RICT 2016

Interfacing Chemical Biology and Drug Discovery

52nd International Conference on Medicinal Chemistry
52èmes Rencontres Internationales de Chimie Thérapeutique

 Caen, Normandy, France    July 6-8, 2016

Scientific Programme


08:00

Registration & Welcome Coffee

09:00

RICT 2016 Opening

Prof. Patrick DALLEMAGNE
UNIVERSITY OF CAEN, Caen, France
Dr Luc VAN HIJFTE
SCT & NOVALIX, Nijmegen, The Netherlands
Prof. Pierre DENISE
UNIVERSITY OF CAEN, Caen, France

Session 1: Paul Ehrlich Award Lecture
Sponsored by Janssen Research & Development

Session Chairs

Mrs Magali MOTTE
JANSSEN R&D, Val de Reuil, France
Dr Luc VAN HIJFTE
SCT & NOVALIX, Nijmegen, The Netherlands

09:30

Paul Ehrlich Prize Lecture
Trip in Drug Discovery (PL01)

Prof. Jean-Daniel BRION
UNIVERSITÉ PARIS-SUD, Chatenay-Malabry, France

10:30

Coffee break & Exhibition

Session 2: Target Identification

Session Chair

Mr Jean-Damien CHARRIER
VERTEX PHARMACEUTICALS, OXON, United Kingdom

11:00

Human Proteomes – from Basic Biology to Understanding Drug Action (PL02)

Prof. Bernhard KÜSTER
TECHNICAL UNIVERSITY MUNICH, Munich, Germany

11:45

Target Deconvolution Efforts Around Wnt Pathway Screen Reveal Parallel Mechanisms of Action for 1,2,3-Thiadiazole-5-Carboxamide Series (PL03)

Dr Andrew ZHANG
ASTRAZENECA R&D, Waltham, United States

12:30

Lunch break & Exhibition

13:30

Poster Session 1

Session 3: Chemical Biology

Session Chair

Dr Gordon TANG
ROCHE R&D CENTER (CHINA) LTD, Shanghai, China

15:00

Protein Modification: from Chemical Biology to Drug Discovery (PL04)

Prof. Edward TATE
IMPERIAL COLLEGE LONDON, London, United Kingdom

15:45

A Role of SIRT2 in Cellular Response to Environmental Signals (PL05)

Dr Minoru YOSHIDA
RIKEN ADVANCED SCIENCE INSTITUTE (ASI), Saitama, Japan

16:30

Coffee break & Exhibition

Session 4: Inflammation and Nociception

Session Chair

Dr Henning STEINHAGEN
APTUIT, Verona, Italy

17:00

The Discovery and Optimization of Benzimidzoles as Selective NAV1.8 Blockers for the Treatment of Pain (PL06)

Dr Alan BROWN
STRATIFIED MEDICAL, Deal, United Kingdom

17:45

Optimization and Exploration of Bradykinin 1 Receptor Antagonists for Inflammation (PL07)

Dr Sven KÜHNERT
GRUENENTHAL GMBH, Aachen, Germany

18:30

Welcome Reception

20:30

End of Day 1

Session 5: Macrocycles

Session Chair

Dr Alexis DENIS
GSK, Courtaboeuf, France

08:30

Nanocyclix: a Chemical Biology Approach for Next Generation Kinase Inhibitors (PL08)

Dr Jan HOFLACK
ONCODESIGN, Dijon, France

09:45

Start of sessions

Session 6: Case Study
Sponsored by Elsevier
Session 7: Kinases
Sponsored by Elsevier
Session 6: Case Study
Sponsored by Elsevier
Session Chair
Dr Alexis DENIS
GSK, Courtaboeuf, France
Session 7: Kinases
Sponsored by Elsevier
Session Chair
Prof. Anne Sophie VOISIN-CHIRET
UNIVERSITY OF CAEN, Caen, France
10:15

Coffee break & Exhibition

Session 8: CNS Targets

Session Chair

Prof. Christophe ROCHAIS
UNIVERSITY OF CAEN, Caen, France

10:45

MT5-MMP, a New Potential Therapeutic Target in Alzheimer’s Disease (PL09)

