13th EFMC Short Course on Medicinal Chemistry

A Matter of Time: A Kinetic Perspective on Drug-Target Interactions

 Oegstgeest (near Leiden), The Netherlands    April 23-26, 2017

Programme


17:00

Registration

18:00

Dinner

07:30

Breakfast

08:30

Introduction

09:00

Mathematics of binding kinetics

Prof. Georges VAUQUELIN
VUB, Brussel, Belgium

10:30

Coffee Break

11:00

Mathematics of binding kinetics - Part II

Prof. Georges VAUQUELIN
VUB, Brussel, Belgium

12:30

Lunch

13:30

Characterizing the Dynamics of Molecular Interactions

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

15:00

Coffee Break

15:30

Characterizing the Dynamics of Molecular Interactions - Part II

Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden

17:00

Day End

18:00

Dinner and walking tour through Leiden

07:30

Breakfast

08:30

Kinetics for drug discovery: In vitro assays to study GPCRs

Dr Laura HEITMAN
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

10:00

Coffee Break

10:30

Kinetics in Drug Discovery - A Case for G Protein-coupled Receptors

Prof. Ad P. IJZERMAN
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

12:00

Lunch

13:00

Pharmacokinetic-pharmacodynamic Relationships, the Connecting Role of Binding Kinetics

Dr Liesbeth DE LANGE
UNIVERSITY OF LEIDEN, Leiden, The Netherlands


Mr Wilbert DE WITTE
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

15:00

Coffee Break

15:30

Pharmacokinetic-pharmacodynamic Relationships, the Connecting Role of Binding Kinetics - Part II

Mr Wilbert DE WITTE
UNIVERSITY OF LEIDEN, Leiden, The Netherlands


Dr Liesbeth DE LANGE
UNIVERSITY OF LEIDEN, Leiden, The Netherlands

17:00

Day End

18:00

Dinner

07:30

Breakfast

08:30

The Use of Kinetic Data in Early Drug Discovery: HSP90 as a Model to Gain Mechanistic Insight into Drug Binding Kinetics

Dr Matthias FRECH
MERCK, Darmstadt, Germany

10:00

Coffee Break

10:30

The Use of Kinetic Data in Early Drug Discovery: HSP90 as a Model to Gain Mechanistic Insight into Drug Binding Kinetics - Part II

Dr Matthias FRECH
MERCK, Darmstadt, Germany

12:00

Wrap-up and Lunch