EFMC-ISMC 2016

XXIV EFMC International Symposium on Medicinal Chemistry

 Manchester, UK    August 28

Award & Prize Lectures

Prof. François DIEDERICH
NAUTA AWARD FOR PHARMACOCHEMISTRY
Molecular Recognition Studies with Chemical and Biological Systems: A Multi-Dimensional Approach to Support Structure-Based Drug Design
Prof. Paul J. HERGENROTHER
UCB-EHRLICH AWARD FOR EXCELLENCE IN MEDICINAL CHEMISTRY
Traversing the Valley of Death in Anticancer Drug Discovery
Dr Michael SOFIA
IUPAC-RICHTER PRIZE
The Discovery of Sofosbuvir: A Breakthrough Curative Therapy for Hepatitis C
Prof. Jan STEYAERT
PROUS INSTITUTE-OVERTON AND MEYER AWARD FOR NEW TECHNOLOGIES IN DRUG DISCOVERY
Nanobody-Enabled HTS for the Discovery of GPCR Agonists
 
 

Plenary Lectures

Prof. Klaus BOCK
The European Research Council (ERC) and its Support for Medicinal Chemistry
Prof. Jeffrey BODE
Cross-Coupling Approaches to Saturated N-Heterocycles
Sir Simon CAMPBELL
Science, Art and Drug Discovery, a Personal Perspective
Dr Derek LOWE
Robotics, Artificial Intelligence, and Medicinal Chemistry: A Look Into the Future
Prof. Dario NERI
DNA-Encoded Chemical Libraries
Prof. Tobias RITTER
Late-Stage Fluorination
Dr Anthony WOOD
Heterocycles and Medicinal Chemistry: The Importance of Innovative Synthesis 
 
 

