St. Anton, Austria January 28
Opening Remarks
KL01 - Recent Developments in Strategies and Tactics Towards the Synthesis of Complex Secondary Metabolites as Enabling Tools for the Study of Biology and Medicine
Poster Session & Welcome Reception
End of Day 1
Session Chair
PL02 - Photochemical Reactions en route to Structurally Complex Molecules
Coffee Break
PL03 - Expanding the Potential of Organocatalysis with Light
OC01 - Exploring 3-D Pharmaceutical Space: New CH Functionalisation Reactions of Oxygen and Sulfur Heterocycles
End of the morning session
Session Chair
PL04 - Mechanism-Based Toxicities Associated With NAMPT Inhibition and Related Mitigation Strategies
PL05 - Utilizing in Depth Understanding of a Molecules Off-Target Profile to Tailor Clinical and Preclinical Safety Assessments
Coffee Break
PL06 - Reducing Bioactivation Potential of Drug Candidates: Implications for Preclinical Drug Optimization
OC02 - Small Structural Changes Leading to Major Impact on Safety: Developing Safety Strategies in Medicinal Chemistry
Panel Discussion
End of Day 2
Session Chair
PL07 - ADAS (Affinity Directed Automated Synthesis): A New Technology to Accelerate Lead Generation
PL08 - A Chemist’s Guide to Modern Phenotypic Drug Discovery
Coffee Break
OC03 - CDK8 Inhibitors with Pre-Engineerd Long Residence Time, Exhibiting Efficacy in Tumor Xenograft Models
PL09 - From Multiple Hit Series to (Pre)Clinical Candidates Using DNA-Encoded Library Technology
End of the morning session
Session Chair
PL10 - Fluorescent and Bioluminescent Sensor Proteins
OC04 - Chemical Physiology of Antibody Conjugates and Natural Products
Coffee Break
KL02 - Activity-based proteomics – Protein and Ligand Discovery on a Global Scale
End of Day 3
Session Chair
PL11 - Intracellular Delivery of Macromolecules
PL12 - New Modalities Probe and Hit Finding for Challenging Targets in Cardiovascular and Metabolic Diseases
Coffee Break
PL13 - Messenger RNA as a Novel Therapeutic Approach
OC05 - Proteolysis Targetting Chimera: A New Frontier in Medicinal Chemistry
End of the morning session
Session Chair
PL14 - New Chemical Tools for the Late Stage Functionalization of Biomolecules
PL15 - The Quest for Efficient Ligands in Asymmetric C-H Functionalizations
Coffee Break
PL16 - Catalytic Approaches to Simplifying Synthesis
OC06 - Synthetic Routes to Oxindoles via Metal Catalysis
End of the Scientific Programme on Day 4
Conference Dinner
End of Day 4
Session Chair
PL17 - Drug Discovery for Challenging Targets by X-ray Crystallographic Fragment Screening
PL18 - The Impact of Fragments on Drug Discovery
Coffee Break
OC12 - Rational Design of Small-Molecules Inhibitors of Human Cyclophilins with a Pan Viral Activities by Fragment Based Drug Design Using a Linking Strategy
OC07 - Fragment-Centric Methodologies for the Discovery of DOT1L Inhibitors
End of the morning session
Session Chair
OC08 - Discovery of Allosteric Malt1 Protease Inhibitors with High in Vivo Efficacy
OC09 - Discovery of Tak-041: A Potent and Selective Gpr139 Agonist for the Treatment of Negative Symptoms Associated with Schizophrenia
OC10 - Molecular Accessibility - Measuring and Understanding the Intracellular Free Concentration of Drugs During Lead Optimisation
OC11 - Discovery of a Ketohexokinase Inhibitor for the Treatment of Nafld/Nash: Fragment-to-Candidate via Structure-Based Drug Design and Parallel Chemistry
Coffee Break
KL03 - Novel Approaches in the Design of CNS Drug Candidates and PET Ligands
Closing Remarks
End of Symposium