EFMC-ASMC'15

6th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry

 Rehovot, Israel    November 15-18, 2015

Programme


Session chair:

Prof. Hans Ulrich STILZ
NOVO NORDISK, Malov, Denmark

09:00

Opening

Prof. Hans Ulrich STILZ
NOVO NORDISK, Malov, Denmark
Prof. Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium
Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States
Dr Raphael NUDELMAN
TEVA PHARMACEUTICAL INDUSTRIES, Petah Tikva, Israel

09:30

Directed Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions

Prof. Manfred T. REETZ
MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG, Mulheim / Ruhr, Germany

10:20

Coffee break and Exhibition

10:50

Studying and Targeting Deubiquitinases

Prof. Ashraf BRIK
TECHNION-ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel

11:35

Setting a Course for Biomedical Innovation in the 21st Century

Dr Alan D. PALKOWITZ
ELI LILLY & CO.

12:20

Lunch and Exhibition

Session chair:

Dr Raphael NUDELMAN
TEVA PHARMACEUTICAL INDUSTRIES, Petah Tikva, Israel

14:00

Traceless Transition Metal Catalysis for Synthetic Applications

Prof. Valentine P. ANANIKOV
ZELINSKY INSTITUTE OF ORGANIC CHEMISTRY, Moscow, Russia

14:45

Protein Imprinted Polymers. What’s the Problem Here?

Dr Bernard S. GREEN
SEMOREX TECHNOLOGIES, Ness Ziona, Israel

15:30

OC01 - A Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron-Catalyzed Chelated Radical-Anion Oxidative Coupling

Dr Doron PAPPO
BEN-GURION UNIVERSITY, Beer Sheva, Israel

15:45

Coffee break and Exhibition

16:15

OC02 - Development of Novel Nuclear Receptor Modulators Based on Silyl Functionality as Hydrophobic Core Structure

Dr Shinya FUJII
UNIVERSITY OF TOKYO, Tokyo, Japan

16:30

Chemical Research in Space and under Microgravity Conditions

Dr Shimon AMSELEM
SPACEPHARMA, Herzliya Pituach, Israel

17:15

Targeted Cancer Diagnosis and Therapy with Peptide Conjugates

Prof. Annette BECK-SICKINGER
LEIPZIG UNIVERSITY, Leipzig, Germany

18:00

Closing of the day

19:30

Welcome Reception

Session chair:

Dr Gene VAISBERG
CHEMBRIDGE CORPORATION, San Diego, United States

08:30

Crystalline Sponge Method as Applied to Pharmaceutical Studies

Prof. Makoto FUJITA
UNIVERSITY OF TOKYO, Tokyo, Japan

09:15

Stimuli-Responsive Drug Carriers for Controlled Delivery and Nano-Medicine Applications

Prof. Itamar WILLNER
THE HEBREW UNIVERSITY OF JERUSALEM, Jerusalem, Israel

10:05

Coffee break and Exhibition

10:35

Quinone-Methide Species - a Gateway to Functional Molecular Systems

Prof. Doron SHABAT
TEL AVIV UNIVERSITY, Tel Aviv, Israel

11:20

Exploration of Innovative Chemical Space for Biological Screening: the European Lead Factory Perspective

Dr Fabrizio GIORDANETTO
TAROS CHEMICALS, New York, United States

12:05

OC04 - Hypervalent Iodine Fluoroalkylating Reagents - Going Beyond Trifluoromethylation

Ms Julie CHARPENTIER
ETH ZÜRICH, Zürich, Switzerland

12:20

Lunch and Exhibition

13:00

Start of sessions

Poster Session
Company Workshops
Poster Session
13:00
Poster session (even numbers)
Company Workshops
13:00
Moving from Small Molecule Patent Searching to Patent Evaluation - Applications of SciFinder with PatentPak
Mr Paul PETERS
CAS, Hannover, Germany

Session chair:

Dr Doron PAPPO
BEN-GURION UNIVERSITY, Beer Sheva, Israel

14:00

The Art of Building Small

Prof. Ben FERINGA
UNIVERSITY OF GRONINGEN, Groningen, The Netherlands

14:45

Personalized Medicine - Will it Really Happen?

Dr Aharon SCHWARTZ
SCHWARTZ INNOVATIONS, Mevaseret Zion, Israel

15:30

OC05 - Multi-Responsive Polymeric Assemblies

Dr Roey AMIR
SCHOOL OF CHEMISTRY - TEL AVIV UNIVERSITY, Tel Aviv, Israel

15:45

Coffee break and Exhibition

16:15

Expanding Medicinal Chemistry Space: The Compact Module Initiative and Beyond

Dr Jean-Marc PLANCHER
F. HOFFMANN-LA ROCHE, Basel, Switzerland

17:00

Assembly Line Synthesis

Prof. Varinder K. AGGARWAL
UNIVERSITY OF BRISTOL, Bristol, United Kingdom

17:45

Closing of the day

Session chair:

Prof. Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium

08:30

Harnessing Fluorine - Induced Ion - Dipole Attractive Forces in Enantioselective Catalysis

Prof. Amir H. HOVEYDA
BOSTON COLLEGE, Chestnut Hill, United States

09:15

Drug Discovery in the Ubiquitin Pathway : the E3 Ligases

Dr Philippe NAKACHE
METABOMED, Yavne, Israel

10:00

OC06 - Computational Discovery of Liposomal Drugs: from in Silico Predictions to in Vivo Validation

Prof. Amiram GOLDBLUM
HEBREW UNIVERSITY OF JERUSALEM, Jerusalem, Israel

10:15

Coffee break and Exhibition

10:45

Tailor-made Enzymes –Nature’s and Ours

Dr Dan TAWFIK
WEIZMANN INSTITUTE OF SCIENCE, Rehovot, Israel

11:30

Discovery of a Potent and Selective Reversible BTK Inhibitor for the Treatment of Autoimmune Diseases

Dr Robert PULZ
NOVARTIS PHARMA, Basel, Switzerland

12:15

Prize Ceremony

12:20

EFMC Prize for a Young Medicinal Chemist in Academia
Achieving Intra-BET Selectivity of BET Bromodomain Chemical Probes: Bump-And Hole and PROTAC Approaches

Prof. Alessio CIULLI
UNIVERSITY OF DUNDEE, Dundee, United Kingdom

12:35

EFMC Prize for a Young Medicinal Chemist in Industry
Structure-Based Drug Design with G Protein-Coupled Receptors

Dr Steve ANDREWS
HEPTARES, Welwyn Garden City, United Kingdom

12:50

Lunch and Exhibition

13:15

Start of sessions

Poster Session
Company Workshops
Poster Session
13:15
Poster Session (odd numbers)
Company Workshops
13:15
Data-Driven Approaches to Medicinal Chemistry
Mr Joannis TELIORIDIS
ELSEVIER, Issy les Moulineaux , France
14:15

Free afternoon

15:00

Excursions

Session chair:

Dr Micha FRIDMAN
TEL AVIV UNIVERSITY, Ramat Aviv, Tel Aviv, Israel

08:30

Versatile Iridium Catalysts for a Broad Range of Asymmetric Transformations

Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

09:20

Challenges and Synthetic Ingenuity in the Generic World

Dr Lilach HEDVATI
TEVA, Petah-Tiqva, Israel

10:00

OC07 - Synthesis and Application of Unnatural Proline Analogues: Advanced Building Blocks for Medicinal Chemistry

Dr Pavel MYKHAILIUK
ENAMINE, Kyiv, Ukraine

10:15

Coffee break and Exhibition

10:45

Evolving GPCRs to Favorable Biophysical Properties: Enabling Drug Screening and Structural Studies

Prof. Andreas PLÜCKTHUN
UNIVERSITY OF ZÜRICH, Zurich, Switzerland

11:35

The Power of Integrated Technological Platforms to Advance Science and Medicine

Dr Berta STRULOVICI
WEIZMANN INSTITUTE OF SCIENCE, Rehovot, Israel

12:15

OC08 - Necrosis: Cellular Mechanisms and Treatment

Prof. Amnon ALBECK
BAR ILAN UNIVERSITY, Ramat Gan, Israel

12:45

Lunch and Exhibition

Session chair:

Prof. Ilan MAREK
ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel

14:00

OC09 - Catalytic Asymmetric Synthesis of Caprazamycin B and Caprazol

Dr Takumi WATANABE
INSTITUTE OF MICROBIAL CHEMISTRY (BIKAKEN), Tokyo, Japan

14:15

OC10 - Synthesis of Archazolid F and Other Novel Archazolids: Highly Potent V-Atpase Inhibitors

Mr Stephan SCHEEFF
UNIVERSITY OF BONN, Bonn, Germany

14:30

OC11 - Protecting Group-Free Strategies for The Synthesis of Nucleosides

Mr Mike DOWNEY
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY, Prague-6, Czech Republic

14:45

OC12 - Development of Anti-Influenza Drugs

Prof. Jim-Min FANG
NATIONAL TAIWAN UNIVERSITY, Taipei, Taiwan

15:00

OC13 - Cross Metathesis of Sulfonamides and Sulfoxides

Mr Adam RAJKIEWICZ
UNIVERSITY OF WARSAW, Warsaw, Poland

15:15

Coffee break and Exhibition

15:45

The Barry Cohen Award for Excellence in Medicinal Chemistry Prize Ceremony

Synthesis-Informed Design Directed at Transformative Therapies: Eradication of Hiv/Aids, Alzheimer's Disease and Resistant Cancer

Prof. Paul A. WENDER
STANFORD UNIVERSITY, Stanford, United States

16:30

Closing remarks

Prof. Ilan MAREK
ISRAEL INSTITUTE OF TECHNOLOGY, Haifa, Israel

20:00

Banquet