Invited Speakers

Peptide Drugs to Target GPCR - State of the Art and Innovative Applications
Dr Carmen ALMANSA
Challenges in the Discovery of Sigma-1 Receptor Antagonists for the Treatment of Pain
Prof. Jonathan BAELL
Histone Acetyltransferase Inhibitors, from Screening to Optimization - a Tricky Track
Dr Makonen BELEMA
Direct and Synergistic Inhibition of The HCV NS5A Protein
Dr Goncalo BERNARDES
RSC Prize Lecture:
Chemical Pharmacology of Protein Conjugates and Natural Products (2016 Chem Soc Rev Emerging Investigator Lectureship)
Dr Paul BESWICK
The Painful Reality of Drug Discovery and Development
Prof. Maria Laura BOLOGNESI
Tackling Neurodegenerative Diseases Through Multi-Target and Theranostic Small Molecules
Prof. Martin D. BURKE
Towards a More Generalized and Automated Approach for Small Molecule Synthesis
Dr Michael BÖTTGER
Regorafenib Eye Drops for Wet AMD – Challenges in Translatability of Preclinical Data Into Clinical Efficacy
Prof. Giulia CARON
The Need of Implementing Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery and How to do it
Prof. Alessio CIULLI
RSC Prize Lecture:
Advanced Chemical Genetics for Epigenetics: Bump and Hole and PROTACs (2016 MedChemComm Emerging Investigator Lectureship)
Dr Miles CONGREVE
Identification of Allosteric Inhibitors of GPCRs Using SBDD
Prof. Benoit DEPREZ
Pharmacological Reversion of Antibiotic Resistance in Mycobacterium Tuberculosis : Design of SMART Trojan Molecules to Reprogram The Bacteria
Dr Eric DESARBRE
New Antibacterial Agents in the Pipeline
Prof. Alexander DÖMLING
Expanding the Macrocycle Chemical Space
Prof. Gerhard ECKER
Exploiting Linked Open Data - Transporter Profiling and Beyond
Dr Steven ELMORE
Releasing the Brake on Apoptosis. Discovery of Bcl-2 Family Protein Inhibitors
Prof. Patrick EYERS
New Pseudokinase Drug Targets in the Human Kinome
Dr Daniel FLYNN
Switch Control Inhibitors: an Advance in Type II Kinase Inhibition
Dr Fabrizio GIORDANETTO
Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry
Dr Cristiano GUIMARAES
Research, Development & Innovation at Aché Laboratórios Farmacêuticos
Dr Wolfgang HAAP
Discovery and Development of the Highly Potent, Highly Selective Cathepsin S Inhibitor RG7625 for the Treatment of Autoimmune Diseases
Prof. Christian HEINIS
Phage-Encoded Combinatorial Chemical Libraries Based on Bicyclic Peptides
Dr David HEPWORTH
The Design and Evaluation of URAT1 Inhibitors for the Treatment of Hyperuricemia and Gout
Dr Jörg HOLENZ
Discovery of AZD3241 is a Potent and Selective Myeloperoxidase Inhibitor for the Treatment of Neurodegenerative Disorders
Dr Philip HOWARD
The Development of Pyrrolobenzodiazepine in Antibody Drug Conjugates
Dr Robert T. JACOBS
Utilization of Novel Benzoxaboroles as Drug Candidates to Treat Neglected Tropical Diseases
Dr Johanna JANSEN
Inhibition of Prenylated KRAS: Tools to Discover and Characterize RAS Ligands
Dr Neil W. JOHNSON
The Identification of GSK2879552, a Mechanism Based Irreversible Inhibitor of the Histone Lysine Demethylase LSD1
Dr Eric KARRAN
Possibilities and Pitfalls: Disease Modifying Drugs for Alzheimer's Disease
Prof. Douglas KELL
The Cellular Uptake of Pharmaceutical Drugs is Transporter-Mediated - A Problem not of Biophysics but of Systems Biology
Dr Horst KESSLER
Peptides and Peptidomimetics: Overcoming Problems of Activity, Selectivity and Bioavailability of Integrin Ligands
Prof. Ross KING
Robot Scientists, the Replication Crisis, and Cancer
