MedChem 2014

New Vistas in GPCR Research: the Dawn of an Exciting Drug Discovery Era?

Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV

 Braine-L'Alleud, Belgium    November 21, 2014

Programme


08:00

Registration

08:50

Opening

Dr Laurent PROVINS
UCB, Braine-l'Alleud, Belgium

09:00

L01 - GPCR-ligand Structures through the Looking Glass: Computer-Aided Prediction of GPCR-Ligand Interactions

Dr Chris DE GRAAF
VU UNIVERSITY AMSTERDAM, Cambridge, United Kingdom

09:50

L02 - Nanobodies to Study GPCR Transmembrane Signaling: From Structures to Function to Drugs

Prof. Jan STEYAERT
VUB, Brussels, Belgium

10:40

Coffee Break

11:15

OC01 - Discovery of Donecopride: Design of Dual 5-HT4R Agonists/AChE Inhibitors Multi-Target Directed Ligands for Alzheimer's Disease Treatment

Prof. Christophe ROCHAIS
UNIVERSITY OF CAEN, Caen, France

11:35

L03 - Dual A2A-NR2B Antagonists: Potential for Unprecedented Activity in Parkinson’s Disease

Mr Joël MERCIER
UCB, BRAINE-L'ALLEUD, Belgium

12:25

Sandwich Lunch

14:00

L04 - Biased Ligands, Allosteric Modulation: New Technological Approaches

Dr Stephan SCHANN
DOMAIN THERAPEUTICS, Strasbourg, France

14:50

OC02 - Novel Histamine H1-Receptor Fluorescent Antagonists for the Study of Receptor-Ligand Interactions

Dr Leigh STODDART
UNIVERISITY OF NOTTINGHAM , Nottingham, United Kingdom

15:10

OC03 - Identification of Modulators for SUCNR1 BY Screening of a SOSA Library with a Bioluminescent cAMP Assay

Mrs Julie GILISSEN
ULG, Liege, Belgium

15:30

Coffee Break and Poster Session

16:05

L05 - Developing Ligands to Validate the Role of Receptors for Long-chain Fatty Acids in the Treatment of Type II Diabetes

Prof. Graeme MILLIGAN
UNIVERSITY OF GLASGOW, Glasgow, United Kingdom

16:55

L06 - Positive Allosteric Modulators of mGlu2 Receptors for the Treatment of CNS Disorders

Dr Daniel OEHLRICH
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT, Beerse, Belgium

17:45

Closing Remarks

Prof. Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium