10th EFMC Short Course on Medicinal Chemistry

Small-Molecule Modulation of Protein-Protein Interactions (PPIs)

 Oegstgeest (near Leiden), The Netherlands    April 12-15, 2015

Programme


18:00

Dinner

Breakfast (as of 7:30)

08:30

Introduction

09:00

Nuclear Receptor Protein-Protein Interactions

Prof. Luc BRUNSVELD
EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands

10:30

Coffee Break

11:00

Nuclear Receptor Protein-Protein Interactions - Part II

Prof. Luc BRUNSVELD
EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands

12:30

Lunch

13:30

Stabilization of PPIs: the Other Side of PPI Modulation

Dr Christian OTTMANN
EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands

15:30

Coffee Break

16:00

Stabilization of PPIs: the Other Side of PPI Modulation - Part II

Dr Christian OTTMANN
EINDHOVEN UNIVERSITY OF TECHNOLOGY, Eindhoven, The Netherlands

17:30

Day End

Breakfast (as of 7:30)

08:30

Modern Methods for Targeting Low Affinity Protein-Protein Interactions: Structure and Function

Prof. Anna MAPP
UNIVERSITY OF MICHIGAN, Ann-Arbor, United States

10:30

Coffee Break

11:00

Modern Methods for Targeting Low Affinity Protein-Protein Interactions: Structure and Function - Part II

Prof. Anna MAPP
UNIVERSITY OF MICHIGAN, Ann-Arbor, United States

12:30

Lunch

13:30

Design and Synthesis of PPI-focussed Chemical Libraries

Dr Fabrizio GIORDANETTO
TAROS CHEMICALS, New York, United States

15:30

Coffee Break

16:00

Design and Evaluation of Biophysical Assays for the Identification of PPI-Modulators

Dr Alexander WOLF
LEAD DISCOVERY, Dortmund, Germany

17:30

Day End

Breakfast (as of 7:30)

08:30

Developing Small Molecule Inhibitors of Bromodomain-Based Protein-Protein Interactions

Prof. Stuart CONWAY
UNIVERSITY OF OXFORD, Oxford, United Kingdom

10:30

Coffee Break

11:00

Structure-Based Guided Development & Experimental Validation of a Focused Chemical Library Dedicated to Orthosteric Modulation of Protein-Protein Interactions

Dr Xavier MORELLI
CNRS, MARSEILLE CEDEX 9, France

12:30

Wrap up and Lunch