. Tivadar Farkas is a constant contributor to the major chromatography scientific meetings and to the Journal of Chromatography.
14:30
KL05 - New Trends in Liquid Chromatography for the Analytical Characterization of Proteins Biopharmaceuticals
Dr Davy GUILLARME
UNIVERSITY OF GENEVA, Geneva, Switzerland
Dr Davy Guillarme obtained PhD degree in analytical chemistry from the University of Lyon, France in 2004. He is working at the University of Geneva in Switzerland for more than 13 years as a senior lecturer. Davy Guillarme authored more than 210 journal articles related to pharmaceutical analysis. His expertise includes HPLC, UHPLC, HILIC, LC-MS, SFC, SFC-MS and analysis of proteins and mAbs. He is an editor of Journal of chromatography B since 2018, and an editorial advisory board member of several journals including Analytical Chemistry, Journal of Chromatography A, Journal of Separation Science, LC-GC North America and others... He is the recipient of the LC-GC emerging leader award in chromatography in 2013 and won the Silver Jubilee medal in 2018.
15:00
OC04 - Insights into the Retention Modelling in Cyclodextrin Modified Green Liquid Chromatographic Methods
Dr Ana PROTIC
UNIVERSITY OF BELGRADE, Belgrade, Serbia
Ana Protić is an assistant professor at the Department of Drug Analysis, University of Belgrade-Faculty of Pharmacy. She obtained a PhD degree in the field of Pharmaceutical chemistry and Drug analysis in 2011. Currently participates in teaching process within undergraduated and postgraduated studies.
She has been working on development of (U)HPLC methods with different detection techniques. Nowadays, her research is focused on the examination of quantitative relationship between structure and retention or property behavior (QSR(P)Rs) of group of compounds in different chromatographic systems. Moreover, the research is mainly directed towards investigating beta-cyclodextrin modified HPLC systems as they offer possibility of developing ecologically acceptable chromatographic methods. In light of this, chemometric approach by means of experimental design, methodology of multi-criteria optimization and determination of relevant molecular descriptors, has been used in clarifying the molecular mechanisms of retention in reverse phased and modified HPLC systems. This complex modelling of retention and property behavior of drugs and structurally related compounds requires the aid of machine learning techniques, such as artificial neural networks, computer technology that has the ability to "learn", since it is a simulation of neural activity in the brain.
15:20
OC05 - Regulatory Quality Analytics in Advanced Therapy Medicinal Products: Raw Materials
Prof. Bart DE SPIEGELEER
UNIVERSITY OF GHENT, Ghent, Belgium
15:40
Session 4 - SFC and NMR Spectroscopy for Pharmaceutical Analysis
Session Chairs
Dr Davy GUILLARME
UNIVERSITY OF GENEVA, Geneva, Switzerland
Dr Davy Guillarme obtained PhD degree in analytical chemistry from the University of Lyon, France in 2004. He is working at the University of Geneva in Switzerland for more than 13 years as a senior lecturer. Davy Guillarme authored more than 210 journal articles related to pharmaceutical analysis. His expertise includes HPLC, UHPLC, HILIC, LC-MS, SFC, SFC-MS and analysis of proteins and mAbs. He is an editor of Journal of chromatography B since 2018, and an editorial advisory board member of several journals including Analytical Chemistry, Journal of Chromatography A, Journal of Separation Science, LC-GC North America and others... He is the recipient of the LC-GC emerging leader award in chromatography in 2013 and won the Silver Jubilee medal in 2018.
Prof. Shaoping LI
UNIVERSITY OF MACAU, Macau, China
Dr. Shao-ping Li is a Professor on Quality Control of Chinese Medicine and Deputy Director at the State Key Laboratory of Quality Research in Chinese Medicine, University of Macau.
Prof. Li is an Editor of Journal of Pharmaceutical and Bioanalytical Analysis, an Associate Editor of Journal of Separation Science, and Chinese Medicine. He is also Editorial Board member of Journal of Function Foods, Journal of Food and Drug Analysis, American Journal of Chinese Medicine, International Journal of Analytical Chemistry, Journal of Pharmaceutical Analysis, etc.
