EFMC-ASMC'17

EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Vienna, Austria    August 27-31, 2017

Programme


09:30

Excursion 1

14:00

Registration

14:00

Excursion 2

17:00

Opening

Karin BRINER
NOVARTIS, Cambridge, United States
Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland


Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium
Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States
Thierry LANGER
UNIVERSITY OF VIENNA, Vienna, Austria

17:15

Opening Lecture
T01 - Photochemistry and Photopharmacology in Medicine

Dirk TRAUNER
NEW YORK UNIVERSITY, New York, United States

18:30

Welcome Reception

Session chair

Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

08:30

T02 - Next-Generation Small Molecule Therapeutics

James E BRADNER
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Cambridge, MA, United States

09:15

T03 - Drugging the Undruggable

Mark BUNNAGE
VERTEX PHARMACEUTICALS, Boston, United States

10:00

OC01 - Stereoselective Peptide Modifications – Efficient Tools for Natural Product and Drug Synthesis

Uli KAZMAIER
SAARLAND UNIVERSITY, Saarbrücken, Germany

10:15

Coffee Break and Exhibition

10:45

T04 - Bioinspired Asymmetric Catalysis

Helma WENNEMERS
ETH ZURICH, Zürich, Switzerland

11:30

T05 - Strategies to Facilitate the Discovery of Novel CNS PET Ligands

Lei ZHANG
PFIZER, Cambridge, United States

12:15

OC02 - Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

Peter ETTMAYER
BOEHRINGER-INGELHEIM, Vienna, Austria

12:30

Lunch and Exhibition

13:30

Poster Session 1

Session chair

Helma WENNEMERS
ETH ZURICH, Zürich, Switzerland

14:30

T06 - Single Electron Processes to Enable Organic Synthesis

Gary A. MOLANDER
UNIVERSITY OF PENNSYLVANIA, Philadelphia, United States

15:15

T07 - Beta-secretase Inhibitors as a Therapy for Alzheimer’s Disease – Where Are We Now?

Roland BÜRLI
ASTRAZENECA, Cambridge, United Kingdom

15:45

OC03 - Mimicking Nature Complexity with 3D-Fragments Assembly

Hugues LEMOINE
EDELRIS, LYON, France

16:15

Coffee Break and Exhibition

16:45

PRIZE winner EFMC-YMCS 2016
OC04 - Development of Highly Selective and Reversible Diacylglycerol Lipase Inhibitors

Freek JANSSEN
LEIDEN UNIVERSITY, Nijmegen, The Netherlands

17:00

T08 - Idea2Data: Augmenting Drug Discovery Efforts through Synthetic Reaction Data Mining and Automation

Christos A. NICOLAOU
ELI LILLY, Indianapolis, United States

17:45

T09 - A RaPID Way to Discover Pseudo-natural Peptides

Hiroaki SUGA
UNIVERSITY OF TOKYO, Tokyo, Japan

18:30

Closing of the day

Session chair

Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium

08:30

T10 - Azidoperfluoroalkanes - Neglected, Stable and Useful Fluorinated Synthons

Petr BEIER
ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, Prague, Czech Republic

09:15

T11 - HIV-1 Maturation Inhibitors

Nicholas MEANWELL
BRISTOL-MYERS SQUIBB, Wallingford, United States

10:00

OC05 - Discovery of RG7314, a Vasopressin 1a Receptor Antagonist for the Treatment of Social Communication Deficits in Autism Spectrum Disorders

Patrick SCHNIDER
F. HOFFMANN-LA ROCHE, Basel, Switzerland

10:15

Coffee Break and Exhibition

10:45

T12 - Organic Synthesis with Rearrangements - Adventures in Total Synthesis

Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria

11:30

T13 - Isosteric-Switch Strategies: New Concepts and Recent Advances

Thomas C. FESSARD
SPIROCHEM AG, Basel, Switzerland

12:15

OC06 - Expanding Screening Decks by Innovative MCR Scaffolds

Alexander DÖMLING
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands

12:30

Lunch and Exhibition

13:30

Poster Session 2

Session chair

Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

14:30

T14 - Iron(III)-Catalyzed Carbonyl-Olefin Metathesis

Corinna SCHINDLER
UNIVERSITY OF MICHIGAN, Ann Arbor, United States

15:15

T15 - Ring Construction by Pd-catalyzed C(sp3)-H Activation

Olivier BAUDOIN
UNIVERSITY OF BASEL, Basel, Switzerland

16:00

OC07 - The Discovery of Soluble Guanylate Cyclase Stimulators for the Treatment of Pulmonary Arterial Hypertension

