ETH ZÜRICH, Milano, Italy
KL05 - Understanding Protein Unfolding and Aggregation in Cation Exchange and Protein A Chromatography Columns
UNIVERSITY OF VIRGINIA, Charlottesville, United States
Giorgio Carta is the Lawrence R. Quarles professor in the Department of Chemical Engineering at the University of Virginia. He has authored over 140 refereed journal articles in the area of protein chromatography and biochemical engineering, is a co-author of the book “Protein Chromatography – Process Development and Scale-Up” published by Wiley-VCH in 2010, and a co-author of Section 16 Adsorption and Ion Exchange of Perry's Chemical Engineers' Handbook, 7th and 8th Editions. He has served on the Organizing Committee of PREP International Symposium, Exhibit & Workshop on Preparative Chromatography annually since 1997 and continues to serve as Chair annually since 2009.
OC13 - Preparative Separation and Characterization of Charge Variants of Several Blockbuster Antibody Therapeutics
UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, VIENNA, Vienna, Austria
Nico Lingg is a postdoctoral fellow in the working group of Alois Jungbauer at the University of Natural Resources and Life Sciences (BOKU) in Vienna. He graduated with a doctoral degree at BOKU in 2014, with a thesis was focused on monoclonal antibody charge variant separation and was jointly performed at BOKU and the Bioprocessing Technology Institute in Singapore. His current research focuses on Protein separation, purification and downstream processing.
OC14 - Polyvalent Buffers in Ion Exchange Chromatography Using Salt Tolerant Resins
TOSOH BIOSCIENCE GMBH, Darmstadt, Germany
1983 Diploma thesis in chemical Thermodynamics (TH Merseburg)
1986 Ph.D. in Liquid-Liquid Equilibria Thermodynamics (TH Merseburg)
1986-1989 Head of the analytical group at the department for insulin and peptide purification at the comp. Berlin-Chemie
1990-2001 Development of resins and membranes for Bioseparation at the research department of comp. Merck KGaA (Darmstadt)
2003 Habilitation in the area of bioseparation entitled „Polymer Surface Modifications - a Method for the Preparation of Resins for Biochromatography“
2001 until today Technical Director, Separation Techniques comp. TOSOH Bioscience GmbH (Stuttgart and Griesheim)
Lecturer at the University of Darmstadt for "Industrial Biotechnology" and at the University of Karlsruhe for “Analytical Bioseparation”
OC15 - Effect of Isotherm Nonlinearity on the Retention Behaviour of Proteins in Hydrophobic Interaction and Multimodal Chromatography
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
Dorota Antos received a Ph.D. in chemical engineering from Technical University of Wroclaw, Poland, in 1998. The Ph.D. thesis was awarded by Polish Minister of Education.
She conducted research at Politecnico di Milano, Italy in 1997, at Max-Planck-Institute in Magdeburg, Germany in 1999-2001 and in the frame of Fulbright Grant, at University of Virginia in 2006.
She habilitated in the field of chromatography and adsorption at Otto-von-Guericke Universitaet in Magdeburg, Germany in 2003. In 2012 she was nominated as a full professor.
Since 2014 she is a chair of Department of Chemical Engineering and Processing, Faculty of Chemistry, of Rzeszow University of Technology, Rzeszow. Since 2016 she is a dean of Faculty of Chemistry.
OC16 - SMB Separation of Peptides
GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany
Coffee Break & Exhibition
GEORG-SIMON-OHM UNIVERSITY OF APPLIED SCIENCES, Nuernberg, Germany
OC17 - General Gradients for Preparative Protein Chomatography
LUND UNIVERSITY, Lund, Sweden
OC18 - PAT for Preparative Chromatography of Proteins: Real-Time Monitoring of a Capture and Polishing Step
KARLSRUHE INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
01/2015 - now PhD student at the Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology (KIT)
01/2014 - 10/2014 Scientist in Tech. Dev. in Downstream-Processing at Lek Pharmaceuticals d.d. (Sandoz), Slovenia
04/2013 - 12/2013 Internship on Model-based Chromatography Development in the Biologics Downstream-Processing Group, Novartis Pharma, Switzerland
03/2012 - 09/2012 Master thesis titled Studies on Multilayer Micropost Arrays in the Microsystems Group at Stanford University, California, USA
09/2011 - 02/2013 Master studies in biotechnology at the ETH Zürich, Switzerland
09/2010 - 08/2011 Bachelor studies in biotechnology at ETH Zürich, Switzerland
09/2008 - 08/2010 Basic studies in chemistry at ETH Zürich, Switzerland
OC19 - Pore Diffusion Coefficients of Proteins in Multicomponent Mixtures
BOKU VIENNA, Vienna, Austria
Alexander Matlschweiger is a PhD student in the working group of Rainer Hahn at the University of Natural Resources and Life Sciences Vienna (BOKU) in Vienna. She graduated with a degree in biotechnology at BOKU in 2014. He achieved his master’s degree at BOKU in 2012 in the field of biotechnology. Since 2012 he is working on his PhD thesis dealing with the purification of secretory antibodies from animal whey. The work is focused on the development of a fast and straight-forward purification process of the antibodies to be easily applicable in the industry.
