RICT 2014

Interfacing Chemical Biology and Drug Discovery

50th International Conference on Medicinal Chemistry
50èmes Rencontres Internationales de Chimie Thérapeutique

 Rouen, Normandy, France    July 2-4, 2014

Programme


13:45

Opening Ceremony

Prof. Xavier PANNECOUCKE
INSA ROUEN, Saint Etienne du Rouvray, France

Prof. Hubert VAUDRY
UNIVERSITY OF ROUEN, Mont-Saint-Aignan, France


THERMO FISHER SCIENTIFIC

Mr Nicolas MAYER-ROSSIGNOL
PRÉSIDENT DU CONSEIL RÉGIONAL DE HAUTE-NORMANDIE, Rouen, France

Mr Frédéric SANCHEZ
PRÉSIDENT DE LA CREA, Rouen, France

Dr Pascal GEORGE
SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France

Session 1: Ehrlich Prize
Sponsored by Janssen-Cilag

Session Chair:

Dr Jean-François BONFANTI
JANSSEN R&D, Val de Reuil, France

14:00

Ehrlich Prize Winner
Natural Antitumor Macrolides Acting on Tubulin: Synthesis and Functional Exploration

Prof. Karl-Heinz ALTMANN
SCS DMCCB & SWISS FEDERAL INSTITUTE OF TECHNOLOGY, Zurich, Switzerland

Session 2: Epigenetics

Session Chair:

Dr Luc VAN HIJFTE
SCT & NOVALIX, Nijmegen, The Netherlands

15:00

Discovery and Optimisation of a Novel Series of EZH2 Inhibitors, Challenges and Clinical Perspectives

Dr Jean-Christophe HARMANGE
CONSTELLATION PHARMACEUTICALS, Cambridge, United States

15:45

Coffee Break and Exhibition

Session 3: Stabilized Peptides
Sponsored by Ipsen

Session Chair:

Dr Olivier LAVERGNE
., Palaiseau, France

16:45

2-Clips Peptides: A Novel Class of Biopharmaceuticals

Prof. Peter TIMMERMAN
PEPSCAN THERAPEUTICS, Lelystad, The Netherlands

17:30

Design and Applications of Protein Epitope Mimetics

Prof. John ROBINSON
UNIVERSITY OF ZÜRICH, Zürich, Switzerland

18:30

Welcome Reception

20:30

Public Lecture: La recherche des médicaments d’hier à aujourd’hui
Open to the general public of Rouen and all symposium participants (venue: Hôtel de Région, room Hémicycle)

Prof. Jean COSTENTIN
UNIVERSITY OF ROUEN, Rouen, France

Session 4: Molecular Space
Sponsored by LabEx SynOrg

Session Chair:

Prof. Xavier PANNECOUCKE
INSA ROUEN, Saint Etienne du Rouvray, France

08:30

Excursions in Uncharted Structural Space

Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland

09:15

Start of sessions

Session 5: Short Communications
Sponsored by SCT
Session 5: Short Communications
Sponsored by SCT
Session Chair:
Prof. Patrick DALLEMAGNE
UNIVERSITY OF CAEN, Caen, France
Session Chair:
Prof. Nicolas WILLAND
UNIVERSITY OF LILLE, Lille, France
10:15

Coffee Break, Exhibition and Poster Session (odd numbers)

11:00

Start of sessions

Session 7: Cardiac/Geno Safety
Session 6: Protein-protein Interactions
Sponsored by ACS
Session 7: Cardiac/Geno Safety
Session Chair:
Prof. Gérard SIEST
UNIVERSITY OF LORRAINE & PRESIDENT OF THE EUROPEAN SOCIETY OF PHARMACOGENOMICS AND THERANOSTICS, Nancy, France
Session 6: Protein-protein Interactions
Sponsored by ACS
Session Chair:
Dr Gilles GUICHARD
CBMN & IECB, UNIVERSITY OF BORDEAUX, CNRS, BORDEAUX INP, Pessac, France
12:30

