MedChem 2012 - From Rapid Dissociation to Irreversible Inhibition
Optimisation of Drug-Target Residence Time

Annual One-Day Meeting on Medicinal Chemistry of SRC & KVCV

 Liège, Belgium    November 30, 2012

Programme


08:00

Registration

08:50

Opening

09:00

Looking Beyond Potency: Importance of Assessing Residence Time in Chemistry and Its Impact on Drug Discovery

Dr Yogesh SABNIS
UCB PHARMA, Braine-l'Alleud, Belgium
09:50

Kinetics in Drug Discovery. A case for G Protein-Coupled Receptors

Prof. Ad P. IJZERMAN
LEIDEN UNIVERSITY, Leiden, The Netherlands
10:40

Coffee Break

11:15

Kinetics Based Early Drug Screening : a New Application for DNA-Encoded Chemical Libraries

Dr Peter BLAKSKJÆR
VIPERGEN, Copenhagen, Denmark
11:35

A ‘Fast’ Track to Atypicality – The Discovery of JNJ37822681 for the Treatment of Schizophrenia

Dr Gregor J. MACDONALD
JANSSEN RESEARCH & DEVELOPMENT, Beerse, Belgium
12:25

Sandwich Lunch

14:00

Kinetic Screening in Drug Discovery

Prof. Andrew HOPKINS
UNIVERSITY OF DUNDEE, Dundee, United Kingdom
14:50

How to Design Better Small Molecule Ligands: a Case of CCR2 Antagonists

Mr Maris VILUMS
LEIDEN UNIVERSITY, Leiden, The Netherlands
15:10

A Computational Approach to Predict Inhibitor Binding Kinetics : the PNP Case

Dr Walter ROCCHIA
ITALIAN INSTITUTE OF TECHNOLOGY, Genova, Italy
15:30

Coffee Break and Poster Session

16:05

The Resurgence of Covalent Inhibitors

Dr Russell PETTER
CELGENE AVILOMICS RESEARCH, Bedford, United States
16:55

Irreversible Inhibitors of Serine Proteases: Tools or Drugs?

Prof. Koen AUGUSTYNS
UNIVERSITY OF ANTWERP, Antwerp, Belgium
17:45

Closing Remarks