OC20 - Improving Washing Strategies of Human Mesenchymal Stem Cells Using Negative Mode Expanded Bed Chromatography
IBET, Oeiras, Portugal
Cristina Peixoto graduated in Applied Chemistry (Branch Biotechnology) New University of Lisbon and holds a PhD in Engineering Sciences from Instituto de Tecnologia Quimica Biológica (ITQB) from New University of Lisbon.
She is invited lecturer since 2010 in several PhD programs. The main research activities are related with the development and optimization of downstream process of different products with applications as therapeutics or vaccines associated with several biological systems. She published over 50 manuscripts in refereed international journals.
Since 2009, Cristina Peixoto is responsible of the downstream process development laboratory at Animal Cell Technology Unit at IBET (Instituto de Biologia Experimental e Tecnológica) and also Project Manager in research contract projects with Industrial partners.
Lunch Break sponsored by AMPAC Fine Chemicals & Exhibition
Vendor Seminars by AKZO Nobel/Kromasil & Chiral Technologies Europe (12:30-13:30)
Poster Session 2 (odd numbers)
MERCK KGAA, Darmstadt, Germany
KL06 - Strategies for Improving the Productivity of Chromatography or Proteins
YAMAGUCHI UNIVERSITY, Ube, Japan
Professor of Chemical Engineering
Bio-Process Engineering Laboratory
School of Engineering & Graduate School of Medicine
Director, Biomedical Engineering Center(YUBEC)
Yamaguchi University, Ube, 755-8611, Japan
Birth date: July 31, 1953 Male
He received a BS degree in 1976, a MS in 1978 and a Ph. D in 1981 in the department of Food Science and technology at Kyoto University. He has been at Yamaguchi University since 1981 (Assistant Professor 1981-1988, Associate Professor 1989-1997, Professor 1998-present).
He teaches basic chemical engineering, biochemical engineering, separation engineering, transport phenomena, computer calculations for chemical engineering and process design.
His research interests are in the field of biochemical engineering, food engineering and mass transfer.
- a 2004 research excellence award from the Society of Chemical Engineers Japan
on “Engineering analysis of chromatography of proteins” and
- a 2005 research excellence award from Japan Society for Food Engineering
on “Drying of liquid foods and inactivation of enzymes during drying”.
The following paper has been recognized in the "Top-75 most cited articles" as published in the IChemE journals 2006 – 2009. Shuichi Yamamoto and Ayako Kita,
Rational design calculation method for stepwise elution chromatography of proteins,
Trans.IChemE.Part C., Food and Bioproducts Processsing, Vol.84, C1, 72-77,2006
He has published more than 100 scientific papers. Among them, his monograph published in 1988 by Marcel Dekker "Ion-Exchange Chromatography of Proteins" is well-known. His chromatography model better known as "Yamamoto Model" and “Yamamoto number” has been employed by various biotech companies as well as by academic researchers. It is partly explained in Perry's Chemical Engineering Handbook (pp.16-44, 16-45). A text book “Bioseparations Science and Engineering” by R.G.Harris et al. (Oxford press, 2003) describes in detail how to use his model with a Yamamoto number. His diffusion-based drying model is also called “Yamamoto model” as well, and has been used by many researchers.
He is a sub project leader of the National research project (Manufacturing Technology Association of Biologics).
He has also published several text books (chapters) for drying, mass transfer and adsorptions. He has been organizing a course “Basic Chemical Engineering“, for those who are working at chemical industries.
Currently he is Vice President of Asian Pacific Confederation of Chemical Engineers (APCChE) and a board member of World Chemical Engineering Council (WCEC) as a representative of the Society of Chemical Engineers, Japan (SCEJ).
He also serves as an editorial board member for the following journals; Separation Science and Technology, Preparative Biochemistry and Biotechnology, BioProcess International, Japan Journal of Food Engineering (Chief Editor).
For his university, he serves as the vice director of the university library and the director of Biomedical Engineering Center (YUBEC).
OC21 - Optimization of Primary Recovery and Downsteam Processing for Protein Purification from E. Coli Homogenates
BOKU VIENNA, Vienna, Austria
Rainer Hahn received a PhD in Biotechnology from the University of Natural Resources and Life Sciences (BOKU Vienna, Austria). Currently he is Associate Professor for Bioprocess Engineering at the Department of Biotechnology at BOKU. His general field of research is processing of biomolecules from fermentation broths and covers a full range of unit operations like centrifugation, homogenization, filtration, ultrafiltration and chromatographic techniques. Research activities are focused on preparative separations as well as mechanistic modelling and engineering aspects. He conducted several benchmark studies comparing commercial chromatography media, e.g. HIC, hydroxyapatite and Protein A affinity sorbents. Rainer Hahn is also key researcher in the Austrian Centre of Industrial Biotechnology (ACIB), a competence centre of several academic institutions and major international pharmaceutical companies. Rainer Hahn and his group are integral members of the BioIndustrial Pilot Plant at the Department of Biotechnology. This plant represents a research and training center for bioprocessing at laboratory and pilot scale. He has more than 60 peer-reviewed papers and 9 patents in the area of bioprocessing engineering and chromatography.
