5th International Symposium on Advances in Synthetic and Medicinal Chemistry
Moscow, Russia
May 5-8, 2013
Registration
Pre-symposium Excursions (optional, and subject to registration)
Welcome Reception
Opening Ceremony
Session Chair
Targeting Protein Surfaces Using Designed Proteomimetics
Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to the Clinical Candidate AZD7687
New Inhibitors of the Enzyme Isoprenylcysteine Carboxyl Methyltransferase (ICMT)
Coffee break and Exhibition
Oligonucleotide Synthesis Interfaced with Molecular Biology and Nanotechnology
BETting on Epigenetic Targets : From Phenotypic Discovery to First Time in Man
Virtual Screening and Design of New Pharmaceutical Agents Using PASS Approach
Lunch and Exhibition
Session Chair
Synthetic Organic Photochemistry in Batch and Flow
The Discovery of the Macrocyclic HCV NS3/4A Protease Inhibitor MK-5172
Novel Synthetic Chemical Chaperones as a New Basis For Amyotrophic Lateral Sclerosis (ALS) Treatment
Discovery of Highly Potent S1P1 Receptor Antagonists with in vivo Efficacy
Coffee break and Exhibition
A New Approach to Tuberculosis Research: The Lilly TB Drug Discovery Initiative
Making Molecular Prosthetics via Iterative Cross-Coupling with MIDA Boronates
Closing of the day
Moscow by Night Tour (free of charge, but subject to registration)
Session Chair
Versatile Synthetic Methods: Access to Bioactive Molecules
EFMC Prize for a Young Medicinal Chemist in Academia
Chemical Approaches to Biology and Therapeutics
EFMC Prize for a Young Medicinal Chemist in Industry
Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11β-Hydroxysteroid Dehydrogenase Type 1 (11β -HSD1) Inhibitors
Rapid Kinase SAR Generation: an Integrated Approach to Synthesis, Screening and Molecular Design
Coffee break and Exhibition
Highly Anti-inflammatory Dendritic Polyglycerol Sulfates - a Multiple Target Approach
Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors
Lunch and Exhibition
Poster Session 1
Organic Molecules as Biological Probes...an exciting journey
Discovery and Initial Clinical Results of [18F]-UCB-H, First PET Radiotracer Targeting Synaptic Vesicle 2A
Self-Immolative Spacers in Prodrug/Profluorophore Strategies: Determination of Kinetic Parameters for Release of Single or Multiple Substrates.
Synthetic Approach to Novel Melatonin Receptor Ligands
Coffee break and Exhibition
The Design and Characterization of Targeted Covalent Inhibitors of Btk
P2X Receptors: ATP-Gated Ion Channels as Novel Drug Targets
Closing of the day
Session Chair
Harnessing Synergy Between Natural Products and Synthesis Towards Drug Discovery
Advances in Targeting Voltage-Gated Sodium Channels with Small Molecules
Design, Synthesis and Application Of Fluorinated Amino Acids as Labels to Study the Membrane Active Peptides by Solid State 19F NMR
Coffee break and Exhibition
Engineering of Small Non-Antibody Protein Scaffolds as Novel Biopharmaceuticals: from Anticalins to PASylation
Bitopertin (RG1678), a Potent and Selective Glycine Re-Uptake Inhibitor for the Treatment of Schizophrenia
Fragment-Based Design of Inhibitors of The Antituberculotic Target 1-Deoxy-D-Xylulose-5-Phosphate Synthase Exploiting an Innovative Combination of NMR Techniques
Lunch and Exhibition
Poster Session 2
Session Chair
New Strategies in Organic Synthesis: Recent Advances Based on Catalytic Reactions of Boron Reagents
Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture
Antibody Drug Conjugates for the Treatment of Cancer
Coffee break and Exhibition
From Organic Synthesis to Biomedical Sciences - from Polyhydroxybutyrate (PHB) to Cell-Penetrating Peptides
Closing of the day
Symposium Banquet (optional, and subject to registration)
Post-symposium Excursions (optional, and subject to registration)