Lunch

13:15

Exhibition and Poster Session (Odd numbers)

14:00

Career Session

14:30

Start of sessions

Session 9: Biophysic tools and SPR
Sponsored by NovAliX
Session 9: Biophysic tools and SPR
Sponsored by NovAliX
Session Chair:
Dr Denis ZEYER
NOVALIX, Illkirch, France
16:00

Coffee Break and Exhibition

17:15

Start of sessions

Session 10: Epigenetics
Sponsored by Inventiva
Session 11: Biophysics and Kinetics
Session 10: Epigenetics
Sponsored by Inventiva
Session Chair:
Dr Alexis DENIS
GSK, Courtaboeuf, France
Session 11: Biophysics and Kinetics
Session Chair:
Dr Frank LEEMHUIS
MERCACHEM-SYNCOM, Nijmegen, The Netherlands

Session 12: Physicochemical Properties

Session Chair:

Dr Gerardo TURCATTI
ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland

18:00

Polar Units and Dipolar Interactions Modulating, Conformation, Lipophilicity, and other Physicochemical Properties

Prof. Klaus MÜLLER
F. HOFFMANN-LA ROCHE, Switzerland

20:00

Symposium Banquet

Session 13: Kinases
Sponsored by Servier

Session Chair:

Dr Arnaud LE TIRAN
INSTITUT DE RECHERCHES SERVIER, Croissy sur Seine, France

08:30

The Lab Oddity Prevails - Discovery of pan-CDK Inhibitor BAY 1000394 (Roniciclib) for the Treatment of Cancer

Dr Ulrich LÜCKING
BAYER HEALTHCARE, Berlin, Germany

09:15

The Design and Optimisation of Selective Protein Kinase C Theta Inhibitors for the Treatment of Autoimmune Diseases

Dr Juan-Miguel JIMENEZ
VERTEX PHARMACEUTICALS, Abingdon, United Kingdom

10:00

Coffee Break, Exhibition and Poster Session (Even numbers)

Session 14: Non Standard Tools

Session Chair:

Dr Kenichiro KATAOKA
TEIJIN PHARMA LIMITED, Tokyo, Japan

10:45

Specific Antidotes for Dabigatran: Structure-Guided Affinity Optimisation and Functional Characterisation

Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany

11:30

Pseudo-Natural Product Synthesis and Drug Applications

Prof. Hiroaki SUGA
UNIVERSITY OF TOKYO, Tokyo, Japan

12:30

Lunch

13:00

Exhibition and Poster Session (Even numbers)

Session 15: CNS - Psychiatry

Session Chair:

Dr Dominique LESUISSE
SCT & SANOFI, Chilly-Mazarin, France

14:00

PDE10A Inhibitors as Potential Treatments for Schizophrenia

Dr Jose Manuel BARTOLOME
JANSSEN RESEARCH & DEVELOPMENT, Toledo, Spain

14:45

Novel Imidazoles as Selective TAAR1 Partial Agonists for the Treatment of Psychiatric Disorders

Dr Giuseppe CECERE
F. HOFFMANN-LA ROCHE, Basel, Switzerland

Session 16: Pierre Fabre Award for Therapeutic Innovation
Sponsored by Pierre Fabre

Session Chair:

Dr PHILIPPE MAILLOS
INSTITUT DE RECHERCHE PIERRE FABRE, CASTRES, France

15:30

Pierre Fabre Lecture

Prof. Sebastien PAPOT
SCT & UNIVERSITY OF POITIERS, Poitiers, France

Session 17: Closing

Session Chair:

Prof. Janos SAPI
SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France

16:15

Prizes and Closing Remarks

Session Chair:

Dr Christine CONTINO-PEPIN
UNIVERSITY OF AVIGNON, Avignon, France

16:25

RICT 2015

16:30

End of the Symposium