OC22- Influence of Mixed Electrolytes and PH on HIC-Adsorption and Partial Molar Volume of Proteins
TU KAISERSLAUTERN, Kaiserslautern, Germany
2007 - 2012: Studies in Biological and Environmental Engineering, University of Kaiserslautern
2012: Diploma thesis " Temperature dependence on adsorption of PEGylated lysozyme on a hydrophobic resin"
since 2013: PhD student, Laboratory of Engineering Thermodynamics (LTD), University of Kaiserslautern
OC23 - Negative and Positive Multi-Column Chromatographic Strategies for the Purification of Enveloped Virus-Like Particles
IBET - INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECHNOLOGICA, Oeiras, Portugal
Ricardo Silva received his PhD degree in Chemical and Biochemical Engineering from New University of Lisbon in 2013. His studies focused on the development and optimization of countercurrent adsorption processes for purification of (bio)pharmaceutical products. Since 2014 he is a postdoc at Animal Cell Technology Unit in iBET, pursuing the development of new purification strategies for vaccines, gene therapy vectors and cell based products.
Coffee Break & Exhibition
MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS, Magdeburg, Germany
OC24 - Model Predictive Control of 4-Zone Simulated Moving Bed Chromatography for the Separation of Bicalutamide Enantiomers
Ju Weon LEE
MAX-PLANCK-INSTITUTE FOR DYNAMICS OF COMPLEX TECHINCAL SYSTEMS, Magdeburg, Germany
• Feb. 1997. Bachelor, Department of Chemical Engineering, Inha University, Republic of Korea
• Feb. 1999. Master, Department of Chemical Engineering, Inha University, Republic of Korea
• Aug. 2007. Ph.D., Department of Chemical Engineering, Inha University, Republic of Korea
• “Study of retention behaviors in gradient elution and SMB process”, Inha University, Aug. 2007. Advisor: Prof. Kyung Ho Row
• Dec. 2009– Present
Postdoctoral associate, Max-Planck Institute for Dynamics of Complex Technical Systems, Sandtorstr. 1, 39106 Magdeburg, Germany Advisor: Prof. Andreas Seidel-Morgenstern
• Sept. 2007– Nov. 2009
Postdoctoral associate, School of Chemical Engineering, Purdue University, West Lafayette, IN, U.S.A. Advisor: Prof. Phillip C. Wankat
OC25 - Concurrent Modeling and Design Approach for Development of Multi-Component Simulated Moving Bed Processes
GEORGIA INSTITUTE OF TECHNOLOGY, Atlanta, United States
Yoshiaki Kawajiri is an Associate Professor and Thomas Malone Faculty Fellow in the School of Chemical & Biomolecular Engineering, and the Director of the Specialty Separation Center at Georgia Institute of Technology. He obtained his Master and Bachelor of Engineering degrees in chemical engineering from Kansai University in Osaka, Japan in 1997 and 1999, respectively. After working as an R&D engineer at Organo Corporation in Saitama, he completed his Ph.D. in chemical engineering at Carnegie Mellon University in the U.S. in 2007. Then he carried out his postdoctoral study at the Max Planck Institute for Dynamics of Complex Technical Systems in Magdeburg, Germany. His research interests include modeling, optimization, and design of chromatography processes.
OC26 - A Method for Designing Flow-Through Chromatography Processes
YAMAGUCHI UNIVERSITY, Ube, Japan
OC27 - Simulated Periodic Counter-Current Chromatography (SPCCC) - A Scale-Down Model for Multicolumn Continuous Chromatography Process Development
KARLSRUHE INSTITUTE OF TECHNOLOGY (KIT), Karlsruhe, Germany
Gang Wang is currently PhD student at Karlsruhe Institute of Technology (KIT). He earned his Ba-chelor of Science from KIT in 2012. During his internship at Roche Diagnostics in Penzberg in 2013, he focused in particular on development and chromatographic purification of recombinant mono-clonal antibodies. In 2014, he finished the Master of Science in Bio-engineering from KIT with his Master‘s thesis about the application of Optimum Experimental Design in protein chromatography modeling for model parameter estimation with increased reliability.
OC28 - Integrated Counter Current Chromatography (iCCC) - A Platform Alternative for a Protein a Free mAB and SCFV Downstream
CLAUSTHAL UNIVERSITY OF TECHNOLOGY, Clausthal-Zellerfeld, Germany
Fabian Mestmäcker was born in 1992. He studied process engineering at Technical University of Clausthal. He finished his studies with the academical degree of Bachelor of Science in 2014 and Master of Science in 2016.
At the moment, he is a scientific assistant at the institute for separation and process technology at the Technical University of Clausthal. His field of research for his PhD studies under Prof. Strube are adsorptive processes, especially continuous chromatography.