Professor Li is an advisor of American Herbal Pharmacopoeia and a member of Chinese Pharmacopoeia Commission. He is also the author of over 300 peer refereed journal papers and book chapters, and holder of ten items of China patent and 1 US patent.
16:00
KL06 - Impact of the Additive in Supercritical Fluid Chromatography
Dr David SPEYBROUCK
JANSSEN-CILAG, Val de Reuil, France
David Speybrouck is a senior scientist. He studied analytical chemistry at the university in Rouen in France. he joined Johnson & Johnson in 1996. He was in charge of the purification laboratory until 2012 and he has been responsible for analytical chemistry department.
His main field of interest is the chromatography, especially Supercritical Fluid Chromatography and enantiomer separations. he initiated the implementation of SFC in 2004 and nowadays his department is the centre of expertise for chiral prep SFC for Johnson and Johnson discovery with more than 800 preparative separation per year
16:30
OC06 - From Impurity Profiling to Purified Metabolites: Drug Discovery Supported by Analytical and Preparative Supercritical Fluid Chromatography
Dr Caroline WEST
UNIVERSITY OF ORLEANS, ICOA, Orleans, France
Caroline West obtained her PhD in physical chemistry (chromatography) from the University of South-Paris in 2005. She then joined the University of Orleans, France first as an assistant professor, then associate professor in analytical chemistry. She is a Junior member of the French University Institute, a service of the Ministry of Higher education distinguishing a small number of university professors for excellent research.
Her main scientific interests lie in fundamentals of chromatographic selectivity, both in the achiral and chiral modes mainly in SFC, but also in HPLC. She has authored 3 book chapters and about 80 papers in international peer-reviewed journals, and has presented over 40 lectures in national and international conferences. In 2015, she received the “LC-GC Emerging Leader in Chromatography” award from LC-GC North America and was ranked among the “Top 40 under 40” by The Analytical Scientist.
16:50
OC07 - Purification and Characterization of Sildenafil and Fifteen Analogues in One Dietary Supplement Marketed for Sexual Dysfunction
Prof. Veronique GILARD
PAUL SABATIER UNIVERSITY, Toulouse, France
Véronique GILARD is a full professor in analytical chemistry at the University of Toulouse (France). She obtained her MS degree in physical chemistry and her PhD in biomolecular sciences in 1993.
Her previous research interests were in the field of degradation and metabolism of fluorinated or phosphorated anticancer drugs followed by 31P and 19F NMR and in the analysis of brain metabolites by proton NMR.
Her main topics of research are currently oriented towards NMR applied to quality control of health products (counterfeited drugs, dietary supplements) and to the analysis of illicit drugs. Her main expertise is in analytical applications of NMR (quantitative, DOSY) and structure elucidation using NMR and mass spectrometry. Furthermore, she is also involved in NMR-based metabolomics projects for biomarkers research.
17:10
PL02 - NMR Spectroscopy in Quality Analysis of Drugs and Excipients
Prof. Ulrike HOLZGRABE
UNIVERSITY OF WUERZBURG, Wuerzburg, Germany
Prof. Dr. Ulrike Holzgrabe received her diploma degree in Chemistry at the University of Marburg in 1979, her approbation in Pharmacy in 1982, and her PhD in Pharmaceutical Chemistry in 1983 both at the University of Kiel. After habilitation in Pharmaceutical Chemistry Kiel in 1989 she became an associate professor at the University of Bonn (1990-1999). In 1988 she was a post-doc fellow at the University of Bath, UK, with Alan Casy, in 1994 a visiting professor at the University of Erlangen with J. Gasteiger, and 1995 at the University of Illinois at Chicago with A.F. Hopfinger. Since 1999 she holds a full professorship at the University of Würzburg (declining offers from the universities of Tübingen, Münster and Berlin, and the CEO position of the BfArM). She served as vice-rector of the University of Bonn from 1997-1999, as a president of the German Pharmaceutical Society from 2004 till 2007. She is a member of the German and European Committee of the Pharmacopoeia (BfArM, EDQM), and a member of the scientific boards of the BfArM, BPS of FIP, and the HIPS as well as a collegiate of the DFG.
17:55
Guided tour of Lille’s city center
20:00
Conference Banquet, Hotel Carlton
(3 Rue Pierre Mauroy, 59000 Lille)