Dr Santiago RIVERA
CNRS / AIX-MARSEILLE UNIVERSITY, Marseille, France

11:30

Discovery of Selective Dopaminergic D3 Receptor Antagonists with Potent 5HT6 Affinity (PL10)

Dr Jean-Claude ORTUNO
INSTITUT DE RECHERCHES SERVIER, SURESNES, France

12:15

Lunch break & Exhibition

13:15

Poster Session 2

13:45

Career Session

14:45

Start of sessions

Session 9: Fragment Based Drug Design
Sponsored by Elsevier
Session 10: Breakthrough in Therapeutics
Sponsored by Elsevier
Session 9: Fragment Based Drug Design
Sponsored by Elsevier
Session Chair
Dr Laure HABERKORN
INSTITUT DE RECHERCHES SERVIER, Suresnes, France
Session 10: Breakthrough in Therapeutics
Sponsored by Elsevier
Session Chair
Dr Olivier BARBERAN
ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany
15:45

Start of sessions

Session 11: Mechanism Based Approaches
Session 10 (cont'd): Breakthrough in Therapeutics
Sponsored by Elsevier
Session 11: Mechanism Based Approaches
Session Chair
Dr Francine ACHER
CNRS - UNIVERSITY PARIS DESCARTES, Paris, France
Session 10 (cont'd): Breakthrough in Therapeutics
Sponsored by Elsevier
Session Chair
Dr Olivier BARBERAN
ELSEVIER PHARMA AND BIOTECH GROUP, Frankfurt, Germany
16:30

Coffee break & Exhibition

17:00

Start of sessions

Session 12: Structure Based Drug Design
Sponsored by IPSEN
Session 13: CNS Disorders mGluR
Session 12: Structure Based Drug Design
Sponsored by IPSEN
Session Chair
Dr Olivier LAVERGNE
, Palaiseau, France
Session 13: CNS Disorders mGluR
Session Chair
Dr Pascal GEORGE
SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France
18:30

End of Day 2

20:00

Symposium Banquet

08:30

Start of sessions

Session 14: Imaging
Session 15: Molecular Diversity and Drug Efficiency
Sponsored by Galapagos
Session 14: Imaging
Session Chair
Prof. Ronan BUREAU
UNIVERSITY OF CAEN, Caen, France
Session 15: Molecular Diversity and Drug Efficiency
Sponsored by Galapagos
Session Chair
Dr Pierre DEPREZ
GALAPAGOS, Romainville, France
10:00

Coffee break & Exhibition

Session 16: Case Study - Cancer
Sponsored by Idenix, an MSD Company

Session Chair

Dr Christophe PARSY
IDENIX SARL, AN MSD COMPANY, MONTPELLIER, France

10:30

Conquering the p53-MDM2 Protein-Protein Interaction Target at Novartis (PL21)

Dr Pascal FURET
NOVARTIS, Basel, Switzerland

11:15

Discovery of the Type II Kinase Inhibitor LY3009120; a Pan-RAF Inhibitor Showing Minimal Paradoxical Activation and Anti-Cancer Activity Against BRAF or RAS Mutant Tumor Cells (PL22)

Dr James R. HENRY
ELI LILLY & CO., Indianapolis, United States

Session 17: Pierre Fabre Award Lecture

Session Chair

Dr Frédéric MARION
INSTITUT DE RECHERCHE PIERRE FABRE, Toulouse, France

12:00

Pierre Fabre Award for Therapeutic Innovation
A Scien-trepreneur Journey From Digital to In-vivo Organic Chemistry (PL23)

Dr Alain WAGNER
CNRS/UNIVERSITY OF STRASBOURG, Illkirch, France

Session 18: RICT 2016 Prizes, Future Event & Closing Remarks

13:00

RICT 2016 Closing remarks & Prizes

Prof. Janos SAPI
SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France

13:15

Introduction to RICT 2017

Dr Michel BALTAS
CNRS, UNIVERSITY OF TOULOUSE, Toulouse, France

13:30

End of Day 3 & Lunch box