Subharekha RAGHAVAN
MERCK & CO. INC (MSD), Kenilworth, New Jersey, United States

16:15

Coffee Break and Exhibition

16:45

T16 - Merck Drug Discovery through Enabling Capabilities

Petr VACHAL
MERCK & CO. INC (MSD), Kenilworth, United States

17:30

T17 - Adventures in Catalysis: from Mechanisms to Applications

Franziska SCHOENEBECK
RWTH AACHEN, Aachen, Germany

18:15

Closing of the day

Session chair

Thierry LANGER
UNIVERSITY OF VIENNA, Vienna, Austria

08:30

T18 - Exploiting Physical Organic Principles in Reaction Design

Ryan GILMOUR
UNIVERSITY OF MÜNSTER, Münster, Germany

09:15

T19 - Automation, Integration and Miniaturization In Drug Discovery Synthesis

Guido KOCH
NOVARTIS PHARMA AG, Schlieren, Switzerland

10:00

OC08 - Exploring New Methods for Facile Synthesis of Some Biologically Interesting Molecules

Ming-Hua XU
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, Shanghai, China

10:15

Coffee Break and Exhibition

10:45

T20 - Design and Evolution of New Biocatalysts for Organic Synthesis

Nicholas John TURNER
UNIVERSITY OF MANCHESTER, Manchester, United Kingdom

11:30

T21 - With Asymmetric Hydrogenation towards a Scalable, Stereoselective Synthesis of Bitopertin

Michelangelo SCALONE
F. HOFFMANN-LA ROCHE AG, Basel, Switzerland

12:15

OC09 - Development of Synthesis Strategies to DNA-Encoded Compound Libraries - of a Chemoresistant Sequence, and Micellar Nanoreactors

Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany

12:30

Lunch and Exhibition

13:30

Poster Session 3

Session chair

Yves P. AUBERSON
NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, Basel, Switzerland

14:30

T22 - Collaborative Academic/Industrial Research Under the Umbrella of the NSF Center for Selective C-H Functionalization

Huw DAVIES
EMORY UNIVERSITY, Atlanta, United States

15:15

Roundtable discussion: “Enabling Advances in the Science of Synthesis through Industry-Academic collaborations in the 21st Century”

16:15

Coffee Break and Exhibition

16:45

Prize Ceremony

Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium

16:50

EFMC Prize for a Young Medicinal Chemist in Academia
OC10 - Nature-Derived Peptides as Pharmacological Tools to Design Novel Therapeutics

Christian W. GRUBER
MEDICAL UNIVERSITY OF VIENNA, Vienna, Austria

17:35

EFMC Prize for a Young Medicinal Chemist in Industry:
OC11 - The Development of non-BET Bromodomain Chemical Probes

Phil HUMPHREYS
GLAXOSMITHKLINE, Stevenage, United Kingdom

17:50

T23 - Strategies towards Increasing the 3-Dimensionality of the Medicinal Chemistry Design Space

Antonia F. STEPAN
PFIZER, Basel, Switzerland

18:35

Closing of the day

20:00

Symposium banquet

Session chair

Karin BRINER
NOVARTIS, Cambridge, United States

08:30

T24 - Synthetic, Mechanistic and Computational Studies on Reactions of Interest

Scott E. DENMARK
UNIVERSITY OF ILLINOIS, Urbana, United States

09:15

T25 - More Options, More Complexity: Medicinal Chemistry Mastering Mixed Modalities

Werngard CZECHTIZKY
SANOFI, Mölndal, Sweden

10:00

OC12 - Discovery of UCB0942, the First Rationally Designed Antiepileptic Drug with a Dual Mechanism of Action for the Treatment of Drug-Resistant Epilepsy

Laurent PROVINS
UCB, Braine-l'Alleud, Belgium

10:15

Coffee break and Exhibition

10:45

T26 - DNA Repair Inhibition in Cancer Therapy: DNA-PK Inhibitor M3814

Thomas FUCHSS
MERCK KGAA, Darmstadt, Germany

11:30

T27 - Late Stage 18F-Fluorination for PET Imaging

Véronique GOUVERNEUR
UNIVERSITY OF OXFORD, Oxford, United Kingdom

12:15

Poster Prizes Ceremony

12:30

Closing remarks

13:00

End of the Symposium