Prof. Stefan KNAPP
Validating New Epigenetic Targets by Selective Protein Interaction Inhibitors of Bromodomains
Dr Joe KOZLOWSKI
Discovery of the HCV NS5A Inhibitor MK-8408 (RUZASVIR)
Dr Bernd KUHN
Intramolecular Hydrogen Bonding as a Design Element in Medicinal Chemistry
Dr Jin LI
DNA-Encoded Chemical Library for Protein-Protein Interactions
Dr John LIDDLE
First Time Disclosure of a Development Candidate to Treat Severe Acute Pancreatitis through a Drug Discovery Partnership Between GSK and the University of Edinburgh
Prof. Philip S. LOW
Ligand-Targeted Therapeutic and Imaging Agents for Multiple Human Diseases
Prof. Antonio MACCHIARULO
Targeting the Janus-Faced Nature of IDO1 in Immuno-Oncology
Dr Gaëtan MISLIN
Enterobactin-Dependent Iron Uptake Pathway as a Gate for Antibiotic Trojan Horse Strategies Against Pseudomonas Aeruginosa
Dr Muneto MOGI
The Back of The Eye: Treatment Challenges and Opportunities
Prof. Carlos MONTANARI
Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors
Prof. Christa MÜLLER
Medicinal Chemistry of Purinergic Signalling: Targets and Drugs for the Immunotherapy of Cancer
Prof. Cristina NEVADO
Potent and Highly Selective Bromodomain Ligands… a Platform for Reaction Discovery
Dr Ronan O'HAGAN
Small Molecule Approaches to Immune-Modulation in Cancer
Prof. Krzysztof PALCZEWSKI
Molecular Pharmacodynamics of Visual Cycle Modulators in Protection Against Retinal Degeneration
Prof. Zhengying PAN
Targeted Covalent Inhibitors of Bruton's Tyrosine Kinases - Design, Evaluation and Follow-up
Dr Janeta POPOVICI-MULLER
Discovery of AG-120 – A First-in-class Inhibitor of IDH1 Mutant Enzymes for the Treatment of Cancers Harboring IDH1 Mutations
Dr Scott PRIESTLEY
Discovery of a First-in-Class PAR4 Antagonist as a Novel Antithrombotic
Dr Marc ROBILLARD
Antibody Imaging and Therapy Using in Vivo Click and Click-to-Release Strategies
Dr Carsten SCHMECK
Discovery of Clinical Candidate Ribuvaptan, a Dual Acting Vasopressin V1a/V2 Receptor Antagonist for the Treatment of Heart Failure
Prof. Gisbert SCHNEIDER
Big Dada in Medicinal Chemistry?
Prof. Christopher J. SCHOFIELD
Mechanistic and Inhibition Studies on Metallo-Beta-Lactamases
Prof. Giulio SUPERTI-FURGA
Solute Carriers, Metabolism and Drug Response: a Magic Triangle
Dr Masahiko TERAKADO
Discovery of Novel LPA1 Antagonist: Design and SAR Studies
Prof. Peter TIMMERMAN
Discovery & Optimzation of Clips-Constrained Bicyclic Peptides (2clips) Using Pepscan Peptide Arrays
Prof. Mariola TORTOSA
Nucleophilic Boron for the Preparation of Highly Functionalized Small Rings
Prof. Trond ULVEN
Targeting Long-Chain Fatty Acid Receptors FFA1 and FFA4 for Treatment of Metabolic Diseases
Dr Herman VAN VLIJMEN
Broad Multiparametric Profiling of Kinase Inhibitors
Dr Thomas VON GELDERN
The Discovery and Development of Novel Macrofilaricidal Agents for the Treatment of Onchocerciasis and Lymphatic Filariasis
Prof. Herbert WALDMANN
Chemical Biological Modulation of KRas-Signaling
Dr. Jon WINTER-HOLT
Small Molecule Binding Sites on the RAS: SOS Complex Can Be Exploited for Inhibition of RAS Activation
Prof. Alfred WITTINGHOFER
Studying Ciliary Trafficking and How it Leads to RAS Drug Candidates
Dr Gail WRIGLEY
Advances in the Development of Covalent EGFR Inhibitors: from Early Hits to Osimertinib
Dr Xiaomin ZHANG
Discovery of Brain-Penetrable LpPLA2 Inhibitor for Alzheimer’s Disease
Prof. Huchen ZHOU
Chemical Biology Efforts in Cancer Drug Discovery
 
