FMC 2015

Frontiers in Medicinal Chemistry

 Antwerp, Belgium    September 14-16, 2015

Vorapaxar Discovery and Clinical Benefits

Dr Patrick ANDRE
Dr Patrick ANDRE
MERCK & CO., Kenilworth, United States
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Discovery and Development of Bedaquiline: A Rocky Road

Prof. Koen ANDRIES
Prof. Koen ANDRIES
JANSSEN PHARMACEUTICA NV, Beerse, Belgium
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High Affinity Bicyclic Peptides: Application to Payloads in Oncology

Dr Gavin BENNETT
Dr Gavin BENNETT
BICYCLE THERAPEUTICS , Cambridge, United Kingdom
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A Novel Retinoic Acid Receptor Agonist for Dermatological Indications with Specific Design Parameters for Topical Administration to Manage Safety

Dr Claire BOUIX-PETER
Dr Claire BOUIX-PETER
GALDERMA R&D, Sophia-Antipolis, France
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Panellist 2

Prof. Chas BOUNTRA
Prof. Chas BOUNTRA
UNIVERSITY OF OXFORD, Oxford, United Kingdom
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Structure-Based Design of Inhibitors of Factor XIa

Dr James CORTE
Dr James CORTE
BRISTOL MYERS SQUIBB, Princeton, United States
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Sharing Compound Collections: UCB's First Experiences from the European Lead Factory

Dr Jeremy DAVIS
Dr Jeremy DAVIS
UCB, Slough, United Kingdom
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Science, Business & Innovation in Medicinal Chemistry

Prof. Iwan DE ESCH
Prof. Iwan DE ESCH
VRIJE UNIVERSITEIT AMSTERDAM, Amsterdam, The Netherlands
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Inhaled PDE4 Inhibitors with Low Emetic Potential and Long Duration of Action for the Treatment of COPD

Dr Chris DE SAVI
Dr Chris DE SAVI
ASTRAZENECA R&D, Boston, United States
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Locally-acting ROCK Inhibitors for the Treatment of Eye Diseases

Dr Olivier DEFERT
Dr Olivier DEFERT
AMAKEM, Diepenbeek, Belgium
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Revealing The Structural Basis for GPCR Drug Action through Atomic-Level Simulation

Prof. Ron DROR
Prof. Ron DROR
STANFORD UNIVERSITY, Stanford, United States
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The Discovery Of A New Validated Target For Tuberculosis Via Phenotypic Screening

Ms Raquel FERNANDEZ
Ms Raquel FERNANDEZ
GLAXOSMITHKLINE, Tres Cantos, Spain
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Drug Target Residence Time: HSP90, a Model to Gain Insight into the Molecular Mechanism of Binding

Dr Matthias FRECH
Dr Matthias FRECH
MERCK, Darmstadt, Germany
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Targeting Protein-Protein Interactions in the Heat Shock Protein 70 (Hsp70) Complex

Prof. Jason  GESTWICKI
Prof. Jason GESTWICKI
UNIVERSITY OF CALIFORNIA, San Francisco, United States
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Kinetics in Drug discovery - A Case for the Adenosine Receptors

Mr Dong GUO
Mr Dong GUO
LEIDEN UNIVERSITY, Leiden , The Netherlands

The Discovery of Chemical Probes for Bromodomain Containing Proteins
Prize winner EFMC-YMCS 2014

Dr Duncan HAY
Dr Duncan HAY
EVOTEC, Abingdon, United Kingdom
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Discovery & Optimisation of Novel Antagonists to the Human Neurokinin-3 Receptor for the Treatment of Sex-Hormone Disorders: From Hit to Clinic

Dr Hamid HOVEYDA
Dr Hamid HOVEYDA
EUROSCREEN, Woluwe-Saint-Lambert, Belgium
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Novel JAK Inhibitors for Inhaled and Topical Delivery

Dr Peter JONES
Dr Peter JONES
PFIZER, Cambridge, United States
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Discovering A Potent Allosteric Kinase Modulator Employing A Computational And Synthetic Toolbox

Mr Edwin KROON
Mr Edwin KROON
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands
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Towards 3rd Generation Antihistamines: Fact or Fiction?

Prof. Rob LEURS
Prof. Rob LEURS
VU UNIVERSITY AMSTERDAM, Amsterdam, The Netherlands
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The Role of CXCR4 Modulators in Controlling HIV Entry, Stem Cell Mobilisation and Certain Types of Cancer

Prof. Dennis LIOTTA
Prof. Dennis LIOTTA
EMORY UNIVERSITY, Atlanta, United States
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Discovery and Optimisation of Bioactive Macrocycles from DNA-Encoded Libraries

Dr Patrick MCENANEY
Dr Patrick MCENANEY
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, United States
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Panellist 1

Prof. Christa MÜLLER
Prof. Christa MÜLLER
UNIVERSITY OF BONN, Bonn, Germany
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Privileged Structures Unlocking Therapeutic Target Families

Dr Gerhard MÜLLER
Dr Gerhard MÜLLER
MERCACHEM, Martinsried, Germany
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Translating Medicinal Chemistry Research into Targeted Therapeutics. Building on Academic Knowledge

Prof. Roberto PELLICCIARI
Prof. Roberto PELLICCIARI
UNIVERSITY OF PERUGIA, Corciano, Italy
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Sanford-Burnham’s Experience with the NIH’s Molecular Libraries Program

Dr Anthony PINKERTON
Dr Anthony PINKERTON
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE, La Jolla, United States
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Targeting Factor XII in Thrombosis and Inflammation

Prof. Thomas  RENNE
Prof. Thomas RENNE
KAROLINSKA INSTITUTET, Stockholm, Sweden
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Measuring The Dynamics Of Target Engagement Inside Cells Using Bret

Dr Matthew ROBERS
Dr Matthew ROBERS
PROMEGA, Madison, United States
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Story of the Hsp27 Inhibitor Apatorsen

Dr Palma ROCCHI
Dr Palma ROCCHI
MARSEILLE CANCEROLOGY RESEARCH CENTER, Marseille, France
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Exploring Macrocycles for Protein-protein Interaction Targets: the Discovery of Novel Bifunctional XIAP Antagonists

Dr Nick TERRETT
Dr Nick TERRETT
ENSEMBLE THERAPEUTICS CORPORATION, Kriens, Switzerland
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Discovery of Highly Efficacious Potentiators for the Treatment of Cystic Fibrosis

Dr Steven VAN DER PLAS
Dr Steven VAN DER PLAS
GALAPAGOS, Mechelen, Belgium
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The Design of mGlu2 Negative Allosteric Modulators for the Treatment of Neuropsychiatric Disorders

Dr Michiel VAN GOOL
Dr Michiel VAN GOOL
JANSSEN R&D, Toledo, Spain
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Regulated Necrosis: Disease Relevance and Therapeutic Opportunities

Prof. Peter VANDENABEELE
Prof. Peter VANDENABEELE
UNIVERSITY OF GHENT, Ghent, Belgium
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Selective JAK1 Inhibitor for the Treatment of Autoimmune Diseases

Dr Michael L. VAZQUEZ
Dr Michael L. VAZQUEZ
PFIZER, Cambridge, United States
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Update on Hsp90 Inhibitors as Cancer Therapeutics

Dr Weiwen YING
Dr Weiwen YING
SYNTA PHARMACEUTICALS, Lexington, United States
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