RICT 2014

Interfacing Chemical Biology and Drug Discovery

50th International Conference on Medicinal Chemistry
50èmes Rencontres Internationales de Chimie Thérapeutique

 Rouen, Normandy, France    July 2-4, 2014

Confirmed Speakers

Ehrlich Prize Winner
Natural Antitumor Macrolides Acting on Tubulin: Synthesis and Functional Exploration

Prof. Karl-Heinz ALTMANN
Prof. Karl-Heinz ALTMANN
SCS DMCCB & SWISS FEDERAL INSTITUTE OF TECHNOLOGY, Zurich, Switzerland
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PDE10A Inhibitors as Potential Treatments for Schizophrenia

Dr Jose Manuel BARTOLOME
Dr Jose Manuel BARTOLOME
JANSSEN RESEARCH & DEVELOPMENT, Toledo, Spain
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Recent Advances in Predicting Cardiac Risk during Drug Development

Dr Arthur BROWN
Dr Arthur BROWN
CHANTEST, Cleveland, United States
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Excursions in Uncharted Structural Space

Prof. Erick M. CARREIRA
Prof. Erick M. CARREIRA
ETH ZÜRICH, Zürich, Switzerland
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Novel Imidazoles as Selective TAAR1 Partial Agonists for the Treatment of Psychiatric Disorders

Dr Giuseppe CECERE
Dr Giuseppe CECERE
F. HOFFMANN-LA ROCHE, Basel, Switzerland
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Exploiting the Information Rich Output of SPR Biosensor Technology in Drug Discovery – From Target Evaluation to Fragment and Lead

Prof. Helena DANIELSON
Prof. Helena DANIELSON
UPPSALA UNIVERSITY, Uppsala, Sweden
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Translational Biophysics: Using Biophysical Data in Medicinal Chemistry

Dr Matthias FRECH
Dr Matthias FRECH
MERCK, Darmstadt, Germany
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Use of Peptides to Modulate Protein-Protein Interactions

Prof. Ernest GIRALT
Prof. Ernest GIRALT
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB), Barcelona, Spain
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Discovery and Optimisation of a Novel Series of EZH2 Inhibitors, Challenges and Clinical Perspectives

Dr Jean-Christophe HARMANGE
Dr Jean-Christophe HARMANGE
CONSTELLATION PHARMACEUTICALS, Cambridge, United States
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Molecular Basis of Ligand Dissociation from GPCRs – a Molecular Dynamics and Mutagenesis Study on the Adenosine A2A Receptor

Dr Laura HEITMAN
Dr Laura HEITMAN
UNIVERSITY OF LEIDEN, Leiden, The Netherlands
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The Design and Optimisation of Selective Protein Kinase C Theta Inhibitors for the Treatment of Autoimmune Diseases

Dr Juan-Miguel JIMENEZ
Dr Juan-Miguel JIMENEZ
VERTEX PHARMACEUTICALS, Abingdon, United Kingdom
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Cell Identity Loss in Cancer: a Source of New Biomarkers and Therapeutic Targets

Dr Saadi KHOCHBIN
Dr Saadi KHOCHBIN
JOSEPH FOURIER UNIVERSITY, Grenoble, France
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The Lab Oddity Prevails - Discovery of pan-CDK Inhibitor BAY 1000394 (Roniciclib) for the Treatment of Cancer

Dr Ulrich LÜCKING
Dr Ulrich LÜCKING
BAYER HEALTHCARE, Berlin, Germany
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Targeting BAX for Cancer Therapy: from Computer Screen to Mouse

Dr Luciana MARINELLI
Dr Luciana MARINELLI
UNIVERSITY OF NAPOLI, Napoli, Italy
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Polar Units and Dipolar Interactions Modulating, Conformation, Lipophilicity, and other Physicochemical Properties

Prof. Klaus MÜLLER
Prof. Klaus MÜLLER
F. HOFFMANN-LA ROCHE, Switzerland
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Specific Antidotes for Dabigatran: Structure-Guided Affinity Optimisation and Functional Characterisation

Dr Herbert NAR
Dr Herbert NAR
BOEHRINGER INGELHEIM, Biberach, Germany
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High-Throughput Chemical Microarray SPR: The Biophysical Tool for Fragment Based Screening in Drug Discovery

Dr Thomas NEUMANN
Dr Thomas NEUMANN
GRAFFINITY PHARMACEUTICALS, Illkirch, France
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Discovery of TAK-632: Pan-RAF Inhibitor with Potent Antitumor Activity against BRAF and NRAS Mutant Melanomas

Dr Masanori OKANIWA
Dr Masanori OKANIWA
TAKEDA PHARMACEUTICAL COMPANY, Kanagawa, Japan
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Chemical Probes for Epigenetics

Dr Dafydd OWEN
Dr Dafydd OWEN
PFIZER, Cambridge, United States
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Design and Applications of Protein Epitope Mimetics

Prof. John ROBINSON
Prof. John ROBINSON
UNIVERSITY OF ZÜRICH, Zürich, Switzerland
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Pseudo-Natural Product Synthesis and Drug Applications

Prof. Hiroaki SUGA
Prof. Hiroaki SUGA
UNIVERSITY OF TOKYO, Tokyo, Japan
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2-Clips Peptides: A Novel Class of Biopharmaceuticals

Prof. Peter TIMMERMAN
Prof. Peter TIMMERMAN
PEPSCAN THERAPEUTICS, Lelystad, The Netherlands
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Genotoxicity Screening can guide Lead Optimisation and Reduce Late Stage Attrition

Prof. Richard WALMSLEY
Prof. Richard WALMSLEY
UNIVERSITY OF MANCHESTER, Manchester, United Kingdom
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Strategies to Target Protein-Protein Interactions: from Discovery to Clinical Development

Prof. Shaomeng WANG
Prof. Shaomeng WANG
UNIVERSITY OF MICHIGAN, Michigan, United States
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Short Communications

Identification of Cell-penetrating Compounds and their Use for Intracellular Delivery of Cathepsin D Inhibitors

Prof. Muriel AMBLARD
Prof. Muriel AMBLARD
CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France
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Silicon-containing Tetrahydrocyclopenta[c]acridine Derivatives as CDKs Inhibitors: Design, Organometallic Synthesis, Metabolic Stability and Optimisation

Prof. Philippe BELMONT
Prof. Philippe BELMONT
UNIVERSITY PARIS DESCARTES, Paris, France
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Innovative Fluorescent-Based Approaches to GPCR Screening and Functional Architecture Studies

Prof. Dominique BONNET
Prof. Dominique BONNET
UNIVERSITY OF STRASBOURG, Illkirch, France
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Combining Organic Synthesis, Software Development and Biochemistry for the Design and Discovery of Prolyl oligopeptidase Inhibitors

Prof. Nicolas MOITESSIER
Prof. Nicolas MOITESSIER
MCGILL UNIVERSITY, Montreal, Canada
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