 

Oral Communication

Dr Neil G BERRY
Anti-Wolbachia (A·WOL) Drug Discovery: Novel Hit Finding Via Ligand Based Virtual Screening Combined With HTS
Prof. Frank BÖCKLER
EFMC Prize for a Young Medicinal Chemist in Academia
Sigma Hole Bonding in Kinase Drug Discovery
Prof. Stuart CONWAY
Intramolecular Hydrogen Bonds in the Design of CREBBP Bromodomain Ligands
Dr Stefano CROSIGNANI
Discovery of PF-06840003, a Novel IDO1 Inhibitor for Cancer Immunotherapy
Dr Chris DE GRAAF
Mining Structural Protein-Ligand Interactions to Navigate Medicinal Chemistry Space
Dr Daniela DIGLES
Drug Targets in the Solute Carrier Classification (SLC)
Mr Luiz Antonio DUTRA
Antiplatelet and Antithrombotic Activity of 1,2,5-Oxadiazole-2-N-Oxide Derivatives
Dr Mark FRALEY
Discovery of Ubrogepant (MK-1602): a Potent, Selective and Orally Bioavailable CGRP Receptor Antagonist for the Acute Treatment of Migraine
Dr Marcus GASTREICH
The evoSpace - A Synthesis-Driven Environment that Finds Accessible, Well-Behaved Compounds by Design
Prof. Antimo GIOIELLO
Atypical Bile Acids as Chemical Probes for Diagnosis and Therapy Monitoring of Progressive Cholestatic Liver Disease in HSD3B7 Patients
Mr Xavier GÓMEZ-SANTACANA
Photoisomerisable Allosteric Modulators Allow a Fine Control of mGlu Receptors with Light in Vivo (EFMC-YMCS Presentation Prize)
Dr Mark HEALY
Optimising Membrane Interactions to Achieve Duration of Action for Inhaled Drug Candidates
Ms Shalinee JHA
Towards Low-Risk Painkillers: Human Dipeptidyl Peptidase III (hDPPIII) as a Novel Target for Therapeutic Pain Intervention
Dr Allan JORDAN
Delivering First-in-Class In Vitro Chemical Probes Against Poly (ADP Ribose) Glycohydrolase (PARG)
Dr Nir LONDON
Rapid Discovery of Potent and Selective Covalent Inhibitors via Covalent Docking
Dr Claudio MAPELLI
Attempts at Oral Delivery of a Series of Short Unnatural Peptides: Still Like Pushing a Camel Through the Eye of a Needle?
Prof. Ana MARTINEZ
Systemic Administration of an Allosteric GSK-3 Inhibitor Delays Photoreceptor Cell Death and Preserves Visual Function in a Retinitis Pigmentosa Mouse Model
Ms Leticia MONJAS GOMEZ
Exploring Hit-Identification Strategies for Energy-Coupling Factor Transporters, a Novel Target for the Development of Antibiotics
Mrs Michaela MÜLLER
Classification of Adamts Binding Sites: the First Step Toward Selective ADAMTS7 Inhibitors
Dr Philippe NANTERMET
Functionally Irreversible Non-Covalent Inhibitors of FAAH: a Safer Approach?
Dr David NORTON
From Fragment to in vivo Activity for a Challenging PPI Target: the Discovery of Potent Inhibitors of the KEAP1-NRF2 Interaction
Dr Alleyn T. PLOWRIGHT
Phenotypic Screening for the Discovery of Novel Molecules for Therapeutic Heart Regeneration
Dr Jean QUANCARD
EFMC Prize for a Young Medicinal Chemist in Industry
Inhibition of the COP9 Signalosome as a Novel Approach to Treat Cancer”
Dr Neil RANSON
How can Advances in Cryo-Electron Microscopy Revolutionize Medicinal Chemistry?
Dr Orr RAVITZ
Identifying Synthetic Opportunities Using Chemplanner - How Computers Assist Chemists in Covering a Greater Synthetic Space
Prof. Christophe ROCHAIS
Modulation of RS67,333: from a 5-HT4R Partial Agonist to the Identification of Several Promising Multi-Target Directed Ligands for Alzheimer's Disease
Mr Eduardo RUIVO
Novel Antibody-Tetrazine Conjugate for Breast Cancer Imaging
Dr Volker K. SCHULZE
Driving Tumors into Mitotic Catastrophe - Lead Generation of MPS1 Inhibitors Leading to Two Clinical Candidates BAY 1161909 and BAY 1217389
Mrs Gisele SILVESTRE DA SILVA
Effects of Novel Acylhydrazones Derived From 4-Quinolone on the Acetylcholinesterase Activity and Aβ42 Peptide Fibrils Formation
Dr Graham SMITH
Non Coding RNA as a Small Molecule Druggable Target
Dr Nicolas SOLDERMANN
First Disclosure of CDZ173 - Discovery of a New Generation of Potent and Selective PI3K Delta Inhibitors for Autoimmune and Inflammatory Diseases
Dr Michael THOMAS
The Development of DDD853651; a Potential Candidate for the Treatment of Visceral Leishmaniasis
Dr Tihomir TOMASIC
Interaction of 4,5,6,7-Tetrahydrobenzo[1,2-D]Thiazoles with the Cellular Chaperone HSP90 as a Potential Pathway to Inhibit Hepatitis C Virus Replication
Dr Dmitry TSVELIKHOVSKY
Rapid Composition of Tricyclic Spiranoid Lactones: Access to Natural Frames and Application in Selective Silencing of the Pain Receptor TRPV1
Dr Mario VAN DER STELT
Discovery of In Vivo Active and Selective Diacylglycerol Lipase-Alpha Inhibitors